{"id":"https://openalex.org/W162420458","doi":"https://doi.org/10.1007/978-1-4939-1176-9_17","title":"Targeting the PI3K/AKT/mTOR Pathway in Prostate Cancer","display_name":"Targeting the PI3K/AKT/mTOR Pathway in Prostate Cancer","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W162420458","doi":"https://doi.org/10.1007/978-1-4939-1176-9_17","mag":"162420458"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4939-1176-9_17","doi":"https://doi.org/10.1007/978-1-4939-1176-9_17","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4939-1176-9_17","pdf_url":null,"source":{"id":"https://openalex.org/S4210192721","display_name":"Current clinical urology","issn_l":"2197-7194","issn":["2197-7194","2197-7208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Clinical Urology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2476182623","display_name":"Management of Castration Resistant Prostate Cancer"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103085920","display_name":"Hans J. Hammers","orcid":"https://orcid.org/0000-0002-6224-4559","observed_orcids":["https://orcid.org/0000-0002-6224-4559"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hans J. Hammers","raw_affiliation_strings":["The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, CRB1-1 M45, 1650 Orleans Street, Baltimore, MD, 21231-1000, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, CRB1-1 M45, 1650 Orleans Street, Baltimore, MD, 21231-1000, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714","https://openalex.org/I4210164401"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018645768","display_name":"Emmanuel S. Antonarakis","orcid":"https://orcid.org/0000-0003-0031-9655","observed_orcids":["https://orcid.org/0000-0003-0031-9655","https://orcid.org/0000-0003-3531-3851"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emmanuel S. Antonarakis","raw_affiliation_strings":["The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, CRB1-1 M45, 1650 Orleans Street, Baltimore, MD, 21231-1000, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, CRB1-1 M45, 1650 Orleans Street, Baltimore, MD, 21231-1000, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714","https://openalex.org/I4210164401"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5103085920"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714","https://openalex.org/I4210164401"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.06880628,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"249","last_page":"252"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.9940000176429749},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.9150000214576721},{"id":"https://openalex.org/keywords/pten-loss","display_name":"PTEN loss","score":0.8539999723434448},{"id":"https://openalex.org/keywords/mtor-inhibitors","display_name":"mTOR inhibitors","score":0.984000027179718},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/everolimus","display_name":"everolimus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/temsirolimus","display_name":"temsirolimus","score":1.0},{"id":"https://openalex.org/keywords/dual-pi3k-mtor-inhibitor","display_name":"PI3K/mTOR dual inhibitor","score":0.9309999942779541},{"id":"https://openalex.org/keywords/androgen-receptor-pathway-inhibitors","display_name":"androgen receptor pathway inhibitors","score":0.8930000066757202},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8379999995231628}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.9477928876876831},{"id":"https://openalex.org/C2776820818","wikidata":"https://www.wikidata.org/wiki/Q7699074","display_name":"Temsirolimus","level":5,"score":0.7586772441864014},{"id":"https://openalex.org/C2779699572","wikidata":"https://www.wikidata.org/wiki/Q421052","display_name":"Everolimus","level":2,"score":0.7461329698562622},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.7285529375076294},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6791499853134155},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6333936452865601},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5340731739997864},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48587530851364136},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41520795226097107},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3526880443096161},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3165966272354126},{"id":"https://openalex.org/C183713625","wikidata":"https://www.wikidata.org/wiki/Q5282002","display_name":"Discovery and development of mTOR inhibitors","level":4,"score":0.3054004907608032},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27456557750701904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24816706776618958},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.08110305666923523}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4939-1176-9_17","doi":"https://doi.org/10.1007/978-1-4939-1176-9_17","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4939-1176-9_17","pdf_url":null,"source":{"id":"https://openalex.org/S4210192721","display_name":"Current clinical urology","issn_l":"2197-7194","issn":["2197-7194","2197-7208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Clinical Urology","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1682032966","https://openalex.org/W1972943971","https://openalex.org/W1977267072","https://openalex.org/W2000110198","https://openalex.org/W2006771504","https://openalex.org/W2007137602","https://openalex.org/W2027114592","https://openalex.org/W2047155047","https://openalex.org/W2073100248","https://openalex.org/W2086382688","https://openalex.org/W2107296734","https://openalex.org/W2107633226","https://openalex.org/W2114553148","https://openalex.org/W2127063807","https://openalex.org/W2148842373","https://openalex.org/W2158305336","https://openalex.org/W2165404212","https://openalex.org/W2273740586","https://openalex.org/W2586714326"],"related_works":["https://openalex.org/W2008473350","https://openalex.org/W2483602080","https://openalex.org/W2115806147","https://openalex.org/W2319564781","https://openalex.org/W7163130009","https://openalex.org/W3188824512","https://openalex.org/W2334271578","https://openalex.org/W2155968314","https://openalex.org/W7122492686","https://openalex.org/W3188367623"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}
