{"id":"https://openalex.org/W162364532","doi":"https://doi.org/10.1016/s0168-8278(05)80244-2","title":"Primary biliary cirrhosis","display_name":"Primary biliary cirrhosis","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W162364532","doi":"https://doi.org/10.1016/s0168-8278(05)80244-2","mag":"162364532","pmid":"https://pubmed.ncbi.nlm.nih.gov/8409333"},"language":"en","primary_location":{"id":"doi:10.1016/s0168-8278(05)80244-2","doi":"https://doi.org/10.1016/s0168-8278(05)80244-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-8278(05)80244-2","pdf_url":null,"source":{"id":"https://openalex.org/S83651209","display_name":"Journal of Hepatology","issn_l":"0168-8278","issn":["0168-8278","1600-0641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068853056","display_name":"Stefan G. H\u00fcbscher","orcid":"https://orcid.org/0000-0003-1609-8527","observed_orcids":["https://orcid.org/0000-0003-1609-8527"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Stefan G. Hubscher","raw_affiliation_strings":["Department of Pathology, Medical School, University of Birmingham, UK","Department of Pathology, the Medical School, University of Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Medical School, University of Birmingham, UK","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Department of Pathology, the Medical School, University of Birmingham, UK","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112125336","display_name":"Elwyn Elias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elwyn Elias","raw_affiliation_strings":["The Liver Unit, Queen Elizabeth Hospital, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Liver Unit, Queen Elizabeth Hospital, Birmingham, UK","institution_ids":["https://openalex.org/I2799307867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109245804","display_name":"John A. C. Buckels","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John A.C. Buckels","raw_affiliation_strings":["The Liver Unit, Queen Elizabeth Hospital, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Liver Unit, Queen Elizabeth Hospital, Birmingham, UK","institution_ids":["https://openalex.org/I2799307867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110006908","display_name":"A. David Mayer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. David Mayer","raw_affiliation_strings":["The Liver Unit, Queen Elizabeth Hospital, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Liver Unit, Queen Elizabeth Hospital, Birmingham, UK","institution_ids":["https://openalex.org/I2799307867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046845442","display_name":"Paul D. McMaster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul McMaster","raw_affiliation_strings":["The Liver Unit, Queen Elizabeth Hospital, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Liver Unit, Queen Elizabeth Hospital, Birmingham, UK","institution_ids":["https://openalex.org/I2799307867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009370449","display_name":"James Neuberger","orcid":"https://orcid.org/0000-0002-6079-002X","observed_orcids":["https://orcid.org/0000-0002-6079-002X"]},"institutions":[{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James M. Neuberger","raw_affiliation_strings":["The Liver Unit, Queen Elizabeth Hospital, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Liver Unit, Queen Elizabeth Hospital, Birmingham, UK","institution_ids":["https://openalex.org/I2799307867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068853056"],"corresponding_institution_ids":["https://openalex.org/I79619799"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":4.7218,"has_fulltext":false,"cited_by_count":180,"citation_normalized_percentile":{"value":0.95214021,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"18","issue":"2","first_page":"173","last_page":"184"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-biliary-cholangitis","display_name":"primary biliary cirrhosis","score":1.0},{"id":"https://openalex.org/keywords/orthotopic-liver-transplantation","display_name":"orthotopic liver transplantation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/liver-biopsy-histopathology","display_name":"liver biopsy histology","score":0.8550000190734863},{"id":"https://openalex.org/keywords/epithelioid-granulomas","display_name":"epithelioid granulomas","score":0.9010000228881836},{"id":"https://openalex.org/keywords/bile-duct-injury","display_name":"bile duct injury","score":0.9129999876022339},{"id":"https://openalex.org/keywords/ductopenia","display_name":"ductopenia","score":0.9390000104904175},{"id":"https://openalex.org/keywords/bile-ductular-proliferation","display_name":"bile ductular proliferation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/portal-fibrosis","display_name":"portal fibrosis","score":0.878000020980835},{"id":"https://openalex.org/keywords/copper-deposition","display_name":"copper deposition","score":0.9710000157356262},{"id":"https://openalex.org/keywords/micronodular-cirrhosis","display_name":"micronodular cirrhosis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/portal-inflammation","display_name":"portal inflammation","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C2780366471","wikidata":"https://www.wikidata.org/wiki/Q1072420","display_name":"Primary biliary cirrhosis","level":2,"score":0.8814707398414612},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6280296444892883},{"id":"https://openalex.org/C2994419564","wikidata":"https://www.wikidata.org/wiki/Q1072420","display_name":"Biliary cirrhosis","level":4,"score":0.5457767844200134},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5159767270088196},{"id":"https://openalex.org/C2777977315","wikidata":"https://www.wikidata.org/wiki/Q7243056","display_name":"Primary (astronomy)","level":2,"score":0.49227896332740784},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4645141661167145},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1009228527545929},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.03994414210319519},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001652","descriptor_name":"Bile Ducts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002779","descriptor_name":"Cholestasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006505","descriptor_name":"Hepatitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008105","descriptor_name":"Liver Cirrhosis, Biliary","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008105","descriptor_name":"Liver Cirrhosis, Biliary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008105","descriptor_name":"Liver Cirrhosis, Biliary","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0168-8278(05)80244-2","doi":"https://doi.org/10.1016/s0168-8278(05)80244-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-8278(05)80244-2","pdf_url":null,"source":{"id":"https://openalex.org/S83651209","display_name":"Journal of Hepatology","issn_l":"0168-8278","issn":["0168-8278","1600-0641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hepatology","raw_type":"journal-article"},{"id":"pmid:8409333","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8409333","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hepatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W51141202","https://openalex.org/W140612521","https://openalex.org/W208521481","https://openalex.org/W1503866127","https://openalex.org/W1613664893","https://openalex.org/W1617091465","https://openalex.org/W1799876023","https://openalex.org/W1960846678","https://openalex.org/W1968122174","https://openalex.org/W1979828496","https://openalex.org/W1998086920","https://openalex.org/W1998347371","https://openalex.org/W2009256994","https://openalex.org/W2016199063","https://openalex.org/W2026559399","https://openalex.org/W2028798921","https://openalex.org/W2037831395","https://openalex.org/W2044423148","https://openalex.org/W2054859285","https://openalex.org/W2078738277","https://openalex.org/W2085668981","https://openalex.org/W2094683980","https://openalex.org/W2139224962","https://openalex.org/W2143657599","https://openalex.org/W2144740719","https://openalex.org/W2171382393","https://openalex.org/W2334124108","https://openalex.org/W2338915176","https://openalex.org/W2408858656","https://openalex.org/W2413168144","https://openalex.org/W2416483464","https://openalex.org/W2461525237","https://openalex.org/W2801873603","https://openalex.org/W3025514193","https://openalex.org/W4233058507","https://openalex.org/W4233457312","https://openalex.org/W4251308287"],"related_works":["https://openalex.org/W1999764452","https://openalex.org/W2086612029","https://openalex.org/W2095611466","https://openalex.org/W2088462710","https://openalex.org/W2132632746","https://openalex.org/W2107271601","https://openalex.org/W2444206968","https://openalex.org/W1965490685","https://openalex.org/W2118600753","https://openalex.org/W2048630146"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}