{"id":"https://openalex.org/W162231871","doi":null,"title":"Generation of Dopaminergic Neurons from Human Embryonic Stem Cells","display_name":"Generation of Dopaminergic Neurons from Human Embryonic Stem Cells","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W162231871","mag":"162231871"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:kth-9591","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-9591","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-9591","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028400865","display_name":"Tandis Vazin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tandis Vazin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5028400865"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/midbrain-dopaminergic-neurons","display_name":"midbrain dopaminergic neurons","score":0.9490000009536743},{"id":"https://openalex.org/keywords/human-embryonic-stem-cells","display_name":"human embryonic stem cells","score":0.9509999752044678},{"id":"https://openalex.org/keywords/neurospheres","display_name":"neurospheres","score":0.5600000023841858},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.6069999933242798},{"id":"https://openalex.org/keywords/nigrostriatal-pathway","display_name":"nigrostriatal pathway","score":0.8560000061988831},{"id":"https://openalex.org/keywords/dopamine-transporter","display_name":"dopamine transporter","score":0.6579999923706055},{"id":"https://openalex.org/keywords/secreted-factors","display_name":"secreted factors","score":0.8870000243186951},{"id":"https://openalex.org/keywords/striatal-transplantation","display_name":"striatal transplantation","score":0.4440000057220459},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.33399999141693115},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.8812724947929382},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6139901876449585},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5153772234916687},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.5034880042076111},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4923628568649292},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46644991636276245},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.4607658386230469},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.41964587569236755},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.2745169997215271},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12285590171813965},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09517163038253784}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:kth-9591","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-9591","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:162231871","doi":null,"is_oa":false,"landing_page_url":"http://kth.diva-portal.org/smash/get/diva2:126660/FULLTEXT01","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:kth-9591","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-9591","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":406,"referenced_works":["https://openalex.org/W15418036","https://openalex.org/W32913599","https://openalex.org/W39369524","https://openalex.org/W82895945","https://openalex.org/W99762335","https://openalex.org/W101044497","https://openalex.org/W134606390","https://openalex.org/W175006040","https://openalex.org/W199354732","https://openalex.org/W368807300","https://openalex.org/W1481472040","https://openalex.org/W1482452656","https://openalex.org/W1507664203","https://openalex.org/W1515523742","https://openalex.org/W1526738019","https://openalex.org/W1527671059","https://openalex.org/W1532405552","https://openalex.org/W1533388322","https://openalex.org/W1533708729","https://openalex.org/W1539479682","https://openalex.org/W1560435618","https://openalex.org/W1561496651","https://openalex.org/W1570846537","https://openalex.org/W1576773659","https://openalex.org/W1596063541","https://openalex.org/W1599568627","https://openalex.org/W1606843899","https://openalex.org/W1622452015","https://openalex.org/W1643680178","https://openalex.org/W1656848960","https://openalex.org/W1795682777","https://openalex.org/W1822449379","https://openalex.org/W1857559187","https://openalex.org/W1922106993","https://openalex.org/W1925492557","https://openalex.org/W1930159471","https://openalex.org/W1959046600","https://openalex.org/W1963719827","https://openalex.org/W1965340376","https://openalex.org/W1965405390","https://openalex.org/W1966300591","https://openalex.org/W1966476278","https://openalex.org/W1967784117","https://openalex.org/W1968009280","https://openalex.org/W1969252837","https://openalex.org/W1969832217","https://openalex.org/W1970200774","https://openalex.org/W1970209262","https://openalex.org/W1970797118","https://openalex.org/W1971019443","https://openalex.org/W1971258758","https://openalex.org/W1971684996","https://openalex.org/W1971780034","https://openalex.org/W1972354147","https://openalex.org/W1973897139","https://openalex.org/W1974521830","https://openalex.org/W1974873948","https://openalex.org/W1975112659","https://openalex.org/W1976345822","https://openalex.org/W1976637499","https://openalex.org/W1978387829","https://openalex.org/W1978590853","https://openalex.org/W1978809889","https://openalex.org/W1979670158","https://openalex.org/W1980202815","https://openalex.org/W1980505651","https://openalex.org/W1981088384","https://openalex.org/W1981364695","https://openalex.org/W1981437331","https://openalex.org/W1981621010","https://openalex.org/W1981821582","https://openalex.org/W1982501879","https://openalex.org/W1982527650","https://openalex.org/W1983274440","https://openalex.org/W1984288177","https://openalex.org/W1984680724","https://openalex.org/W1984767115","https://openalex.org/W1984942174","https://openalex.org/W1985623406","https://openalex.org/W1986757689","https://openalex.org/W1988791308","https://openalex.org/W1988865085","https://openalex.org/W1989194294","https://openalex.org/W1989558097","https://openalex.org/W1989877475","https://openalex.org/W1989915490","https://openalex.org/W1990185237","https://openalex.org/W1990280414","https://openalex.org/W1990726987","https://openalex.org/W1992068513","https://openalex.org/W1992838550","https://openalex.org/W1992865216","https://openalex.org/W1993534485","https://openalex.org/W1994055253","https://openalex.org/W1994254814","https://openalex.org/W1994651714","https://openalex.org/W1994984635","https://openalex.org/W1996492268","https://openalex.org/W1996659151","https://openalex.org/W1998041123","https://openalex.org/W1998052230","https://openalex.org/W1998777048","https://openalex.org/W1999914688","https://openalex.org/W2000453258","https://openalex.org/W2000572318","https://openalex.org/W2000734457","https://openalex.org/W2001248401","https://openalex.org/W2001977333","https://openalex.org/W2002506451","https://openalex.org/W2002508731","https://openalex.org/W2002559713","https://openalex.org/W2002930046","https://openalex.org/W2003357682","https://openalex.org/W2003932465","https://openalex.org/W2004201400","https://openalex.org/W2004275727","https://openalex.org/W2004314923","https://openalex.org/W2004338203","https://openalex.org/W2004596698","https://openalex.org/W2004872916","https://openalex.org/W2005296007","https://openalex.org/W2005646823","https://openalex.org/W2005972147","https://openalex.org/W2006136865","https://openalex.org/W2008289317","https://openalex.org/W2008827081","https://openalex.org/W2008995006","https://openalex.org/W2011850308","https://openalex.org/W2012426004","https://openalex.org/W2012899237","https://openalex.org/W2013170765","https://openalex.org/W2013393348","https://openalex.org/W2013734734","https://openalex.org/W2014572511","https://openalex.org/W2015160990","https://openalex.org/W2015500392","https://openalex.org/W2015710294","https://openalex.org/W2015974087","https://openalex.org/W2016526297","https://openalex.org/W2017020944","https://openalex.org/W2017049975","https://openalex.org/W2019480285","https://openalex.org/W2020005796","https://openalex.org/W2021133234","https://openalex.org/W2021721582","https://openalex.org/W2021823732","https://openalex.org/W2022000183","https://openalex.org/W2022257616","https://openalex.org/W2023009416","https://openalex.org/W2023315677","https://openalex.org/W2023792909","https://openalex.org/W2024861179","https://openalex.org/W2024977477","https://openalex.org/W2027027008","https://openalex.org/W2027050775","https://openalex.org/W2027246053","https://openalex.org/W2027309763","https://openalex.org/W2028497134","https://openalex.org/W2029115771","https://openalex.org/W2030180991","https://openalex.org/W2030997373","https://openalex.org/W2031317888","https://openalex.org/W2031807447","https://openalex.org/W2032126895","https://openalex.org/W2032138788","https://openalex.org/W2032278237","https://openalex.org/W2032616821","https://openalex.org/W2033284482","https://openalex.org/W2033290532","https://openalex.org/W2033291406","https://openalex.org/W2033956559","https://openalex.org/W2034302726","https://openalex.org/W2034564714","https://openalex.org/W2034745491","https://openalex.org/W2034951155","https://openalex.org/W2035687277","https://openalex.org/W2035786076","https://openalex.org/W2036519060","https://openalex.org/W2037388456","https://openalex.org/W2038210942","https://openalex.org/W2039824179","https://openalex.org/W2040111843","https://openalex.org/W2041695960","https://openalex.org/W2041844029","https://openalex.org/W2041901744","https://openalex.org/W2042109654","https://openalex.org/W2042598793","https://openalex.org/W2042750514","https://openalex.org/W2042895504","https://openalex.org/W2043173210","https://openalex.org/W2043300325","https://openalex.org/W2043622238","https://openalex.org/W2043713881","https://openalex.org/W2043726739","https://openalex.org/W2045497152","https://openalex.org/W2045839099","https://openalex.org/W2045899482","https://openalex.org/W2046450144","https://openalex.org/W2047982757","https://openalex.org/W2048064435","https://openalex.org/W2048643498","https://openalex.org/W2050041497","https://openalex.org/W2050232580","https://openalex.org/W2050786534","https://openalex.org/W2050907040","https://openalex.org/W2052583566","https://openalex.org/W2052615066","https://openalex.org/W2052898353","https://openalex.org/W2053727139","https://openalex.org/W2054174339","https://openalex.org/W2054300604","https://openalex.org/W2054438521","https://openalex.org/W2054463240","https://openalex.org/W2054703329","https://openalex.org/W2054779757","https://openalex.org/W2054810445","https://openalex.org/W2055110202","https://openalex.org/W2055981668","https://openalex.org/W2056707698","https://openalex.org/W2056994384","https://openalex.org/W2057159461","https://openalex.org/W2057962057","https://openalex.org/W2058500387","https://openalex.org/W2058695074","https://openalex.org/W2059362512","https://openalex.org/W2059614045","https://openalex.org/W2060299616","https://openalex.org/W2061185374","https://openalex.org/W2061253933","https://openalex.org/W2061657391","https://openalex.org/W2061681231","https://openalex.org/W2062508396","https://openalex.org/W2062849851","https://openalex.org/W2063213362","https://openalex.org/W2063503250","https://openalex.org/W2064202144","https://openalex.org/W2064953018","https://openalex.org/W2065275335","https://openalex.org/W2065564530","https://openalex.org/W2065601975","https://openalex.org/W2065796189","https://openalex.org/W2065978481","https://openalex.org/W2066413879","https://openalex.org/W2066717075","https://openalex.org/W2067466635","https://openalex.org/W2068437492","https://openalex.org/W2068602040","https://openalex.org/W2068718620","https://openalex.org/W2069236638","https://openalex.org/W2070672203","https://openalex.org/W2071189762","https://openalex.org/W2071948878","https://openalex.org/W2073812826","https://openalex.org/W2074030659","https://openalex.org/W2074245416","https://openalex.org/W2075453897","https://openalex.org/W2075927534","https://openalex.org/W2076098479","https://openalex.org/W2076397245","https://openalex.org/W2076695294","https://openalex.org/W2076892678","https://openalex.org/W2078918257","https://openalex.org/W2079694641","https://openalex.org/W2082292567","https://openalex.org/W2082851956","https://openalex.org/W2083224632","https://openalex.org/W2083249373","https://openalex.org/W2083312275","https://openalex.org/W2083939751","https://openalex.org/W2084412384","https://openalex.org/W2084543881","https://openalex.org/W2085518524","https://openalex.org/W2086074591","https://openalex.org/W2086857730","https://openalex.org/W2086943348","https://openalex.org/W2088088839","https://openalex.org/W2089138901","https://openalex.org/W2089383143","https://openalex.org/W2089683266","https://openalex.org/W2089734647","https://openalex.org/W2090217399","https://openalex.org/W2090356618","https://openalex.org/W2090661065","https://openalex.org/W2090966817","https://openalex.org/W2091790925","https://openalex.org/W2092079816","https://openalex.org/W2092085550","https://openalex.org/W2092283730","https://openalex.org/W2094697836","https://openalex.org/W2095022753","https://openalex.org/W2096021672","https://openalex.org/W2096657752","https://openalex.org/W2098509726","https://openalex.org/W2101362932","https://openalex.org/W2101763092","https://openalex.org/W2102091298","https://openalex.org/W2102842575","https://openalex.org/W2102974928","https://openalex.org/W2103017866","https://openalex.org/W2104027922","https://openalex.org/W2104269891","https://openalex.org/W2105508698","https://openalex.org/W2105688544","https://openalex.org/W2106411439","https://openalex.org/W2107486301","https://openalex.org/W2107499423","https://openalex.org/W2108401330","https://openalex.org/W2108613636","https://openalex.org/W2108758429","https://openalex.org/W2109972689","https://openalex.org/W2110301828","https://openalex.org/W2111191613","https://openalex.org/W2111334408","https://openalex.org/W2111473755","https://openalex.org/W2111525324","https://openalex.org/W2111837903","https://openalex.org/W2112053431","https://openalex.org/W2112174848","https://openalex.org/W2112877380","https://openalex.org/W2114737664","https://openalex.org/W2115628640","https://openalex.org/W2116334147","https://openalex.org/W2116715929","https://openalex.org/W2117058176","https://openalex.org/W2119092360","https://openalex.org/W2119284420","https://openalex.org/W2120672831","https://openalex.org/W2121530025","https://openalex.org/W2124868173","https://openalex.org/W2125014620","https://openalex.org/W2126499376","https://openalex.org/W2127228122","https://openalex.org/W2127300454","https://openalex.org/W2127333745","https://openalex.org/W2127362646","https://openalex.org/W2128033750","https://openalex.org/W2128087515","https://openalex.org/W2129534940","https://openalex.org/W2132333739","https://openalex.org/W2132950259","https://openalex.org/W2133241531","https://openalex.org/W2135180965","https://openalex.org/W2135425431","https://openalex.org/W2136125227","https://openalex.org/W2138088258","https://openalex.org/W2138178479","https://openalex.org/W2138442302","https://openalex.org/W2138462240","https://openalex.org/W2138979073","https://openalex.org/W2139373056","https://openalex.org/W2139727029","https://openalex.org/W2141115444","https://openalex.org/W2142115579","https://openalex.org/W2143819718","https://openalex.org/W2147015050","https://openalex.org/W2148512749","https://openalex.org/W2148633182","https://openalex.org/W2150163104","https://openalex.org/W2150656456","https://openalex.org/W2150817988","https://openalex.org/W2150857721","https://openalex.org/W2151557352","https://openalex.org/W2152200638","https://openalex.org/W2153556389","https://openalex.org/W2153932596","https://openalex.org/W2154046995","https://openalex.org/W2154069538","https://openalex.org/W2154610626","https://openalex.org/W2155639936","https://openalex.org/W2159791483","https://openalex.org/W2159999899","https://openalex.org/W2160266371","https://openalex.org/W2161264600","https://openalex.org/W2161276023","https://openalex.org/W2161822359","https://openalex.org/W2161949020","https://openalex.org/W2162054698","https://openalex.org/W2162811821","https://openalex.org/W2164007801","https://openalex.org/W2165747554","https://openalex.org/W2167102345","https://openalex.org/W2167266034","https://openalex.org/W2169859308","https://openalex.org/W2171248814","https://openalex.org/W2171281715","https://openalex.org/W2171298950","https://openalex.org/W2171864329","https://openalex.org/W2172503413","https://openalex.org/W2183282212","https://openalex.org/W2184947876","https://openalex.org/W2231280347","https://openalex.org/W2261797661","https://openalex.org/W2267177307","https://openalex.org/W2317804643","https://openalex.org/W2318463768","https://openalex.org/W2321447516","https://openalex.org/W2322912881","https://openalex.org/W2334461448","https://openalex.org/W2396346835","https://openalex.org/W2400944989","https://openalex.org/W2400982678","https://openalex.org/W2461508939","https://openalex.org/W2464261275","https://openalex.org/W2488670476","https://openalex.org/W2796575992","https://openalex.org/W2992136976"],"related_works":["https://openalex.org/W2144093871","https://openalex.org/W2037562977","https://openalex.org/W2111191613","https://openalex.org/W1650660125","https://openalex.org/W4405180799","https://openalex.org/W2157071148","https://openalex.org/W4380344753","https://openalex.org/W1966476278","https://openalex.org/W576298966","https://openalex.org/W2071001529"],"abstract_inverted_index":{"Since":[0],"the":[1,17,31,47,79,97,112,145,154,162,193,245,256,266,332,343,359,387,392,398,413,470,495],"first":[2],"successful":[3],"derivation":[4],"of":[5,19,23,34,42,67,73,75,96,114,148,215,244,258,265,303,308,335,341,346,374,396,402,409,418,477,499,509],"human":[6],"embryonic":[7],"stem":[8],"cells":[9,25,37,187,204,318,404,434],"(hESC),":[10],"rapid":[11],"progress":[12],"has":[13,135],"been":[14,136],"attained":[15],"in":[16,21,46,65,78,101,199,225,239,276,310,325,337,432,487,516],"development":[18,427],"strategies":[20],"differentiation":[22,104,243,291,476],"these":[24,36,317,463],"into":[26,221,331],"various":[27],"neural":[28,185,210],"lineages,":[29],"with":[30,84,425],"fundamental":[32],"objective":[33],"using":[35],"for":[38,181,263,282,371,391,523],"replacement":[39],"and":[40,109,178,195,212,219,234,242,261,321,350,367,458,481,506],"repair":[41],"damaged":[43],"neuronal":[44,232,475],"circuits":[45],"central":[48,63],"nervous":[49],"system":[50],"(CNS).":[51],"Of":[52],"particular":[53],"interest":[54],"are":[55],"midbrain":[56],"dopaminergic":[57,107,183,339,474],"(mDA)":[58],"neurons,":[59],"which":[60],"play":[61],"a":[62,106,208,251,297,504,517,521],"role":[64,334],"regulation":[66],"voluntary":[68],"movement.":[69],"Degeneration":[70],"or":[71,122,528],"loss":[72],"function":[74],"mDA":[76,141,157,223,229],"neurons":[77,142,158,224,230,515],"nigrostriatal":[80],"pathway":[81],"is":[82,92,150,179],"associated":[83,424],"Parkinson":[85],"disease":[86],"(PD).":[87],"Stromal-Derived":[88],"Inducing":[89],"Activity":[90],"(SDIA)":[91],"recognized":[93],"as":[94,120,280,437],"one":[95],"most":[98],"efficient":[99],"methods":[100],"restricting":[102],"ESC":[103,126],"to":[105,111,124,127,129,139,197,207,284,385,407,422,469,512],"lineage,":[108,211],"refers":[110],"property":[113,498],"mouse":[115],"stromal":[116,446],"cell":[117,347,361,365,410,526],"lines":[118,411,486],"such":[119],"PA6":[121,360,403,433],"MS5":[123],"cause":[125],"differentiate":[128,198],"DA":[130,290,380,393,439,496,514],"neurons.":[131],"Although":[132],"this":[133],"strategy":[134],"extensively":[137],"used":[138],"generate":[140],"from":[143,161,192],"hESC,":[144,342,375,471],"biochemical":[146,333],"nature":[147],"SDIA":[149,171,336],"yet":[151],"unknown.":[152],"In":[153,383],"present":[155],"study":[156],"were":[159,189,205,213,353,429,435,467],"generated":[160],"BG01V2":[163,480],"hESC":[164,177,478,485,511],"line":[165],"by":[166,250,278],"SDIA.":[167,500],"To":[168,327],"examine":[169],"whether":[170],"exerts":[172],"its":[173],"effect":[174],"directly":[175],"on":[176],"responsible":[180,370,390],"early":[182,338],"induction,":[184],"progenitor":[186],"(NPC)":[188],"enyzmatically":[190],"isolated":[191,203],"co-cultures":[194],"allowed":[196],"feeder-free":[200,226],"conditions.":[201,227],"The":[202,228,238,271,355],"committed":[206],"mesencephalic":[209,267],"capable":[214],"maintaining":[216],"their":[217,289,323],"phenotype":[218,299,324],"developing":[220],"postmitotic":[222],"showed":[231],"excitability":[233],"dopamine":[235],"transporter":[236],"function.":[237],"vitro":[240,277],"proliferation":[241,264],"NPC":[246,268,272],"was":[247,269,368,405],"also":[248],"investigated":[249],"BrDU":[252],"incorporation":[253],"assay.":[254],"Next,":[255],"maintenance":[257],"cellular":[259],"memory":[260],"capacity":[262],"assessed.":[270],"could":[273,319],"be":[274,423],"expanded":[275],"five-fold":[279],"neurospheres":[281,309],"up":[283],"two":[285],"weeks":[286],"while":[287],"retaining":[288],"potential,":[292],"but":[293],"did":[294],"not":[295],"retain":[296],"stable":[298],"over":[300],"extended":[301],"periods":[302],"time.":[304],"Preliminary":[305],"transplantation":[306],"experiments":[307],"striatal":[311],"lesioned":[312],"animals":[313],"indicated,":[314],"however,":[315],"that":[316,358,408,428,492],"survive":[320],"conserve":[322],"vivo.":[326],"gain":[328],"additional":[329],"insight":[330],"induction":[340],"separate":[344],"contributions":[345],"surface":[348,362],"activity":[349,363],"secreted":[351,377],"factors":[352,378,389,420],"examined.":[354],"data":[356],"revealed":[357],"promoted":[364],"survival":[366],"mainly":[369],"enhanced":[372],"neurogenesis":[373],"whereas":[376],"provided":[379],"lineage-specific":[381],"instructions.":[382],"order":[384],"identify":[386],"soluble":[388,419],"phenotype-inducing":[394,497],"component":[395],"SDIA,":[397],"gene":[399],"expression":[400],"profile":[401],"compared":[406],"lacking":[412],"DA-inducing":[414],"property.":[415],"A":[416],"number":[417],"known":[421],"CNS":[426],"highly":[430],"expressed":[431],"identified":[436],"potential":[438],"differentiation-inducing":[440],"candidates.":[441],"These":[442],"differentially-expressed":[443],"genes":[444],"included":[445],"cell-derived":[447],"factor":[448,455],"1":[449],"(SDF-1/CXCL12),":[450],"pleiotrophin":[451],"(PTN),":[452],"insulin-like":[453],"growth":[454],"2":[456],"(IGF2),":[457],"ephrin":[459],"B1":[460],"(EFNB1).":[461],"When":[462],"factors,":[464],"termed":[465],"SPIE,":[466],"applied":[468],"they":[472],"induced":[473],"line,":[479],"other":[482],"karyotypically":[483],"normal":[484],"vitro.":[488],"Thus,":[489],"it":[490],"appears":[491],"SPIE":[493],"comprises":[494],"This":[501],"may":[502],"provide":[503],"simple":[505],"direct":[507],"means":[508],"differentiating":[510],"form":[513],"single":[518],"step,":[519],"without":[520],"requirement":[522],"co-culture,":[524],"animal":[525,529],"lines,":[527],"products.":[530]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
