{"id":"https://openalex.org/W162187101","doi":"https://doi.org/10.1007/978-3-642-30018-9_209","title":"Reactive Oxygen Species \u2013 Key Immune Mediators in Type 1 Diabetes","display_name":"Reactive Oxygen Species \u2013 Key Immune Mediators in Type 1 Diabetes","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W162187101","doi":"https://doi.org/10.1007/978-3-642-30018-9_209","mag":"162187101"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-642-30018-9_209","doi":"https://doi.org/10.1007/978-3-642-30018-9_209","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-30018-9_209","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Systems Biology of Free Radicals and Antioxidants","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2548559942","display_name":"Systems Biology of Free Radicals and Antioxidants"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060109722","display_name":"Lindsey E. Padgett","orcid":"https://orcid.org/0000-0002-2925-0076","observed_orcids":["https://orcid.org/0000-0002-2925-0076"]},"institutions":[{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsey E. Padgett","raw_affiliation_strings":["Department of Microbiology, Comprehensive Diabetes Center, University of Alabama \u2013 Birmingham School of Medicine, Birmingham, USA","Comprehensive Diabetes Center, University of Alabama \u2013 Birmingham School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Comprehensive Diabetes Center, University of Alabama \u2013 Birmingham School of Medicine, Birmingham, USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Comprehensive Diabetes Center, University of Alabama \u2013 Birmingham School of Medicine","institution_ids":["https://openalex.org/I17301866","https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025318890","display_name":"Ashley R. Burg","orcid":"https://orcid.org/0000-0001-7754-8355","observed_orcids":["https://orcid.org/0000-0001-7754-8355"]},"institutions":[{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley R. Burg","raw_affiliation_strings":["Department of Microbiology, Comprehensive Diabetes Center, University of Alabama \u2013 Birmingham School of Medicine, Birmingham, USA","Comprehensive Diabetes Center, University of Alabama \u2013 Birmingham School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Comprehensive Diabetes Center, University of Alabama \u2013 Birmingham School of Medicine, Birmingham, USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Comprehensive Diabetes Center, University of Alabama \u2013 Birmingham School of Medicine","institution_ids":["https://openalex.org/I17301866","https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026708404","display_name":"Hubert Ming Tse","orcid":"https://orcid.org/0000-0001-5861-7597","observed_orcids":["https://orcid.org/0000-0001-5861-7597"]},"institutions":[{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hubert M. Tse","raw_affiliation_strings":["Department of Microbiology, Comprehensive Diabetes Center, University of Alabama \u2013 Birmingham School of Medicine, Birmingham, USA","Comprehensive Diabetes Center, University of Alabama \u2013 Birmingham School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Comprehensive Diabetes Center, University of Alabama \u2013 Birmingham School of Medicine, Birmingham, USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Comprehensive Diabetes Center, University of Alabama \u2013 Birmingham School of Medicine","institution_ids":["https://openalex.org/I17301866","https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026708404"],"corresponding_institution_ids":["https://openalex.org/I17301866","https://openalex.org/I32389192","https://openalex.org/I4390039250"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04582133,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"3493","last_page":"3520"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9440000057220459},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9919999837875366},{"id":"https://openalex.org/keywords/autoimmune-diabetes","display_name":"autoimmune diabetes","score":0.47999998927116394},{"id":"https://openalex.org/keywords/pancreatic-beta-cell-death","display_name":"pancreatic beta-cell destruction","score":0.7929999828338623},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9940000176429749},{"id":"https://openalex.org/keywords/redox-signaling","display_name":"redox signaling","score":0.9110000133514404},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.9440000057220459},{"id":"https://openalex.org/keywords/macrophage-phenotype","display_name":"macrophage phenotype","score":0.734000027179718},{"id":"https://openalex.org/keywords/viral-triggers","display_name":"viral triggers","score":0.7770000100135803},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.9539999961853027},{"id":"https://openalex.org/keywords/diabetogenic-t-cells","display_name":"diabetogenic T cells","score":0.8600000143051147},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6501304507255554},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.5966644883155823},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5504926443099976},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5471280813217163},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5462054014205933},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5141535401344299},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4962936043739319},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4821302890777588},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.44576090574264526},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4419037401676178},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.41594892740249634},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.08690458536148071},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05910733342170715},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-642-30018-9_209","doi":"https://doi.org/10.1007/978-3-642-30018-9_209","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-30018-9_209","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Systems Biology of Free Radicals and Antioxidants","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":175,"referenced_works":["https://openalex.org/W109978787","https://openalex.org/W111394220","https://openalex.org/W208343037","https://openalex.org/W220993559","https://openalex.org/W1509560407","https://openalex.org/W1527257674","https://openalex.org/W1550431800","https://openalex.org/W1562045776","https://openalex.org/W1562441478","https://openalex.org/W1573317982","https://openalex.org/W1573547824","https://openalex.org/W1582379379","https://openalex.org/W1585826109","https://openalex.org/W1586099293","https://openalex.org/W1587695215","https://openalex.org/W1598004361","https://openalex.org/W1598741049","https://openalex.org/W1602691311","https://openalex.org/W1606441102","https://openalex.org/W1639627597","https://openalex.org/W1804861156","https://openalex.org/W1925035762","https://openalex.org/W1933681664","https://openalex.org/W1950487794","https://openalex.org/W1963651122","https://openalex.org/W1964399995","https://openalex.org/W1964641780","https://openalex.org/W1965056301","https://openalex.org/W1966599724","https://openalex.org/W1967291007","https://openalex.org/W1967727543","https://openalex.org/W1971683622","https://openalex.org/W1971692004","https://openalex.org/W1972272933","https://openalex.org/W1974601505","https://openalex.org/W1976018499","https://openalex.org/W1976043505","https://openalex.org/W1976874472","https://openalex.org/W1979769420","https://openalex.org/W1979912709","https://openalex.org/W1984858835","https://openalex.org/W1984959662","https://openalex.org/W1987478650","https://openalex.org/W1988225951","https://openalex.org/W1989026631","https://openalex.org/W1989488426","https://openalex.org/W1990092210","https://openalex.org/W1991033052","https://openalex.org/W1992607364","https://openalex.org/W1992680340","https://openalex.org/W1993948601","https://openalex.org/W1994402720","https://openalex.org/W1997215097","https://openalex.org/W1997546191","https://openalex.org/W1997723053","https://openalex.org/W2000549941","https://openalex.org/W2004668797","https://openalex.org/W2005299533","https://openalex.org/W2005525391","https://openalex.org/W2006266799","https://openalex.org/W2006449726","https://openalex.org/W2008649874","https://openalex.org/W2009588836","https://openalex.org/W2010290591","https://openalex.org/W2015376574","https://openalex.org/W2017377709","https://openalex.org/W2022030273","https://openalex.org/W2024988150","https://openalex.org/W2027552805","https://openalex.org/W2027632585","https://openalex.org/W2028701745","https://openalex.org/W2031769026","https://openalex.org/W2031980581","https://openalex.org/W2037571897","https://openalex.org/W2037777433","https://openalex.org/W2040098705","https://openalex.org/W2041063292","https://openalex.org/W2041651596","https://openalex.org/W2042209841","https://openalex.org/W2043204562","https://openalex.org/W2043549608","https://openalex.org/W2044279473","https://openalex.org/W2045819374","https://openalex.org/W2046225888","https://openalex.org/W2046901206","https://openalex.org/W2046916629","https://openalex.org/W2046957298","https://openalex.org/W2047380363","https://openalex.org/W2054472394","https://openalex.org/W2056766936","https://openalex.org/W2061152334","https://openalex.org/W2063060777","https://openalex.org/W2067555058","https://openalex.org/W2071170605","https://openalex.org/W2071177946","https://openalex.org/W2071995082","https://openalex.org/W2075008661","https://openalex.org/W2076741305","https://openalex.org/W2077142023","https://openalex.org/W2077180958","https://openalex.org/W2080086829","https://openalex.org/W2083232191","https://openalex.org/W2083860566","https://openalex.org/W2085069618","https://openalex.org/W2085767196","https://openalex.org/W2086667809","https://openalex.org/W2087411894","https://openalex.org/W2088350742","https://openalex.org/W2088400959","https://openalex.org/W2088978171","https://openalex.org/W2089934054","https://openalex.org/W2093677269","https://openalex.org/W2093933609","https://openalex.org/W2094929545","https://openalex.org/W2096090669","https://openalex.org/W2099887519","https://openalex.org/W2101331467","https://openalex.org/W2101823304","https://openalex.org/W2102473693","https://openalex.org/W2102541996","https://openalex.org/W2104663495","https://openalex.org/W2107513655","https://openalex.org/W2109202813","https://openalex.org/W2110044750","https://openalex.org/W2114528797","https://openalex.org/W2114628315","https://openalex.org/W2118705059","https://openalex.org/W2121613610","https://openalex.org/W2122002245","https://openalex.org/W2122336761","https://openalex.org/W2122417664","https://openalex.org/W2122742816","https://openalex.org/W2124995095","https://openalex.org/W2126643398","https://openalex.org/W2127424425","https://openalex.org/W2127444703","https://openalex.org/W2128140659","https://openalex.org/W2131423590","https://openalex.org/W2135167801","https://openalex.org/W2135982188","https://openalex.org/W2136252190","https://openalex.org/W2138751131","https://openalex.org/W2138846538","https://openalex.org/W2139707983","https://openalex.org/W2144002476","https://openalex.org/W2145937691","https://openalex.org/W2147196312","https://openalex.org/W2147934559","https://openalex.org/W2147993424","https://openalex.org/W2148426299","https://openalex.org/W2150210328","https://openalex.org/W2151734135","https://openalex.org/W2152093499","https://openalex.org/W2152611311","https://openalex.org/W2155742781","https://openalex.org/W2158101216","https://openalex.org/W2158201714","https://openalex.org/W2161816553","https://openalex.org/W2161993072","https://openalex.org/W2163187840","https://openalex.org/W2163215987","https://openalex.org/W2165110544","https://openalex.org/W2165738704","https://openalex.org/W2168419126","https://openalex.org/W2169870204","https://openalex.org/W2328643786","https://openalex.org/W2398816734","https://openalex.org/W2412319728","https://openalex.org/W2425256690","https://openalex.org/W2462837542","https://openalex.org/W2580409377","https://openalex.org/W4243058767","https://openalex.org/W4246204066","https://openalex.org/W4255211517","https://openalex.org/W4313333698"],"related_works":["https://openalex.org/W2083232191","https://openalex.org/W7097297723","https://openalex.org/W2760835443","https://openalex.org/W2769772366","https://openalex.org/W1598741049","https://openalex.org/W2801684129","https://openalex.org/W2781586813","https://openalex.org/W4200034327","https://openalex.org/W1601643744","https://openalex.org/W4313385896"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}