{"id":"https://openalex.org/W16200669","doi":"https://doi.org/10.1097/00000478-199512000-00010","title":"Clinical and Histoimmunophenotypic Findings and Association with Epstein\u2014Barr Virus in 16 Cases","display_name":"Clinical and Histoimmunophenotypic Findings and Association with Epstein\u2014Barr Virus in 16 Cases","publication_year":1995,"publication_date":"1995-12-01","ids":{"openalex":"https://openalex.org/W16200669","doi":"https://doi.org/10.1097/00000478-199512000-00010","mag":"16200669","pmid":"https://pubmed.ncbi.nlm.nih.gov/7503365"},"language":"en","primary_location":{"id":"doi:10.1097/00000478-199512000-00010","doi":"https://doi.org/10.1097/00000478-199512000-00010","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000478-199512000-00010","pdf_url":null,"source":{"id":"https://openalex.org/S37879208","display_name":"The American Journal of Surgical Pathology","issn_l":"0147-5185","issn":["0147-5185","1532-0979"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Surgical Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109966997","display_name":"Silloo B. Kapadia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151970","display_name":"Armed Forces Institute of Pathology","ror":"https://ror.org/04se3fj97","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210151970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Silloo B. Kapadia","raw_affiliation_strings":["Department of Otolaryngic Pathology, Armed Forces Institute of Pathology, Washington, D.C., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngic Pathology, Armed Forces Institute of Pathology, Washington, D.C., USA","institution_ids":["https://openalex.org/I4210151970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108602335","display_name":"Lydia N. Rom\u00e1n","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lydia N. Roman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110357507","display_name":"Douglas W. Kingma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Douglas W. Kingma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089779163","display_name":"Elaine S. Jaffe","orcid":"https://orcid.org/0000-0003-4632-0301","observed_orcids":["https://orcid.org/0000-0003-4632-0301"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elaine S. Jaffe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5050662951","display_name":"Glauco Frizzera","orcid":"https://orcid.org/0000-0001-7294-1967","observed_orcids":["https://orcid.org/0000-0001-7294-1967"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Glauco Frizzera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4264,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.82004132,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"19","issue":"12","first_page":"1431","last_page":"1439"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.6079000234603882,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.6079000234603882,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.3743000030517578,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hodgkin-lymphoma","display_name":"Hodgkin's disease","score":0.890999972820282},{"id":"https://openalex.org/keywords/waldeyer-s-ring","display_name":"Waldeyer's ring","score":0.9959999918937683},{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.9240000247955322},{"id":"https://openalex.org/keywords/reed-sternberg-cells","display_name":"Reed-Sternberg cells","score":0.9139999747276306},{"id":"https://openalex.org/keywords/histological-subtypes","display_name":"histological subtypes","score":0.6119999885559082},{"id":"https://openalex.org/keywords/immunophenotype","display_name":"immunophenotype","score":0.8399999737739563},{"id":"https://openalex.org/keywords/mixed-cellularity","display_name":"mixed cellularity","score":0.6209999918937683},{"id":"https://openalex.org/keywords/nodular-sclerosis","display_name":"nodular sclerosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/lymphocyte-predominance","display_name":"lymphocyte predominance","score":0.8679999709129333},{"id":"https://openalex.org/keywords/tonsil","display_name":"tonsil","score":0.6140000224113464},{"id":"https://openalex.org/keywords/airway-obstruction","display_name":"airway obstruction","score":0.6700000166893005},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.4189999997615814},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.40799999237060547},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.41600000858306885},{"id":"https://openalex.org/keywords/local-recurrence","display_name":"local recurrence","score":0.5320000052452087},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.34299999475479126}],"concepts":[{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.5259566307067871},{"id":"https://openalex.org/C2781375147","wikidata":"https://www.wikidata.org/wiki/Q6900","display_name":"Epstein\u2013Barr virus","level":3,"score":0.4702151119709015},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46306437253952026},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4291592836380005},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.40176481008529663},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2420717477798462},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.05602109432220459}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009959","descriptor_name":"Oropharyngeal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009959","descriptor_name":"Oropharyngeal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009959","descriptor_name":"Oropharyngeal Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00000478-199512000-00010","doi":"https://doi.org/10.1097/00000478-199512000-00010","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000478-199512000-00010","pdf_url":null,"source":{"id":"https://openalex.org/S37879208","display_name":"The American Journal of Surgical Pathology","issn_l":"0147-5185","issn":["0147-5185","1532-0979"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Surgical Pathology","raw_type":"journal-article"},{"id":"pmid:7503365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7503365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of surgical pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4230084546","https://openalex.org/W4313370349","https://openalex.org/W2118994709","https://openalex.org/W2086343702","https://openalex.org/W417764","https://openalex.org/W2052967285","https://openalex.org/W2412306841","https://openalex.org/W2045693877","https://openalex.org/W2022558877","https://openalex.org/W2099263543"],"abstract_inverted_index":{"Waldeyer's":[0,61,285,332],"ring":[1,62,333],"is":[2,122,299,323,334],"an":[3],"uncommon,":[4],"rarely":[5],"reported":[6],"primary":[7],"site":[8,322],"for":[9,119,337],"Hodgkin's":[10,144,275,307,318],"disease.":[11],"We":[12,270],"report":[13],"a":[14,96,325,335],"series":[15],"of":[16,24,29,67,128,142,151,196,205,223,227,252,254,277,289,316,327],"16":[17],"such":[18],"cases":[19,156,195,204,256],"culled":[20],"from":[21],"the":[22,25,32,60,72,82,209,220,293,310,328,331],"files":[23],"Armed":[26],"Forces":[27],"Institute":[28],"Pathology":[30],"and":[31,45,69,80,111,146,169,189,199,202,263,280],"National":[33],"Cancer":[34],"Institute.":[35],"The":[36,55,186,287,313],"patients'":[37],"median":[38],"age":[39],"was":[40,57,105],"41":[41],"years":[42],"(range,":[43],"14-74),":[44],"they":[46,225],"presented":[47],"with":[48,91],"airway":[49],"obstruction":[50],"or":[51,92],"unilateral":[52],"tonsillar":[53],"enlargement.":[54],"disease":[56,129,145,276,308,319],"localized":[58],"to":[59,71,81,132],"(stage":[63,76,84],"I)":[64],"in":[65,78,86,99,108,114,193,249,260,268,284,292,296,305,309],"46%":[66],"patients":[68,118],"extended":[70],"cervical":[73],"lymph":[74],"nodes":[75],"II)":[77],"39%":[79],"spleen":[83],"III)":[85],"15%.":[87],"Local":[88],"radiation":[89],"therapy,":[90],"without":[93,126],"chemotherapy,":[94],"obtained":[95],"complete":[97],"response":[98],"all":[100,203],"but":[101,266],"two":[102,139,147],"patients.":[103],"There":[104],"local":[106],"recurrence":[107],"one":[109,170],"patient":[110],"distant":[112],"spread":[113],"three":[115,177],"others.":[116],"All":[117],"whom":[120],"follow-up":[121],"available":[123],"are":[124],"alive":[125],"evidence":[127],"at":[130,320],"9":[131],"216":[133],"months":[134],"(median,":[135],"20":[136],"months)":[137],"except":[138],"who":[140,149],"died":[141,150],"widespread":[143],"others":[148,178],"other":[152],"causes.":[153],"Histologically,":[154],"eight":[155,253],"were":[157,183,226],"classified":[158],"as":[159,165,171],"mixed":[160,197,261],"cellularity":[161,198,262],"type":[162],"(50%),":[163],"four":[164],"nodular":[166,174,206,264],"sclerosis":[167,207],"(25%),":[168],"lymphocyte":[172],"predominance,":[173],"(LPn;":[175],"6.3%);":[176],"that":[179,302,330],"showed":[180],"interfollicular":[181,200],"involvement":[182],"unclassified":[184],"(18.7%).":[185],"Reed-Sternberg":[187],"(RS)":[188],"atypical":[190],"mononuclear":[191],"cells":[192,251,295],"most":[194],"types":[201],"had":[208],"classic":[210],"immunophenotype":[211,281],"(CD45-,":[212],"CD20-":[213],"and/or":[214,217],"CD45RO-,":[215,232],"CD15+":[216],"CD30+).":[218],"In":[219,235],"single":[221],"case":[222],"LPn,":[224],"B-cell":[228],"lineage":[229],"(CD45+,":[230],"CD20+,":[231],"CD15-,":[233],"CD30-).":[234],"situ":[236],"hybridization":[237],"performed":[238],"on":[239],"routinely":[240],"processed":[241],"sections":[242],"revealed":[243],"Epstein-Barr":[244],"virus":[245],"(EBV)":[246],"EBER1":[247],"mRNA":[248],"RS":[250,294],"12":[255],"studied":[257],"(67%)":[258],"only":[259],"sclerosis,":[265],"not":[267],"LPn.":[269],"conclude":[271],"that,":[272],"however":[273],"rarely,":[274],"typical":[278],"morphology":[279],"can":[282],"originate":[283],"ring.":[286],"incidence":[288],"EBV":[290],"detection":[291],"our":[297],"study":[298],"greater":[300,314],"than":[301],"usually":[303],"seen":[304],"nodal":[306],"United":[311],"States.":[312],"prevalence":[315],"EBV-related":[317],"this":[321],"probably":[324],"reflection":[326],"fact":[329],"reservoir":[336],"EBV.":[338]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}