{"id":"https://openalex.org/W1617675989","doi":null,"title":"No modification of the beneficial effect of NSAIDs on colorectal cancer by CYP2C9 genotype.","display_name":"No modification of the beneficial effect of NSAIDs on colorectal cancer by CYP2C9 genotype.","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W1617675989","mag":"1617675989","pmid":"https://pubmed.ncbi.nlm.nih.gov/19581657"},"language":"en","primary_location":{"id":"pmid:19581657","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19581657","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Netherlands journal of medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043288483","display_name":"Claire Siemes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"C Siemes","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, Erasmus University Medical Centre, Rotterdam, the Netherland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, Erasmus University Medical Centre, Rotterdam, the Netherland","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064749131","display_name":"Mark Eijgelsheim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Eijgelsheim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083640173","display_name":"J P Dieleman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J P Dieleman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112254985","display_name":"Ron H. N. van Schaik","orcid":"https://orcid.org/0000-0003-1864-2151","observed_orcids":["https://orcid.org/0000-0003-1864-2151"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R H N van Schaik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031530236","display_name":"Andr\u00e9 Gerardus Uitterlinden","orcid":"https://orcid.org/0000-0002-7276-3387","observed_orcids":["https://orcid.org/0000-0002-7276-3387"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A G Uitterlinden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017009749","display_name":"Cornelia M. van Duijn","orcid":"https://orcid.org/0000-0002-2374-9204","observed_orcids":["https://orcid.org/0000-0002-2374-9204","https://orcid.org/0000-0001-8766-6224"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C M van Duijn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039611937","display_name":"Albert Hofman D","orcid":"https://orcid.org/0000-0002-9865-121X","observed_orcids":["https://orcid.org/0000-0002-9865-121X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Hofman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033644402","display_name":"J.W.W. Coebergh","orcid":"https://orcid.org/0000-0002-2419-3930","observed_orcids":["https://orcid.org/0000-0002-2419-3930"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J W W Coebergh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007319489","display_name":"Bruno H. Ch. Stricker","orcid":"https://orcid.org/0000-0003-3713-9762","observed_orcids":["https://orcid.org/0000-0003-3713-9762"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B H Ch Stricker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5054663156","display_name":"LE Visser","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L E Visser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3971,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.58375188,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"67","issue":"4","first_page":"134","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.5083000063896179,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.5083000063896179,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.47609999775886536,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8859999775886536},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.847000002861023},{"id":"https://openalex.org/keywords/cyp2c9","display_name":"CYP2C9","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cyp2c9-2","display_name":"CYP2C9*2","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cyp2c9-3","display_name":"CYP2C9*3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-gene-interactions","display_name":"drug-gene interactions","score":0.7829999923706055},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.6480000019073486},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.7229999899864197},{"id":"https://openalex.org/keywords/cancer-risk-reduction","display_name":"cancer risk reduction","score":0.6589999794960022},{"id":"https://openalex.org/keywords/enzyme-activity","display_name":"enzyme activity","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8960252404212952},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.8527963161468506},{"id":"https://openalex.org/C3946865","wikidata":"https://www.wikidata.org/wiki/Q5014962","display_name":"CYP2C9","level":4,"score":0.6626144051551819},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6528429388999939},{"id":"https://openalex.org/C204452808","wikidata":"https://www.wikidata.org/wiki/Q7370668","display_name":"Rotterdam Study","level":3,"score":0.6458457708358765},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5787836909294128},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5362566709518433},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.471068799495697},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44646385312080383},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.44443267583847046},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.4430631101131439},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43858981132507324},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37492460012435913},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32784503698349},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19392243027687073},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19034025073051453},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.1250033974647522},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.12049317359924316},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06380999088287354},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001189","descriptor_name":"Aryl Hydrocarbon Hydroxylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009426","descriptor_name":"Netherlands","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065729","descriptor_name":"Cytochrome P-450 CYP2C9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:19581657","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19581657","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Netherlands journal of medicine","raw_type":"Journal Article"},{"id":"pmh:eur:oai:pure.eur.nl:publications/20f5b8f0-15f3-45f2-9143-46cdbf370097","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/20f5b8f0-15f3-45f2-9143-46cdbf370097","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Netherlands Journal of Medicine, 67(4), 134 - 141. Van Zuiden Communications","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.eur.nl:openaire_cris_publications/20f5b8f0-15f3-45f2-9143-46cdbf370097","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1765/16442","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Siemes, C, Eijgelsheim, M, Dieleman, J, van Schaik, R, Uitterlinden, A, Duijn, C, Hofman, B, Coebergh, J W, Stricker, B & Visser, L 2009, 'No modification of the beneficial effect of NSAIDs on colorectal cancer by CYP2C9 genotype', Netherlands Journal of Medicine, vol. 67, no. 4, pp. 134-141. < http://hdl.handle.net/1765/16442 >","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1480887469","https://openalex.org/W1533049846","https://openalex.org/W1850092360","https://openalex.org/W1967970335","https://openalex.org/W1972663613","https://openalex.org/W1974578483","https://openalex.org/W1979374480","https://openalex.org/W1980263659","https://openalex.org/W1990719139","https://openalex.org/W1997048544","https://openalex.org/W1997591997","https://openalex.org/W2000435171","https://openalex.org/W2008297770","https://openalex.org/W2008984280","https://openalex.org/W2009313893","https://openalex.org/W2013862513","https://openalex.org/W2019222237","https://openalex.org/W2030388684","https://openalex.org/W2034595467","https://openalex.org/W2035091931","https://openalex.org/W2037180460","https://openalex.org/W2049480378","https://openalex.org/W2051700726","https://openalex.org/W2059689162","https://openalex.org/W2066629760","https://openalex.org/W2069677295","https://openalex.org/W2080436457","https://openalex.org/W2082472491","https://openalex.org/W2085963018","https://openalex.org/W2088479878","https://openalex.org/W2104446579","https://openalex.org/W2109252993","https://openalex.org/W2109453128","https://openalex.org/W2114055180","https://openalex.org/W2120216632","https://openalex.org/W2127989833","https://openalex.org/W2137520566","https://openalex.org/W2140587505","https://openalex.org/W2154775432","https://openalex.org/W2164066961","https://openalex.org/W2263192284","https://openalex.org/W2330709704","https://openalex.org/W2410208721","https://openalex.org/W2898253233"],"related_works":["https://openalex.org/W2506419396","https://openalex.org/W1979374480","https://openalex.org/W2008297770","https://openalex.org/W4300190494","https://openalex.org/W1531445873","https://openalex.org/W2154775432","https://openalex.org/W2565361279","https://openalex.org/W2032334516","https://openalex.org/W2104446579","https://openalex.org/W4298079731"],"abstract_inverted_index":{"BACKGROUND:":[0],"CYP2C9":[1,120],"enzymes":[2,22],"are":[3,160],"involved":[4],"in":[5,53,98,116],"non-steroidal":[6],"anti-inflammatory":[7],"drug":[8],"(NSAID)":[9],"metabolism.":[10],"Therefore,":[11],"we":[12],"investigated":[13],"whether":[14],"CYP2C9*2":[15,43,155],"and":[16,37,42,44,68,115,154],"*3":[17,45,158],"variant":[18,46,121],"alleles,":[19],"encoding":[20],"for":[21,103],"with":[23,48,124,142,162],"lower":[24,125],"activity,":[25],"increased":[26],"the":[27,173],"protective":[28],"effect":[29,70],"of":[30,40,57,85,93,118,137,166],"NSAIDs":[31,41,102],"on":[32],"colorectal":[33,49,86,94,167],"cancer.":[34,168],"METHODS:":[35],"Individual":[36],"combined":[38],"associations":[39],"alleles":[47],"cancer":[50,87,95],"were":[51,73,81],"studied":[52],"7757":[54],"Caucasian":[55],"individuals":[56,99],"The":[58,135],"Rotterdam":[59],"Study,":[60],"a":[61,106,143,163],"population-based":[62],"prospective":[63],"cohort":[64],"since":[65],"1990.":[66],"Additive":[67],"multiplicative":[69],"modification":[71],"models":[72],"used":[74,101],"to":[75,113,133],"examine":[76],"drug-gene":[77],"interactions.":[78],"RESULTS:":[79],"There":[80],"212":[82],"incident":[83],"cases":[84],"during":[88],"follow-up.":[89],"A":[90],"reduced":[91,164],"risk":[92,145,165],"was":[96,140,175],"observed":[97],"who":[100],"more":[104],"than":[105],"year":[107],"(HR":[108,128],"0.45;":[109],"95%":[110,130],"CI":[111,131],"0.28":[112],"0.71),":[114],"carriers":[117],"an":[119],"allele":[122],"associated":[123,141,161],"enzymatic":[126],"activity":[127],"0.67;":[129],"0.47":[132],"0.96).":[134],"combination":[136],"both":[138],"determinants":[139,174],"further":[144],"reduction":[146],"but":[147],"without":[148],"synergy.":[149],"CONCLUSION:":[150],"Both":[151],"NSAID":[152],"use":[153],"and/":[156],"or":[157],"carriage":[159],"However,":[169],"no":[170],"interaction":[171],"between":[172],"found,":[176],"which":[177],"might":[178],"indicate":[179],"independent":[180],"pathophysiological":[181],"mechanisms.":[182]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}