{"id":"https://openalex.org/W1616632163","doi":"https://doi.org/10.1111/j.1939-1676.2010.0498.x","title":"Oxidative Stress and Neutrophil Function in Cats with Chronic Renal Failure","display_name":"Oxidative Stress and Neutrophil Function in Cats with Chronic Renal Failure","publication_year":2010,"publication_date":"2010-04-02","ids":{"openalex":"https://openalex.org/W1616632163","doi":"https://doi.org/10.1111/j.1939-1676.2010.0498.x","mag":"1616632163","pmid":"https://pubmed.ncbi.nlm.nih.gov/20384951"},"language":"en","primary_location":{"id":"doi:10.1111/j.1939-1676.2010.0498.x","doi":"https://doi.org/10.1111/j.1939-1676.2010.0498.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1939-1676.2010.0498.x","pdf_url":null,"source":{"id":"https://openalex.org/S69093139","display_name":"Journal of Veterinary Internal Medicine","issn_l":"0891-6640","issn":["0891-6640","1939-1676"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016608487","display_name":"Rosie Keegan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.F. Keegan","raw_affiliation_strings":["College of Veterinary Medicine and Biomedical Sciences, Colorado State University Department of Clinical Sciences, , Fort Collins, CO","Department of Clinical Sciences College of Veterinary Medicine and Biomedical Sciences Colorado State University Fort Collins CO USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine and Biomedical Sciences, Colorado State University Department of Clinical Sciences, , Fort Collins, CO","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"Department of Clinical Sciences College of Veterinary Medicine and Biomedical Sciences Colorado State University Fort Collins CO USA","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109698317","display_name":"Craig B. Webb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.B. Webb","raw_affiliation_strings":["College of Veterinary Medicine and Biomedical Sciences, Colorado State University Department of Clinical Sciences, , Fort Collins, CO","Department of Clinical Sciences College of Veterinary Medicine and Biomedical Sciences Colorado State University, Fort Collins, Co"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine and Biomedical Sciences, Colorado State University Department of Clinical Sciences, , Fort Collins, CO","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"Department of Clinical Sciences College of Veterinary Medicine and Biomedical Sciences Colorado State University, Fort Collins, Co","institution_ids":["https://openalex.org/I92446798"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I92446798"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":null,"fwci":10.2208,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.98586973,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"24","issue":"3","first_page":"514","last_page":"519"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11580","display_name":"Veterinary Medicine and Surgery","score":0.35420000553131104,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11580","display_name":"Veterinary Medicine and Surgery","score":0.35420000553131104,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.2502000033855438,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.24300000071525574,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9120000004768372},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7369999885559082},{"id":"https://openalex.org/keywords/neutrophil-function","display_name":"neutrophil function","score":0.9240000247955322},{"id":"https://openalex.org/keywords/antioxidant-capacity","display_name":"antioxidant capacity","score":0.6759999990463257},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9480000138282776},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.7419999837875366},{"id":"https://openalex.org/keywords/neutrophil-respiratory-burst","display_name":"neutrophil respiratory burst","score":0.7900000214576721},{"id":"https://openalex.org/keywords/neutrophil-phagocytosis","display_name":"neutrophil phagocytosis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cats","display_name":"cats","score":0.5910000205039978},{"id":"https://openalex.org/keywords/antioxidant-supplementation","display_name":"antioxidant supplementation","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C2779904517","wikidata":"https://www.wikidata.org/wiki/Q5008900","display_name":"CATS","level":2,"score":0.9017084836959839},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7600215673446655},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6721604466438293},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.667861819267273},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6197764873504639},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.6085922122001648},{"id":"https://openalex.org/C2778176769","wikidata":"https://www.wikidata.org/wiki/Q764079","display_name":"Blood urea nitrogen","level":3,"score":0.5472918152809143},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5256422758102417},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.5131910443305969},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.45595645904541016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22113296389579773},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1748260259628296}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002371","descriptor_name":"Cat Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002371","descriptor_name":"Cat Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002371","descriptor_name":"Cat Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1939-1676.2010.0498.x","doi":"https://doi.org/10.1111/j.1939-1676.2010.0498.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1939-1676.2010.0498.x","pdf_url":null,"source":{"id":"https://openalex.org/S69093139","display_name":"Journal of Veterinary Internal Medicine","issn_l":"0891-6640","issn":["0891-6640","1939-1676"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Internal Medicine","raw_type":"journal-article"},{"id":"pmid:20384951","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20384951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of veterinary internal medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306437","display_name":"Morris Animal Foundation","ror":"https://ror.org/05pg13f04"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W61657103","https://openalex.org/W121857531","https://openalex.org/W184376475","https://openalex.org/W1485087964","https://openalex.org/W1556885643","https://openalex.org/W1605194707","https://openalex.org/W1738546326","https://openalex.org/W1971566316","https://openalex.org/W1989020927","https://openalex.org/W1989893606","https://openalex.org/W1996976658","https://openalex.org/W2009399860","https://openalex.org/W2011927381","https://openalex.org/W2017292179","https://openalex.org/W2017990228","https://openalex.org/W2022539296","https://openalex.org/W2023427279","https://openalex.org/W2024610760","https://openalex.org/W2030913606","https://openalex.org/W2039260613","https://openalex.org/W2063137485","https://openalex.org/W2066162788","https://openalex.org/W2068006849","https://openalex.org/W2078085111","https://openalex.org/W2080739904","https://openalex.org/W2084433053","https://openalex.org/W2085198506","https://openalex.org/W2086398123","https://openalex.org/W2095877588","https://openalex.org/W2096401930","https://openalex.org/W2100709457","https://openalex.org/W2103675799","https://openalex.org/W2111539598","https://openalex.org/W2115100915","https://openalex.org/W2129572380","https://openalex.org/W2136128927","https://openalex.org/W2166283151","https://openalex.org/W2169514299","https://openalex.org/W2473550748","https://openalex.org/W4248465139"],"related_works":["https://openalex.org/W1948603161","https://openalex.org/W2909812024","https://openalex.org/W2411849704","https://openalex.org/W1564222293","https://openalex.org/W2387860588","https://openalex.org/W393698729","https://openalex.org/W2050789305","https://openalex.org/W2313598751","https://openalex.org/W2398053996","https://openalex.org/W1991584706"],"abstract_inverted_index":{"BACKGROUND:":[0],"Oxidative":[1],"stress":[2,31],"is":[3,223],"an":[4,186],"important":[5],"component":[6],"in":[7,132,152,172,188,195,220,253],"the":[8,133,146,153,170,244],"progression":[9],"of":[10,227,246,251],"chronic":[11],"renal":[12,46],"failure":[13,47],"(CRF)":[14],"and":[15,32,76,79,107,113,117,174,216],"neutrophil":[16,34,77],"function":[17,35],"may":[18],"be":[19,234,250],"impaired":[20],"by":[21],"oxidative":[22,30,80,178],"stress.":[23],"HYPOTHESIS:":[24],"Cats":[25],"with":[26,37,43,50,225,238,255],"CRF":[27,97,134,154,175,196,221],"have":[28],"increased":[29],"decreased":[33],"compared":[36,49],"control":[38,53,111,122,173,247],"cats.":[39,54,123,176],"ANIMALS:":[40],"Twenty":[41],"cats":[42,98,197,222,248,254],"previously":[44],"diagnosed":[45],"were":[48,82,88],"10":[51],"age-matched":[52],"METHODS:":[55],"A":[56],"biochemical":[57],"profile,":[58],"CBC,":[59],"urinalysis,":[60],"antioxidant":[61,147,218,228],"capacity,":[62],"superoxide":[63],"dismutase":[64],"(SOD)":[65],"enzyme":[66],"activity,":[67],"reduced":[68],"to":[69,233],"oxidized":[70],"glutathione":[71],"ratio":[72,128,215],"(GSH":[73],":":[74,126,213],"GSSG),":[75],"phagocytosis":[78],"burst":[81,179],"measured.":[83],"Statistical":[84],"comparisons":[85],"(2-tailed":[86],"t-test)":[87],"reported":[89],"as":[90,185,241],"mean":[91,189],"+/-":[92,137,140,157,160,201,204],"standard":[93],"deviation.":[94],"RESULTS:":[95],"The":[96,124,210],"had":[99],"significantly":[100,114,130,150,193],"higher":[101,131,194,211],"serum":[102],"blood":[103],"urea":[104],"nitrogen,":[105],"creatinine,":[106],"phosphorus":[108],"concentrations":[109],"than":[110,121,198],"cats,":[112],"lower":[115,217],"PCV":[116],"urine":[118],"specific":[119],"gravity":[120],"GSH":[125,212],"GSSG":[127,214],"was":[129,149,169,192],"group":[135,155],"(177.6":[136],"197,":[138],"61.7":[139],"33;":[141],"P":[142,164,206],"<":[143,165,207],".02)":[144],"whereas":[145],"capacity":[148,219],"less":[151],"(0.56":[156],"0.21,":[158],"0.81":[159],"0.13":[161],"Trolox":[162],"units;":[163],".005).":[166],"SOD":[167,242],"activity":[168],"same":[171],"Neutrophil":[177],"after":[180],"Escherichia":[181],"coli":[182],"phagocytosis,":[183],"measured":[184],"increase":[187],"fluorescence":[190],"intensity,":[191],"controls":[199],"(732":[200],"253,":[202],"524":[203],"54;":[205],".05).":[208],"CONCLUSIONS:":[209],"consistent":[224],"activation":[226],"defense":[229],"mechanisms.":[230],"It":[231],"remains":[232],"determined":[235],"if":[236],"supplementation":[237],"antioxidants":[239],"such":[240],"beyond":[243],"level":[245],"would":[249],"benefit":[252],"CRF.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
