{"id":"https://openalex.org/W1616409268","doi":"https://doi.org/10.1089/154099903321667591","title":"A Pilot Study of Treatment of Bacterial Vaginosis with a Buffering Vaginal Microbicide","display_name":"A Pilot Study of Treatment of Bacterial Vaginosis with a Buffering Vaginal Microbicide","publication_year":2003,"publication_date":"2003-04-01","ids":{"openalex":"https://openalex.org/W1616409268","doi":"https://doi.org/10.1089/154099903321667591","mag":"1616409268","pmid":"https://pubmed.ncbi.nlm.nih.gov/12804356"},"language":"en","primary_location":{"id":"doi:10.1089/154099903321667591","doi":"https://doi.org/10.1089/154099903321667591","is_oa":false,"landing_page_url":"https://doi.org/10.1089/154099903321667591","pdf_url":null,"source":{"id":"https://openalex.org/S191117624","display_name":"Journal of Women s Health","issn_l":"1059-7115","issn":["1059-7115","1540-9996","1931-843X","2168-7668"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Women's Health","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008270657","display_name":"Joseph Irvin Harwell","orcid":"https://orcid.org/0000-0002-8853-9603","observed_orcids":["https://orcid.org/0000-0002-8853-9603"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800640726","display_name":"Miriam Hospital","ror":"https://ror.org/053exzj86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800640726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph I. Harwell","raw_affiliation_strings":["The Miriam Hospital, Providence, Rhode Island","Brown University, The Miriam Hospital, Providence, Rhode Island 02906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Miriam Hospital, Providence, Rhode Island","institution_ids":["https://openalex.org/I2800640726"]},{"raw_affiliation_string":"Brown University, The Miriam Hospital, Providence, Rhode Island 02906, USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800640726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080688116","display_name":"Thomas R. Moench","orcid":"https://orcid.org/0000-0001-8447-3507","observed_orcids":["https://orcid.org/0000-0001-8447-3507"]},"institutions":[{"id":"https://openalex.org/I4210107377","display_name":"ReProtect (United States)","ror":"https://ror.org/01q2xjy72","country_code":"US","type":"company","lineage":["https://openalex.org/I4210107377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Moench","raw_affiliation_strings":["ReProtect, Inc., Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ReProtect, Inc., Baltimore, Maryland","institution_ids":["https://openalex.org/I4210107377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025150770","display_name":"Kenneth Hugh Mayer","orcid":"https://orcid.org/0000-0001-7460-733X","observed_orcids":["https://orcid.org/0000-0001-7460-733X","https://orcid.org/0000-0001-8034-5110"]},"institutions":[{"id":"https://openalex.org/I2800640726","display_name":"Miriam Hospital","ror":"https://ror.org/053exzj86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800640726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth H. Mayer","raw_affiliation_strings":["Miriam Hospital, Providence, Rhode Island"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miriam Hospital, Providence, Rhode Island","institution_ids":["https://openalex.org/I2800640726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056424459","display_name":"Stacey Chapman","orcid":"https://orcid.org/0000-0003-4788-853X","observed_orcids":["https://orcid.org/0000-0003-4788-853X"]},"institutions":[{"id":"https://openalex.org/I2800640726","display_name":"Miriam Hospital","ror":"https://ror.org/053exzj86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800640726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacey Chapman","raw_affiliation_strings":["Miriam Hospital, Providence, Rhode Island"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miriam Hospital, Providence, Rhode Island","institution_ids":["https://openalex.org/I2800640726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069402053","display_name":"Irma Rodriguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800640726","display_name":"Miriam Hospital","ror":"https://ror.org/053exzj86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800640726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irma Rodriguez","raw_affiliation_strings":["Miriam Hospital, Providence, Rhode Island"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miriam Hospital, Providence, Rhode Island","institution_ids":["https://openalex.org/I2800640726"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006144681","display_name":"Susan Cu\u2010Uvin","orcid":"https://orcid.org/0000-0001-5633-071X","observed_orcids":["https://orcid.org/0000-0001-5633-071X"]},"institutions":[{"id":"https://openalex.org/I2800640726","display_name":"Miriam Hospital","ror":"https://ror.org/053exzj86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800640726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Cu-Uvin","raw_affiliation_strings":["Miriam Hospital, Providence, Rhode Island"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miriam Hospital, Providence, Rhode Island","institution_ids":["https://openalex.org/I2800640726"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4671,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.78704883,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"12","issue":"3","first_page":"255","last_page":"259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11589","display_name":"Gynecological conditions and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacterial-vaginosis","display_name":"bacterial vaginosis","score":1.0},{"id":"https://openalex.org/keywords/vaginal-microbicides","display_name":"vaginal microbicides","score":0.906000018119812},{"id":"https://openalex.org/keywords/metronidazole","display_name":"metronidazole","score":0.8840000033378601},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.5509999990463257},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.7979999780654907},{"id":"https://openalex.org/keywords/gram-stain","display_name":"Gram staining","score":0.6610000133514404},{"id":"https://openalex.org/keywords/pregnancy-outcomes","display_name":"pregnancy outcomes","score":0.5950000286102295},{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C2779952448","wikidata":"https://www.wikidata.org/wiki/Q804521","display_name":"Bacterial vaginosis","level":2,"score":0.9775442481040955},{"id":"https://openalex.org/C197746943","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Microbicide","level":3,"score":0.9265393614768982},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8191784024238586},{"id":"https://openalex.org/C2777700855","wikidata":"https://www.wikidata.org/wiki/Q18211693","display_name":"Vaginal disease","level":3,"score":0.6750472784042358},{"id":"https://openalex.org/C2777617518","wikidata":"https://www.wikidata.org/wiki/Q676191","display_name":"Vaginitis","level":2,"score":0.5970229506492615},{"id":"https://openalex.org/C97228660","wikidata":"https://www.wikidata.org/wiki/Q7908502","display_name":"Vaginal microbicide","level":5,"score":0.5941599011421204},{"id":"https://openalex.org/C117214928","wikidata":"https://www.wikidata.org/wiki/Q7905570","display_name":"Microbicides for sexually transmitted diseases","level":4,"score":0.5474822521209717},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.52314293384552},{"id":"https://openalex.org/C2910082039","wikidata":"https://www.wikidata.org/wiki/Q977090","display_name":"Vulvovaginal Candidiasis","level":3,"score":0.46181026101112366},{"id":"https://openalex.org/C2777744392","wikidata":"https://www.wikidata.org/wiki/Q5880","display_name":"Vagina","level":2,"score":0.4588000178337097},{"id":"https://openalex.org/C2777454759","wikidata":"https://www.wikidata.org/wiki/Q676191","display_name":"Vaginal infections","level":2,"score":0.4483833312988281},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.435880184173584},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16922438144683838},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.14344140887260437},{"id":"https://openalex.org/C2986740045","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health services","level":3,"score":0.13840094208717346},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.10990074276924133},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.09717303514480591},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.08633631467819214},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.08459395170211792},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000180","descriptor_name":"Acrylic Resins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000282","descriptor_name":"Administration, Intravaginal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000891","descriptor_name":"Anti-Infective Agents, Local","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008795","descriptor_name":"Metronidazole","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013089","descriptor_name":"Spermatocidal Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014621","descriptor_name":"Vagina","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014621","descriptor_name":"Vagina","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D016585","descriptor_name":"Vaginosis, Bacterial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016585","descriptor_name":"Vaginosis, Bacterial","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D016585","descriptor_name":"Vaginosis, Bacterial","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/154099903321667591","doi":"https://doi.org/10.1089/154099903321667591","is_oa":false,"landing_page_url":"https://doi.org/10.1089/154099903321667591","pdf_url":null,"source":{"id":"https://openalex.org/S191117624","display_name":"Journal of Women s Health","issn_l":"1059-7115","issn":["1059-7115","1540-9996","1931-843X","2168-7668"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Women's Health","raw_type":"journal-article"},{"id":"pmid:12804356","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12804356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of women's health (2002)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G9000866469","display_name":"Providence/Boston Center for AIDS Research (CFAR)","funder_award_id":"P30AI042853","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1511490662","https://openalex.org/W1868667984","https://openalex.org/W1963487580","https://openalex.org/W2040706286","https://openalex.org/W2045200735","https://openalex.org/W2079404022","https://openalex.org/W2109513353","https://openalex.org/W2137680765","https://openalex.org/W2145649150","https://openalex.org/W2157531977","https://openalex.org/W2163397075","https://openalex.org/W2317599024"],"related_works":["https://openalex.org/W2314524590","https://openalex.org/W2151220267","https://openalex.org/W2400035855","https://openalex.org/W2033098185","https://openalex.org/W2970136275","https://openalex.org/W2174150882","https://openalex.org/W2079404022","https://openalex.org/W2196819834","https://openalex.org/W7118908804","https://openalex.org/W1988293848"],"abstract_inverted_index":{"BACKGROUND:":[0],"Bacterial":[1],"vaginosis":[2],"(BV)":[3],"is":[4,12],"an":[5],"extremely":[6],"common":[7],"problem":[8],"for":[9,119,189],"women":[10,134,155,165],"and":[11,18,86,89,112,141,161],"associated":[13],"with":[14,60,122,147],"adverse":[15],"pregnancy":[16],"outcomes":[17],"HIV":[19],"infection.":[20],"Currently":[21],"available":[22],"antibiotic":[23],"treatments":[24],"are":[25],"moderately":[26,186],"effective":[27,151,187],"but":[28],"may":[29],"need":[30],"to":[31,66,117,183],"be":[32,184],"repeated":[33],"frequently":[34],"because":[35],"of":[36,40,48,56,74,93,105,110,126,154,164,176],"the":[37,41,54,102,144],"recurrent":[38],"nature":[39],"disease.":[42],"We":[43],"undertook":[44],"a":[45,49,82,108,180,185],"pilot":[46],"study":[47],"buffering":[50],"vaginal":[51,84],"microbicide":[52],"in":[53,152,162],"treatment":[55,160,188],"BV.":[57,190],"METHODS:":[58],"Women":[59],"clinically":[61,150],"diagnosed":[62],"BV":[63,123],"were":[64,96,128,135,138],"recruited":[65],"receive":[67],"seven":[68],"applications":[69],"(5":[70],"g":[71,175],"per":[72],"application)":[73],"BufferGel":[75,106,148,177],"trade":[76],"mark":[77],"(ReProtect,":[78],"LLC,":[79],"Baltimore,":[80],"MD),":[81],"topical":[83],"microbicide,":[85],"had":[87],"clinical":[88],"gram":[90],"stain":[91],"evaluation":[92],"response.":[94],"Subjects":[95,121],"evaluated":[97],"at":[98,114,124,156],"2-3":[99,157],"days":[100,158],"after":[101,159],"last":[103],"application":[104],"as":[107],"test":[109,125],"cure":[111,127],"again":[113],"1":[115],"month":[116],"assess":[118],"relapse.":[120],"offered":[129,139],"oral":[130],"metronidazole.":[131],"RESULTS:":[132],"Thirty-one":[133],"screened,":[136],"16":[137],"enrollment,":[140],"10":[142],"completed":[143],"study.":[145],"Treatment":[146],"was":[149],"70%":[153],"40%":[163],"by":[166],"1-month":[167],"follow-up.":[168],"CONCLUSIONS:":[169],"These":[170],"results":[171],"suggest":[172],"that":[173],"5":[174],"vaginally":[178],"once":[179],"day":[181],"appears":[182]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
