{"id":"https://openalex.org/W1615513261","doi":null,"title":"Stimulation of c-myc oncogene expression associated with estrogen-induced proliferation of human breast cancer cells.","display_name":"Stimulation of c-myc oncogene expression associated with estrogen-induced proliferation of human breast cancer cells.","publication_year":1987,"publication_date":"1987-12-15","ids":{"openalex":"https://openalex.org/W1615513261","mag":"1615513261","pmid":"https://pubmed.ncbi.nlm.nih.gov/3677090"},"language":"en","primary_location":{"id":"pmid:3677090","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3677090","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065727588","display_name":"Don Dubik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"D Dubik","raw_affiliation_strings":["Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109116546","display_name":"Thomas C. Dembinski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T C Dembinski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111411888","display_name":"Robert P. C. Shiu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R P Shiu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6732,"has_fulltext":false,"cited_by_count":275,"citation_normalized_percentile":{"value":0.91466208,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"47","issue":"24 Pt 1","first_page":"6517","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.8209999799728394},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.6290000081062317},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.8840000033378601},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.9980000257492065},{"id":"https://openalex.org/keywords/breast-cancer-cell-proliferation","display_name":"breast cancer cell proliferation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/c-myc-mrna-expression","display_name":"c-myc mRNA expression","score":0.8529999852180481},{"id":"https://openalex.org/keywords/c-h-ras","display_name":"c-H-ras","score":0.8299999833106995},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.7110000252723694},{"id":"https://openalex.org/keywords/t-47d","display_name":"T-47D","score":0.8880000114440918},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9779999852180481},{"id":"https://openalex.org/keywords/bt-20","display_name":"BT-20","score":0.9359999895095825},{"id":"https://openalex.org/keywords/oncogene-regulation","display_name":"oncogene regulation","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.7925658822059631},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.7750552892684937},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.7692893743515015},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.6321610808372498},{"id":"https://openalex.org/C2776067312","wikidata":"https://www.wikidata.org/wiki/Q50429983","display_name":"Antiestrogen","level":5,"score":0.591522753238678},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5475930571556091},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5436978936195374},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5021052360534668},{"id":"https://openalex.org/C96307122","wikidata":"https://www.wikidata.org/wiki/Q15329133","display_name":"Estrogen receptor beta","level":5,"score":0.490031361579895},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.4875907301902771},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4733279347419739},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45018258690834045},{"id":"https://openalex.org/C2780482068","wikidata":"https://www.wikidata.org/wiki/Q5508491","display_name":"Fulvestrant","level":5,"score":0.4432031512260437},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41745516657829285},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.41667309403419495},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39599907398223877},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3728862702846527},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.30960601568222046},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1767379343509674},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.057592540979385376},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3677090","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3677090","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1615513261","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3677090","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2083200046","https://openalex.org/W2471591161","https://openalex.org/W1494515794","https://openalex.org/W2107877605","https://openalex.org/W1572225275","https://openalex.org/W2122280948","https://openalex.org/W154891151","https://openalex.org/W2029327979","https://openalex.org/W1997053696","https://openalex.org/W204411172"],"abstract_inverted_index":{"Regulation":[0],"of":[1,12,26,37,46,60,66,100,138,168,190,200,225,236],"c-myc":[2,47,61,146,169,192,226],"expression":[3,45,147,199,227],"is":[4,21],"known":[5],"to":[6,9,126,216],"be":[7,229],"sensitive":[8],"a":[10,22,64,92,142,152],"variety":[11],"mitogenic":[13],"stimuli":[14],"in":[15,48,63,109,141,145,158,180,206,233],"various":[16],"cell":[17,50,68,71,95,134,164,184,211],"types.":[18],"Since":[19],"estrogen":[20,77,85,102,177,217],"well":[23],"documented":[24],"mitogen":[25],"estrogen-responsive":[27],"human":[28],"breast":[29,94],"cancer":[30,183],"(HBC)":[31],"cells,":[32],"we":[33,56],"studied":[34,73],"the":[35,44,58,75,83,107,132,136,162,166,181,191,198],"influence":[36],"estradiol":[38,127,139],"and":[39,91,118,173,209,213,218],"its":[40],"antagonist":[41],"tamoxifen":[42,119],"on":[43],"HBC":[49,67,237],"lines.":[51,69],"Using":[52],"Northern":[53],"hybridization":[54],"analysis,":[55],"monitored":[57],"accumulation":[59],"mRNA":[62,170],"number":[65],"The":[70,98],"lines":[72,135,165,212],"included":[74],"estrogen-responsive,":[76],"receptor":[78,86],"positive":[79],"(ER+)":[80],"MCF-7,":[81],"T-47D,":[82],"nonresponsive,":[84],"negative":[87],"(ER-)":[88],"MDA-MB-231,":[89],"BT-20,":[90],"nontumorous":[93],"line,":[96],"HBL-100.":[97],"effects":[99],"endogenous":[101],"were":[103],"minimized":[104],"by":[105,176],"culturing":[106],"cells":[108],"medium":[110],"containing":[111],"10%":[112],"(v/v)":[113],"charcoal-treated":[114],"fetal":[115],"bovine":[116],"serum":[117],"(10(-6)":[120],"M)":[121,129],"for":[122],"48":[123],"h":[124],"prior":[125],"(10(-7)":[128],"treatment.":[130],"In":[131,161,196],"ER+":[133,208],"addition":[137],"resulted":[140],"noticeable":[143],"increase":[144],"after":[148],"15":[149],"min":[150],"with":[151],"maximal":[153],"(greater":[154],"than":[155],"10-fold)":[156],"induction":[157],"1-2":[159],"h.":[160],"ER-":[163,182,210],"level":[167],"was":[171,174,194,214],"high":[172],"unaffected":[175],"or":[178],"tamoxifen;":[179],"lines,":[185],"neither":[186],"amplification":[187],"nor":[188],"rearrangement":[189],"gene":[193],"observed.":[195],"contrast,":[197],"another":[201],"oncogene,":[202],"c-H-ras,":[203],"remained":[204],"constant":[205],"both":[207],"insensitive":[215],"antiestrogen.":[219],"These":[220],"results":[221],"suggest":[222],"that":[223],"regulation":[224],"may":[228],"an":[230],"important":[231],"step":[232],"estrogen-induced":[234],"proliferation":[235],"cells.":[238]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}