{"id":"https://openalex.org/W1614756392","doi":"https://doi.org/10.1016/s0021-9258(19)38883-0","title":"Purification and characterization of two novel phosphoglycerides that modulate the glucocorticoid-receptor complex. Evidence for two modulator binding sites in the occupied/unactivated steroid hormone receptor.","display_name":"Purification and characterization of two novel phosphoglycerides that modulate the glucocorticoid-receptor complex. Evidence for two modulator binding sites in the occupied/unactivated steroid hormone receptor.","publication_year":1990,"publication_date":"1990-06-01","ids":{"openalex":"https://openalex.org/W1614756392","doi":"https://doi.org/10.1016/s0021-9258(19)38883-0","mag":"1614756392","pmid":"https://pubmed.ncbi.nlm.nih.gov/2345182"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)38883-0","doi":"https://doi.org/10.1016/s0021-9258(19)38883-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)38883-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)38883-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021968564","display_name":"Peter V.N. Bodine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P V Bodine","raw_affiliation_strings":["Fels Institute for Cancer Research and Molecular Biology, Temple University Medicine, Philadelphia, Pennsylvania 19140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fels Institute for Cancer Research and Molecular Biology, Temple University Medicine, Philadelphia, Pennsylvania 19140","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062814155","display_name":"Gerald Litwack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Litwack","raw_affiliation_strings":["Fels Institute for Cancer Research and Molecular Biology, Temple University Medicine, Philadelphia, Pennsylvania 19140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fels Institute for Cancer Research and Molecular Biology, Temple University Medicine, Philadelphia, Pennsylvania 19140","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I84392919"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.2988,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.94258016,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"265","issue":"16","first_page":"9544","last_page":"9554"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modulators","display_name":"modulators","score":0.8629999756813049},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.8429999947547913},{"id":"https://openalex.org/keywords/phospholipids","display_name":"phospholipids","score":0.7960000038146973},{"id":"https://openalex.org/keywords/receptor-isoforms","display_name":"receptor isoforms","score":0.8159999847412109},{"id":"https://openalex.org/keywords/rat-liver","display_name":"rat liver","score":0.6539999842643738},{"id":"https://openalex.org/keywords/steroid-hormone-receptors","display_name":"steroid hormone receptors","score":0.3889999985694885},{"id":"https://openalex.org/keywords/additive-and-synergistic-effects","display_name":"synergistic and additive effects","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.7275457382202148},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.5482743382453918},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.525990903377533},{"id":"https://openalex.org/C2776888042","wikidata":"https://www.wikidata.org/wiki/Q422137","display_name":"Steroid hormone","level":3,"score":0.5239867568016052},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5233218669891357},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.4704289436340332},{"id":"https://openalex.org/C2779544216","wikidata":"https://www.wikidata.org/wiki/Q411546","display_name":"Steroid hormone receptor","level":5,"score":0.4420751929283142},{"id":"https://openalex.org/C124170894","wikidata":"https://www.wikidata.org/wiki/Q14914591","display_name":"Nuclear receptor coactivator 2","level":5,"score":0.41554003953933716},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.37437158823013306},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37433651089668274},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.3639470934867859},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34638649225234985},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31086885929107666},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1911298930644989},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.16088971495628357},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.11487454175949097},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10692083835601807},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07907426357269287},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.05288046598434448},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002852","descriptor_name":"Chromatography, Ion Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005994","descriptor_name":"Glycerophosphates","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D005994","descriptor_name":"Glycerophosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005994","descriptor_name":"Glycerophosphates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(19)38883-0","doi":"https://doi.org/10.1016/s0021-9258(19)38883-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)38883-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:2345182","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2345182","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)38883-0","doi":"https://doi.org/10.1016/s0021-9258(19)38883-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)38883-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1141793848","display_name":null,"funder_award_id":"CA-12227","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1275303223","display_name":null,"funder_award_id":"DK42353","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2383201025","display_name":"TRAINING IN CANCER AND CANCER RELATED RESEARCH","funder_award_id":"T32CA009214","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3602932867","display_name":"CORE PROGRAM ON CARCINOGENESIS","funder_award_id":"5p30ca012227-20","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6615040380","display_name":"MODULATOR AND THE GLUCOCORTICOID RECEPTOR","funder_award_id":"5r01dk042353-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7834384845","display_name":null,"funder_award_id":"5-T-32-CA-09214-11","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W162906798","https://openalex.org/W1516283219","https://openalex.org/W1541332557","https://openalex.org/W1563644794","https://openalex.org/W1567759240","https://openalex.org/W1568701525","https://openalex.org/W1574867324","https://openalex.org/W1934538449","https://openalex.org/W1970782117","https://openalex.org/W1979286967","https://openalex.org/W2010397795","https://openalex.org/W2024098392","https://openalex.org/W2039409343","https://openalex.org/W2042851875","https://openalex.org/W2060903877","https://openalex.org/W2089250490","https://openalex.org/W2104360623","https://openalex.org/W2126534142","https://openalex.org/W2162491741","https://openalex.org/W2342073136","https://openalex.org/W2895738616"],"related_works":["https://openalex.org/W1563644794","https://openalex.org/W2412702184","https://openalex.org/W2073911512","https://openalex.org/W1970782117","https://openalex.org/W1988953264","https://openalex.org/W2420606532","https://openalex.org/W1541332557","https://openalex.org/W2001744408","https://openalex.org/W1969937911","https://openalex.org/W1993423492"],"abstract_inverted_index":{"Modulator":[0],"is":[1,7],"a":[2,62],"novel":[3],"ether":[4],"aminophosphoglyceride":[5],"that":[6,144,169,181,215,272],"commonly":[8],"known":[9],"as":[10],"the":[11,54,78,129,145,164,182,192,203,207,216,219,236,252,259,263,274,283,296],"low-molecular":[12],"weight":[13],"inhibitor":[14],"of":[15,23,56,73,157,163,172,206,218,238,262,295],"glucocorticoid-receptor":[16],"complex":[17],"activation.":[18],"An":[19],"ultra-large":[20],"scale":[21],"purification":[22,33],"modulator":[24,74,185,195,242,280,288],"has":[25,277,286],"been":[26],"performed":[27],"from":[28,77],"1000":[29],"rat":[30,58],"livers.":[31],"This":[32],"was":[34,186],"similar":[35,149,256],"to":[36,100,154],"our":[37],"previous":[38],"one":[39,279,291],"(Bodine,":[40],"P.":[41],"V.,":[42],"and":[43,82,87,115,123,137,151,174,200,209,229,240],"Litwack,":[44],"G.":[45],"(1988)":[46],"J.":[47],"Biol.":[48],"Chem.":[49],"263,":[50],"3501-3512),":[51],"but":[52],"involved":[53],"chromatography":[55],"heated":[57],"liver":[59],"cytosol":[60],"on":[61,92,243],"7-liter":[63],"bed":[64],"volume":[65],"Sephadex":[66],"G-15":[67],"gel":[68],"filtration":[69],"column.":[70],"Two":[71],"peaks":[72],"activity":[75],"eluted":[76],"giant":[79],"gel-filtration":[80],"column,":[81],"these":[83,269],"two":[84,130,146,220,253,264,287],"modulators":[85,97,131,147,165,221,254],"(peak-1":[86],"peak-2)":[88],"were":[89,98,222,248],"chromatographed":[90],"separately":[91],"Dowex-1":[93],"anion-exchange":[94],"columns.":[95],"Both":[96],"determined":[99],"be":[101,155],"homogeneous":[102],"after":[103],"this":[104],"step":[105],"by":[106,133],"analytical":[107,111],"high-performance":[108,112,135,138],"thin-layer":[109],"chromatography,":[110,114],"liquid":[113,139],"nuclear":[116],"magnetic":[117],"resonance":[118],"spectroscopy.":[119],"Furthermore,":[120],"although":[121,251,273],"peak-1":[122,184,239],"peak-2":[124,194,241],"differed":[125],"in":[126],"molecular":[127],"weight,":[128],"co-chromatographed":[132],"anion-exchange,":[134],"thin-layer,":[136],"chromatography.":[140],"These":[141],"results":[142,270],"suggest":[143,271],"have":[148,255],"structures":[150],"therefore":[152],"appear":[153],"isoforms":[156],"each":[158,294],"other.":[159],"In":[160],"addition,":[161],"both":[162,225],"are":[166,170,266],"organic":[167],"molecules":[168],"devoid":[171],"molybdenum":[173],"62":[175],"other":[176],"metals.":[177],"Activity":[178],"assays":[179],"indicated":[180,214],"larger":[183],"five":[187],"times":[188],"more":[189],"potent":[190],"than":[191],"smaller":[193],"at":[196,201],"inhibiting":[197],"receptor":[198,226,232,245,276,285],"activation":[199,227],"stabilizing":[202],"steroid-binding":[204,233,246],"ability":[205],"occupied":[208,231],"unoccupied":[210,244],"receptors.":[211],"Mixing":[212],"experiments":[213],"activities":[217],"synergistic":[223],"for":[224,230,293],"inhibition":[228],"stabilization.":[234],"However,":[235],"effects":[237],"stabilization":[247],"additive.":[249],"Thus,":[250],"chemical":[257],"structures,":[258],"biological":[260],"potencies":[261],"compounds":[265],"different.":[267],"Moreover,":[268],"unoccupied/unactivated":[275],"only":[278],"binding":[281,289],"site,":[282],"occupied/unactivated":[284],"sites,":[290],"site":[292],"isoforms.":[297]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
