{"id":"https://openalex.org/W16144058","doi":null,"title":"The cancer-associated retinopathy antigen is a recoverin-like protein.","display_name":"The cancer-associated retinopathy antigen is a recoverin-like protein.","publication_year":1992,"publication_date":"1992-09-01","ids":{"openalex":"https://openalex.org/W16144058","mag":"16144058","pmid":"https://pubmed.ncbi.nlm.nih.gov/1388144"},"language":"en","primary_location":{"id":"pmid:1388144","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1388144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058521729","display_name":"Charles E. Thirkill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C E Thirkill","raw_affiliation_strings":["Ophthalmology Research, University of California Davis Medical Center, Sacramento"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology Research, University of California Davis Medical Center, Sacramento","institution_ids":["https://openalex.org/I4210160527"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R C Tait","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R C Tait","raw_affiliation_strings":["Ophthalmology Research, University of California Davis Medical Center, Sacramento"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology Research, University of California Davis Medical Center, Sacramento","institution_ids":["https://openalex.org/I4210160527"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046465490","display_name":"Nancy K. Tyler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N K Tyler","raw_affiliation_strings":["Ophthalmology Research, University of California Davis Medical Center, Sacramento"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology Research, University of California Davis Medical Center, Sacramento","institution_ids":["https://openalex.org/I4210160527"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022005075","display_name":"Alan M. Roth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A M Roth","raw_affiliation_strings":["Ophthalmology Research, University of California Davis Medical Center, Sacramento"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology Research, University of California Davis Medical Center, Sacramento","institution_ids":["https://openalex.org/I4210160527"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112387826","display_name":"John L. Keltner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J L Keltner","raw_affiliation_strings":["Ophthalmology Research, University of California Davis Medical Center, Sacramento"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology Research, University of California Davis Medical Center, Sacramento","institution_ids":["https://openalex.org/I4210160527"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210160527"],"apc_list":null,"apc_paid":null,"fwci":28.0217,"has_fulltext":false,"cited_by_count":233,"citation_normalized_percentile":{"value":0.99806422,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"33","issue":"10","first_page":"2768","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.6987000107765198,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.6987000107765198,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.1860000044107437,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":0.07410000264644623,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-associated-retinopathy","display_name":"cancer-associated retinopathy","score":1.0},{"id":"https://openalex.org/keywords/recoverin","display_name":"recoverin","score":0.9089999794960022},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.8360000252723694},{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.7910000085830688},{"id":"https://openalex.org/keywords/photoreceptor-proteins","display_name":"photoreceptor proteins","score":0.7860000133514404},{"id":"https://openalex.org/keywords/autoimmune-retinopathy","display_name":"autoimmune retinopathy","score":0.6759999990463257},{"id":"https://openalex.org/keywords/gene-cloning","display_name":"gene cloning","score":0.3720000088214874},{"id":"https://openalex.org/keywords/sequence-homology","display_name":"sequence homology","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C2781139644","wikidata":"https://www.wikidata.org/wiki/Q18031078","display_name":"Recoverin","level":4,"score":0.9577920436859131},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.6123580932617188},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5887115597724915},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5234678983688354},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49419716000556946},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.4717108905315399},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.46805068850517273},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4632132947444916},{"id":"https://openalex.org/C2778313320","wikidata":"https://www.wikidata.org/wiki/Q550455","display_name":"Retinopathy","level":3,"score":0.4625311493873596},{"id":"https://openalex.org/C189482833","wikidata":"https://www.wikidata.org/wiki/Q869146","display_name":"cDNA library","level":4,"score":0.42902565002441406},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38492074608802795},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.3694155216217041},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2899305522441864},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2471022605895996},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1529051959514618},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.11968988180160522},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09532126784324646},{"id":"https://openalex.org/C202033177","wikidata":"https://www.wikidata.org/wiki/Q423107","display_name":"Rhodopsin","level":3,"score":0.057804644107818604},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000912","descriptor_name":"Antibodies, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010257","descriptor_name":"Paraneoplastic Syndromes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010257","descriptor_name":"Paraneoplastic Syndromes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010786","descriptor_name":"Photoreceptor Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051597","descriptor_name":"Hippocalcin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051603","descriptor_name":"Recoverin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1388144","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1388144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:16144058","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1388144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3495110347","display_name":"Molecular Analysis of Ocular Lens Beaded Filaments","funder_award_id":"R01EY008747","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1969900854","https://openalex.org/W1991622845","https://openalex.org/W2020295187","https://openalex.org/W2086703017","https://openalex.org/W2115201271","https://openalex.org/W2150521622"],"related_works":["https://openalex.org/W1988312770","https://openalex.org/W2139683857","https://openalex.org/W2163868238","https://openalex.org/W4255013776","https://openalex.org/W123456836","https://openalex.org/W2085981775","https://openalex.org/W3163632422","https://openalex.org/W1964552031","https://openalex.org/W7024372491","https://openalex.org/W2376806406"],"abstract_inverted_index":{"Cancer-associated":[0],"retinopathy":[1],"(CAR)":[2],"is":[3,76],"a":[4,28,59,117],"rare":[5],"form":[6],"of":[7,17,25,61,68,86,96,120,141],"retinal":[8,34,73],"degeneration":[9],"that":[10,127],"occurs":[11],"in":[12,40,82],"association":[13],"with":[14],"certain":[15],"forms":[16],"cancer.":[18],"CAR":[19,35,46,74,87,103,114,129],"patients":[20,47,104],"typically":[21],"possess":[22],"high":[23],"titers":[24],"autoantibodies":[26],"against":[27],"specific":[29,66],"photoreceptor":[30],"protein--the":[31],"23":[32],"kD":[33],"antigen.":[36],"The":[37],"mechanisms":[38],"involved":[39,81],"the":[41,55,69,72,77,83,94,110,113,128,136],"vision":[42],"loss":[43],"experienced":[44],"by":[45],"are":[48],"not":[49],"understood,":[50],"but":[51],"serologic":[52],"studies":[53],"indicate":[54],"process":[56],"could":[57],"include":[58],"series":[60],"autoimmune":[62,98],"reactions":[63],"directed":[64],"at":[65],"components":[67],"retina.":[70,122],"Because":[71],"antigen":[75,115,130],"principal":[78],"ocular":[79],"autoantigen":[80],"antibody":[84],"response":[85],"patients,":[88],"characterizing":[89],"it":[90],"would":[91],"contribute":[92],"to":[93,108,135],"understanding":[95],"putative":[97],"involvement.":[99],"Serum":[100],"antibodies":[101],"from":[102,116],"have":[105],"been":[106],"used":[107],"isolate":[109],"gene":[111],"encoding":[112],"cDNA":[118],"library":[119],"human":[121],"Nucleotide":[123],"sequence":[124,140],"analysis":[125],"suggests":[126],"shows":[131],"approximately":[132],"90%":[133],"homology":[134],"published":[137],"amino":[138],"acid":[139],"bovine":[142],"recoverin.":[143]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
