{"id":"https://openalex.org/W1612041908","doi":"https://doi.org/10.4049/jimmunol.174.2.619","title":"Peripheral \u201cCD8 Tuning\u201d Dynamically Modulates the Size and Responsiveness of an Antigen-Specific T Cell Pool In Vivo","display_name":"Peripheral \u201cCD8 Tuning\u201d Dynamically Modulates the Size and Responsiveness of an Antigen-Specific T Cell Pool In Vivo","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W1612041908","doi":"https://doi.org/10.4049/jimmunol.174.2.619","mag":"1612041908","pmid":"https://pubmed.ncbi.nlm.nih.gov/15634879"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.174.2.619","doi":"https://doi.org/10.4049/jimmunol.174.2.619","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.174.2.619","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007601702","display_name":"Robert Maile","orcid":"https://orcid.org/0000-0002-9126-4188","observed_orcids":["https://orcid.org/0000-0002-9126-4188"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert Maile","raw_affiliation_strings":["Department of Microbiology and Immunology, University of North Carolina , Chapel Hill, NC 27599","Department of Surgery, University of North Carolina , Chapel Hill, NC 27599","* Microbiology and Immunology,","\u2020Surgery, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of North Carolina , Chapel Hill, NC 27599","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Surgery, University of North Carolina , Chapel Hill, NC 27599","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"* Microbiology and Immunology,","institution_ids":[]},{"raw_affiliation_string":"\u2020Surgery, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043091429","display_name":"Catherine A. Siler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine A Siler","raw_affiliation_strings":["Department of Microbiology and Immunology, University of North Carolina , Chapel Hill, NC 27599","* Microbiology and Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of North Carolina , Chapel Hill, NC 27599","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"* Microbiology and Immunology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109101609","display_name":"Samantha E. Kerry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samantha E Kerry","raw_affiliation_strings":["Department of Microbiology and Immunology, University of North Carolina , Chapel Hill, NC 27599","* Microbiology and Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of North Carolina , Chapel Hill, NC 27599","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"* Microbiology and Immunology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033154676","display_name":"Katherine E. Midkiff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine E Midkiff","raw_affiliation_strings":["Department of Microbiology and Immunology, University of North Carolina , Chapel Hill, NC 27599","* Microbiology and Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of North Carolina , Chapel Hill, NC 27599","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"* Microbiology and Immunology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101699137","display_name":"Edward J. Collins","orcid":"https://orcid.org/0000-0002-3523-8532","observed_orcids":["https://orcid.org/0000-0002-3523-8532"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward J Collins","raw_affiliation_strings":["Department of Biochemistry and Biophysics, University of North Carolina , Chapel Hill, NC 27599","Department of Microbiology and Immunology, University of North Carolina , Chapel Hill, NC 27599","* Microbiology and Immunology,","\u2021Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of North Carolina , Chapel Hill, NC 27599","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of North Carolina , Chapel Hill, NC 27599","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"* Microbiology and Immunology,","institution_ids":[]},{"raw_affiliation_string":"\u2021Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008183954","display_name":"Jeffrey A. Frelinger","orcid":"https://orcid.org/0000-0002-2503-6267","observed_orcids":["https://orcid.org/0000-0002-2503-6267"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A Frelinger","raw_affiliation_strings":["Department of Microbiology and Immunology, University of North Carolina , Chapel Hill, NC 27599","* Microbiology and Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of North Carolina , Chapel Hill, NC 27599","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"* Microbiology and Immunology,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007601702"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":3.3964,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.92813745,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"174","issue":"2","first_page":"619","last_page":"627"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-avidity","display_name":"T cell avidity","score":0.7509999871253967},{"id":"https://openalex.org/keywords/altered-peptide-ligands","display_name":"altered peptide ligands","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cd8-deficient-mice","display_name":"CD8-deficient mice","score":0.5839999914169312},{"id":"https://openalex.org/keywords/t-cell-tolerance","display_name":"T cell tolerance","score":0.7279999852180481},{"id":"https://openalex.org/keywords/t-cell-responsiveness","display_name":"T cell responsiveness","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.7059717178344727},{"id":"https://openalex.org/C179223381","wikidata":"https://www.wikidata.org/wiki/Q419425","display_name":"Avidity","level":3,"score":0.6739746332168579},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5865216851234436},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.5666197538375854},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5533426403999329},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5467920303344727},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.455878883600235},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4213932454586029},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4205765724182129},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.4190571904182434},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3873014748096466},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3535088300704956},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3480840027332306},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33688563108444214},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3226354122161865},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.299049437046051},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2560139298439026},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2440294623374939},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13073909282684326},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11791419982910156}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006182","descriptor_name":"H-Y Antigen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006182","descriptor_name":"H-Y Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006182","descriptor_name":"H-Y Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016827","descriptor_name":"CD8 Antigens","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D023001","descriptor_name":"Transplantation Tolerance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.174.2.619","doi":"https://doi.org/10.4049/jimmunol.174.2.619","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.174.2.619","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:15634879","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15634879","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1878385081","display_name":"Targeting CD8+ T Cell to Prevent B Cell Destruction","funder_award_id":"R01AI052435","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2707641798","display_name":null,"funder_award_id":"AI52435","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5723008927","display_name":"Role of the MHC Class I in CD8 T Cell Activation","funder_award_id":"R01GM067143","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1481172479","https://openalex.org/W1482928030","https://openalex.org/W1507800008","https://openalex.org/W1540372987","https://openalex.org/W1542971120","https://openalex.org/W1547913407","https://openalex.org/W1562079541","https://openalex.org/W1823106884","https://openalex.org/W1859429438","https://openalex.org/W1910510739","https://openalex.org/W1966989202","https://openalex.org/W1977507710","https://openalex.org/W1984337138","https://openalex.org/W1985402375","https://openalex.org/W1986216579","https://openalex.org/W1986356667","https://openalex.org/W1992678959","https://openalex.org/W1995698907","https://openalex.org/W2000734326","https://openalex.org/W2005314275","https://openalex.org/W2005541017","https://openalex.org/W2006561389","https://openalex.org/W2008366157","https://openalex.org/W2016429173","https://openalex.org/W2019835477","https://openalex.org/W2020927234","https://openalex.org/W2026891958","https://openalex.org/W2029607309","https://openalex.org/W2032225182","https://openalex.org/W2039672885","https://openalex.org/W2050911784","https://openalex.org/W2051539551","https://openalex.org/W2065431537","https://openalex.org/W2080789248","https://openalex.org/W2094213517","https://openalex.org/W2099326339","https://openalex.org/W2100140378","https://openalex.org/W2101643778","https://openalex.org/W2102635642","https://openalex.org/W2108861854","https://openalex.org/W2111686340","https://openalex.org/W2117582013","https://openalex.org/W2127794555","https://openalex.org/W2135489733","https://openalex.org/W2140018744","https://openalex.org/W2141205048","https://openalex.org/W2142256483","https://openalex.org/W2142381543","https://openalex.org/W2154700048","https://openalex.org/W2156835139","https://openalex.org/W2158069920","https://openalex.org/W2159814728","https://openalex.org/W2163900612","https://openalex.org/W2165051352","https://openalex.org/W2889168750","https://openalex.org/W2920917588","https://openalex.org/W4249889741"],"related_works":["https://openalex.org/W2112859782","https://openalex.org/W2039206013","https://openalex.org/W1976120351","https://openalex.org/W12132115","https://openalex.org/W2063259139","https://openalex.org/W2580990716","https://openalex.org/W1549160904","https://openalex.org/W1507930766","https://openalex.org/W2148698828","https://openalex.org/W2153742280"],"abstract_inverted_index":{"In":[0,99],"this":[1],"study,":[2],"we":[3,49,74,86],"suggest":[4],"that":[5,135],"CD8":[6,31,110,137],"levels":[7,138],"on":[8],"T":[9,23,54,79,91,158,189,214,222],"cells":[10,55,80,92,159],"are":[11],"not":[12],"static,":[13],"but":[14],"can":[15],"change":[16],"and,":[17],"as":[18,121],"a":[19,106,144,182,197],"result,":[20],"modulate":[21,206],"CD8(+)":[22],"cell":[24,215,223],"responses.":[25],"We":[26],"describe":[27],"three":[28,132],"models":[29,133],"of":[30,43,65,105,109,115,160,167,185,211,220,228,238],"modulation":[32],"using":[33],"novel":[34],"weak-agonist":[35],"(K1A)":[36],"and":[37,70,101,126,170,209,241],"super-agonist":[38],"(C2A)":[39],"altered":[40],"peptide":[41],"ligands":[42],"the":[44,113,116,141,150,161,207,221,225,236],"HY":[45,67,95,119,175],"smcy":[46],"peptide.":[47],"First,":[48],"used":[50,75,87],"peripheral":[51,58,186],"nonresponsive":[52,89,187],"CD8(low)":[53,90,100,188],"produced":[56],"after":[57],"HY-D(b)":[59,169],"MHC":[60],"class":[61],"I":[62],"tetramer":[63],"stimulation":[64],"female":[66,174,178],"TCR":[68,96,120,151,176],"transgenic":[69,97],"wild-type":[71,168],"mice.":[72,84,98],"Second,":[73],"genetically":[76],"lowered":[77],"CD8(int)":[78],"from":[81,93],"heterozygote":[82],"CD8(+/0)":[83],"Finally,":[85],"pre-existing":[88],"male":[94],"CD8(high)":[102,157],"mice,":[103],"presence":[104],"lower":[107],"level":[108],"greatly":[111],"decreased":[112],"avidity":[114,124,146],"peptide-MHC":[117,147],"for":[118,143,235],"reflected":[122],"by":[123,217],"(K(D))":[125],"dissociation":[127],"constant":[128],"(T(1/2))":[129],"measurements.":[130],"All":[131],"demonstrated":[134],"lowering":[136],"resulted":[139],"in":[140,195],"requirement":[142],"higher":[145],"interaction":[148],"with":[149],"to":[152,155,204],"respond":[153],"equivalently":[154],"unmanipulated":[156],"same":[162],"specificity.":[163],"Additionally,":[164],"direct":[165],"injections":[166],"C2A-D(b)":[171,192],"tetramers":[172],"into":[173],"or":[177],"B6":[179],"mice":[180],"induced":[181],"high":[183],"frequency":[184],"cells,":[190],"yet":[191],"was":[193],"superior":[194],"inducing":[196],"primed":[198],"CD8(+)CD44(+)":[199],"memory":[200],"population.":[201],"The":[202],"ability":[203],"dynamically":[205],"size":[208],"responsiveness":[210],"an":[212,229],"Ag-specific":[213],"pool":[216],"\"CD8":[218],"tuning\"":[219],"during":[224],"early":[226],"phases":[227],"immune":[230],"response":[231],"has":[232],"important":[233],"implications":[234],"balance":[237],"responsiveness,":[239],"memory,":[240],"tolerance.":[242]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
