{"id":"https://openalex.org/W1610241671","doi":"https://doi.org/10.4049/jimmunol.156.1.322","title":"Activation of NK cells by CC chemokines. Chemotaxis, Ca2+ mobilization, and enzyme release","display_name":"Activation of NK cells by CC chemokines. Chemotaxis, Ca2+ mobilization, and enzyme release","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W1610241671","doi":"https://doi.org/10.4049/jimmunol.156.1.322","mag":"1610241671","pmid":"https://pubmed.ncbi.nlm.nih.gov/8598480"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.156.1.322","doi":"https://doi.org/10.4049/jimmunol.156.1.322","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.156.1.322","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1610241671"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070673649","display_name":"Pius Loetscher","orcid":"https://orcid.org/0000-0003-1912-4436","observed_orcids":["https://orcid.org/0000-0003-1912-4436"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"P Loetscher","raw_affiliation_strings":["Theodor-Kocher Institute, University of Bern ,","Theodor-Kocher Institute, University of Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Theodor-Kocher Institute, University of Bern ,","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Theodor-Kocher Institute, University of Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Seitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"M Seitz","raw_affiliation_strings":["Theodor-Kocher Institute, University of Bern ,","Theodor-Kocher Institute, University of Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Theodor-Kocher Institute, University of Bern ,","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Theodor-Kocher Institute, University of Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091242881","display_name":"Ian Clark\u2010Lewis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"I Clark-Lewis","raw_affiliation_strings":["Theodor-Kocher Institute, University of Bern ,","Theodor-Kocher Institute, University of Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Theodor-Kocher Institute, University of Bern ,","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Theodor-Kocher Institute, University of Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004188962","display_name":"Marco Baggiolini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"M Baggiolini","raw_affiliation_strings":["Theodor-Kocher Institute, University of Bern ,","Theodor-Kocher Institute, University of Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Theodor-Kocher Institute, University of Bern ,","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Theodor-Kocher Institute, University of Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019701092","display_name":"Bernhard Moser","orcid":"https://orcid.org/0000-0002-4354-4572","observed_orcids":["https://orcid.org/0000-0002-4354-4572"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"B Moser","raw_affiliation_strings":["Theodor-Kocher Institute, University of Bern ,","Theodor-Kocher Institute, University of Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Theodor-Kocher Institute, University of Bern ,","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Theodor-Kocher Institute, University of Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I118564535"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":7.5039,"has_fulltext":false,"cited_by_count":282,"citation_normalized_percentile":{"value":0.97810219,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"156","issue":"1","first_page":"322","last_page":"327"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.05209999904036522,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8519999980926514},{"id":"https://openalex.org/keywords/cc-chemokines","display_name":"CC chemokines","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cxc-chemokines","display_name":"CXC chemokines","score":0.8970000147819519},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/calcium-mobilization","display_name":"calcium mobilization","score":0.8510000109672546},{"id":"https://openalex.org/keywords/gzma","display_name":"granzyme A","score":0.7279999852180481},{"id":"https://openalex.org/keywords/n-acetyl-beta-d-glucosaminidase","display_name":"N-acetyl-beta-D-glucosaminidase","score":0.9100000262260437},{"id":"https://openalex.org/keywords/granule-exocytosis","display_name":"granule exocytosis","score":0.921999990940094},{"id":"https://openalex.org/keywords/ccl5","display_name":"RANTES","score":0.7549999952316284},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9070000052452087},{"id":"https://openalex.org/keywords/mip-1alpha","display_name":"MIP-1\u03b1","score":0.8090000152587891},{"id":"https://openalex.org/keywords/mip-1beta","display_name":"MIP-1\u03b2","score":0.9710000157356262},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.8190000057220459},{"id":"https://openalex.org/keywords/cxcl10","display_name":"CXCL10","score":0.996999979019165},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/nk-cell-activation","display_name":"NK cell activation","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.6905160546302795},{"id":"https://openalex.org/C116484652","wikidata":"https://www.wikidata.org/wiki/Q3492926","display_name":"CCL5","level":5,"score":0.670569896697998},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.6451637744903564},{"id":"https://openalex.org/C170217031","wikidata":"https://www.wikidata.org/wiki/Q6725509","display_name":"Macrophage inflammatory protein","level":4,"score":0.5640778541564941},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44065332412719727},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41977688670158386},{"id":"https://openalex.org/C143172330","wikidata":"https://www.wikidata.org/wiki/Q1069599","display_name":"CCL17","level":5,"score":0.419401079416275},{"id":"https://openalex.org/C49802076","wikidata":"https://www.wikidata.org/wiki/Q5251810","display_name":"Degranulation","level":3,"score":0.4190514087677002},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40682491660118103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3792719542980194},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.34499019384384155},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23964792490005493},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.21389687061309814},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.20996946096420288},{"id":"https://openalex.org/C5858377","wikidata":"https://www.wikidata.org/wiki/Q986112","display_name":"CXCL10","level":4,"score":0.19090232253074646},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1300666332244873},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.12316688895225525},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11773094534873962}],"mesh":[{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.156.1.322","doi":"https://doi.org/10.4049/jimmunol.156.1.322","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.156.1.322","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:8598480","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8598480","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1511263879","https://openalex.org/W2000430541","https://openalex.org/W2032352828","https://openalex.org/W2030411262","https://openalex.org/W1548455476","https://openalex.org/W2142688519","https://openalex.org/W2165234706","https://openalex.org/W2011680430","https://openalex.org/W1575826610","https://openalex.org/W2336153715"],"abstract_inverted_index":{"The":[0,86,220],"responses":[1,253],"of":[2,55,105,111,119,155,175,210,214,222,247],"cloned":[3,181,223],"human":[4],"NK":[5,57,134,149,184,202,224,268],"cells":[6,58,135,191,225,229],"(ERNK57)":[7],"to":[8,78,113,206,230,232,258],"seven":[9],"CC":[10,51,84,156,163,265],"chemokines":[11,41,52,64,157,164,233,266],"(monocyte":[12],"chemotactic":[13],"protein-1":[14,30],"(MCP-1),":[15],"MCP-2,":[16],"MCP-3,":[17],"RANTES":[18],"(regulated":[19],"on":[20,158,235],"activation,":[21],"normal":[22],"T":[23,190,228,278],"cell":[24],"expressed":[25],"and":[26,36,38,43,76,168,178,182,204,208,217,226,251,270,280,282],"secreted),":[27],"macrophage":[28],"inflammatory":[29],"alpha":[31],"(MIP-1":[32],"alpha),":[33],"MIP-1":[34],"beta,":[35],"1309)":[37],"two":[39],"CXC":[40,63],"(IL-8":[42],"IP-10)":[44],"were":[45,65,254],"studied.":[46],"Except":[47],"for":[48,74,81,98,128,148,276],"1309,":[49],"all":[50,95,139],"induced":[53,101,166,172],"chemotaxis":[54,167],"the":[56,62,82,108,120,153,173,211,236,245],"in":[59,94,133,238,244],"vitro,":[60],"whereas":[61],"inactive.":[66],"Maximal":[67],"activity":[68],"was":[69,131,160,199],"obtained":[70,200],"at":[71],"1":[72],"nM":[73,80],"MCP-1":[75],"10":[77,257],"100":[79],"other":[83],"chemokines.":[85,142],"response":[87],"showed":[88],"a":[89,102],"typically":[90],"bimodal":[91],"concentration":[92,109,123],"dependence":[93],"cases,":[96],"except":[97],"RANTES,":[99],"which":[100,125],"linear":[103],"increase":[104],"migration":[106],"over":[107],"range":[110],"0.1":[112],"1000":[114],"nM.":[115],"A":[116,177,216],"transient":[117],"rise":[118],"cytosolic-free":[121],"Ca2+":[122],"([Ca2+]i),":[124],"is":[126,146],"characteristic":[127],"chemokine-stimulated":[129],"leukocytes,":[130],"observed":[132,255],"after":[136,192,240,256],"stimulation":[137,241],"with":[138,194,242],"six":[140],"active":[141],"Since":[143],"granule":[144],"exocytosis":[145,159],"required":[147],"cell-dependent":[150],"target":[151],"killing,":[152],"effect":[154],"tested.":[161],"All":[162],"that":[165,264],"[Ca2+]i":[169],"changes":[170],"also":[171],"release":[174,198],"granzyme":[176,215],"N-acetyl-beta-D-glucosaminidase":[179],"from":[180,201],"blood":[183],"cells,":[185,203,250,269],"as":[186,188],"well":[187],"CD8+":[189,227],"pretreatment":[193],"cytochalasin":[195],"B.":[196],"Maximum":[197],"amounted":[205],"35%":[207],"13%":[209],"total":[212],"content":[213],"N-acetyl-beta-D-glucosaminidase,":[218],"respectively.":[219],"capacity":[221],"respond":[231],"depended":[234],"time":[237],"culture":[239],"PHA":[243],"presence":[246],"irradiated":[248],"feeder":[249],"maximum":[252],"16":[259],"days.":[260],"Our":[261],"results":[262],"demonstrate":[263],"activate":[267],"are,":[271],"therefore,":[272],"not":[273],"only":[274],"attractants":[275],"monocytes,":[277],"lymphocytes,":[279],"eosinophil":[281],"basophil":[283],"granulocytes.":[284]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}