{"id":"https://openalex.org/W1609176262","doi":null,"title":"Synchronous oral carcinomas: independent or common clonal origin?","display_name":"Synchronous oral carcinomas: independent or common clonal origin?","publication_year":1998,"publication_date":"1998-05-01","ids":{"openalex":"https://openalex.org/W1609176262","mag":"1609176262","pmid":"https://pubmed.ncbi.nlm.nih.gov/9581845"},"language":"en","primary_location":{"id":"pmid:9581845","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9581845","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110896713","display_name":"Andrea G. M. Scholes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A G Scholes","raw_affiliation_strings":["Molecular Genetics and Oncology Group, Clinical Dental Sciences, The University of Liverpool, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics and Oncology Group, Clinical Dental Sciences, The University of Liverpool, United Kingdom","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075057487","display_name":"Julia Anne Woolgar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Woolgar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052823843","display_name":"M A Boyle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Boyle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046439936","display_name":"J.S. Brown","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J S Brown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"E D Vaughan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E D Vaughan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113766018","display_name":"C. Anthony Hart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C A Hart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017566352","display_name":"Andrew Simpson Jones","orcid":"https://orcid.org/0000-0003-1580-2447","observed_orcids":["https://orcid.org/0000-0003-1580-2447"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A S Jones","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034359692","display_name":"John K. Field","orcid":"https://orcid.org/0000-0003-3951-6365","observed_orcids":["https://orcid.org/0000-0003-3951-6365"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J K Field","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.7912,"has_fulltext":false,"cited_by_count":126,"citation_normalized_percentile":{"value":0.97412788,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"58","issue":"9","first_page":"2003","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.611299991607666,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.611299991607666,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.2831999957561493,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.03500000014901161,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/second-primary-tumors","display_name":"second primary tumors","score":0.8669999837875366},{"id":"https://openalex.org/keywords/clonal-origin","display_name":"clonal origin","score":0.7879999876022339},{"id":"https://openalex.org/keywords/field-cancerization","display_name":"field cancerization","score":0.9580000042915344},{"id":"https://openalex.org/keywords/allelic-imbalance","display_name":"allelic imbalance","score":0.9010000228881836},{"id":"https://openalex.org/keywords/microsatellite-markers","display_name":"microsatellite markers","score":0.8949999809265137},{"id":"https://openalex.org/keywords/chromosome-3p","display_name":"chromosome 3p","score":0.7540000081062317},{"id":"https://openalex.org/keywords/chromosome-9p","display_name":"chromosome 9p","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chromosome-17p","display_name":"chromosome 17p","score":1.0},{"id":"https://openalex.org/keywords/oral-epithelial-dysplasia","display_name":"oral dysplasia","score":0.8870000243186951}],"concepts":[{"id":"https://openalex.org/C60120401","wikidata":"https://www.wikidata.org/wiki/Q17119253","display_name":"Field cancerization","level":3,"score":0.923194944858551},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6694884896278381},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6574185490608215},{"id":"https://openalex.org/C2775894508","wikidata":"https://www.wikidata.org/wiki/Q1128996","display_name":"Dysplasia","level":2,"score":0.6322956681251526},{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.5277408361434937},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5251001119613647},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.5125007629394531},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.49396735429763794},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.48183929920196533},{"id":"https://openalex.org/C113968399","wikidata":"https://www.wikidata.org/wiki/Q7559241","display_name":"Somatic evolution in cancer","level":3,"score":0.47419267892837524},{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.46491748094558716},{"id":"https://openalex.org/C2994460389","wikidata":"https://www.wikidata.org/wiki/Q681817","display_name":"Epidermoid carcinoma","level":3,"score":0.4459366798400879},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4137859344482422},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36649543046951294},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.3382120132446289},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2340298295021057},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2115139663219452},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09750965237617493}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002886","descriptor_name":"Chromosomes, Human, Pair 17","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002893","descriptor_name":"Chromosomes, Human, Pair 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002899","descriptor_name":"Chromosomes, Human, Pair 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007972","descriptor_name":"Leukoplakia, Oral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007972","descriptor_name":"Leukoplakia, Oral","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018895","descriptor_name":"Microsatellite Repeats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019656","descriptor_name":"Loss of Heterozygosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9581845","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9581845","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Comparative Study"},{"id":"mag:1609176262","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9581845","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2413926588","https://openalex.org/W2137341964","https://openalex.org/W2046339703","https://openalex.org/W7095234658","https://openalex.org/W1986973901","https://openalex.org/W2044954013","https://openalex.org/W2062380506","https://openalex.org/W1933079398","https://openalex.org/W1623369171","https://openalex.org/W2063272535"],"abstract_inverted_index":{"Second":[0],"primary":[1],"tumors":[2,31,60,90],"in":[3,69,88,103,129,139,147,158,176,186],"patients":[4,21,94,135,178],"with":[5,95,150],"head":[6],"and":[7,102,113],"neck":[8],"cancer":[9],"have":[10,81],"a":[11,54],"detrimental":[12],"impact":[13],"on":[14,109],"long-term":[15],"survival;":[16],"at":[17,122],"least":[18],"15%":[19],"of":[20,53,77,85,119,173,182],"develop":[22],"additional":[23],"tumors.":[24,79,141],"Originally,":[25],"it":[26],"was":[27,127],"hypothesized":[28],"that":[29,166],"multiple":[30,59],"developed":[32],"independently":[33],"after":[34],"widespread":[35],"epithelial":[36],"exposure":[37],"to":[38,75],"carcinogens":[39],"(the":[40],"field":[41],"cancerization":[42],"theory),":[43],"but":[44,179],"recent":[45],"molecular":[46],"studies":[47],"now":[48],"support":[49],"the":[50,63,78,83,123,159],"alternative":[51],"theory":[52],"common":[55,74,183],"clonal":[56,184],"origin.":[57],"If":[58],"originate":[61],"from":[62,91],"same":[64,124],"clone,":[65],"early":[66,146],"genetic":[67],"alterations":[68,138],"these":[70,154],"cells":[71],"should":[72],"be":[73,181],"all":[76],"We":[80],"compared":[82],"pattern":[84],"allelic":[86],"imbalance":[87],"paired":[89],"five":[92],"male":[93],"two":[96,130],"synchronous":[97,167],"oral":[98,168],"squamous":[99,169],"cell":[100,170],"carcinomas":[101,171],"peripheral":[104],"dysplasia":[105],"using":[106],"microsatellite":[107,125],"markers":[108],"chromosomes":[110],"3p,":[111],"9p,":[112],"17p.":[114],"Discordance,":[115],"usually":[116],"through":[117],"loss":[118],"alternate":[120],"alleles":[121],"loci,":[126],"detected":[128],"patients.":[131],"The":[132,142],"remaining":[133],"three":[134],"had":[136],"identical":[137],"their":[140],"changes":[143],"identified":[144],"occurred":[145],"tumorigenesis,":[148],"because,":[149],"only":[151],"one":[152],"exception,":[153],"were":[155],"also":[156],"present":[157],"associated":[160],"dysplasia.":[161],"Thus,":[162],"we":[163],"provide":[164],"evidence":[165],"are":[172],"independent":[174],"origin":[175,185],"some":[177],"may":[180],"others.":[187]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}