{"id":"https://openalex.org/W1608697802","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1165.10","title":"High salt intake and aldosterone independently augment the exercise pressor reflex in rats (1165.10)","display_name":"High salt intake and aldosterone independently augment the exercise pressor reflex in rats (1165.10)","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W1608697802","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1165.10","mag":"1608697802"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.28.1_supplement.1165.10","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1165.10","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.1165.10","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080909826","display_name":"Masaki Mizuno","orcid":"https://orcid.org/0000-0003-4455-8084","observed_orcids":["https://orcid.org/0000-0003-4455-8084"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masaki Mizuno","raw_affiliation_strings":["Health Care Sciences University of Texas Southwestern Medical Center Dallas TX United States","2Health Care Sciences University of Texas Southwestern Medical Center Dallas TX United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Care Sciences University of Texas Southwestern Medical Center Dallas TX United States","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"2Health Care Sciences University of Texas Southwestern Medical Center Dallas TX United States","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063417875","display_name":"Ryan M. Downey","orcid":"https://orcid.org/0000-0003-4144-1155","observed_orcids":["https://orcid.org/0000-0003-4144-1155"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Downey","raw_affiliation_strings":["Internal Medicine University of Texas Southwestern Medical Center Dallas TX United States","3Internal Medicine University of Texas Southwestern Medical Center Dallas TX United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine University of Texas Southwestern Medical Center Dallas TX United States","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"3Internal Medicine University of Texas Southwestern Medical Center Dallas TX United States","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108494122","display_name":"Jere H. Mitchell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jere Mitchell","raw_affiliation_strings":["Internal Medicine University of Texas Southwestern Medical Center Dallas TX United States","3Internal Medicine University of Texas Southwestern Medical Center Dallas TX United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine University of Texas Southwestern Medical Center Dallas TX United States","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"3Internal Medicine University of Texas Southwestern Medical Center Dallas TX United States","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085330812","display_name":"Scott A. Smith","orcid":"https://orcid.org/0000-0002-2143-2342","observed_orcids":["https://orcid.org/0000-0002-2143-2342"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Smith","raw_affiliation_strings":["Health Care Sciences University of Texas Southwestern Medical Center Dallas TX United States","2Health Care Sciences University of Texas Southwestern Medical Center Dallas TX United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Care Sciences University of Texas Southwestern Medical Center Dallas TX United States","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"2Health Care Sciences University of Texas Southwestern Medical Center Dallas TX United States","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084255283","display_name":"Wanpen Vongpatanasin","orcid":"https://orcid.org/0000-0002-7531-9388","observed_orcids":["https://orcid.org/0000-0002-7531-9388"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wanpen Vongpatanasin","raw_affiliation_strings":["Cardiology Division University of Texas Southwestern Medical Center Dallas TX United States","1Cardiology Division University of Texas Southwestern Medical Center Dallas TX United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division University of Texas Southwestern Medical Center Dallas TX United States","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"1Cardiology Division University of Texas Southwestern Medical Center Dallas TX United States","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.15506617,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"28","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.02410000003874302,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exercise-pressor-reflex","display_name":"exercise pressor reflex","score":0.9990000128746033},{"id":"https://openalex.org/keywords/high-salt-diet","display_name":"high-salt diet","score":0.8299999833106995},{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":0.9729999899864197},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.953000009059906},{"id":"https://openalex.org/keywords/renal-sympathetic-nerve-activity","display_name":"renal sympathetic nerve activity","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mean-arterial-pressure","display_name":"mean arterial pressure","score":0.925000011920929},{"id":"https://openalex.org/keywords/muscle-stretching","display_name":"muscle stretching","score":0.49399998784065247},{"id":"https://openalex.org/keywords/capsaicin","display_name":"capsaicin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/sympathetic-activation","display_name":"sympathetic activation","score":0.3149999976158142},{"id":"https://openalex.org/keywords/blood-pressure-response-to-exercise","display_name":"blood pressure response to exercise","score":0.7310000061988831},{"id":"https://openalex.org/keywords/mechanoreflex","display_name":"mechanoreflex","score":0.5220000147819519},{"id":"https://openalex.org/keywords/muscle-metaboreflex","display_name":"muscle metaboreflex","score":0.9890000224113464}],"concepts":[{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.9086798429489136},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.7212272882461548},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7047115564346313},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6744164228439331},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6014054417610168},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.5865586996078491},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5740503668785095},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5722512602806091},{"id":"https://openalex.org/C2776452961","wikidata":"https://www.wikidata.org/wiki/Q1940733","display_name":"Mean arterial pressure","level":4,"score":0.47099608182907104},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.21555626392364502}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.28.1_supplement.1165.10","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1165.10","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.1165.10","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.46000000834465027}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7691689282","display_name":"The Role of Aldosterone on Augmented Exercise Pressor Reflex in Hypertension","funder_award_id":"R01HL113738","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1953516944","https://openalex.org/W2096728019","https://openalex.org/W7098964541","https://openalex.org/W2266629125","https://openalex.org/W2150063472","https://openalex.org/W2077845855","https://openalex.org/W2154016433","https://openalex.org/W2049483851","https://openalex.org/W2056670739","https://openalex.org/W3177214964"],"abstract_inverted_index":{"Evidence":[0],"suggests":[1],"the":[2,12,55,89,136,154,169,173],"exercise":[3,183],"pressor":[4,122],"reflex":[5],"(EPR)":[6],"is":[7],"overactive":[8],"in":[9,38,41,59,95,97,135,176,184],"hypertension.":[10,185],"However,":[11],"underlying":[13,172],"mechanisms":[14,171],"are":[15],"poorly":[16],"understood.":[17],"The":[18,119],"purpose":[19],"of":[20,33,54,88],"this":[21],"study":[22],"was":[23,116],"to":[24,52,79,82,124,168],"determine":[25],"whether":[26],"excessive":[27],"salt":[28,77,161],"intake":[29,162],"and/or":[30],"chronic":[31],"administration":[32,131],"aldosterone":[34,62,140,164],"potentiates":[35],"EPR":[36,56,90],"function":[37],"rats.":[39],"Changes":[40],"renal":[42],"sympathetic":[43,120,177],"nerve":[44],"activity":[45,178],"(RSNA)":[46],"and":[47,61,100,106,121,128,139,146,163,179],"mean":[48],"arterial":[49],"pressure":[50,181],"(MAP)":[51],"stimulation":[53,87],"were":[57,132],"assessed":[58],"vehicle":[60],"treated":[63,141],"(4":[64],"weeks":[65],"via":[66],"osmotic":[67],"mini\u2010pump)":[68],"Sprague\u2010Dawley":[69],"rats":[70],"given":[71],"either":[72],"water":[73],"or":[74],"saline":[75],"(elevated":[76],"load)":[78],"drink.":[80],"Compared":[81],"vehicle/water\u2010treated":[83],"rats,":[84,142],"contraction":[85],"induced":[86],"evoked":[91],"significantly":[92],"greater":[93],"increases":[94],"RSNA":[96],"vehicle/saline,":[98],"aldosterone/water":[99],"aldosterone/saline\u2010treated":[101],"animals":[102],"(39\u00b111,":[103],"98\u00b119,":[104],"110\u00b120,":[105],"154\u00b129%/kg,":[107],"respectively,":[108],"P<0.01":[109],").":[110],"A":[111],"similar":[112],"MAP":[113],"response":[114],"profile":[115],"likewise":[117],"produced.":[118],"responses":[123],"passive":[125],"muscle":[126],"stretch":[127],"intra\u2010arterial":[129],"capsaicin":[130],"also":[133],"augmented":[134],"vehicle/saline":[137],"group":[138],"suggesting":[143],"both":[144,159],"mechano\u2010":[145],"metaboreflex":[147],"sensitization.":[148],"In":[149],"conclusion,":[150],"our":[151],"data":[152],"provide":[153],"first":[155],"direct":[156],"evidence":[157],"for":[158],"high":[160],"as":[165],"major":[166],"contributors":[167],"neural":[170],"exaggerated":[174],"rise":[175],"blood":[180],"during":[182],"Supported":[186,194],"by":[187,195],"NIH":[188,196],"HL\u2010113738":[189,197],"Grant":[190],"Funding":[191],"Source":[192],":":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}