{"id":"https://openalex.org/W1608360834","doi":"https://doi.org/10.1371/journal.pone.0007410","title":"Ocular Delivery of Compacted DNA-Nanoparticles Does Not Elicit Toxicity in the Mouse Retina","display_name":"Ocular Delivery of Compacted DNA-Nanoparticles Does Not Elicit Toxicity in the Mouse Retina","publication_year":2009,"publication_date":"2009-10-09","ids":{"openalex":"https://openalex.org/W1608360834","doi":"https://doi.org/10.1371/journal.pone.0007410","mag":"1608360834","pmid":"https://pubmed.ncbi.nlm.nih.gov/19823583","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2756629"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0007410","doi":"https://doi.org/10.1371/journal.pone.0007410","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0007410","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007410&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007410&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073022367","display_name":"Xi\u2010Qin Ding","orcid":"https://orcid.org/0000-0002-0482-2226","observed_orcids":["https://orcid.org/0000-0002-0482-2226"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xi-Qin Ding","raw_affiliation_strings":["The Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America. xi-qin-ding@ouhsc.edu","Cell Biology, Univ Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America. xi-qin-ding@ouhsc.edu","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Cell Biology, Univ Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078421408","display_name":"Alexander B. Quiambao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander B. Quiambao","raw_affiliation_strings":["The Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America","Cell Biology, Univ Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Cell Biology, Univ Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071261394","display_name":"J. Browning Fitzgerald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Browning Fitzgerald","raw_affiliation_strings":["The Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America","Cell Biology, Univ Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Cell Biology, Univ Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065198906","display_name":"Mark J. Cooper","orcid":"https://orcid.org/0000-0003-2008-622X","observed_orcids":["https://orcid.org/0000-0003-2008-622X"]},"institutions":[{"id":"https://openalex.org/I4210125596","display_name":"Copernicus Therapeutics (United States)","ror":"https://ror.org/034a7fc11","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark J. Cooper","raw_affiliation_strings":["Copernicus Therapeutics, Inc., Cleveland, Ohio, United States of America","Copernicus Therapeutics, Inc., Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Copernicus Therapeutics, Inc., Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I4210125596"]},{"raw_affiliation_string":"Copernicus Therapeutics, Inc., Cleveland, Ohio","institution_ids":["https://openalex.org/I4210125596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025204714","display_name":"Shannon M. Conley","orcid":"https://orcid.org/0000-0002-7550-3898","observed_orcids":["https://orcid.org/0000-0002-7550-3898","https://orcid.org/0000-0002-4959-1652"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon M. Conley","raw_affiliation_strings":["The Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America","Cell Biology, Univ Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Cell Biology, Univ Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031536121","display_name":"Muna I. Naash","orcid":"https://orcid.org/0000-0002-6534-5144","observed_orcids":["https://orcid.org/0000-0002-6534-5144"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muna I. Naash","raw_affiliation_strings":["The Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America","Cell Biology, Univ Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Cell Biology, Univ Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I49332381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073022367"],"corresponding_institution_ids":["https://openalex.org/I49332381"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.9778,"has_fulltext":true,"cited_by_count":71,"citation_normalized_percentile":{"value":0.8550692,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"4","issue":"10","first_page":"e7410","last_page":"e7410"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.035999998450279236,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ocular-gene-delivery","display_name":"ocular gene delivery","score":0.722000002861023},{"id":"https://openalex.org/keywords/subretinal-injection","display_name":"subretinal injection","score":0.9760000109672546},{"id":"https://openalex.org/keywords/retinal-toxicity","display_name":"retinal toxicity","score":0.7319999933242798},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5389999747276306},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.6480000019073486},{"id":"https://openalex.org/keywords/kc-chemokine","display_name":"KC chemokine","score":0.8379999995231628},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.7770000100135803},{"id":"https://openalex.org/keywords/f4-80","display_name":"F4/80","score":0.7200000286102295},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.9739999771118164},{"id":"https://openalex.org/keywords/egfp-expression","display_name":"EGFP expression","score":0.5569999814033508},{"id":"https://openalex.org/keywords/polyethylene-glycol","display_name":"polyethylene glycol","score":0.7459999918937683},{"id":"https://openalex.org/keywords/nanotherapeutics","display_name":"nanotherapeutics","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.5926651954650879},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.52118319272995},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4919874370098114},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.43363526463508606},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4202061891555786},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.16886508464813232},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1669352948665619},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.16633760929107666},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1290026605129242},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09912168979644775},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053761","descriptor_name":"Nanocomposites","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0007410","doi":"https://doi.org/10.1371/journal.pone.0007410","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0007410","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007410&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2756629","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2756629","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:19823583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19823583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.810.521","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.810.521","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/51/33/pone.0007410.PMC2756629.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:7961d501e2434284ab3237479c1a5dad","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7961d501e2434284ab3237479c1a5dad","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 4, Iss 10, p e7410 (2009)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/146070","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Ocular_Delivery_of_Compacted_DNA_Nanoparticles_Does_Not_Elicit_Toxicity_in_the_Mouse_Retina/146070","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"mag:1608360834","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2364149","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0007410","doi":"https://doi.org/10.1371/journal.pone.0007410","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0007410","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007410&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4048590753","display_name":"Using Nanotechnology to Rescue Visual Loss in A Model of Human Blinding Disorder","funder_award_id":"R21EY017031","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G5988839538","display_name":"Compacted DNA Nanoparticles for Ocular Therapy","funder_award_id":"R01EY018656","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1608360834.pdf","grobid_xml":"https://content.openalex.org/works/W1608360834.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W799836324","https://openalex.org/W1577441858","https://openalex.org/W1965340455","https://openalex.org/W1967423482","https://openalex.org/W1969461625","https://openalex.org/W1973893754","https://openalex.org/W1975730784","https://openalex.org/W1982483820","https://openalex.org/W1982690958","https://openalex.org/W1992009563","https://openalex.org/W1996875707","https://openalex.org/W1999093640","https://openalex.org/W2002645517","https://openalex.org/W2009227956","https://openalex.org/W2014356856","https://openalex.org/W2016489998","https://openalex.org/W2020955029","https://openalex.org/W2022040013","https://openalex.org/W2022137963","https://openalex.org/W2030953063","https://openalex.org/W2033833740","https://openalex.org/W2037703905","https://openalex.org/W2047329666","https://openalex.org/W2048305864","https://openalex.org/W2052479752","https://openalex.org/W2055714163","https://openalex.org/W2061726838","https://openalex.org/W2062899453","https://openalex.org/W2068403296","https://openalex.org/W2070526348","https://openalex.org/W2075139742","https://openalex.org/W2081571534","https://openalex.org/W2086866768","https://openalex.org/W2096993232","https://openalex.org/W2101037432","https://openalex.org/W2105022733","https://openalex.org/W2108170959","https://openalex.org/W2109571250","https://openalex.org/W2119324304","https://openalex.org/W2127286505","https://openalex.org/W2130322765","https://openalex.org/W2130694284","https://openalex.org/W2131138524","https://openalex.org/W2137222303","https://openalex.org/W2138084996","https://openalex.org/W2138549894","https://openalex.org/W2141354154","https://openalex.org/W2144261986","https://openalex.org/W2151809142","https://openalex.org/W2156373321","https://openalex.org/W2159728076","https://openalex.org/W2172107348","https://openalex.org/W2311972351","https://openalex.org/W2333429511","https://openalex.org/W4256502130"],"related_works":["https://openalex.org/W7099431164","https://openalex.org/W2157843864","https://openalex.org/W2075139742","https://openalex.org/W2057295305","https://openalex.org/W1969461625","https://openalex.org/W2164992413","https://openalex.org/W2007158114","https://openalex.org/W1985307250","https://openalex.org/W2791638265","https://openalex.org/W1453596778"],"abstract_inverted_index":{"Subretinal":[0],"delivery":[1],"of":[2,24,54,66,78,123,160,175,183],"polyethylene":[3],"glycol-substituted":[4],"lysine":[5],"peptide":[6],"(CK30PEG)-compacted":[7],"DNA":[8,26,185],"nanoparticles":[9,29,105],"results":[10],"in":[11,15,38,73,89,100,128],"efficient":[12],"gene":[13],"expression":[14,33],"retinal":[16],"cells.":[17],"This":[18],"work":[19],"evaluates":[20],"the":[21,90,189],"ocular":[22],"safety":[23],"compacted":[25,184],"nanoparticles.":[27],"CK30PEG-compacted":[28],"containing":[30],"an":[31],"EGFP":[32],"plasmid":[34],"were":[35,50,168],"subretinally":[36],"injected":[37,91,102,147],"adult":[39],"mice":[40],"(1":[41],"microl":[42],"at":[43,56,108,117,138,155],"0.3,":[44],"1.0":[45],"and":[46,60,145],"3.0":[47],"microg/microl).":[48],"Retinas":[49],"examined":[51],"for":[52,142,196],"signs":[53,174],"inflammation":[55],"1,":[57],"2,":[58],"4":[59],"7":[61],"days":[62,119],"post-injection.":[63,120],"Neither":[64],"infiltration":[65],"polymorphonuclear":[67],"neutrophils":[68],"or":[69,82,106,166],"lymphocytes":[70],"was":[71,86,126],"detected":[72,88],"retinas.":[74],"In":[75],"addition,":[76],"elevation":[77,122],"macrophage":[79],"marker":[80,84],"F4/80":[81],"myeloid":[83],"myeloperoxidase":[85],"not":[87],"eyes.":[92],"The":[93,131],"chemokine":[94],"KC":[95,124],"mRNA":[96,165],"increased":[97,135],"3-4":[98,136],"fold":[99,137],"eyes":[101],"with":[103,180],"either":[104],"saline":[107,146],"1":[109,139],"day":[110,140],"post-injection,":[111],"but":[112,149],"returned":[113,151],"to":[114,152],"control":[115,153],"levels":[116,154],"2":[118,156],"No":[121,158],"protein":[125,167],"observed":[127],"these":[129],"mice.":[130],"monocyte":[132],"chemotactic":[133],"protein-1,":[134],"post-injection":[141],"both":[143],"nanoparticle":[144],"eyes,":[148],"also":[150],"days.":[157],"elevations":[159],"tumor":[161],"necrosis":[162],"factor":[163],"alpha":[164],"detected.":[169],"These":[170],"investigations":[171],"show":[172],"no":[173],"local":[176],"inflammatory":[177],"responses":[178],"associated":[179],"subretinal":[181],"injection":[182],"nanoparticles,":[186],"indicating":[187],"that":[188],"retina":[190],"may":[191],"be":[192],"a":[193],"suitable":[194],"target":[195],"clinical":[197],"nanoparticle-based":[198],"interventions.":[199]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
