{"id":"https://openalex.org/W1608288709","doi":null,"title":"Thin-fibre signalling in humans: Cortical processing of sensory afference and autonomic efference","display_name":"Thin-fibre signalling in humans: Cortical processing of sensory afference and autonomic efference","publication_year":2010,"publication_date":"2010-03-04","ids":{"openalex":"https://openalex.org/W1608288709","mag":"1608288709"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/21181","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/21181","pdf_url":"http://hdl.handle.net/2077/21181","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2077/21181","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109178549","display_name":"Karin Rylander","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Karin Rylander","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5109178549"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10914","display_name":"Tactile and Sensory Interactions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10914","display_name":"Tactile and Sensory Interactions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/unmyelinated-afferents","display_name":"unmyelinated afferents","score":0.8299999833106995},{"id":"https://openalex.org/keywords/insular-cortex","display_name":"insula","score":0.8270000219345093},{"id":"https://openalex.org/keywords/somatosensory-cortex","display_name":"somatosensory cortex","score":0.8209999799728394},{"id":"https://openalex.org/keywords/ventromedial-prefrontal-cortex","display_name":"ventromedial prefrontal cortex","score":0.968999981880188},{"id":"https://openalex.org/keywords/rectal-distension","display_name":"rectal distension","score":0.859000027179718},{"id":"https://openalex.org/keywords/inferior-frontal-gyrus","display_name":"inferior frontal gyrus","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C2778942571","wikidata":"https://www.wikidata.org/wiki/Q1430868","display_name":"Efference copy","level":3,"score":0.8001934289932251},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6994346976280212},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.6369882225990295},{"id":"https://openalex.org/C2776861996","wikidata":"https://www.wikidata.org/wiki/Q241849","display_name":"Sensory processing","level":3,"score":0.46109023690223694},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3643907308578491},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.3263700008392334}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/21181","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/21181","pdf_url":"http://hdl.handle.net/2077/21181","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:1608288709","doi":null,"is_oa":false,"landing_page_url":"https://gupea.ub.gu.se/handle/2077/21181","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/21181","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/21181","pdf_url":"http://hdl.handle.net/2077/21181","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1608288709.pdf","grobid_xml":"https://content.openalex.org/works/W1608288709.grobid-xml"},"referenced_works_count":91,"referenced_works":["https://openalex.org/W7508719","https://openalex.org/W175791812","https://openalex.org/W1522809190","https://openalex.org/W1538916083","https://openalex.org/W1563342819","https://openalex.org/W1581387623","https://openalex.org/W1766894222","https://openalex.org/W1824892726","https://openalex.org/W1896419431","https://openalex.org/W1909424429","https://openalex.org/W1966117108","https://openalex.org/W1967318820","https://openalex.org/W1967764695","https://openalex.org/W1968869699","https://openalex.org/W1969150052","https://openalex.org/W1969298833","https://openalex.org/W1972094807","https://openalex.org/W1975312927","https://openalex.org/W1981100423","https://openalex.org/W1981585593","https://openalex.org/W1983542297","https://openalex.org/W1987599891","https://openalex.org/W1988548196","https://openalex.org/W1992848642","https://openalex.org/W1996343883","https://openalex.org/W2002220726","https://openalex.org/W2005238835","https://openalex.org/W2008512583","https://openalex.org/W2016521818","https://openalex.org/W2017210051","https://openalex.org/W2020180345","https://openalex.org/W2021721006","https://openalex.org/W2022644793","https://openalex.org/W2022689346","https://openalex.org/W2025224324","https://openalex.org/W2027404236","https://openalex.org/W2028159422","https://openalex.org/W2028850601","https://openalex.org/W2037543907","https://openalex.org/W2038379220","https://openalex.org/W2042522004","https://openalex.org/W2042618263","https://openalex.org/W2045448984","https://openalex.org/W2045812316","https://openalex.org/W2050717100","https://openalex.org/W2050732854","https://openalex.org/W2051497534","https://openalex.org/W2054041622","https://openalex.org/W2055210002","https://openalex.org/W2058713030","https://openalex.org/W2062831890","https://openalex.org/W2065989997","https://openalex.org/W2066519584","https://openalex.org/W2071714163","https://openalex.org/W2082219803","https://openalex.org/W2083956595","https://openalex.org/W2086073246","https://openalex.org/W2087961547","https://openalex.org/W2088443095","https://openalex.org/W2089584955","https://openalex.org/W2090664493","https://openalex.org/W2090839097","https://openalex.org/W2092724034","https://openalex.org/W2095024518","https://openalex.org/W2099660465","https://openalex.org/W2105558714","https://openalex.org/W2107187638","https://openalex.org/W2117649346","https://openalex.org/W2119084915","https://openalex.org/W2119183851","https://openalex.org/W2119884239","https://openalex.org/W2124790162","https://openalex.org/W2128766452","https://openalex.org/W2129219475","https://openalex.org/W2138900344","https://openalex.org/W2141796362","https://openalex.org/W2142213531","https://openalex.org/W2142823391","https://openalex.org/W2162130009","https://openalex.org/W2164121465","https://openalex.org/W2166557169","https://openalex.org/W2169985903","https://openalex.org/W2223209212","https://openalex.org/W2266355581","https://openalex.org/W2331067916","https://openalex.org/W2399138436","https://openalex.org/W2400652664","https://openalex.org/W2401690763","https://openalex.org/W2429862435","https://openalex.org/W2544894372","https://openalex.org/W4244157404"],"related_works":["https://openalex.org/W2075188166","https://openalex.org/W2530637859","https://openalex.org/W1985144092","https://openalex.org/W2124790162","https://openalex.org/W7126295398","https://openalex.org/W2002522691","https://openalex.org/W2072415649","https://openalex.org/W2134681037","https://openalex.org/W4376226266","https://openalex.org/W2592005218"],"abstract_inverted_index":{"Thin":[0],"nerve":[1,415],"fibres":[2,204,349,368],"innervate":[3],"the":[4,42,47,55,64,69,73,132,169,189,200,231,241,254,256,276,313,320,324,335,345,375,381,386,409],"entire":[5],"human":[6],"body":[7],"and":[8,14,67,84,160,165,205,301,334,374,401,445],"mediate":[9],"sensations":[10],"such":[11,430],"as":[12,425,431],"pain,\\ntemperature":[13],"visceral":[15,402],"sensory":[16],"input.":[17],"Moreover,":[18],"a":[19,250,262,269,280,285,393],"special":[20],"class":[21],"of":[22,54,72,80,104,124,147,193,202,240,355,383,413,421,428],"unmyelinated":[23],"afferents\\nresponsive":[24],"to":[25,215,229,234,261,312,319,323,340,398],"light":[26],"touch":[27],"has":[28],"recently":[29],"been":[30],"found":[31],"in":[32,46,110,150,253,290,317,380],"humans:":[33],"C-tactile":[34],"(CT)":[35],"fibres.":[36,116],"In":[37],"the\\nefferent":[38],"side,":[39],"C-fibres":[40,62],"are":[41],"path":[43],"for":[44,188,238,395,411],"signalling":[45],"autonomic":[48,88,206,282,299,384],"nervous":[49],"system,":[50],"controlling\\nthe":[51],"internal":[52],"milieu":[53],"body.":[56,74],"There":[57],"is":[58,392],"growing":[59],"evidence":[60],"that":[61,128,347,362,389],"form":[63],"basis":[65],"for\\nmonitoring":[66],"regulating":[68],"physical":[70],"status":[71],"This":[75],"thesis":[76],"focuses":[77],"on":[78,122,168,199],"central\\nprojections":[79],"mild":[81],"thin-fibre":[82],"input":[83,289],"their":[85,227],"integration":[86],"with":[87,93],"reactions.":[89],"Brain\\nactivity":[90],"was":[91,243,266],"studied":[92,275],"functional":[94],"magnetic":[95],"resonance":[96],"imaging":[97],"(fMRI).\\nThe":[98],"first":[99],"paper":[100,142,197,274],"examined":[101,226],"cortical":[102,145,277,302],"activation":[103,309,333],"selective":[105],"CT-stimulation":[106],"by":[107,178,181,268,284],"soft":[108,161],"tactile\\nstimulation":[109],"two":[111,211],"rare":[112],"patients":[113,214],"lacking":[114],"A\u03b2":[115,158,164,212],"The":[117,171,357],"results":[118],"confirmed":[119],"previous":[120],"findings\\nbased":[121],"one":[123],"these":[125,348],"patients,":[126,255],"showing":[127],"CT":[129,136,148,166,203,218,232,257,330,400],"stimulation":[130,137,149,219,343],"activates":[131],"insular":[133,306,332,363],"cortex.":[134,307],"In\\naddition,":[135],"deactivated":[138],"somatosensory":[139],"cortices.\\nThe":[140],"second":[141],"further":[143],"investigated":[144],"effects":[146],"healthy":[151,291],"controls":[152],"by\\ncomparing":[153],"rapid":[154],"vibration":[155],"(predominantly":[156],"activating":[157],"fibres)":[159],"brush":[162],"stroking\\n(combined":[163],"activation)":[167],"skin.":[170],"ventromedial":[172],"prefrontal":[173],"cortex":[174],"was\\nsignificantly":[175],"more":[176],"activated":[177],"brushing":[179],"than":[180],"vibration,":[182],"an":[183,194],"area":[184],"previously":[185],"implied":[186],"in\\ncoding":[187],"expected":[190],"emotional":[191],"value":[192],"event.\\nThe":[195],"third":[196],"focused":[198],"role":[201],"function.":[207],"We":[208,224,293],"again":[209],"studied\\nthe":[210],"deafferented":[213],"examine":[216],"whether":[217],"could":[220],"evoke":[221],"an\\nautonomic":[222],"response.":[223],"also":[225],"ability":[228,339],"localise":[230,341],"stimulations":[233],"the\\ncorrect":[235],"limb.":[236],"Capacity":[237],"localisation":[239],"stimulus":[242,258,390],"poor":[244,338],"but":[245],"above":[246],"chance.":[247],"Despite\\nproducing":[248],"only":[249],"vague":[251],"percept":[252],"gave":[259],"rise":[260],"skin\\nsympathetic":[263],"reaction":[264],"which":[265,435],"indexed":[267],"galvanic":[270],"skin":[271,314],"response.\\nThe":[272],"fourth":[273],"mechanisms":[278,420],"behind":[279],"restricted":[281],"response\\nelicited":[283],"perceptually":[286],"weak":[287],"C-fibre":[288],"subjects.":[292],"used":[294],"low-intensity":[295],"rectal\\ndistension":[296],"while":[297],"recording":[298],"variables":[300],"responses.":[303],"Rectal":[304],"distension\\nactivated":[305],"Central":[308],"specifically":[310],"related":[311],"sympathetic\\nresponse":[315],"was,":[316],"addition":[318],"brainstem,":[321],"limited":[322],"right":[325],"inferior":[326],"frontal":[327],"gyrus":[328],"(IFG).\\nThe":[329],"evoked":[331],"A\u03b2-denervated":[336],"patients\u2019":[337],"a\\nCT":[342],"support":[344],"concept":[346],"underpin":[350],"affective":[351],"rather":[352],"than\\ndiscriminative":[353],"aspects":[354],"touch.":[356],"rectal":[358],"distension":[359],"study":[360],"indicated":[361],"activation\\nvia":[364],"low-threshold":[365],"mechanovisceral":[366],"thin":[367,403,414],"predominantly":[369],"reflects":[370],"afferent":[371,441],"processing\\nwhereas":[372],"IFG":[373],"brainstem":[376],"may":[377],"be":[378],"important":[379],"generation":[382],"responses.\\nFurther,":[385],"studies":[387,427],"suggest":[388],"perception":[391],"prerequisite":[394],"cutaneous":[396],"autonomic\\nresponses":[397],"both":[399],"fibre":[404,416],"stimuli.":[405],"These":[406],"findings":[407],"set":[408],"stage":[410],"future\\nstudies":[412],"function,":[417],"including":[418],"neural":[419],"hedonic":[422],"processing":[423,444],"as\\nwell":[424],"pathophysiological":[426],"conditions":[429],"irritable":[432],"bowel":[433],"syndrome,":[434],"may\\ntease":[436],"out":[437],"putative":[438],"contributions":[439],"from":[440],"input,":[442],"cognitive":[443],"autonomic\\nconsequences.":[446]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}