{"id":"https://openalex.org/W1607944265","doi":"https://doi.org/10.1248/cpb.26.936","title":"3-Hydroxy-2-naphthoates of lidocaine, mepivacaine, and bupivacaine and their dissolution characteristics.","display_name":"3-Hydroxy-2-naphthoates of lidocaine, mepivacaine, and bupivacaine and their dissolution characteristics.","publication_year":1978,"publication_date":"1978-01-01","ids":{"openalex":"https://openalex.org/W1607944265","doi":"https://doi.org/10.1248/cpb.26.936","mag":"1607944265"},"language":"en","primary_location":{"id":"doi:10.1248/cpb.26.936","doi":"https://doi.org/10.1248/cpb.26.936","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.26.936","pdf_url":"https://www.jstage.jst.go.jp/article/cpb1958/26/3/26_3_936/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical and Pharmaceutical Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/cpb1958/26/3/26_3_936/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026094829","display_name":"Naomi I. Nakano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"NAOMII. NAKANO","raw_affiliation_strings":["Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060426185","display_name":"Norio Kawahara","orcid":"https://orcid.org/0000-0002-4348-897X","observed_orcids":["https://orcid.org/0000-0002-4348-897X"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"NORIO KAWAHARA","raw_affiliation_strings":["Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030833123","display_name":"Takashi Amiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TAKASHI AMIYA","raw_affiliation_strings":["Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071049742","display_name":"Yasuyuki Gotoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"YASUYUKI GOTOH","raw_affiliation_strings":["Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111733414","display_name":"KODO FURUKAWA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KODO FURUKAWA","raw_affiliation_strings":["Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I205349734"],"apc_list":null,"apc_paid":null,"fwci":1.3347,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.7219917,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"3","first_page":"936","last_page":"941"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.3472000062465668,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.3472000062465668,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.2515000104904175,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.12720000743865967,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lidocaine","display_name":"lidocaine","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mepivacaine","display_name":"mepivacaine","score":1.0},{"id":"https://openalex.org/keywords/bupivacaine","display_name":"bupivacaine","score":1.0},{"id":"https://openalex.org/keywords/local-anesthetics","display_name":"local anesthetics","score":0.8550000190734863},{"id":"https://openalex.org/keywords/solubility","display_name":"solubility","score":0.656000018119812},{"id":"https://openalex.org/keywords/dissolution-rate","display_name":"dissolution rate","score":0.9779999852180481},{"id":"https://openalex.org/keywords/solubilization","display_name":"solubilization","score":0.5410000085830688},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9443098306655884},{"id":"https://openalex.org/C2779429755","wikidata":"https://www.wikidata.org/wiki/Q416760","display_name":"Mepivacaine","level":3,"score":0.9117367267608643},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.9106946587562561},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.7505072355270386},{"id":"https://openalex.org/C2778994108","wikidata":"https://www.wikidata.org/wiki/Q1868462","display_name":"Local anesthetic","level":2,"score":0.6283085346221924},{"id":"https://openalex.org/C2781328992","wikidata":"https://www.wikidata.org/wiki/Q422806","display_name":"Bupivacaine","level":2,"score":0.5764332413673401},{"id":"https://openalex.org/C2776371256","wikidata":"https://www.wikidata.org/wiki/Q12370","display_name":"Salt (chemistry)","level":2,"score":0.5484951734542847},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.5468591451644897},{"id":"https://openalex.org/C2780149897","wikidata":"https://www.wikidata.org/wiki/Q216935","display_name":"Lidocaine","level":2,"score":0.5466811656951904},{"id":"https://openalex.org/C203036418","wikidata":"https://www.wikidata.org/wiki/Q284256","display_name":"Crystallization","level":2,"score":0.5061690211296082},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.40031591057777405},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.3883683681488037},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.25179070234298706},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.12900689244270325},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1248/cpb.26.936","doi":"https://doi.org/10.1248/cpb.26.936","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.26.936","pdf_url":"https://www.jstage.jst.go.jp/article/cpb1958/26/3/26_3_936/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical and Pharmaceutical Bulletin","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1248/cpb.26.936","doi":"https://doi.org/10.1248/cpb.26.936","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.26.936","pdf_url":"https://www.jstage.jst.go.jp/article/cpb1958/26/3/26_3_936/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical and Pharmaceutical Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1607944265.pdf","grobid_xml":"https://content.openalex.org/works/W1607944265.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1983497945","https://openalex.org/W647863927","https://openalex.org/W1969909571","https://openalex.org/W1975689028","https://openalex.org/W2252684927","https://openalex.org/W2077864564","https://openalex.org/W2374477860","https://openalex.org/W2015196789","https://openalex.org/W2281647175","https://openalex.org/W4387042102"],"abstract_inverted_index":{"3-Hydroxy-2-naphthoates":[0],"of":[1,15,19,33,52,56,74,80],"lidocaine":[2],"(I),":[3],"mepivacine":[4],"(II),":[5],"and":[6,46,63,82],"bupivacaine":[7],"(III)":[8],"were":[9,59,92],"prepared":[10],"as":[11],"a":[12],"potential":[13],"means":[14],"prolonging":[16],"the":[17,34,47,75,95,104,110],"action":[18],"these":[20,57,99],"local":[21,35],"anesthetic":[22,36],"amines":[23],"through":[24],"their":[25,89],"sparingly":[26],"soluble":[27],"salt":[28],"forms.":[29],"The":[30,78],"molar":[31],"ratio":[32],"base":[37,111],"to":[38],"3-hydroxy-2-naphthoic":[39],"acid":[40],"(IV)":[41],"was":[42],"1":[43,45],":":[44],"hydroxynaphthoates":[48,58,79],"contained":[49],"no":[50],"solvent":[51],"crystallization.":[53],"Dissolution":[54],"characteristics":[55],"determined":[60],"in":[61,98,112],"water":[62],"0.7M":[64],"phosphate":[65],"buffer,":[66],"pH":[67],"7.46":[68],"at":[69],"37\u00b0and":[70],"compared":[71],"with":[72],"those":[73],"corresponding":[76,96],"bases.":[77],"I":[81],"II":[83],"exhibited":[84],"lower":[85],"equilibrium":[86],"solubilities":[87],"but":[88],"dissolution":[90],"rates":[91],"greater":[93],"than":[94,109],"bases":[97],"media.":[100],"As":[101],"for":[102],"III,":[103],"hydroxynaphthoate":[105],"showed":[106],"higher":[107],"solubility":[108],"water.":[113]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2016-06-24T00:00:00"}
