{"id":"https://openalex.org/W1607110292","doi":null,"title":"A mathematical model for the mechanism of rapid eye movements induced by an anticholinesterase in the decerebrate cat.","display_name":"A mathematical model for the mechanism of rapid eye movements induced by an anticholinesterase in the decerebrate cat.","publication_year":1976,"publication_date":"1976-06-01","ids":{"openalex":"https://openalex.org/W1607110292","mag":"1607110292","pmid":"https://pubmed.ncbi.nlm.nih.gov/190960"},"language":"en","primary_location":{"id":"pmid:190960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/190960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives italiennes de biologie","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087442618","display_name":"Ottavio Pompeiano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"O Pompeiano","raw_affiliation_strings":["Istituto di Fisiologia Umana, Cattedra II, Universit\u00e0 di Pisa,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Fisiologia Umana, Cattedra II, Universit\u00e0 di Pisa,","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066615788","display_name":"Max E. Valentinuzzi","orcid":"https://orcid.org/0000-0001-7133-2908","observed_orcids":["https://orcid.org/0000-0001-7133-2908"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Valentinuzzi","raw_affiliation_strings":["Instituto de Cibern\u00e9tica, Sociedad Cient\u00ecfica Argentina, Buenos Aires"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Cibern\u00e9tica, Sociedad Cient\u00ecfica Argentina, Buenos Aires","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8179,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.67610558,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"114","issue":"2","first_page":"103","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rapid-eye-movements","display_name":"rapid eye movements","score":0.9649999737739563},{"id":"https://openalex.org/keywords/rem-sleep","display_name":"REM sleep","score":0.968999981880188},{"id":"https://openalex.org/keywords/cholinesterase-inhibitors","display_name":"cholinesterase inhibitors","score":0.8880000114440918},{"id":"https://openalex.org/keywords/pontine-reticular-formation","display_name":"pontine reticular formation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/vestibular-nuclei","display_name":"vestibular nuclei","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mathematical-model","display_name":"mathematical model","score":0.5619999766349792},{"id":"https://openalex.org/keywords/decerebrate-cats","display_name":"decerebrate cats","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C2781203944","wikidata":"https://www.wikidata.org/wiki/Q950852","display_name":"Oculomotor nucleus","level":4,"score":0.8039923310279846},{"id":"https://openalex.org/C2776486484","wikidata":"https://www.wikidata.org/wiki/Q1282504","display_name":"Paramedian pontine reticular formation","level":4,"score":0.7455130815505981},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7322189211845398},{"id":"https://openalex.org/C2778655484","wikidata":"https://www.wikidata.org/wiki/Q750588","display_name":"Reticular formation","level":3,"score":0.6939393877983093},{"id":"https://openalex.org/C2778421575","wikidata":"https://www.wikidata.org/wiki/Q2004165","display_name":"Vestibular nuclei","level":3,"score":0.6609116196632385},{"id":"https://openalex.org/C24566897","wikidata":"https://www.wikidata.org/wiki/Q943621","display_name":"Tegmentum","level":4,"score":0.6287013292312622},{"id":"https://openalex.org/C2779845715","wikidata":"https://www.wikidata.org/wiki/Q2004202","display_name":"Abducens nucleus","level":3,"score":0.6213643550872803},{"id":"https://openalex.org/C190041318","wikidata":"https://www.wikidata.org/wiki/Q596832","display_name":"Vestibular system","level":2,"score":0.6033666133880615},{"id":"https://openalex.org/C153050134","wikidata":"https://www.wikidata.org/wiki/Q760256","display_name":"Eye movement","level":2,"score":0.5975000858306885},{"id":"https://openalex.org/C127573956","wikidata":"https://www.wikidata.org/wiki/Q7821376","display_name":"Tonic (physiology)","level":2,"score":0.54278165102005},{"id":"https://openalex.org/C191789040","wikidata":"https://www.wikidata.org/wiki/Q912716","display_name":"Optokinetic reflex","level":3,"score":0.5294404029846191},{"id":"https://openalex.org/C122845125","wikidata":"https://www.wikidata.org/wiki/Q1883898","display_name":"Vestibulo\u2013ocular reflex","level":3,"score":0.4811919331550598},{"id":"https://openalex.org/C2781007269","wikidata":"https://www.wikidata.org/wiki/Q223903","display_name":"Oculomotor nerve","level":2,"score":0.477952241897583},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4668859541416168},{"id":"https://openalex.org/C136686920","wikidata":"https://www.wikidata.org/wiki/Q750588","display_name":"Reticular activating system","level":4,"score":0.4486095607280731},{"id":"https://openalex.org/C552161191","wikidata":"https://www.wikidata.org/wiki/Q185080","display_name":"Midbrain","level":3,"score":0.33057862520217896},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.25451892614364624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25128310918807983}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003655","descriptor_name":"Decerebrate State","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009801","descriptor_name":"Oculomotor Muscles","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012895","descriptor_name":"Sleep, REM","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014726","descriptor_name":"Vestibular Nuclei","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:190960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/190960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives italiennes de biologie","raw_type":"Journal Article"},{"id":"mag:1607110292","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/190960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2441495741","https://openalex.org/W1539044385","https://openalex.org/W1613947923","https://openalex.org/W2029310162","https://openalex.org/W4239914080","https://openalex.org/W7165804481","https://openalex.org/W2434167858","https://openalex.org/W324078523","https://openalex.org/W2147715743","https://openalex.org/W1989416541"],"abstract_inverted_index":{"The":[0,136,256,295,307],"oculomotor":[1,30,83,152,171,283,291],"pattern":[2,31,81,281],"which":[3,40,85,105,168,204],"appears":[4],"in":[5,53,60,93,126,184,199,222,310,320],"intact":[6],"preparations":[7],"during":[8,45,90],"desynchronized":[9],"sleep":[10,92],"is":[11,51,160,266,285,301],"characterized":[12],"by":[13,303],"the":[14,34,42,54,58,61,65,68,76,132,148,151,155,162,170,176,185,200,206,219,223,237,241,246,261,264,289,298,322,337],"irregular":[15],"occurrence":[16],"of":[17,23,36,48,71,78,82,101,103,123,131,144,164,178,226,240,248,258,260,263,272,282,297,325,339],"isolated":[18],"ocular":[19],"movements":[20,26],"and":[21,154,244,277,327,336],"bursts":[22,102,122,143],"rapid":[24],"eye":[25,299],"(REM).":[27],"This":[28,158],"complex":[29],"results":[32],"from":[33,87],"activity":[35,284],"two":[37],"premotor":[38],"structures":[39,139],"influence":[41,163],"extraocular":[43],"motoneurons":[44],"this":[46,227,311],"phase":[47,233],"sleep:":[49],"one":[50],"located":[52,183,198],"pontine":[55,186,202],"reticular":[56,166,187],"formation,":[57,188],"other":[59,340],"vestibular":[62,133,149],"nuclei.":[63],"In":[64],"decerebrate":[66],"preparation":[67],"intravenous":[69],"injection":[70],"an":[72,194],"anticholinesterase":[73],"leads":[74],"to":[75,270,332],"appearance":[77],"a":[79,179,210,231,252,280,304,317,329],"typical":[80],"activity,":[84],"differs":[86],"that":[88,120,218,245,287],"occurring":[89],"physiological":[91],"so":[94],"far":[95],"as":[96,113,115,268,316,328],"it":[97],"consists":[98],"quite":[99],"exclusively":[100],"REM":[104,124,145,242],"appear":[106],"at":[107],"very":[108],"regular":[109],"intervals.":[110],"Lesion":[111],"experiments":[112],"well":[114],"unit":[116],"recordings":[117],"have":[118,174,215],"shown":[119],"these":[121,142],"depend":[125],"particular":[127],"upon":[128,193],"rhythmic":[129],"discharges":[130],"nuclear":[134],"neurons.":[135],"underlying":[137],"anatomical":[138],"responsible":[140],"for":[141],"are":[146],"therefore":[147],"nuclei,":[150],"nuclei":[153],"oculo-orbital":[156],"system.":[157],"mechanism":[159,324],"under":[161],"cholinergic":[165,181],"neurons":[167],"generate":[169],"rhythm.":[172],"We":[173,214],"postulated":[175],"existence":[177],"self-excitatory":[180],"system,":[182,243],"whose":[189],"steady":[190],"discharge":[191,224],"impinges":[192],"oscillatory":[195,228],"neuronal":[196],"system":[197,229,265],"dorso-lateral":[201],"tegmentum,":[203],"transforms":[205],"tonic":[207],"input":[208],"into":[209],"sinusoidal":[211],"final":[212],"output.":[213],"assumed":[216],"also":[217],"periodic":[220],"increases":[221],"frequency":[225,271],"trigger":[230],"fast":[232],"generator":[234],"acting":[235],"on":[236],"different":[238],"components":[239,262],"behavior":[247],"each":[249],"component":[250],"follows":[251],"first-order":[253],"differential":[254],"equation.":[255],"state":[257],"excitation":[259],"defined":[267],"proportional":[269],"nerve":[273],"impulses.":[274],"Assuming":[275],"ipsilateral":[276],"crossed":[278],"connections,":[279],"obtained":[286],"simulates":[288],"experimental":[290,334],"output":[292],"fairly":[293],"well.":[294],"repetition":[296],"jerks":[300],"described":[302],"Fourier":[305],"series.":[306],"model":[308],"proposed":[309],"paper":[312],"may":[313],"be":[314],"taken":[315],"first":[318],"approach":[319],"describing":[321],"generation":[323],"REM,":[326],"theoretical":[330],"guide":[331],"new":[333],"researches":[335],"development":[338],"more":[341],"realistic":[342],"models.":[343]},"counts_by_year":[{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}