{"id":"https://openalex.org/W1606741593","doi":"https://doi.org/10.1016/s0021-9258(18)33924-3","title":"Transcriptional properties of chick embryonic erythroid nuclei in vitro.","display_name":"Transcriptional properties of chick embryonic erythroid nuclei in vitro.","publication_year":1982,"publication_date":"1982-09-01","ids":{"openalex":"https://openalex.org/W1606741593","doi":"https://doi.org/10.1016/s0021-9258(18)33924-3","mag":"1606741593","pmid":"https://pubmed.ncbi.nlm.nih.gov/6286678"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(18)33924-3","doi":"https://doi.org/10.1016/s0021-9258(18)33924-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)33924-3","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(18)33924-3","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111450314","display_name":"Gregory M. Landes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210143017","display_name":"Sequenom (United States)","ror":"https://ror.org/03rb80v65","country_code":"US","type":"company","lineage":["https://openalex.org/I4210143017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G M Landes","raw_affiliation_strings":["From the Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, California 90024","address, Integrated Genetics, Framingham, MA 01760"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, California 90024","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"address, Integrated Genetics, Framingham, MA 01760","institution_ids":["https://openalex.org/I4210143017"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072578902","display_name":"Harold G. Martinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210143017","display_name":"Sequenom (United States)","ror":"https://ror.org/03rb80v65","country_code":"US","type":"company","lineage":["https://openalex.org/I4210143017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H G Martinson","raw_affiliation_strings":["From the Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, California 90024","address, Integrated Genetics, Framingham, MA 01760"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, California 90024","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"address, Integrated Genetics, Framingham, MA 01760","institution_ids":["https://openalex.org/I4210143017"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.6397,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.82239009,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"257","issue":"18","first_page":"11002","last_page":"11007"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.04569999873638153,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chick-embryo","display_name":"chick embryo","score":0.8029999732971191},{"id":"https://openalex.org/keywords/embryonic-globin","display_name":"embryonic globin","score":0.6880000233650208},{"id":"https://openalex.org/keywords/beta-globin-gene","display_name":"beta-globin gene","score":0.8489999771118164},{"id":"https://openalex.org/keywords/ribosomal-dna","display_name":"ribosomal DNA","score":0.8619999885559082},{"id":"https://openalex.org/keywords/rna-polymerase-i","display_name":"RNA polymerase I","score":0.9039999842643738},{"id":"https://openalex.org/keywords/rna-polymerase-ii","display_name":"RNA polymerase II","score":1.0},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6639999747276306},{"id":"https://openalex.org/keywords/developmental-gene-expression","display_name":"developmental gene expression","score":0.6299999952316284},{"id":"https://openalex.org/keywords/repetitive-dna","display_name":"repetitive DNA","score":0.6069999933242798},{"id":"https://openalex.org/keywords/red-blood-cell-development","display_name":"red blood cell development","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.734866201877594},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6868426203727722},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6019916534423828},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4420683681964874},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3504526615142822},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29530513286590576},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16719156503677368}],"mesh":[{"descriptor_ui":"D000546","descriptor_name":"Amanitins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004262","descriptor_name":"DNA Restriction Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004274","descriptor_name":"DNA, Recombinant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012335","descriptor_name":"RNA, Ribosomal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(18)33924-3","doi":"https://doi.org/10.1016/s0021-9258(18)33924-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)33924-3","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:6286678","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6286678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(18)33924-3","doi":"https://doi.org/10.1016/s0021-9258(18)33924-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)33924-3","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W187132245","https://openalex.org/W1033914640","https://openalex.org/W1452735141","https://openalex.org/W1480811820","https://openalex.org/W1483530708","https://openalex.org/W1492229376","https://openalex.org/W1554003114","https://openalex.org/W1564890115","https://openalex.org/W1595729193","https://openalex.org/W1598530978","https://openalex.org/W1604233325","https://openalex.org/W1900250377","https://openalex.org/W1914532157","https://openalex.org/W1979531485","https://openalex.org/W1981347965","https://openalex.org/W1981829691","https://openalex.org/W1984182494","https://openalex.org/W1986171710","https://openalex.org/W1989781253","https://openalex.org/W1990892959","https://openalex.org/W1992733592","https://openalex.org/W1993604403","https://openalex.org/W1997494728","https://openalex.org/W2001019121","https://openalex.org/W2028082957","https://openalex.org/W2029043076","https://openalex.org/W2038540154","https://openalex.org/W2042242712","https://openalex.org/W2046399641","https://openalex.org/W2049561326","https://openalex.org/W2059148896","https://openalex.org/W2063090102","https://openalex.org/W2071868080","https://openalex.org/W2079337115","https://openalex.org/W2080587793","https://openalex.org/W2080923924","https://openalex.org/W2089031185","https://openalex.org/W2092354805","https://openalex.org/W2095488937","https://openalex.org/W2145059527","https://openalex.org/W2340248890","https://openalex.org/W2346052124","https://openalex.org/W2417993256"],"related_works":["https://openalex.org/W2346052124","https://openalex.org/W2051344975","https://openalex.org/W2145059527","https://openalex.org/W7071451376","https://openalex.org/W2084978373","https://openalex.org/W2011956712","https://openalex.org/W2909298269","https://openalex.org/W2029043076","https://openalex.org/W2021173197","https://openalex.org/W1967494180"],"abstract_inverted_index":{"Chick":[0],"embryo":[1],"red":[2,38,138],"blood":[3,39],"cells":[4,40],"express":[5],"the":[6,10,20,37,55,62,72,80,92,137,167,170,184],"embryonic":[7,158],"globin":[8,22],"and":[9,24,45,69,71,150,159],"rRNA":[11,26],"genes":[12,23,171],"before":[13],"5":[14,118,149],"days":[15,29,119,152],"of":[16,30,41,59,65,75,97,141,153,169],"development":[17,154],"but":[18,120,143],"only":[19],"adult":[21,160],"no":[25],"after":[27],"12":[28,107,124,151],"development.":[31],"We":[32,52],"have":[33,53],"isolated":[34],"nuclei":[35,96,140],"from":[36],"these":[42,60],"developmental":[43],"stages":[44],"allowed":[46],"them":[47],"to":[48,181],"transcribe":[49],"in":[50,79,136,183],"vitro.":[51],"analyzed":[54],"overall":[56,63],"transcriptional":[57,155],"properties":[58],"nuclei,":[61],"activities":[64],"RNA":[66,76,110,133,195],"polymerases":[67],"I":[68,112],"II":[70,78],"sequence-specific":[73],"activity":[74,129],"polymerase":[77,111,196],"beta-globin":[81,161,185],"domain":[82],"using":[83],"cloned":[84],"genomic":[85],"hybridization":[86],"probes.":[87],"Among":[88],"our":[89],"findings":[90],"are":[91,100,192],"following.":[93],"1)":[94],"Erythroid":[95],"5-day":[98,145],"embryos":[99],"more":[101],"transcriptionally":[102],"active":[103,116],"than":[104],"those":[105],"at":[106,117],"days.":[108,125],"2)":[109],"is":[113,121,134],"a":[114],"very":[115],"off":[122],"by":[123,173,194],"3)":[126],"A":[127],"template-independent":[128],"which":[130,179],"yields":[131],"labeled":[132],"present":[135],"cell":[139],"12-day":[142],"not":[144],"embryos.":[146],"4)":[147],"Between":[148],"modulation":[156],"delineates":[157],"domains.":[162],"5)":[163],"These":[164],"domains":[165],"exceed":[166],"boundaries":[168],"themselves":[172],"several":[174],"kilobases.":[175],"6)":[176],"All":[177],"transcripts":[178],"hybridize":[180],"sequences":[182],"gene":[186],"region,":[187],"including":[188],"repeat":[189],"sequence":[190],"transcripts,":[191],"transcribed":[193],"II.":[197]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
