{"id":"https://openalex.org/W1606705437","doi":"https://doi.org/10.1002/j.1939-4640.1999.tb02550.x","title":"Reproductive Aging in the Brown Norway Rat Is Characterized by Accelerated Germ Cell Apoptosis and Is Not Altered by Luteinizing Hormone Replacement","display_name":"Reproductive Aging in the Brown Norway Rat Is Characterized by Accelerated Germ Cell Apoptosis and Is Not Altered by Luteinizing Hormone Replacement","publication_year":1999,"publication_date":"1999-07-08","ids":{"openalex":"https://openalex.org/W1606705437","doi":"https://doi.org/10.1002/j.1939-4640.1999.tb02550.x","mag":"1606705437","pmid":"https://pubmed.ncbi.nlm.nih.gov/10452595"},"language":"en","primary_location":{"id":"doi:10.1002/j.1939-4640.1999.tb02550.x","doi":"https://doi.org/10.1002/j.1939-4640.1999.tb02550.x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/j.1939-4640.1999.tb02550.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/j.1939-4640.1999.tb02550.x","source":{"id":"https://openalex.org/S4394735507","display_name":"Journal of Andrology","issn_l":"0196-3635","issn":["0196-3635","1939-4640"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Andrology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/j.1939-4640.1999.tb02550.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100616719","display_name":"Christina Wang","orcid":"https://orcid.org/0000-0002-8231-792X","observed_orcids":["https://orcid.org/0000-0002-8231-792X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"CHRISTINA WANG","raw_affiliation_strings":["Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, California","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079309491","display_name":"Amiya P. Sinha Hikim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"AMIYA P. SINHA HIKIM","raw_affiliation_strings":["Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, California","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040182243","display_name":"Yanhe Lue","orcid":"https://orcid.org/0000-0003-0458-7841","observed_orcids":["https://orcid.org/0000-0003-0458-7841"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"YAN\u2010HE LUE","raw_affiliation_strings":["Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, California","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113630664","display_name":"Andrew Leung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ANDREW LEUNG","raw_affiliation_strings":["Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, California","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048433868","display_name":"Sima Baravarian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SIMA BARAVARIAN","raw_affiliation_strings":["Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, California","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210165985"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090807122","display_name":"Ronald S. Swerdloff","orcid":"https://orcid.org/0000-0001-6084-6604","observed_orcids":["https://orcid.org/0000-0001-6084-6604"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RONALD S. SWERDLOFF","raw_affiliation_strings":["Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, California","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210165985"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100616719"],"corresponding_institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210165985"],"apc_list":null,"apc_paid":null,"fwci":3.3412,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.9041769,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"20","issue":"4","first_page":"509","last_page":"518"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reproductive-aging","display_name":"reproductive aging","score":0.9459999799728394},{"id":"https://openalex.org/keywords/brown-norway-rats","display_name":"Brown Norway rats","score":0.9110000133514404},{"id":"https://openalex.org/keywords/germ-cell-apoptosis","display_name":"germ cell apoptosis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/leydig-cell-dysfunction","display_name":"Leydig cell dysfunction","score":0.8009999990463257},{"id":"https://openalex.org/keywords/testicular-regression","display_name":"testicular regression","score":0.6489999890327454},{"id":"https://openalex.org/keywords/spermatogenesis","display_name":"spermatogenesis","score":0.7039999961853027},{"id":"https://openalex.org/keywords/spermatogonia","display_name":"spermatogonia","score":0.7900000214576721},{"id":"https://openalex.org/keywords/spermatocytes","display_name":"spermatocytes","score":0.699999988079071},{"id":"https://openalex.org/keywords/spermatids","display_name":"spermatids","score":0.7440000176429749},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.4909999966621399},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.9070000052452087},{"id":"https://openalex.org/keywords/inhibin","display_name":"inhibin","score":0.9470000267028809},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-dysfunction","display_name":"hypothalamic-pituitary dysfunction","score":0.8939999938011169},{"id":"https://openalex.org/keywords/male-fertility","display_name":"male fertility","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.8215914964675903},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8047260642051697},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7911099195480347},{"id":"https://openalex.org/C2779122487","wikidata":"https://www.wikidata.org/wiki/Q281579","display_name":"Germ cell","level":3,"score":0.7343676090240479},{"id":"https://openalex.org/C123765429","wikidata":"https://www.wikidata.org/wiki/Q36961","display_name":"Spermatogenesis","level":2,"score":0.7279178500175476},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.7272523045539856},{"id":"https://openalex.org/C2777736315","wikidata":"https://www.wikidata.org/wiki/Q636846","display_name":"Leydig cell","level":4,"score":0.725958526134491},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5648248195648193},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5309861302375793},{"id":"https://openalex.org/C2779279165","wikidata":"https://www.wikidata.org/wiki/Q200774","display_name":"Follicle-stimulating hormone","level":4,"score":0.5141761302947998},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.5030907988548279},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4984767436981201},{"id":"https://openalex.org/C2778054371","wikidata":"https://www.wikidata.org/wiki/Q503431","display_name":"Seminiferous tubule","level":4,"score":0.4614817500114441},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.44875699281692505},{"id":"https://openalex.org/C2781068068","wikidata":"https://www.wikidata.org/wiki/Q195614","display_name":"Sertoli cell","level":3,"score":0.22758585214614868},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2187899649143219},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005854","descriptor_name":"Germ Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012098","descriptor_name":"Reproduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/j.1939-4640.1999.tb02550.x","doi":"https://doi.org/10.1002/j.1939-4640.1999.tb02550.x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/j.1939-4640.1999.tb02550.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/j.1939-4640.1999.tb02550.x","source":{"id":"https://openalex.org/S4394735507","display_name":"Journal of Andrology","issn_l":"0196-3635","issn":["0196-3635","1939-4640"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Andrology","raw_type":"journal-article"},{"id":"pmid:10452595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10452595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of andrology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.327.3741","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.327.3741","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.andrologyjournal.org/cgi/reprint/20/4/509.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1002/j.1939-4640.1999.tb02550.x","doi":"https://doi.org/10.1002/j.1939-4640.1999.tb02550.x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/j.1939-4640.1999.tb02550.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/j.1939-4640.1999.tb02550.x","source":{"id":"https://openalex.org/S4394735507","display_name":"Journal of Andrology","issn_l":"0196-3635","issn":["0196-3635","1939-4640"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Andrology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1606705437.pdf","grobid_xml":"https://content.openalex.org/works/W1606705437.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W140514885","https://openalex.org/W266714568","https://openalex.org/W1497956057","https://openalex.org/W1568526841","https://openalex.org/W1569245768","https://openalex.org/W1597388884","https://openalex.org/W1603943057","https://openalex.org/W1621904209","https://openalex.org/W1982647833","https://openalex.org/W1986118516","https://openalex.org/W1986858409","https://openalex.org/W2017932465","https://openalex.org/W2051329512","https://openalex.org/W2067813556","https://openalex.org/W2071926776","https://openalex.org/W2080728166","https://openalex.org/W2081676666","https://openalex.org/W2085789685","https://openalex.org/W2098882554","https://openalex.org/W2103212952","https://openalex.org/W2107976115","https://openalex.org/W2108944287","https://openalex.org/W2116879018","https://openalex.org/W2142855123","https://openalex.org/W2159872365","https://openalex.org/W2163970711","https://openalex.org/W2216476764","https://openalex.org/W2326622737","https://openalex.org/W2410284399"],"related_works":["https://openalex.org/W2098882554","https://openalex.org/W1621904209","https://openalex.org/W1597388884","https://openalex.org/W2326622737","https://openalex.org/W2131015676","https://openalex.org/W2108389542","https://openalex.org/W2037738193","https://openalex.org/W266714568","https://openalex.org/W2067813556","https://openalex.org/W140514885"],"abstract_inverted_index":{"Reproductive":[0],"aging":[1,263,278],"in":[2,46,98,154,179,186,243,257,264],"the":[3,41,47,60,126,158,166,180,226,232,244,265,294,307],"male":[4],"Brown":[5],"Norway":[6],"(BN)":[7],"rat":[8,49,267],"is":[9,301,306],"characterized":[10],"by":[11],"decreased":[12],"Leydig":[13,65],"cell":[14,52,66,70,94,142,228,274],"steroidogenesis":[15],"associated":[16,276,297],"with":[17,138,193,277,284,298],"seminiferous":[18],"tubule":[19],"dysfunction.":[20,39],"This":[21],"could":[22],"be":[23],"a":[24,27,30,35],"result":[25],"of":[26,29,62,64,128,157,171,182,237,250,310],"combination":[28],"primary":[31],"testicular":[32,89,112,295,311],"defect":[33],"and":[34,68,72,92,104,122,131,147,150],"secondary":[36],"hypothalamic":[37],"pituitary":[38],"In":[40,165,231],"present":[42],"study,":[43],"we":[44],"determined":[45],"BN":[48,106,208,266],"whether":[50,74],"germ":[51,69,93,141,227],"loss":[53,71,275],"occurred":[54],"via":[55,280],"apoptosis.":[56,281],"We":[57,255],"then":[58],"defined":[59],"age":[61],"onset":[63],"dysfunction":[67,296],"examined":[73],"chronic":[75],"luteinizing":[76],"hormone":[77,87,134,217],"(LH)":[78],"replacement":[79,198],"would":[80],"delay":[81,293],"or":[82,223,225,292],"prevent":[83],"reproductive":[84,262],"aging.":[85,139,299,312],"Plasma":[86],"levels,":[88,218],"sperm":[90,114,117,221],"concentrations,":[91],"apoptosis":[95,143],"were":[96,240],"studied":[97],"6,":[99],"9,":[100],"12,":[101],"15,":[102],"18,":[103],"21-month-old":[105,163],"rats.":[107,164],"Beginning":[108],"at":[109,188,269],"15":[110,271],"months,":[111],"weight,":[113,220],"concentration,":[115],"total":[116],"counts,":[118],"plasma":[119,132,216],"testosterone,":[120],"LH,":[121],"inhibin":[123],"decreased,":[124],"whereas":[125,242],"proportion":[127],"regressed":[129,167],"testes":[130,161,181,219,239,252],"follicle-stimulating":[133],"(FSH)":[135],"levels":[136],"increased":[137],"Accelerated":[140],"involving":[144],"spermatogonia,":[145],"preleptotene":[146],"pachytene":[148],"spermatocytes,":[149],"spermatids":[151],"was":[152,177,253],"evident":[153],"some":[155],"tubules":[156],"relatively":[159],"normal":[160],"from":[162],"testes,":[168],"complete":[169],"cessation":[170],"spermatogenesis":[172],"occurred.":[173],"The":[174],"apoptotic":[175,229],"index":[176],"higher":[178],"old":[183],"(21-month-old)":[184],"rats":[185,209],"particular":[187],"stages":[189],"XII-XIV":[190],"when":[191],"compared":[192],"younger":[194],"animals.":[195],"Chronic":[196],"LH":[197,285],"(0.5":[199],"microg":[200],"i.p.":[201],"twice":[202],"per":[203],"day)":[204],"administered":[205],"to":[206],"15-month-old":[207],"for":[210,286],"6":[211,287],"months":[212,288],"did":[213],"not":[214,290],"alter":[215],"concentration":[222],"content,":[224],"index.":[230],"control":[233],"group,":[234,246],"3":[235],"out":[236,249],"10":[238],"regressed,":[241],"LH-replaced":[245],"only":[247],"1":[248],"12":[251],"regressed.":[254],"show":[256],"this":[258],"study":[259],"that":[260,303],"early":[261],"began":[268],"around":[270],"months.":[272],"Germ":[273],"occurs":[279],"Replacement":[282],"therapy":[283],"does":[289],"decrease":[291],"It":[300],"unlikely":[302],"hypothalamic-pituitary":[304],"dysregulation":[305],"major":[308],"cause":[309]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}