{"id":"https://openalex.org/W1606638524","doi":"https://doi.org/10.1002/jps.24558","title":"The Effect of Additives on the Behavior of Phase Sensitive In Situ Forming Implants","display_name":"The Effect of Additives on the Behavior of Phase Sensitive In Situ Forming Implants","publication_year":2015,"publication_date":"2015-07-14","ids":{"openalex":"https://openalex.org/W1606638524","doi":"https://doi.org/10.1002/jps.24558","mag":"1606638524","pmid":"https://pubmed.ncbi.nlm.nih.gov/26175342","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4564324"},"language":"en","primary_location":{"id":"doi:10.1002/jps.24558","doi":"https://doi.org/10.1002/jps.24558","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jps.24558","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1002/jps.24558","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054791772","display_name":"Luis Solorio","orcid":"https://orcid.org/0000-0003-0135-8728","observed_orcids":["https://orcid.org/0000-0003-0135-8728"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luis solorio","raw_affiliation_strings":["Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, 48109","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006548625","display_name":"Divya Sundarapandiyan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Divya Sundarapandiyan","raw_affiliation_strings":["School of Medicine, New York Medical College, Valhalla, New York, 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, New York Medical College, Valhalla, New York, 10595","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020689924","display_name":"Alexander M. Olear","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Olear","raw_affiliation_strings":["Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, 44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066766358","display_name":"Agata A. Exner","orcid":"https://orcid.org/0000-0003-3913-7066","observed_orcids":["https://orcid.org/0000-0003-3913-7066"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Agata A. Exner","raw_affiliation_strings":["Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, 44106","Department of Radiology, Case Western Reserve University, Cleveland, Ohio, 44106","Department of Radiology, Case Western Reserve University Cleveland Ohio OhioOhioOhioOhioOhio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, 44106","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Radiology, Case Western Reserve University, Cleveland, Ohio, 44106","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Radiology, Case Western Reserve University Cleveland Ohio OhioOhioOhioOhioOhio","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5066766358"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":{"value":3620,"currency":"USD","value_usd":3620},"apc_paid":null,"fwci":1.2009,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.7176699,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"104","issue":"10","first_page":"3471","last_page":"3480"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.8550000190734863,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.8550000190734863,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.11230000108480453,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-situ-forming-implants","display_name":"in situ forming implants","score":0.9190000295639038},{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.8669999837875366},{"id":"https://openalex.org/keywords/pharmaceutical-excipients","display_name":"pharmaceutical excipients","score":0.6209999918937683},{"id":"https://openalex.org/keywords/bovine-serum-albumin","display_name":"bovine serum albumin","score":0.9169999957084656},{"id":"https://openalex.org/keywords/fluorescein","display_name":"fluorescein","score":0.890999972820282},{"id":"https://openalex.org/keywords/burst-release","display_name":"burst release","score":0.8619999885559082},{"id":"https://openalex.org/keywords/swelling","display_name":"swelling","score":0.5630000233650208},{"id":"https://openalex.org/keywords/phase-inversion","display_name":"phase inversion","score":0.9909999966621399},{"id":"https://openalex.org/keywords/implant-degradation","display_name":"implant degradation","score":0.578000009059906},{"id":"https://openalex.org/keywords/ultrasound-monitoring","display_name":"ultrasound monitoring","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C2778540859","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Swelling","level":2,"score":0.7864290475845337},{"id":"https://openalex.org/C2777239854","wikidata":"https://www.wikidata.org/wiki/Q902638","display_name":"Excipient","level":2,"score":0.7830740809440613},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5634152293205261},{"id":"https://openalex.org/C163588942","wikidata":"https://www.wikidata.org/wiki/Q5165929","display_name":"Controlled release","level":2,"score":0.5577542781829834},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.5076740980148315},{"id":"https://openalex.org/C86807702","wikidata":"https://www.wikidata.org/wiki/Q2620381","display_name":"Bovine serum albumin","level":2,"score":0.5047191381454468},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.49660760164260864},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.48401138186454773},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.44852063059806824},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.4370352029800415},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.42604875564575195},{"id":"https://openalex.org/C203220038","wikidata":"https://www.wikidata.org/wiki/Q7226547","display_name":"Polymer degradation","level":3,"score":0.4217841625213623},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.42079973220825195},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.4138599634170532},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.399723082780838},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3528990149497986},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3305472135543823},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.21821901202201843},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.1736564338207245},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.12126865983009338},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.11793252825737},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09991312026977539},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002232","descriptor_name":"Carbocyanines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004343","descriptor_name":"Drug Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005079","descriptor_name":"Excipients","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012710","descriptor_name":"Serum Albumin, Bovine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014465","descriptor_name":"Ultrasonics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019793","descriptor_name":"Fluorescein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/jps.24558","doi":"https://doi.org/10.1002/jps.24558","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jps.24558","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmid:26175342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26175342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmaceutical sciences","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3998405","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4564324","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4564324","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4564324","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Pharm Sci","raw_type":"Text"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/113738","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2027.42/113738","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1002/jps.24558","doi":"https://doi.org/10.1002/jps.24558","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jps.24558","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1584537854","display_name":"Pressure-Driven Local Drug Delivery System for Treatment of Liver Cancer","funder_award_id":"R01EB016960","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G4661649986","display_name":"ETS GENE FUSIONS AS PREDICTIVE BIOMARKERS OF RESISTANCE TO RADIATION THERAPY FOR PROSTATE CANCER","funder_award_id":"W81XWH1010582","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5865105795","display_name":"Functional Polymer Matrixes for Site-Specific, Image Guided Drug Delivery","funder_award_id":"R01CA118399","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W149836168","https://openalex.org/W1682768769","https://openalex.org/W1963579867","https://openalex.org/W1964493417","https://openalex.org/W1965692577","https://openalex.org/W1969206818","https://openalex.org/W1970423232","https://openalex.org/W1984054252","https://openalex.org/W1992801092","https://openalex.org/W1993709219","https://openalex.org/W1997907824","https://openalex.org/W1998221259","https://openalex.org/W1999641513","https://openalex.org/W2000792660","https://openalex.org/W2003429874","https://openalex.org/W2003536565","https://openalex.org/W2006130367","https://openalex.org/W2007430262","https://openalex.org/W2015649805","https://openalex.org/W2016558485","https://openalex.org/W2017686368","https://openalex.org/W2019795361","https://openalex.org/W2022340002","https://openalex.org/W2022834478","https://openalex.org/W2043179283","https://openalex.org/W2047094671","https://openalex.org/W2047901844","https://openalex.org/W2052596703","https://openalex.org/W2052877246","https://openalex.org/W2054459966","https://openalex.org/W2056834871","https://openalex.org/W2063543655","https://openalex.org/W2068228356","https://openalex.org/W2073411708","https://openalex.org/W2073566613","https://openalex.org/W2080920436","https://openalex.org/W2082931695","https://openalex.org/W2084527782","https://openalex.org/W2087834130","https://openalex.org/W2092482647","https://openalex.org/W2097215666","https://openalex.org/W2113940410","https://openalex.org/W2122510226","https://openalex.org/W2124083834","https://openalex.org/W2136943334","https://openalex.org/W2149126197","https://openalex.org/W2170248222"],"related_works":["https://openalex.org/W2019873852","https://openalex.org/W1994620171","https://openalex.org/W7140046745","https://openalex.org/W2979728016","https://openalex.org/W2941881342","https://openalex.org/W2032912941","https://openalex.org/W7160307015","https://openalex.org/W2022340002","https://openalex.org/W2330478484","https://openalex.org/W4408225404"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}