{"id":"https://openalex.org/W1606314293","doi":null,"title":"Position-specific annotation of protein function based on multiple homologs.","display_name":"Position-specific annotation of protein function based on multiple homologs.","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W1606314293","mag":"1606314293","pmid":"https://pubmed.ncbi.nlm.nih.gov/10786283"},"language":"en","primary_location":{"id":"pmid:10786283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10786283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. International Conference on Intelligent Systems for Molecular Biology","raw_type":"Journal Article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010178662","display_name":"Miguel Angel Andrade-Navarro","orcid":"https://orcid.org/0000-0001-6650-1711","observed_orcids":["https://orcid.org/0000-0001-6650-1711"]},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"M A Andrade","raw_affiliation_strings":["European Molecular Biology Laboratory, Heidelberg, Germany. andrade@embl-heidelberg.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, Heidelberg, Germany. andrade@embl-heidelberg.de","institution_ids":["https://openalex.org/I4210138560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010178662"],"corresponding_institution_ids":["https://openalex.org/I4210138560"],"apc_list":null,"apc_paid":null,"fwci":7.1486,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.97060588,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"28","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.6098999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.6098999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.18310000002384186,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.13490000367164612,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-function-annotation","display_name":"protein annotation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/sequence-similarity-search","display_name":"sequence similarity search","score":0.8859999775886536},{"id":"https://openalex.org/keywords/protein-descriptors","display_name":"protein descriptors","score":0.5789999961853027},{"id":"https://openalex.org/keywords/amino-acid-sequence-conservation","display_name":"amino acid conservation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/functional-specificity","display_name":"functional specificity","score":0.49300000071525574},{"id":"https://openalex.org/keywords/automatic-annotation","display_name":"automatic annotation","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.6901605129241943},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5961716771125793},{"id":"https://openalex.org/C2986374874","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Protein function","level":3,"score":0.5753829479217529},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.572202742099762},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5692059397697449},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.49222245812416077},{"id":"https://openalex.org/C198082294","wikidata":"https://www.wikidata.org/wiki/Q3399648","display_name":"Position (finance)","level":2,"score":0.4841623902320862},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.47795724868774414},{"id":"https://openalex.org/C207060522","wikidata":"https://www.wikidata.org/wiki/Q7251473","display_name":"Protein function prediction","level":4,"score":0.47116073966026306},{"id":"https://openalex.org/C2781181686","wikidata":"https://www.wikidata.org/wiki/Q4226068","display_name":"Coherence (philosophical gambling strategy)","level":2,"score":0.4283970892429352},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4099385142326355},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4083767533302307},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3553988039493561},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3502216935157776},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3401062488555908},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.2594073414802551},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.25333625078201294},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1913856863975525},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1166238784790039},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.11659121513366699},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.06605979800224304},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:10786283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10786283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. International Conference on Intelligent Systems for Molecular Biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.56.5923","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.56.5923","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.embl-heidelberg.de/~andrade/papers/function/function.ps","raw_type":"text"},{"id":"mag:1606314293","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10786283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1509280691","https://openalex.org/W1970346761","https://openalex.org/W1975914194","https://openalex.org/W2036224124","https://openalex.org/W2036792999","https://openalex.org/W2113505030","https://openalex.org/W2158714788","https://openalex.org/W2162171603","https://openalex.org/W4239620712"],"related_works":["https://openalex.org/W4200494388","https://openalex.org/W2097263991","https://openalex.org/W2060593022","https://openalex.org/W7097292029","https://openalex.org/W2153245720","https://openalex.org/W2081269341","https://openalex.org/W2419584527","https://openalex.org/W7095777955","https://openalex.org/W4415773190","https://openalex.org/W2123858481"],"abstract_inverted_index":{"I":[0],"present":[1],"in":[2],"this":[3,128],"work":[4],"an":[5,92],"algorithm":[6,129],"for":[7,132],"deriving":[8],"protein":[9,136],"functional":[10,107,137],"annotations":[11],"which":[12,68],"are":[13,38],"position-specific.":[14],"The":[15],"input":[16],"is":[17,60,70],"based":[18],"on":[19],"the":[20,28,41,44,47,52,56,75,83,98,115,120,123],"results":[21],"of":[22,27,36,43,77,82,88,95,97,106,122,127,135],"a":[23,32,64],"sequence":[24,30,33,99],"similarity":[25],"search":[26],"query":[29],"against":[31],"database.":[34],"Strings":[35],"words":[37],"extracted":[39],"from":[40],"descriptions":[42],"proteins,":[45],"and":[46,55,86,139],"correlation":[48],"between":[49],"proteins":[50],"having":[51],"same":[53],"descriptors":[54],"amino":[57],"acid":[58],"conservation":[59],"used":[61],"to":[62,72,101,113],"compute":[63],"score":[65,84],"that":[66,117],"indicates":[67],"descriptor":[69],"likely":[71],"describe":[73],"better":[74,119],"function":[76,121],"each":[78],"particular":[79],"residue.":[80],"Analysis":[81],"curves":[85],"comparison":[87],"different":[89,102],"functions":[90],"allows":[91],"easy":[93],"detection":[94],"parts":[96],"associated":[100],"function.":[103],"Different":[104],"levels":[105],"specificity":[108],"can":[109],"be":[110],"compared,":[111],"allowing":[112],"choose":[114],"one":[116],"suits":[118],"protein.":[124],"Immediate":[125],"applications":[126],"are,":[130],"support":[131],"(automated)":[133],"methods":[134],"annotation,":[138],"database":[140],"coherence":[141],"check.":[142]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}