{"id":"https://openalex.org/W1606176397","doi":null,"title":"Detection of peroxisome proliferators using a reporter construct derived from the rat acyl-CoA oxidase promoter in the rat liver cell line H-4-II-E.","display_name":"Detection of peroxisome proliferators using a reporter construct derived from the rat acyl-CoA oxidase promoter in the rat liver cell line H-4-II-E.","publication_year":1997,"publication_date":"1997-04-15","ids":{"openalex":"https://openalex.org/W1606176397","mag":"1606176397","pmid":"https://pubmed.ncbi.nlm.nih.gov/9108462"},"language":"en","primary_location":{"id":"pmid:9108462","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9108462","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100449730","display_name":"Min Jae Lee","orcid":"https://orcid.org/0000-0002-3252-6467","observed_orcids":["https://orcid.org/0000-0002-3252-6467","https://orcid.org/0009-0005-6857-8241","https://orcid.org/0009-0009-4119-4191"]},"institutions":[{"id":"https://openalex.org/I4210140972","display_name":"ColdQuanta, Inc., DBA Infleqtion (United States)","ror":"https://ror.org/049ykdj13","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140972"]},{"id":"https://openalex.org/I4210147671","display_name":"Institute for Social and Environmental Transition-International","ror":"https://ror.org/049yjjv56","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210147671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M J Lee","raw_affiliation_strings":["Xenometrix, Inc., Boulder, Colorado 80301, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xenometrix, Inc., Boulder, Colorado 80301, USA","institution_ids":["https://openalex.org/I4210140972","https://openalex.org/I4210147671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055404523","display_name":"Pauline Gee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Gee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025198650","display_name":"Shannon E. Beard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S E Beard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4246,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.59699267,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"57","issue":"8","first_page":"1575","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.5365999937057495,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.5365999937057495,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.4408999979496002,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peroxisome-proliferators","display_name":"peroxisome proliferators","score":1.0},{"id":"https://openalex.org/keywords/chloramphenicol-acetyltransferase-reporter","display_name":"chloramphenicol acetyltransferase reporter","score":0.8989999890327454},{"id":"https://openalex.org/keywords/peroxisomal-beta-oxidation","display_name":"peroxisomal beta-oxidation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.8709999918937683},{"id":"https://openalex.org/keywords/non-genotoxic-carcinogens","display_name":"non-genotoxic carcinogens","score":0.8690000176429749},{"id":"https://openalex.org/keywords/wy-14643","display_name":"Wy-14,643","score":0.8539999723434448},{"id":"https://openalex.org/keywords/clofibrate","display_name":"clofibrate","score":0.9800000190734863},{"id":"https://openalex.org/keywords/di-2-ethylhexyl-phthalate","display_name":"DEHP","score":0.9430000185966492},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9309999942779541},{"id":"https://openalex.org/keywords/genotoxic-carcinogens","display_name":"genotoxic carcinogens","score":0.5759999752044678},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C127078168","wikidata":"https://www.wikidata.org/wiki/Q138639","display_name":"Peroxisome","level":3,"score":0.716396152973175},{"id":"https://openalex.org/C130241916","wikidata":"https://www.wikidata.org/wiki/Q20970208","display_name":"Peroxisome proliferator-activated receptor gamma","level":4,"score":0.5866495966911316},{"id":"https://openalex.org/C2779496979","wikidata":"https://www.wikidata.org/wiki/Q2701912","display_name":"Clofibrate","level":2,"score":0.526418149471283},{"id":"https://openalex.org/C188413054","wikidata":"https://www.wikidata.org/wiki/Q18030677","display_name":"Peroxisome proliferator-activated receptor alpha","level":5,"score":0.48444440960884094},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46728405356407166},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.4635666310787201},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38201063871383667},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36606353521347046},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07016253471374512},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.0},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015197","descriptor_name":"Carcinogenicity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015500","descriptor_name":"Chloramphenicol O-Acetyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015500","descriptor_name":"Chloramphenicol O-Acetyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042962","descriptor_name":"Acyl-CoA Oxidase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:9108462","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9108462","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.326.7315","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.326.7315","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/57/8/1575.full.pdf","raw_type":"text"},{"id":"mag:1606176397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9108462","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W39101791","https://openalex.org/W98247596","https://openalex.org/W1964650519","https://openalex.org/W1975401201","https://openalex.org/W1976976178","https://openalex.org/W1979761686","https://openalex.org/W1980487403","https://openalex.org/W1984509210","https://openalex.org/W1985238295","https://openalex.org/W1987892320","https://openalex.org/W1989705993","https://openalex.org/W1996126685","https://openalex.org/W1998108343","https://openalex.org/W2001349068","https://openalex.org/W2003960793","https://openalex.org/W2009998389","https://openalex.org/W2021795224","https://openalex.org/W2040699921","https://openalex.org/W2040918147","https://openalex.org/W2049932841","https://openalex.org/W2055375100","https://openalex.org/W2066092624","https://openalex.org/W2072928055","https://openalex.org/W2081070477","https://openalex.org/W2083436346","https://openalex.org/W2093679589","https://openalex.org/W2094637038","https://openalex.org/W2104996921","https://openalex.org/W2119265707","https://openalex.org/W2122231295","https://openalex.org/W2130085216","https://openalex.org/W2168109557","https://openalex.org/W2196524012","https://openalex.org/W2608448230"],"related_works":["https://openalex.org/W7098894575","https://openalex.org/W2006528381","https://openalex.org/W2066408267","https://openalex.org/W2040918147","https://openalex.org/W2046697184","https://openalex.org/W2009998389","https://openalex.org/W4256641954","https://openalex.org/W2417065626","https://openalex.org/W1969362224","https://openalex.org/W2220828691"],"abstract_inverted_index":{"Peroxisome":[0],"proliferators":[1,33,47,173,204],"are":[2],"nongenotoxic":[3,126],"carcinogens":[4],"capable":[5],"of":[6,11,82,103,142,148,171,188,210],"causing":[7],"rapid":[8],"transcriptional":[9],"activation":[10],"genes":[12],"comprising":[13],"the":[14,63,67,75,83,146,169,182,191],"rodent":[15],"beta-oxidation":[16,69],"pathway.":[17],"Numerous":[18],"compounds,":[19],"such":[20],"as":[21,31,132],"hypolipidemic":[22],"drugs,":[23],"herbicides,":[24],"plasticizers,":[25],"and":[26,96,117,162,174,193,212],"analgesics":[27],"have":[28,37],"been":[29],"identified":[30],"peroxisome":[32,46,89,134,172,203],"in":[34,41,48,66,100,138,151,206],"rodents.":[35],"We":[36],"developed":[38],"a":[39,125,133,139],"whole-cell":[40],"vitro":[42],"assay":[43,197],"to":[44,184,190,200,213],"detect":[45,201],"approximately":[49,207],"48":[50,106,208],"h.":[51],"A":[52],"promoter::chloramphenicol":[53],"acetyltransferase":[54],"(CAT)":[55],"fusion":[56],"construct":[57],"for":[58],"rat":[59,76],"acyl-CoA":[60],"oxidase":[61],"(ACOX),":[62],"rate-limiting":[64],"enzyme":[65],"peroxisomal":[68],"pathway,":[70],"was":[71,198],"stably":[72],"transfected":[73],"into":[74],"liver":[77],"cell":[78,85,149],"line":[79,86],"H-4-II-E.":[80],"Treatment":[81],"recombinant":[84],"(ACOX::CAT)":[87],"with":[88,145],"proliferators,":[90],"WY":[91],"14,643,":[92],"clofibrate,":[93],"di(2-ethylhexyl)":[94],"phtalhate,":[95],"acetylsalicylic":[97],"acid":[98],"resulted":[99,137],"differential":[101],"increases":[102],"CAT":[104],"protein":[105],"h":[107,209],"after":[108],"exposure.":[109],"Nonsteroidal":[110],"anti-inflammatory":[111],"drugs":[112],"including":[113],"ibuprofen,":[114],"fenbupen,":[115],"naproxen,":[116],"acetaminophen":[118],"also":[119,136],"up-regulated":[120],"ACOX::CAT.":[121,167],"Phorbol":[122],"12-myristate":[123],"13-acetate,":[124],"carcinogen":[127],"that":[128],"is":[129,179,187],"not":[130,165],"classified":[131],"proliferator,":[135],"slight":[140],"induction":[141],"ACOX::CAT,":[143],"consistent":[144],"role":[147],"proliferation":[150],"tumor":[152],"progression.":[153],"The":[154],"carcinogenic":[155],"compounds":[156],"4-nitroquinoline":[157],"N-oxide,":[158],"ethyl":[159],"methanesulfonate,":[160],"diethylstilbestrol,":[161],"2-aminoanthracene":[163],"did":[164],"induce":[166],"Although":[168],"significance":[170],"their":[175],"impact":[176],"on":[177],"humans":[178],"still":[180],"unknown,":[181],"ability":[183],"identify":[185],"them":[186,215],"interest":[189],"pharmaceutical":[192],"chemical":[194],"industries.":[195],"This":[196],"able":[199],"known":[202],"tested":[205],"exposure":[211],"distinguish":[214],"from":[216],"genotoxic":[217],"carcinogens.":[218]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}