{"id":"https://openalex.org/W1605945659","doi":null,"title":"Ankyrin repeat and suppressor of cytokine signaling box containing protein-10 is associated with ubiquitin-mediated degradation pathways in trabecular meshwork cells.","display_name":"Ankyrin repeat and suppressor of cytokine signaling box containing protein-10 is associated with ubiquitin-mediated degradation pathways in trabecular meshwork cells.","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W1605945659","mag":"1605945659","pmid":"https://pubmed.ncbi.nlm.nih.gov/23901248","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3724959"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3724959","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3724959/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3724959/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3724959/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021143381","display_name":"Kate E. Keller","orcid":"https://orcid.org/0000-0002-1616-972X","observed_orcids":["https://orcid.org/0000-0002-1616-972X"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kate E Keller","raw_affiliation_strings":["Casey Eye Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA. gregorka@ohsu.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Casey Eye Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA. gregorka@ohsu.edu","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027415557","display_name":"Yong Yang","orcid":"https://orcid.org/0000-0003-4133-2063","observed_orcids":["https://orcid.org/0000-0003-4133-2063"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong-Feng Yang","raw_affiliation_strings":["Oregon Health and Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ying Ying Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Ying Sun","raw_affiliation_strings":["Oregon Health and Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109900883","display_name":"Rene\u00e9 Sykes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renee Sykes","raw_affiliation_strings":["Oregon Health and Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036150001","display_name":"Ted S. Acott","orcid":"https://orcid.org/0000-0002-1445-6012","observed_orcids":["https://orcid.org/0000-0002-1445-6012"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ted S Acott","raw_affiliation_strings":["Ophthalmology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102861274","display_name":"Mary K. Wirtz","orcid":"https://orcid.org/0000-0003-0302-3809","observed_orcids":["https://orcid.org/0000-0003-0302-3809"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary K Wirtz","raw_affiliation_strings":["Ophthalmology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1869,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.89922455,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"19","issue":null,"first_page":"1639","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trabecular-meshwork-cells","display_name":"trabecular meshwork cells","score":0.906000018119812},{"id":"https://openalex.org/keywords/primary-open-angle-glaucoma","display_name":"primary open-angle glaucoma","score":0.9430000185966492},{"id":"https://openalex.org/keywords/ubiquitin-mediated-degradation","display_name":"ubiquitin-mediated proteolysis","score":0.8889999985694885},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.871999979019165},{"id":"https://openalex.org/keywords/autophagy-lysosome-pathway","display_name":"autophagy-lysosome pathway","score":0.8489999771118164},{"id":"https://openalex.org/keywords/aggresomes","display_name":"aggresomes","score":0.7390000224113464},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.8330000042915344},{"id":"https://openalex.org/keywords/protein-colocalization","display_name":"protein colocalization","score":0.5690000057220459},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.30799999833106995},{"id":"https://openalex.org/keywords/glaucoma-pathogenesis","display_name":"glaucoma pathogenesis","score":0.699999988079071},{"id":"https://openalex.org/keywords/super-resolution-microscopy","display_name":"super-resolution microscopy","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6932046413421631},{"id":"https://openalex.org/C40209533","wikidata":"https://www.wikidata.org/wiki/Q5147828","display_name":"Colocalization","level":2,"score":0.6501247882843018},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6353245377540588},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.6080216765403748},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5871700644493103},{"id":"https://openalex.org/C187436293","wikidata":"https://www.wikidata.org/wiki/Q4692265","display_name":"Aggresome","level":4,"score":0.5598484873771667},{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.474446177482605},{"id":"https://openalex.org/C2777135640","wikidata":"https://www.wikidata.org/wiki/Q18028463","display_name":"LAMP1","level":4,"score":0.4368024468421936},{"id":"https://openalex.org/C2781121420","wikidata":"https://www.wikidata.org/wiki/Q750873","display_name":"Trabecular meshwork","level":3,"score":0.42835718393325806},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40073198080062866},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.2384430170059204},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1535918414592743},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.13822466135025024},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1352103352546692},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.1256639063358307},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014129","descriptor_name":"Trabecular Meshwork","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D014129","descriptor_name":"Trabecular Meshwork","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050826","descriptor_name":"Suppressor of Cytokine Signaling Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050826","descriptor_name":"Suppressor of Cytokine Signaling Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:3724959","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3724959/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3724959/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:2718025","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3724959","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:23901248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23901248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"mag:1605945659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23901248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3724959","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3724959/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3724959/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2866313443","display_name":"Genetics of Adult-Onset POAG","funder_award_id":"R01EY011650","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G4309480274","display_name":"Vertebrate Eye: Studies of Aqueous Outflow","funder_award_id":"R01EY003279","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000870284","display_name":"Extracellular Matrix and Outflow Resistance","funder_award_id":"R01EY019643","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000908597","display_name":"Ophthalmology Core Facility","funder_award_id":"P30EY010572","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320309233","display_name":"Oregon Health and Science University","ror":"https://ror.org/009avj582"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1605945659.pdf","grobid_xml":"https://content.openalex.org/works/W1605945659.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W27785370","https://openalex.org/W1866075641","https://openalex.org/W1967515141","https://openalex.org/W1969342645","https://openalex.org/W1971066287","https://openalex.org/W1972005136","https://openalex.org/W1975293376","https://openalex.org/W1983013145","https://openalex.org/W1984109015","https://openalex.org/W1985124617","https://openalex.org/W1987986784","https://openalex.org/W1989812239","https://openalex.org/W1991105254","https://openalex.org/W1992762084","https://openalex.org/W1994332513","https://openalex.org/W1994823455","https://openalex.org/W1998525621","https://openalex.org/W1998855132","https://openalex.org/W2006520238","https://openalex.org/W2007731525","https://openalex.org/W2009125409","https://openalex.org/W2009480413","https://openalex.org/W2011796275","https://openalex.org/W2012921138","https://openalex.org/W2022944155","https://openalex.org/W2024088008","https://openalex.org/W2024782183","https://openalex.org/W2025236720","https://openalex.org/W2025406121","https://openalex.org/W2025665129","https://openalex.org/W2029303246","https://openalex.org/W2037652817","https://openalex.org/W2038215936","https://openalex.org/W2045113104","https://openalex.org/W2047131072","https://openalex.org/W2048997725","https://openalex.org/W2052470191","https://openalex.org/W2053469500","https://openalex.org/W2057899719","https://openalex.org/W2065155413","https://openalex.org/W2073941831","https://openalex.org/W2073963703","https://openalex.org/W2074301486","https://openalex.org/W2074911710","https://openalex.org/W2075286956","https://openalex.org/W2078794317","https://openalex.org/W2084719535","https://openalex.org/W2086249186","https://openalex.org/W2090926709","https://openalex.org/W2093962878","https://openalex.org/W2094272082","https://openalex.org/W2102758832","https://openalex.org/W2103339779","https://openalex.org/W2104195991","https://openalex.org/W2104749531","https://openalex.org/W2105006635","https://openalex.org/W2111837223","https://openalex.org/W2117063200","https://openalex.org/W2117138208","https://openalex.org/W2124644922","https://openalex.org/W2124975942","https://openalex.org/W2125568224","https://openalex.org/W2127446410","https://openalex.org/W2135574023","https://openalex.org/W2142044474","https://openalex.org/W2149241780","https://openalex.org/W2153724411","https://openalex.org/W2154886355","https://openalex.org/W2165444724","https://openalex.org/W2166472696","https://openalex.org/W2171155178","https://openalex.org/W2401475473","https://openalex.org/W2752326209"],"related_works":["https://openalex.org/W2413985582","https://openalex.org/W4402616574","https://openalex.org/W2582914113","https://openalex.org/W7138872338","https://openalex.org/W2987489884","https://openalex.org/W4388553139","https://openalex.org/W1988100478","https://openalex.org/W1499709871","https://openalex.org/W2001024052","https://openalex.org/W2001792122"],"abstract_inverted_index":{"PURPOSE:":[0],"Ankyrin":[1],"repeat":[2],"and":[3,55,59,66,75,102,123,152,181,192,196,221,227,242,288,321],"suppressor":[4],"of":[5,46,62,95,134,145,156,172,208,216,238,247,273,292,303],"cytokine":[6],"signaling":[7],"(SOCS)":[8],"box":[9],"containing":[10],"protein-10":[11],"(ASB10)":[12],"was":[13,81,98,108,137,163],"recently":[14],"identified":[15],"as":[16],"a":[17,89,235,318,322,329,341],"gene":[18],"that":[19,106,257,337],"causes":[20],"primary":[21,325],"open-angle":[22,326],"glaucoma.":[23],"Here,":[24],"we":[25],"investigated":[26],"endogenous":[27],"ASB10":[28,107,140,161,166,239,331,338],"protein":[29,184,200],"expression":[30],"in":[31,110,113,300,343,347],"human":[32],"trabecular":[33],"meshwork":[34],"(HTM)":[35],"cells":[36,52,97,275],"to":[37,42],"provide":[38],"the":[39,43,63,129,132,146,153,157,213,217,244,248,258,264,290,301],"first":[40],"clues":[41],"biologic":[44],"function":[45],"this":[47],"protein.":[48],"METHODS:":[49],"Primary":[50],"HTM":[51,114,274],"were":[53,71,118,311],"cultured":[54],"immunostained":[56],"with":[57,73,143,169,212,240,243,276,307,324],"anti-ASB10":[58],"various":[60],"biomarkers":[61,144,171],"ubiquitin-mediated":[64,147,344],"proteasomal":[65,148],"autophagy-lysosomal":[67],"degradation":[68,345],"pathways.":[69],"Cells":[70],"imaged":[72],"confocal":[74,103,254],"high-resolution":[76],"structured":[77,252],"illumination":[78,253],"microscopy.":[79],"Colocalization":[80],"quantified":[82],"using":[83],"Imaris":[84],"Bitplane":[85],"software,":[86],"which":[87,267],"generated":[88],"Pearson's":[90],"correlation":[91],"coefficient":[92],"value.":[93],"Coimmunoprecipitation":[94,232],"ASB10-transfected":[96],"performed.":[99],"RESULTS:":[100],"Immunofluorescence":[101],"analysis":[104],"showed":[105,234],"localized":[109],"intracellular":[111],"structures":[112,136,211,306],"cells.":[115,349],"Two":[116],"populations":[117],"observed:":[119],"small,":[120],"spherical":[121],"vesicles":[122,261],"larger,":[124],"less":[125],"abundant":[126],"structures.":[127,271],"In":[128],"ASB10-silenced":[130],"cells,":[131],"number":[133,291],"large":[135,209,304],"significantly":[138,286],"decreased.":[139],"partially":[141],"colocalized":[142,168],"pathway":[149],"including":[150],"ubiquitin":[151,223,308],"\u03b14":[154,214,245],"subunit":[155,215,246],"20S":[158,218,249],"proteasome.":[159,250],"However,":[160],"itself":[162],"not":[164],"ubiquitinated.":[165],"also":[167],"numerous":[170],"specific":[173],"autophagic":[174],"structures:":[175],"aggresomes":[176],"(histone":[177],"deacetylase":[178],"6":[179],"[HDAC6]":[180],"heat":[182],"shock":[183],"70":[185],"[HSP70]),":[186],"autophagosomes":[187],"(light":[188],"chain":[189],"3":[190],"[LC3]":[191],"p62),":[193],"amphisomes":[194],"(Rab7),":[195],"lysosomes":[197],"(lysosomal-associated":[198],"membrane":[199],"1":[201],"[LAMP1]).":[202],"Pearson":[203],"coefficients":[204],"indicated":[205],"strong":[206],"colocalization":[207,302],"ASB10-stained":[210,260,294,305],"proteasome,":[219],"K48":[220],"K63-linked":[222],"antibodies,":[224],"p62,":[225],"HSP70,":[226],"HDAC6":[228,310],"(Pearson's":[229],"range,":[230],"0.59-0.82).":[231],"assays":[233],"positive":[236],"interaction":[237],"HSP70":[241],"Super-resolution":[251],"microscopy":[255],"suggested":[256],"smaller":[259],"aggregated":[262],"into":[263],"larger":[265],"structures,":[266],"resembled":[268],"aggresome-like":[269],"induced":[270],"Treatment":[272],"an":[277],"autophagy":[278],"activator":[279],"(MG132)":[280],"or":[281,309],"inhibitors":[282],"(wortmannin,":[283],"bafilomycin":[284],"A1)":[285],"increased":[287],"decreased":[289],"small":[293],"vesicles,":[295],"respectively.":[296],"No":[297],"discernible":[298],"differences":[299],"observed":[312],"between":[313],"dermal":[314],"fibroblasts":[315],"derived":[316],"from":[317],"normal":[319],"individual":[320],"patient":[323],"glaucoma":[327],"carrying":[328],"synonymous":[330],"mutation.":[332],"CONCLUSIONS:":[333],"Our":[334],"evidence":[335],"suggests":[336],"may":[339],"play":[340],"role":[342],"pathways":[346],"TM":[348]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
