{"id":"https://openalex.org/W1605705383","doi":null,"title":"DRUG TREATMENT IN CHILDREN WITH FOCUS ON OFF-LABEL DRUG USE","display_name":"DRUG TREATMENT IN CHILDREN WITH FOCUS ON OFF-LABEL DRUG USE","publication_year":2010,"publication_date":"2010-08-06","ids":{"openalex":"https://openalex.org/W1605705383","mag":"1605705383"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26908816","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Drug_treatment_in_children_with_focus_on_off-label_drug_use/26908816","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/38427","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041076913","display_name":"Elin Eyfells Kimland","orcid":"https://orcid.org/0000-0002-9701-5895","observed_orcids":["https://orcid.org/0000-0002-9701-5895"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Elin Kimland","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9701-5895","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041076913"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/off-label-drug-use","display_name":"off-label drug use","score":0.9330000281333923},{"id":"https://openalex.org/keywords/pediatric-prescribing","display_name":"pediatric prescribing","score":0.906000018119812},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7870000004768372},{"id":"https://openalex.org/keywords/psychotropic-drugs","display_name":"psychotropic drugs","score":0.7599999904632568},{"id":"https://openalex.org/keywords/antiasthmatic-drugs","display_name":"antiasthmatic drugs","score":0.8529999852180481},{"id":"https://openalex.org/keywords/pediatric-drug-safety","display_name":"drug safety in children","score":0.6510000228881836},{"id":"https://openalex.org/keywords/hospital-prescriptions","display_name":"hospital prescriptions","score":0.36500000953674316},{"id":"https://openalex.org/keywords/topical-drugs","display_name":"topical drugs","score":0.5730000138282776},{"id":"https://openalex.org/keywords/drug-labeling","display_name":"drug labeling","score":0.5320000052452087},{"id":"https://openalex.org/keywords/sweden","display_name":"Sweden","score":0.8220000267028809},{"id":"https://openalex.org/keywords/psychiatric-symptoms","display_name":"psychiatric symptoms","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.8108476400375366},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4900142252445221},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.4187781512737274},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3871874213218689},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26908816","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Drug_treatment_in_children_with_focus_on_off-label_drug_use/26908816","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/38427","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/38427","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1605705383","doi":null,"is_oa":false,"landing_page_url":"https://openarchive.ki.se/xmlui/bitstream/10616/38427/1/thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/38427","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/38427","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":85,"referenced_works":["https://openalex.org/W40041486","https://openalex.org/W174327138","https://openalex.org/W1508640870","https://openalex.org/W1530402507","https://openalex.org/W1533759501","https://openalex.org/W1563380376","https://openalex.org/W1567233658","https://openalex.org/W1863178553","https://openalex.org/W1887737698","https://openalex.org/W1964642206","https://openalex.org/W1965800076","https://openalex.org/W1969879564","https://openalex.org/W1971822217","https://openalex.org/W1976631476","https://openalex.org/W1979012581","https://openalex.org/W1979013316","https://openalex.org/W1983029526","https://openalex.org/W1984710954","https://openalex.org/W1985018276","https://openalex.org/W1985547150","https://openalex.org/W1989827781","https://openalex.org/W1990676371","https://openalex.org/W1992746042","https://openalex.org/W1994246667","https://openalex.org/W1999367008","https://openalex.org/W2001619908","https://openalex.org/W2006108600","https://openalex.org/W2009890917","https://openalex.org/W2010865202","https://openalex.org/W2015724156","https://openalex.org/W2017618719","https://openalex.org/W2021188919","https://openalex.org/W2023112383","https://openalex.org/W2027302391","https://openalex.org/W2028354167","https://openalex.org/W2032623171","https://openalex.org/W2037601378","https://openalex.org/W2039495791","https://openalex.org/W2042227314","https://openalex.org/W2043573557","https://openalex.org/W2044862574","https://openalex.org/W2045388039","https://openalex.org/W2047879427","https://openalex.org/W2049125887","https://openalex.org/W2053362665","https://openalex.org/W2056047799","https://openalex.org/W2056635789","https://openalex.org/W2057804412","https://openalex.org/W2060068399","https://openalex.org/W2064240409","https://openalex.org/W2066478784","https://openalex.org/W2068658842","https://openalex.org/W2073354508","https://openalex.org/W2073883467","https://openalex.org/W2092989044","https://openalex.org/W2095925831","https://openalex.org/W2098707960","https://openalex.org/W2104150461","https://openalex.org/W2115156600","https://openalex.org/W2115361107","https://openalex.org/W2122527560","https://openalex.org/W2125868590","https://openalex.org/W2126558335","https://openalex.org/W2131225010","https://openalex.org/W2134845326","https://openalex.org/W2139494906","https://openalex.org/W2140245388","https://openalex.org/W2147291501","https://openalex.org/W2149323011","https://openalex.org/W2155916653","https://openalex.org/W2158887619","https://openalex.org/W2158896861","https://openalex.org/W2158941494","https://openalex.org/W2159807786","https://openalex.org/W2166191708","https://openalex.org/W2170707127","https://openalex.org/W2171592527","https://openalex.org/W2404495107","https://openalex.org/W2406990525","https://openalex.org/W2407881306","https://openalex.org/W2422378094","https://openalex.org/W2437520703","https://openalex.org/W2461896724","https://openalex.org/W2469326375","https://openalex.org/W2601271328"],"related_works":["https://openalex.org/W1552714957","https://openalex.org/W2007591793","https://openalex.org/W1489922680","https://openalex.org/W2134973209","https://openalex.org/W2363115267","https://openalex.org/W1973802256","https://openalex.org/W2019079008","https://openalex.org/W1984710954","https://openalex.org/W1989925167","https://openalex.org/W2912846612"],"abstract_inverted_index":{"There":[0],"is":[1,51,369,391],"a":[2,193,220,257,491,528],"lack":[3,105,371],"of":[4,11,22,55,66,95,106,111,135,155,215,278,301,328,339,342,372,399,408,419,428,437,455,494],"paediatric":[5,67,107,123,144,208,224,246,262,289,329,373,395,463,489],"documentation":[6,247,396,418],"concerning":[7,122,235,248],"efficacy":[8],"and":[9,37,64,142,162,190,201,207,264,325,344,360,385,403,411,422,485,519],"safety":[10],"many":[12],"drugs,":[13,102],"which":[14],"contribute":[15],"to":[16,39,60,104,117,131,147,192,212,242,268,355,382,393,433],"drug":[17,49,86,114,137,170,186,205,217,250,266,308,321,387,420,430,483,521,529],"use":[18,206,267,309],"outside":[19],"the":[20,23,28,62,81,118,126,133,156,181,213,216,249,254,318,332,336,370,377,417,426],"terms":[21],"product":[24],"license":[25],"(off-label).":[26],"In":[27,71,238,256],"present":[29],"thesis,":[30],"four":[31],"studies":[32],"(I-IV),":[33],"using":[34],"different":[35],"settings":[36],"design":[38],"evaluate":[40],"pharmacological":[41],"treatment":[42,421,522],"in":[43,80,125,197,253,272,285,298,346,357,465,497,523],"children,":[44],"with":[45,168],"focus":[46],"on":[47],"off-label":[48,68,91,96,136,169,204,232,243,307,340,353,453,486,520],"use,":[50],"presented.":[52],"Outpatient":[53],"records":[54],"purchased":[56,79],"prescriptions":[57,97,263,294,304],"were":[58,78,151,158,164,174,180,199,226,274],"retrieved":[59,200],"investigate":[61,132],"frequency":[63,134],"characteristics":[65],"prescribing":[69,138,341,354,454,487],"(I).":[70],"Stockholm,":[72],"1.8":[73],"prescribed":[74],"drugs":[75,173,460],"per":[76],"child":[77],"year":[82,127],"2000.":[83],"Every":[84,228],"fifth":[85],"was":[87,98,129,251,317,331],"classified":[88],"as":[89,160,380,525],"an":[90],"prescription.":[92],"The":[93],"proportion":[94,338],"highest":[99],"for":[100,335,367,461,488],"topical":[101,456],"due":[103],"information.":[108],"A":[109,364],"survey":[110,493],"all":[112,302],"adverse":[113,149,185,429],"reaction":[115],"reports":[116,157,496],"Medical":[119],"Products":[120],"Agency":[121],"outpatients":[124,464],"2000":[128],"performed,":[130],"(II).":[139],"One":[140,153],"hundred":[141],"twelve":[143],"cases,":[145],"corresponding":[146],"158":[148],"reactions":[150,484],"reported.":[152,177],"third":[154,229],"regarded":[159],"serious,":[161],"these":[163],"more":[165,279,412],"often":[166,234],"associated":[167],"prescribing.":[171],"Antiasthmatic":[172],"most":[175,182,319],"commonly":[176,183],"Psychiatric":[178],"symptoms":[179],"reported":[184],"reactions.":[187],"Paediatric":[188],"questions":[189,225],"answers":[191],"Drug":[194,500],"Information":[195],"Centre":[196],"Stockholm":[198],"analysed":[202,275],"regarding":[203],"literature":[209],"information":[210,330,530],"adding":[211],"labelling":[214],"(III).":[218],"During":[219],"10-year":[221],"period,":[222],"249":[223],"handled.":[227],"question":[230],"concerned":[231,305],"treatment,":[233],"psychotropic":[236],"drugs.":[237,315],"every":[239],"other":[240],"response":[241],"questions,":[244],"additional":[245],"found":[252],"literature.":[255],"prospective,":[258],"nation-wide,":[259],"cross-sectional":[260],"study,":[261],"offlabel":[265],"children":[269,356,524],"at":[270,527],"hospitals":[271],"Sweden":[273],"(IV).":[276],"Enrolment":[277],"than":[280],"200":[281],"hospital":[282,361],"departments":[283],"resulted":[284],"data":[286],"from":[287],"2947":[288],"patients,":[290],"that":[291],"received":[292],"altogether11294":[293],"within":[295],"two":[296],"two-day-periods":[297],"2008.":[299],"Half":[300],"administered":[303],"either":[306],"or":[310,312],"unlicensed":[311],"extemporaneously":[313],"prepared":[314],"Paracetamol":[316],"common":[320,365],"used":[322],"both":[323,358],"on-":[324],"off-label.":[326],"Absence":[327],"main":[333],"reason":[334,366],"large":[337],"carbohydrates":[343],"electrolytes":[345],"hospitals.":[347],"This":[348],"thesis":[349],"has":[350],"demonstrated":[351],"substantial":[352],"primary":[359],"health":[362],"care.":[363],"this":[368],"documentation.":[374],"Children":[375],"have":[376],"same":[378],"right":[379],"adults":[381],"well":[383],"documented":[384],"safe":[386],"therapy.":[388],"Therefore,":[389],"it":[390],"necessary":[392],"improve":[394],"through":[397],"harmonization":[398],"existing":[400],"scientific":[401,438],"knowledge":[402],"clinical":[404],"experience,":[405],"improved":[406],"structure":[407],"SPC":[409],"information,":[410],"appropriate":[413],"administration":[414],"forms.":[415],"Furthermore,":[416],"its":[423],"outcomes,":[424],"including":[425],"reporting":[427],"reactions,":[431],"need":[432],"be":[434],"improved.":[435],"List":[436],"papers":[439],"I.":[440],"Ufer":[441,475],"M,":[442,476],"Rane":[443],"A,":[444,446],"Karlsson":[445],"Kimland":[447,477,507],"E,":[448,478,508],"Bergman":[449,479,509],"U.":[450,480],"(2003).":[451],"\"Widespread":[452],"but":[457],"not":[458],"systemic":[459],"350,000":[462],"Stockholm.\"":[466],"Eur":[467,532],"J":[468,533],"Clin":[469],"Pharmacol.":[470],"58(11):":[471],"779-783":[472],"https://pubmed.ncbi.nlm.nih.gov/12634986":[473],"II.":[474],"(2004).":[481],"\"Adverse":[482],"outpatients:":[490],"one-year":[492],"spontaneous":[495],"Sweden.\"":[498],"Pharmacoepidemiol":[499],"Saf":[501],"13(3):":[502],"147-152":[503],"https://pubmed.ncbi.nlm.nih.gov/":[504],"15072113":[505],"III.":[506],"U,":[510],"Lindemalm":[511],"S,":[512],"B\u00f6ttiger":[513],"Y":[514],"(2007).":[515],"\"Drug":[516],"related":[517],"problems":[518],"seen":[526],"centre.\"":[531],"Pediatr":[534],"166(6):":[535],"527-532":[536],"https://pubmed.ncbi.nlm.nih.gov/17195069":[537]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}