{"id":"https://openalex.org/W1605685994","doi":"https://doi.org/10.1158/1538-7445.am2014-1640","title":"Abstract 1640: A novel small molecule inhibitor of lysophosphatidic acid acyltransferase-beta inhibits pancreatic cancer cell proliferation and mTOR signaling","display_name":"Abstract 1640: A novel small molecule inhibitor of lysophosphatidic acid acyltransferase-beta inhibits pancreatic cancer cell proliferation and mTOR signaling","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W1605685994","doi":"https://doi.org/10.1158/1538-7445.am2014-1640","mag":"1605685994"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-1640","doi":"https://doi.org/10.1158/1538-7445.am2014-1640","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-1640","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103527984","display_name":"Michelle A. Blaskovich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle A. Blaskovich","raw_affiliation_strings":["H. Lee Moffitt Cancer Center & Res. Institute, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center & Res. Institute, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031144571","display_name":"Yunting Luo","orcid":"https://orcid.org/0000-0003-2503-9510","observed_orcids":["https://orcid.org/0000-0003-2503-9510"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunting Luo","raw_affiliation_strings":["H. Lee Moffitt Cancer Center & Res. Institute, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center & Res. Institute, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084200091","display_name":"Yiyu Ge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiyu Ge","raw_affiliation_strings":["H. Lee Moffitt Cancer Center & Res. Institute, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center & Res. Institute, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103060677","display_name":"Sa\u0131\u0308d M. Sebti","orcid":"https://orcid.org/0000-0001-5163-1038","observed_orcids":["https://orcid.org/0000-0001-5163-1038"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sa\u00efd M. Sebti","raw_affiliation_strings":["H. Lee Moffitt Cancer Center & Res. Institute, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center & Res. Institute, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057921101","display_name":"Harshani R. Lawrence","orcid":"https://orcid.org/0000-0002-9263-7775","observed_orcids":["https://orcid.org/0000-0002-9263-7775"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harshani R. Lawrence","raw_affiliation_strings":["H. Lee Moffitt Cancer Center & Res. Institute, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center & Res. Institute, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027503793","display_name":"Nicholas J. Lawrence","orcid":"https://orcid.org/0000-0003-1129-2558","observed_orcids":["https://orcid.org/0000-0003-1129-2558"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas J. Lawrence","raw_affiliation_strings":["H. Lee Moffitt Cancer Center & Res. Institute, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center & Res. Institute, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047712976","display_name":"Gregory M. Springett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory M. Springett","raw_affiliation_strings":["H. Lee Moffitt Cancer Center & Res. Institute, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center & Res. Institute, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I3019308854"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"1640","last_page":"1640"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.7759000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.7759000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.16529999673366547,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.024299999698996544,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.9380000233650208},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.7879999876022339},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.8220000267028809},{"id":"https://openalex.org/keywords/phosphatidic-acid","display_name":"phosphatidic acid","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/anchorage-independent-growth","display_name":"anchorage-independent growth","score":0.9710000157356262},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.953000009059906},{"id":"https://openalex.org/keywords/lead-optimization","display_name":"lead optimization","score":0.8769999742507935},{"id":"https://openalex.org/keywords/raf-signaling","display_name":"Raf signaling","score":0.44200000166893005},{"id":"https://openalex.org/keywords/pkc-signaling","display_name":"PKC signaling","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C2776661833","wikidata":"https://www.wikidata.org/wiki/Q2823281","display_name":"Lysophosphatidic acid","level":3,"score":0.8798840045928955},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6691628098487854},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5972553491592407},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5311043858528137},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5306443572044373},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4983201026916504},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.49377331137657166},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47155237197875977},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4425897002220154},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4362202286720276},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4085518717765808},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.350278377532959},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26227128505706787},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16128990054130554},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15241166949272156},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07091221213340759}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-1640","doi":"https://doi.org/10.1158/1538-7445.am2014-1640","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-1640","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2092545031","https://openalex.org/W2021751164","https://openalex.org/W2333494031","https://openalex.org/W2127045512","https://openalex.org/W4236001229","https://openalex.org/W2010066721","https://openalex.org/W2276826469","https://openalex.org/W3150773556","https://openalex.org/W4205245434","https://openalex.org/W2900366272"],"abstract_inverted_index":{"Abstract":[0,98],"Lysophosphatidic":[1],"acid":[2,7,189],"acyltransferase":[3],"(LPAAT-\u03b2),":[4],"a":[5,26,44,69,78,111],"phosphatidic":[6],"(PA)-generating":[8],"enzyme,":[9],"plays":[10,43],"an":[11],"essential":[12],"role":[13,20,46,64],"in":[14,47,62,73,93],"triglyceride":[15],"synthesis.":[16],"A":[17,182],"less":[18],"familiar":[19],"for":[21,211],"LPAAT-\u03b2":[22,66,85,90,159],"is":[23,61],"that":[24,65,115,152],"of":[25,28,35,38,50,80,84,137,158,187,202,207],"regulator":[27],"cell":[29,140,194],"growth":[30,136],"and":[31,58,106,121,196],"differentiation":[32],"by":[33],"means":[34],"the":[36,48,156,203,208],"function":[37],"its":[39],"product,":[40],"PA,":[41],"which":[42],"vital":[45],"activation":[49],"key":[51],"signal":[52],"transduction":[53],"proteins":[54],"including":[55],"Raf,":[56],"PKC-\u03b6":[57],"mTOR.":[59],"It":[60],"this":[63],"presents":[67],"as":[68],"potential":[70],"therapeutic":[71],"target":[72],"cancer.":[74],"Accordingly,":[75],"we":[76],"developed":[77],"library":[79],"small":[81,113,184],"molecule":[82,114,185],"inhibitors":[83],"with":[86],"nanomolar":[87,143],"activity":[88,92],"against":[89],"enzyme":[91],"vitro":[94],"(2012":[95],"Annual":[96,205],"Meeting,":[97],"#2470).":[99],"We":[100],"have":[101],"now":[102],"performed":[103],"additional":[104],"SAR":[105],"lead":[107,131],"optimization":[108],"to":[109,155],"produce":[110],"potent":[112],"inhibits":[116,134,191],"proliferation,":[117],"mTOR":[118,197],"signaling":[119,151],"pathways,":[120],"total":[122],"cellular":[123,150],"PA":[124],"levels":[125],"at":[126,142],"low":[127],"micromolar":[128],"concentrations.":[129,144],"The":[130],"compound":[132,146],"also":[133],"anchorage-independent":[135],"pancreatic":[138,192],"cancer":[139,193],"lines":[141],"This":[145],"demonstrates":[147],"effects":[148,157],"on":[149],"are":[153],"similar":[154],"siRNA.":[160],"Citation":[161],"Format:":[162],"Michelle":[163],"A.":[164],"Blaskovich,":[165],"Yunting":[166],"Luo,":[167],"Yiyu":[168],"Ge,":[169],"Sa\u00efd":[170],"M.":[171,180],"Sebti,":[172],"Harshani":[173],"R.":[174],"Lawrence,":[175,178],"Nicholas":[176],"J.":[177],"Gregory":[179],"Springett.":[181],"novel":[183],"inhibitor":[186],"lysophosphatidic":[188],"acyltransferase-beta":[190],"proliferation":[195],"signaling.":[198],"[abstract].":[199],"In:":[200],"Proceedings":[201],"105th":[204],"Meeting":[206],"American":[209],"Association":[210],"Cancer":[212,223],"Research;":[213],"2014":[214],"Apr":[215],"5-9;":[216],"San":[217],"Diego,":[218],"CA.":[219],"Philadelphia":[220],"(PA):":[221],"AACR;":[222],"Res":[224],"2014;74(19":[225],"Suppl):Abstract":[226],"nr":[227],"1640.":[228],"doi:10.1158/1538-7445.AM2014-1640":[229]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2016-06-24T00:00:00"}