{"id":"https://openalex.org/W1605575463","doi":"https://doi.org/10.1016/s0021-9258(17)31463-1","title":"Endothelin induces tyrosine phosphorylation and GRB2 association of Shc in astrocytes.","display_name":"Endothelin induces tyrosine phosphorylation and GRB2 association of Shc in astrocytes.","publication_year":1994,"publication_date":"1994-10-01","ids":{"openalex":"https://openalex.org/W1605575463","doi":"https://doi.org/10.1016/s0021-9258(17)31463-1","mag":"1605575463","pmid":"https://pubmed.ncbi.nlm.nih.gov/7929159"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(17)31463-1","doi":"https://doi.org/10.1016/s0021-9258(17)31463-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)31463-1","pdf_url":"https://doi.org/10.1016/s0021-9258(17)31463-1","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(17)31463-1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032357994","display_name":"Sylvie M. Cazaubon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S.M. Cazaubon","raw_affiliation_strings":["Centre de Recherche de Vitry-Alforuille, France","From the Laboratoire d'Zmmuno-Pharmacologie Moldculaire, Znstitut Cochin de GdnQtique Moldculaire, CNRS UPR 0415, UniversitQ Paris VZZ, 22 rue Mdchain 75014 Paris, France, the","SLaboratoire d'Oncologie Cellulaire et Mole'culaire, ZNSERM U363. Hevital Cochin. 27 rue du Faubourg Saint Jacques 75014 Paris, France, and WhSne-Poulenc Rorer,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche de Vitry-Alforuille, France","institution_ids":[]},{"raw_affiliation_string":"From the Laboratoire d'Zmmuno-Pharmacologie Moldculaire, Znstitut Cochin de GdnQtique Moldculaire, CNRS UPR 0415, UniversitQ Paris VZZ, 22 rue Mdchain 75014 Paris, France, the","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210141964"]},{"raw_affiliation_string":"SLaboratoire d'Oncologie Cellulaire et Mole'culaire, ZNSERM U363. Hevital Cochin. 27 rue du Faubourg Saint Jacques 75014 Paris, France, and WhSne-Poulenc Rorer,","institution_ids":["https://openalex.org/I4210092774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022375669","display_name":"Francisco Ramos\u2010Morales","orcid":"https://orcid.org/0000-0002-1151-4547","observed_orcids":["https://orcid.org/0000-0002-1151-4547"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F. Ramos-Morales","raw_affiliation_strings":["Centre de Recherche de Vitry-Alforuille, France","From the Laboratoire d'Zmmuno-Pharmacologie Moldculaire, Znstitut Cochin de GdnQtique Moldculaire, CNRS UPR 0415, UniversitQ Paris VZZ, 22 rue Mdchain 75014 Paris, France, the","SLaboratoire d'Oncologie Cellulaire et Mole'culaire, ZNSERM U363. Hevital Cochin. 27 rue du Faubourg Saint Jacques 75014 Paris, France, and WhSne-Poulenc Rorer,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche de Vitry-Alforuille, France","institution_ids":[]},{"raw_affiliation_string":"From the Laboratoire d'Zmmuno-Pharmacologie Moldculaire, Znstitut Cochin de GdnQtique Moldculaire, CNRS UPR 0415, UniversitQ Paris VZZ, 22 rue Mdchain 75014 Paris, France, the","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210141964"]},{"raw_affiliation_string":"SLaboratoire d'Oncologie Cellulaire et Mole'culaire, ZNSERM U363. Hevital Cochin. 27 rue du Faubourg Saint Jacques 75014 Paris, France, and WhSne-Poulenc Rorer,","institution_ids":["https://openalex.org/I4210092774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029957820","display_name":"Siegmund Fischer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S. Fischer","raw_affiliation_strings":["From the Laboratoire d'Zmmuno-Pharmacologie Moldculaire , Znstitut Cochin de GdnQtique Moldculaire , CNRS UPR 0415 ,","Centre de Recherche de Vitry-Alforuille, France","From the Laboratoire d'Zmmuno-Pharmacologie Moldculaire, Znstitut Cochin de GdnQtique Moldculaire, CNRS UPR 0415, UniversitQ Paris VZZ, 22 rue Mdchain 75014 Paris, France, the","SLaboratoire d'Oncologie Cellulaire et Mole'culaire, ZNSERM U363. Hevital Cochin. 27 rue du Faubourg Saint Jacques 75014 Paris, France, and WhSne-Poulenc Rorer,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratoire d'Zmmuno-Pharmacologie Moldculaire , Znstitut Cochin de GdnQtique Moldculaire , CNRS UPR 0415 ,","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Centre de Recherche de Vitry-Alforuille, France","institution_ids":[]},{"raw_affiliation_string":"From the Laboratoire d'Zmmuno-Pharmacologie Moldculaire, Znstitut Cochin de GdnQtique Moldculaire, CNRS UPR 0415, UniversitQ Paris VZZ, 22 rue Mdchain 75014 Paris, France, the","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210141964"]},{"raw_affiliation_string":"SLaboratoire d'Oncologie Cellulaire et Mole'culaire, ZNSERM U363. Hevital Cochin. 27 rue du Faubourg Saint Jacques 75014 Paris, France, and WhSne-Poulenc Rorer,","institution_ids":["https://openalex.org/I4210092774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047866778","display_name":"Fabien Schweighoffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F. Schweighoffer","raw_affiliation_strings":["Centre de Recherche de Vitry-Alforuille, France","From the Laboratoire d'Zmmuno-Pharmacologie Moldculaire, Znstitut Cochin de GdnQtique Moldculaire, CNRS UPR 0415, UniversitQ Paris VZZ, 22 rue Mdchain 75014 Paris, France, the","SLaboratoire d'Oncologie Cellulaire et Mole'culaire, ZNSERM U363. Hevital Cochin. 27 rue du Faubourg Saint Jacques 75014 Paris, France, and WhSne-Poulenc Rorer,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche de Vitry-Alforuille, France","institution_ids":[]},{"raw_affiliation_string":"From the Laboratoire d'Zmmuno-Pharmacologie Moldculaire, Znstitut Cochin de GdnQtique Moldculaire, CNRS UPR 0415, UniversitQ Paris VZZ, 22 rue Mdchain 75014 Paris, France, the","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210141964"]},{"raw_affiliation_string":"SLaboratoire d'Oncologie Cellulaire et Mole'culaire, ZNSERM U363. Hevital Cochin. 27 rue du Faubourg Saint Jacques 75014 Paris, France, and WhSne-Poulenc Rorer,","institution_ids":["https://openalex.org/I4210092774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113837546","display_name":"Arthur Donny Strosberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A.D. Strosberg","raw_affiliation_strings":["Centre de Recherche de Vitry-Alforuille, France","From the Laboratoire d'Zmmuno-Pharmacologie Moldculaire, Znstitut Cochin de GdnQtique Moldculaire, CNRS UPR 0415, UniversitQ Paris VZZ, 22 rue Mdchain 75014 Paris, France, the","SLaboratoire d'Oncologie Cellulaire et Mole'culaire, ZNSERM U363. Hevital Cochin. 27 rue du Faubourg Saint Jacques 75014 Paris, France, and WhSne-Poulenc Rorer,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche de Vitry-Alforuille, France","institution_ids":[]},{"raw_affiliation_string":"From the Laboratoire d'Zmmuno-Pharmacologie Moldculaire, Znstitut Cochin de GdnQtique Moldculaire, CNRS UPR 0415, UniversitQ Paris VZZ, 22 rue Mdchain 75014 Paris, France, the","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210141964"]},{"raw_affiliation_string":"SLaboratoire d'Oncologie Cellulaire et Mole'culaire, ZNSERM U363. Hevital Cochin. 27 rue du Faubourg Saint Jacques 75014 Paris, France, and WhSne-Poulenc Rorer,","institution_ids":["https://openalex.org/I4210092774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025747144","display_name":"Pierre\u2010Olivier Couraud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P.O. Couraud","raw_affiliation_strings":["UniversitQ Paris VZZ , 22 rue Mdchain 75014 Paris , France, SLaboratoire d'Oncologie Cellulaire et Mole'culaire ,","ZNSERM U363. Hevital Cochin . 27 rue du Faubourg Saint Jacques 75014 Paris , France,","Centre de Recherche de Vitry-Alforuille, France","From the Laboratoire d'Zmmuno-Pharmacologie Moldculaire, Znstitut Cochin de GdnQtique Moldculaire, CNRS UPR 0415, UniversitQ Paris VZZ, 22 rue Mdchain 75014 Paris, France, the","SLaboratoire d'Oncologie Cellulaire et Mole'culaire, ZNSERM U363. Hevital Cochin. 27 rue du Faubourg Saint Jacques 75014 Paris, France, and WhSne-Poulenc Rorer,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UniversitQ Paris VZZ , 22 rue Mdchain 75014 Paris , France, SLaboratoire d'Oncologie Cellulaire et Mole'culaire ,","institution_ids":[]},{"raw_affiliation_string":"ZNSERM U363. Hevital Cochin . 27 rue du Faubourg Saint Jacques 75014 Paris , France,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092774"]},{"raw_affiliation_string":"Centre de Recherche de Vitry-Alforuille, France","institution_ids":[]},{"raw_affiliation_string":"From the Laboratoire d'Zmmuno-Pharmacologie Moldculaire, Znstitut Cochin de GdnQtique Moldculaire, CNRS UPR 0415, UniversitQ Paris VZZ, 22 rue Mdchain 75014 Paris, France, the","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210141964"]},{"raw_affiliation_string":"SLaboratoire d'Oncologie Cellulaire et Mole'culaire, ZNSERM U363. Hevital Cochin. 27 rue du Faubourg Saint Jacques 75014 Paris, France, and WhSne-Poulenc Rorer,","institution_ids":["https://openalex.org/I4210092774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.1754,"has_fulltext":true,"cited_by_count":93,"citation_normalized_percentile":{"value":0.95153748,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"269","issue":"40","first_page":"24805","last_page":"24809"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/shc","display_name":"Shc","score":0.8920000195503235},{"id":"https://openalex.org/keywords/grb2","display_name":"Grb2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/sh2-domain","display_name":"SH2 domain","score":0.8169999718666077},{"id":"https://openalex.org/keywords/mapk-activation","display_name":"MAPK activation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/raf-1","display_name":"Raf-1","score":0.8309999704360962},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8799999952316284},{"id":"https://openalex.org/keywords/adaptor-proteins","display_name":"adaptor proteins","score":0.8619999885559082},{"id":"https://openalex.org/keywords/fluoroaluminate","display_name":"fluoroaluminate","score":0.8149999976158142},{"id":"https://openalex.org/keywords/g-protein-activation","display_name":"G protein activation","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7745192646980286},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.6620340347290039},{"id":"https://openalex.org/C177917778","wikidata":"https://www.wikidata.org/wiki/Q14905188","display_name":"GRB2","level":4,"score":0.5134561657905579},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4967709183692932},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.49563896656036377},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.48304516077041626},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47588884830474854},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.4270949959754944},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33825814723968506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3282844126224518},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32229745388031006},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.2839013934135437},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2533573508262634},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2336534559726715},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.12030544877052307},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11525943875312805},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011917","descriptor_name":"Rats, Inbred Lew","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016232","descriptor_name":"Endothelins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019908","descriptor_name":"Proto-Oncogene Proteins c-raf","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051380","descriptor_name":"GRB2 Adaptor Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(17)31463-1","doi":"https://doi.org/10.1016/s0021-9258(17)31463-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)31463-1","pdf_url":"https://doi.org/10.1016/s0021-9258(17)31463-1","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:7929159","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7929159","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(17)31463-1","doi":"https://doi.org/10.1016/s0021-9258(17)31463-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)31463-1","pdf_url":"https://doi.org/10.1016/s0021-9258(17)31463-1","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1605575463.pdf","grobid_xml":"https://content.openalex.org/works/W1605575463.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1506671658","https://openalex.org/W1510549216","https://openalex.org/W1551079196","https://openalex.org/W1558848958","https://openalex.org/W1559986791","https://openalex.org/W1577145787","https://openalex.org/W1591823948","https://openalex.org/W1655421004","https://openalex.org/W1956661481","https://openalex.org/W1971475788","https://openalex.org/W1982099849","https://openalex.org/W1986758681","https://openalex.org/W1987308911","https://openalex.org/W1988156929","https://openalex.org/W2000269495","https://openalex.org/W2005529016","https://openalex.org/W2010955929","https://openalex.org/W2011357928","https://openalex.org/W2011845054","https://openalex.org/W2019896687","https://openalex.org/W2021907259","https://openalex.org/W2031513892","https://openalex.org/W2032359283","https://openalex.org/W2041104433","https://openalex.org/W2051538397","https://openalex.org/W2057126981","https://openalex.org/W2066696278","https://openalex.org/W2070023258","https://openalex.org/W2078011486","https://openalex.org/W2089184347","https://openalex.org/W2094645760","https://openalex.org/W2162658068","https://openalex.org/W2223326463","https://openalex.org/W2402181649"],"related_works":["https://openalex.org/W2223326463","https://openalex.org/W2001648235","https://openalex.org/W2054473433","https://openalex.org/W1971613560","https://openalex.org/W2088490834","https://openalex.org/W2054484850","https://openalex.org/W1568015861","https://openalex.org/W1986205526","https://openalex.org/W2137896531","https://openalex.org/W1999088289"],"abstract_inverted_index":{"While":[0],"the":[1,70,79,131,162,210,217,220],"mitogen-activated":[2],"protein":[3],"kinase":[4],"(MAPK)":[5],"pathway":[6,200],"coupled":[7],"to":[8,169],"receptor":[9,227],"tyrosine":[10,99,228],"kinases":[11,229],"has":[12,33,85],"been":[13,34,87],"largely":[14],"clarified,":[15],"little":[16],"is":[17,90,196],"known":[18],"about":[19],"MAPK":[20,46,194,221],"activation":[21,155,195,218],"mediated":[22],"by":[23,159,225,232],"heterotrimeric":[24,41,233],"G":[25,42,157,198,234],"protein-coupled":[26,43,199,235],"receptors.":[27,240],"In":[28,165,208],"a":[29,114,143,167,170,197],"previous":[30],"study,":[31],"it":[32],"shown":[35,91],"that":[36,93,125,192,201],"endothelin-1":[37],"(ET-1)":[38],"signaling":[39],"through":[40],"receptors":[44],"stimulates":[45,98],"activity":[47],"in":[48,94,104,185,216],"primary":[49],"cultures":[50],"of":[51,78,101,134,156,175,219],"astrocytes":[52],"(Cazaubon,":[53],"S.,":[54],"Parker,":[55],"P.":[56],"J.,":[57],"Strosberg,":[58],"A.D.,":[59],"and":[60,83,140,148,205],"Couraud,":[61],"P.O.":[62],"(1993)":[63],"Biochem.":[64],"J.":[65],"293,":[66],"381-386).":[67],"To":[68],"clarify":[69],"molecular":[71,173],"mechanism":[72],"responsible":[73],"for":[74],"this":[75],"response,":[76],"involvement":[77],"adapter":[80],"proteins,":[81],"Shc":[82,127],"Grb2,":[84,204],"now":[86],"investigated.":[88],"It":[89],"here":[92],"these":[95],"cells,":[96],"ET-1":[97,163,239],"phosphorylation":[100],"Shc,":[102,203],"resulting":[103],"its":[105,180],"stable":[106],"association":[107],"with":[108,112,117,130],"Grb2":[109,115],"but":[110,230],"not":[111,223],"Grb3-3,":[113],"isoform":[116],"partially":[118],"deleted":[119],"SH2":[120,132],"domain.":[121],"These":[122,188],"results":[123],"demonstrate":[124],"tyrosine-phosphorylated":[126],"specifically":[128],"interacts":[129],"domain":[133],"Grb2.":[135],"This":[136],"response":[137],"was":[138,182],"rapid":[139],"transient,":[141],"showing":[142],"maximum":[144],"at":[145,150],"10":[146],"min":[147],"declining":[149],"60":[151],"min.":[152],"Interestingly,":[153],"direct":[154],"proteins":[158],"fluoroaluminate":[160],"mimics":[161],"effect.":[164],"addition,":[166],"shift":[168],"higher":[171],"apparent":[172],"mass":[174],"Raf-1":[176],"kinase,":[177],"likely":[178],"reflecting":[179],"hyperphosphorylation,":[181],"also":[183,231],"detected":[184],"ET-1-treated":[186],"cells.":[187],"data":[189],"strongly":[190],"suggest":[191],"ET-1-induced":[193],"involves":[202],"probably":[206],"Raf-1.":[207],"conclusion,":[209],"Shc-Grb2":[211],"complex":[212],"may":[213],"be":[214],"involved":[215],"pathway,":[222],"only":[224],"several":[226],"receptors,":[236],"such":[237],"as":[238]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}