{"id":"https://openalex.org/W1604968519","doi":null,"title":"Fabrication of composite scaffolds impregnated with an optimized fibrin-alginate hydrogel for cartilage tissue engineering","display_name":"Fabrication of composite scaffolds impregnated with an optimized fibrin-alginate hydrogel for cartilage tissue engineering","publication_year":2012,"publication_date":"2012-05-19","ids":{"openalex":"https://openalex.org/W1604968519","mag":"1604968519"},"language":"en","primary_location":{"id":"pmh:oai:ecommons.usask.ca:10388/ETD-2012-04-431","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10388/ETD-2012-04-431","pdf_url":null,"source":{"id":"https://openalex.org/S4377196608","display_name":"University Library - University of Saskatchewan (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32625721","host_organization_name":"University of Saskatchewan","host_organization_lineage":["https://openalex.org/I32625721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038126267","display_name":"Christopher J. Little","orcid":"https://orcid.org/0000-0001-9723-2366","observed_orcids":["https://orcid.org/0000-0001-9723-2366"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Christopher J. Little","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9723-2366","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5038126267"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.47189998626708984,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.47189998626708984,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.39500001072883606,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.04280000180006027,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/articular-cartilage-tissue-engineering","display_name":"articular cartilage tissue engineering","score":0.8840000033378601},{"id":"https://openalex.org/keywords/composite-scaffolds","display_name":"composite scaffolds","score":0.8240000009536743},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.7429999709129333},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.8370000123977661},{"id":"https://openalex.org/keywords/chondroitin-sulfate","display_name":"chondroitin sulfate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cartilage-repair","display_name":"cartilage repair","score":0.5879999995231628},{"id":"https://openalex.org/keywords/type-ii-collagen","display_name":"type II collagen","score":0.5569999814033508},{"id":"https://openalex.org/keywords/extracellular-matrix-production","display_name":"extracellular matrix synthesis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cell-seeding","display_name":"cell seeding","score":0.6299999952316284},{"id":"https://openalex.org/keywords/rapid-prototyping","display_name":"rapid prototyping","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.6810884475708008},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.6562089323997498},{"id":"https://openalex.org/C136525101","wikidata":"https://www.wikidata.org/wiki/Q5428139","display_name":"Fabrication","level":3,"score":0.5831959247589111},{"id":"https://openalex.org/C104779481","wikidata":"https://www.wikidata.org/wiki/Q50707","display_name":"Composite number","level":2,"score":0.5766546726226807},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5631133317947388},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5177382826805115},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.49619823694229126},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.4194338321685791},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.16560760140419006},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12490728497505188},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07216739654541016},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ecommons.usask.ca:10388/ETD-2012-04-431","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10388/ETD-2012-04-431","pdf_url":null,"source":{"id":"https://openalex.org/S4377196608","display_name":"University Library - University of Saskatchewan (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32625721","host_organization_name":"University of Saskatchewan","host_organization_lineage":["https://openalex.org/I32625721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},{"id":"pmh:oai:harvest.usask.ca:10388/ETD-2012-04-431","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10388/ETD-2012-04-431","pdf_url":null,"source":{"id":"https://openalex.org/S7407063267","display_name":"HARVEST (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:1604968519","doi":null,"is_oa":false,"landing_page_url":"https://harvest.usask.ca/bitstream/10388/ETD-2012-04-431/3/LITTLE-THESIS.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":158,"referenced_works":["https://openalex.org/W205941132","https://openalex.org/W1482679004","https://openalex.org/W1484811165","https://openalex.org/W1488796172","https://openalex.org/W1528604920","https://openalex.org/W1533053578","https://openalex.org/W1547172123","https://openalex.org/W1571968199","https://openalex.org/W1722420563","https://openalex.org/W1777800286","https://openalex.org/W1897162455","https://openalex.org/W1920660862","https://openalex.org/W1968637629","https://openalex.org/W1969359829","https://openalex.org/W1969711196","https://openalex.org/W1969836932","https://openalex.org/W1972523055","https://openalex.org/W1973032994","https://openalex.org/W1973343738","https://openalex.org/W1974924100","https://openalex.org/W1975272969","https://openalex.org/W1975471671","https://openalex.org/W1977779461","https://openalex.org/W1978619076","https://openalex.org/W1979837737","https://openalex.org/W1983571336","https://openalex.org/W1985817852","https://openalex.org/W1986485290","https://openalex.org/W1988752437","https://openalex.org/W1989524159","https://openalex.org/W1990513491","https://openalex.org/W1992153982","https://openalex.org/W1992742409","https://openalex.org/W1992750250","https://openalex.org/W1993110461","https://openalex.org/W1993840291","https://openalex.org/W1995483099","https://openalex.org/W1996295528","https://openalex.org/W2000571117","https://openalex.org/W2003340443","https://openalex.org/W2005150459","https://openalex.org/W2006081568","https://openalex.org/W2007924064","https://openalex.org/W2010575269","https://openalex.org/W2010902667","https://openalex.org/W2013529493","https://openalex.org/W2014137292","https://openalex.org/W2014764712","https://openalex.org/W2015165890","https://openalex.org/W2015423555","https://openalex.org/W2020787517","https://openalex.org/W2022804076","https://openalex.org/W2022981155","https://openalex.org/W2023894506","https://openalex.org/W2024443377","https://openalex.org/W2025395652","https://openalex.org/W2026220322","https://openalex.org/W2027358169","https://openalex.org/W2029209385","https://openalex.org/W2029245782","https://openalex.org/W2030585912","https://openalex.org/W2031439609","https://openalex.org/W2032710553","https://openalex.org/W2033133946","https://openalex.org/W2033619938","https://openalex.org/W2036856612","https://openalex.org/W2037174353","https://openalex.org/W2038356358","https://openalex.org/W2038611660","https://openalex.org/W2038646484","https://openalex.org/W2041692576","https://openalex.org/W2042167236","https://openalex.org/W2044274922","https://openalex.org/W2046111776","https://openalex.org/W2047503754","https://openalex.org/W2049411403","https://openalex.org/W2049973324","https://openalex.org/W2051016440","https://openalex.org/W2051994250","https://openalex.org/W2056586234","https://openalex.org/W2057198306","https://openalex.org/W2057344590","https://openalex.org/W2058232580","https://openalex.org/W2058858875","https://openalex.org/W2060414725","https://openalex.org/W2060670644","https://openalex.org/W2061245480","https://openalex.org/W2061344599","https://openalex.org/W2061894880","https://openalex.org/W2062279390","https://openalex.org/W2063014734","https://openalex.org/W2063664421","https://openalex.org/W2066282438","https://openalex.org/W2067555092","https://openalex.org/W2069025518","https://openalex.org/W2069674129","https://openalex.org/W2070050615","https://openalex.org/W2070698616","https://openalex.org/W2070904136","https://openalex.org/W2070927630","https://openalex.org/W2072087534","https://openalex.org/W2075273002","https://openalex.org/W2076440518","https://openalex.org/W2078819653","https://openalex.org/W2079181720","https://openalex.org/W2080520601","https://openalex.org/W2081119898","https://openalex.org/W2081312806","https://openalex.org/W2081966806","https://openalex.org/W2082135472","https://openalex.org/W2084610464","https://openalex.org/W2087230484","https://openalex.org/W2087418982","https://openalex.org/W2088952337","https://openalex.org/W2089537633","https://openalex.org/W2092414458","https://openalex.org/W2093908406","https://openalex.org/W2097844740","https://openalex.org/W2098901994","https://openalex.org/W2099249565","https://openalex.org/W2099285233","https://openalex.org/W2108244474","https://openalex.org/W2116636771","https://openalex.org/W2121275713","https://openalex.org/W2121992912","https://openalex.org/W2123633643","https://openalex.org/W2124084909","https://openalex.org/W2125050513","https://openalex.org/W2125625637","https://openalex.org/W2128767773","https://openalex.org/W2131456542","https://openalex.org/W2132905138","https://openalex.org/W2133235008","https://openalex.org/W2133915381","https://openalex.org/W2134025351","https://openalex.org/W2138453068","https://openalex.org/W2139458479","https://openalex.org/W2142348564","https://openalex.org/W2143953113","https://openalex.org/W2144001850","https://openalex.org/W2148657758","https://openalex.org/W2152541350","https://openalex.org/W2155124369","https://openalex.org/W2157276096","https://openalex.org/W2161067266","https://openalex.org/W2161887455","https://openalex.org/W2168420558","https://openalex.org/W2168897901","https://openalex.org/W2169962658","https://openalex.org/W2170077801","https://openalex.org/W2170996656","https://openalex.org/W2173962683","https://openalex.org/W2175540293","https://openalex.org/W2472216744","https://openalex.org/W2477321274","https://openalex.org/W2505726600","https://openalex.org/W2559764492","https://openalex.org/W3149337173"],"related_works":["https://openalex.org/W7099773904","https://openalex.org/W2069207853","https://openalex.org/W1939312784","https://openalex.org/W1595808075","https://openalex.org/W6981277994","https://openalex.org/W2033619938","https://openalex.org/W2069233781","https://openalex.org/W2078819653","https://openalex.org/W2117469788","https://openalex.org/W2053531870"],"abstract_inverted_index":{"Osteoarthritis":[0],"(OA)":[1],"is":[2],"a":[3,75,82,97,117,152,175,289,294,331,339],"painful":[4],"degenerative":[5],"joint":[6,57],"disease":[7],"that":[8,116,300],"affects":[9],"millions":[10],"of":[11,36,62,70,74,96,138,147,165,196,198,212,222,227,244,247,262,267,297,308,326],"North":[12],"Americans.":[13],"OA":[14],"could":[15,126],"be":[16,127,338],"better":[17,188],"managed":[18],"if":[19],"tissue":[20,33,38,349],"engineers":[21],"can":[22],"develop":[23],"methods":[24],"to":[25,66,151],"create":[26],"long-term":[27],"mechanically":[28],"stable":[29],"engineered":[30,39],"articular":[31,347],"cartilage":[32,40,58,348],"substitutes.":[34],"Many":[35],"the":[37,45,68,107,139,163,213,219,225,248,255,265,283,303,327],"constructs":[41],"currently":[42],"available":[43],"lack":[44],"chemical":[46],"stimuli,":[47],"cell-friendly":[48],"environment,":[49],"and/or":[50,89,167,252],"mechanical":[51],"strength":[52],"needed":[53],"for":[54,344],"use":[55,345],"in":[56,174,182,192,315,346],"repair.":[59],"The":[60,94],"goal":[61],"my":[63,320],"research":[64,321],"was":[65,111,114,178],"test":[67],"efficacy":[69],"composite":[71,276,317,336],"scaffolds":[72,277],"comprised":[73],"solid":[76,118,284],"synthetic":[77,108],"polymer":[78,109],"framework":[79,110],"impregnated":[80],"with":[81,121,250,288,324],"fibrin/alginate":[83],"hydrogel":[84,177],"containing":[85],"hyaluronic":[86],"acid":[87,99],"(HA)":[88],"chondroitin":[90],"sulphate":[91],"supplements":[92,229],"(CS).":[93],"suitability":[95],"polylactic-co-glycolic":[98],"(PLGA)":[100],"and":[101,202,236,264],"iron(III)":[102],"oxide":[103,141,286,335],"material":[104,131,142,156],"slurry":[105],"as":[106,194],"determined.":[112],"It":[113],"found":[115],"three-dimensional":[119,341],"scaffold":[120,287,342],"an":[122,160],"interconnected":[123],"porous":[124],"structure":[125],"fabricated":[128,280],"from":[129],"this":[130],"using":[132],"dispensing-based":[133],"rapid":[134],"prototyping.":[135],"Moreover,":[136],"films":[137],"PLGA-iron":[140,285],"supported":[143],"higher":[144],"cell":[145,257,271,298,304,328],"populations":[146],"porcine":[148],"chondrocytes":[149,172,190],"compared":[150],"previously":[153],"reported":[154],"PLGA-hydroxyapatite":[155],"film.":[157],"In":[158],"addition,":[159],"experiment":[161],"examining":[162],"effects":[164,226,266],"HA":[166,208,251],"CS":[168,210,253,332],"macromolecule":[169,269],"supplementation":[170,211],"on":[171,230,270],"cultured":[173,181,191],"fibrin-alginate":[176,183,291],"performed.":[179],"Chondrocytes":[180],"hydrogels":[184,214,249],"retained":[185],"their":[186],"phenotype":[187],"than":[189],"monolayer":[193],"analysis":[195],"expression":[197],"type":[199,203],"I":[200],"collagen":[201,205],"II":[204],"mRNA":[206],"transcripts.":[207],"or":[209,311],"increased":[215,254],"matrix":[216,231],"production":[217],"during":[218,302],"first":[220],"week":[221],"culture.":[223,245],"However,":[224,293],"these":[228,268,316],"accumulation":[232,314],"were":[233,237,273,278],"not":[234],"additive":[235],"no":[238],"longer":[239],"observed":[240],"after":[241,259],"2":[242],"weeks":[243,261],"Supplementation":[246],"chondrocyte":[256],"population":[258],"two":[260],"culture,":[263],"numbers":[272],"additive.":[274],"Finally,":[275],"successfully":[279],"by":[281],"impregnating":[282],"CS-supplemented":[290],"hydrogel.":[292],"large":[295],"amount":[296],"death":[299],"occurred":[301],"seeding":[305,329],"prevented":[306],"quantification":[307],"cellular":[309],"DNA":[310],"sulphated":[312],"GAG":[313],"scaffolds.":[318],"Nevertheless,":[319],"suggests":[322],"that,":[323],"refinement":[325],"process,":[330],"supplemented":[333],"fibrin-alginate/PLGA-iron":[334],"may":[337],"superior":[340],"system":[343],"engineering":[350],"applications.":[351]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}