{"id":"https://openalex.org/W1604870123","doi":null,"title":"NG2 positive cells of rat spinal cord activated during experimental autoimmune encephalomyelitis are spatially associated with radially oriented astroglia and express p75 receptor: a role for nerve growth factor in oligodendrocyte progenitor migration?","display_name":"NG2 positive cells of rat spinal cord activated during experimental autoimmune encephalomyelitis are spatially associated with radially oriented astroglia and express p75 receptor: a role for nerve growth factor in oligodendrocyte progenitor migration?","publication_year":2009,"publication_date":"2009-12-01","ids":{"openalex":"https://openalex.org/W1604870123","mag":"1604870123","pmid":"https://pubmed.ncbi.nlm.nih.gov/20162860"},"language":"en","primary_location":{"id":"pmid:20162860","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20162860","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives italiennes de biologie","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055373243","display_name":"Barbara Oderfeld-Nowak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16778253","display_name":"Instytut Biologii Do\u015bwiadczalnej im. Marcelego Nenckiego","ror":"https://ror.org/04waf7p94","country_code":"PL","type":"facility","lineage":["https://openalex.org/I16778253","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"B Oderfeld-Nowak","raw_affiliation_strings":["Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland. oderfeld@nencki.gov.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland. oderfeld@nencki.gov.pl","institution_ids":["https://openalex.org/I16778253","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066815401","display_name":"Ma\u0142gorzata Zaremba","orcid":"https://orcid.org/0000-0003-3151-8841","observed_orcids":["https://orcid.org/0000-0003-3151-8841"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Zaremba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034616516","display_name":"B Kwiatkowska-Patzer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Kwiatkowska-Patzer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056231096","display_name":"Andrzej Wojciech Lipkowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A W Lipkowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004366608","display_name":"Iwona Kurkowska\u2010Jastrz\u0119bska","orcid":"https://orcid.org/0000-0001-6553-9080","observed_orcids":["https://orcid.org/0000-0001-6553-9080"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Kurkowska-Jastrzebska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029818421","display_name":"Viviana Triaca","orcid":"https://orcid.org/0000-0001-8290-7279","observed_orcids":["https://orcid.org/0000-0001-8290-7279"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Triaca","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5018870384","display_name":"Luigi Aloe","orcid":"https://orcid.org/0000-0002-9796-1283","observed_orcids":["https://orcid.org/0000-0002-9796-1283"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Aloe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0975,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.48015564,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"147","issue":"4","first_page":"105","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalomyelitis","display_name":"experimental autoimmune encephalomyelitis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/oligodendrocyte-progenitors","display_name":"oligodendrocyte progenitors","score":0.921999990940094},{"id":"https://openalex.org/keywords/p75-neurotrophin-receptor","display_name":"p75 neurotrophin receptor","score":0.9020000100135803},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/astroglia","display_name":"astroglia","score":0.6119999885559082},{"id":"https://openalex.org/keywords/radial-glial-cells","display_name":"radial glia","score":0.6269999742507935},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.7269999980926514},{"id":"https://openalex.org/keywords/nestin","display_name":"nestin","score":0.8360000252723694},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.8980000019073486},{"id":"https://openalex.org/keywords/ependymal-cells","display_name":"ependymal cells","score":0.8059999942779541},{"id":"https://openalex.org/keywords/subventricular-zone","display_name":"subventricular zone","score":0.949999988079071},{"id":"https://openalex.org/keywords/white-matter","display_name":"white matter","score":0.515999972820282},{"id":"https://openalex.org/keywords/central-canal","display_name":"central canal","score":0.4359999895095825},{"id":"https://openalex.org/keywords/lewis-rats","display_name":"Lewis rats","score":0.3440000116825104}],"concepts":[{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.7189760804176331},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6485337018966675},{"id":"https://openalex.org/C2777542384","wikidata":"https://www.wikidata.org/wiki/Q937403","display_name":"Subventricular zone","level":4,"score":0.5855655074119568},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.5573204159736633},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5043438673019409},{"id":"https://openalex.org/C2778486448","wikidata":"https://www.wikidata.org/wiki/Q494066","display_name":"Experimental autoimmune encephalomyelitis","level":3,"score":0.4992179870605469},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.4161611497402191},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.41353660821914673},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.41154247522354126},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2810171842575073},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2650415897369385},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.18697592616081238}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005904","descriptor_name":"Glial Fibrillary Acidic Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007381","descriptor_name":"Intermediate Filament Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011508","descriptor_name":"Chondroitin Sulfate Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011917","descriptor_name":"Rats, Inbred Lew","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020800","descriptor_name":"Receptor, Nerve Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064231","descriptor_name":"Nestin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:20162860","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20162860","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives italiennes de biologie","raw_type":"Journal Article"},{"id":"mag:1604870123","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20162860","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W165833506","https://openalex.org/W1500755288","https://openalex.org/W1541342760","https://openalex.org/W1591058106","https://openalex.org/W1674531727","https://openalex.org/W1760682360","https://openalex.org/W1906455986","https://openalex.org/W1921871464","https://openalex.org/W1927948947","https://openalex.org/W1966170589","https://openalex.org/W1970530128","https://openalex.org/W1971675257","https://openalex.org/W1972856118","https://openalex.org/W1974352283","https://openalex.org/W1985286185","https://openalex.org/W1993969978","https://openalex.org/W1999452690","https://openalex.org/W2000007796","https://openalex.org/W2003814252","https://openalex.org/W2009909585","https://openalex.org/W2011500612","https://openalex.org/W2012707707","https://openalex.org/W2018462517","https://openalex.org/W2019692253","https://openalex.org/W2032888964","https://openalex.org/W2035279761","https://openalex.org/W2050989030","https://openalex.org/W2051396907","https://openalex.org/W2054587629","https://openalex.org/W2057458427","https://openalex.org/W2057873872","https://openalex.org/W2058484494","https://openalex.org/W2059877177","https://openalex.org/W2070108346","https://openalex.org/W2079812109","https://openalex.org/W2080170002","https://openalex.org/W2088834540","https://openalex.org/W2089773021","https://openalex.org/W2095655871","https://openalex.org/W2105349736","https://openalex.org/W2117256328","https://openalex.org/W2118403005","https://openalex.org/W2121400565","https://openalex.org/W2141170572","https://openalex.org/W2141254780"],"related_works":["https://openalex.org/W1979552960","https://openalex.org/W2051396907","https://openalex.org/W1972856118","https://openalex.org/W246675750","https://openalex.org/W2099046663","https://openalex.org/W1704912652","https://openalex.org/W1989501592","https://openalex.org/W1969098091","https://openalex.org/W1582312960","https://openalex.org/W2079812109"],"abstract_inverted_index":{"Data":[0],"have":[1,48],"been":[2],"provided":[3],"from":[4,177],"several":[5],"studies":[6],"that":[7,11,91,166],"support":[8],"the":[9,12,18,29,37,44,50,65,76,92,108,112,120,128,155,159,164,167,182,192,247],"proposal":[10],"adult":[13],"oligodendrocyte":[14],"progenitors":[15,59,100,136,208,232],"migrate":[16],"into":[17],"lesioned":[19],"areas":[20],"under":[21,189],"conditions":[22],"of":[23,31,33,52,56,68,86,96,101,115,143,154,181,196,227,249,251],"experimental":[24],"autoimmune":[25],"encephalomyelitis":[26],"(EAE).":[27],"However,":[28],"routes":[30],"migration":[32,250],"these":[34],"cells":[35,153,180,221],"and":[36,60,145,158,218],"governing":[38],"mechanisms":[39],"are":[40,82],"not":[41],"clear.":[42],"In":[43,140],"present":[45],"studies,":[46],"we":[47],"examined":[49],"effect":[51],"EAE":[53,190,239],"upon":[54],"activation":[55],"endogenous":[57,206],"oligodendroglia":[58,87,99,135,207,219,231,252],"their":[61],"spatial":[62],"distribution":[63],"in":[64,150,222,230,246],"spinal":[66],"cord":[67],"Lewis":[69],"rats":[70],"using":[71],"immunocytochemical":[72],"procedures.":[73],"Antibodies":[74],"against":[75],"marker":[77,123,131],"chondroitin":[78],"sulfate":[79],"proteoglycan":[80],"NG2,":[81],"used":[83],"for":[84,203,216,244],"identification":[85],"progenitors.":[88,253],"We":[89],"find":[90],"activated":[93,168,205],"elongated":[94,134],"subpopulation":[95],"NG2":[97,144],"positive":[98],"white":[102],"matter":[103],"is":[104,147],"spatially":[105],"associated":[106,233],"with":[107,234],"radially-oriented":[109],"astroglia":[110,195,237],"during":[111,238],"acute":[113],"phase":[114],"EAE.":[116],"The":[117,133,225],"latter":[118],"re-expressed":[119],"phenotypic":[121],"embryonic":[122,223],"nestin":[124],"while":[125],"still":[126],"expressing":[127],"mature":[129],"astroglial":[130],"GFAP.":[132],"express":[137],"p75":[138,146,228],"receptor.":[139],"addition,":[141],"colocalization":[142],"observed":[148],"also":[149,174],"ependymal":[151],"neural":[152,179],"central":[156],"canal":[157],"subventricular":[160],"zone.":[161],"This":[162],"raises":[163],"possibility":[165],"NG2+/p75+":[169],"parenchymal":[170],"cell":[171],"pool":[172],"may":[173,199,240],"be":[175],"recruited":[176],"multipotent":[178],"germination":[183],"areas.":[184],"Our":[185],"data":[186],"suggest":[187],"that,":[188],"conditions,":[191],"radially":[193,235],"oriented":[194,236],"juvenile":[197],"phenotype":[198],"serve":[200],"as":[201],"scaffolding":[202],"migrating":[204],"just":[209],"like":[210],"radial":[211],"glia":[212],"provide":[213],"a":[214,242],"path":[215],"neuronal":[217],"progenitor":[220],"stage.":[224],"expression":[226],"receptor":[229],"implicate":[241],"role":[243],"NGF":[245],"regulation":[248]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}