{"id":"https://openalex.org/W1604861887","doi":"https://doi.org/10.1183/13993003/erj.42.suppl_57.p3112","title":"Proapoptotic effects of PAI-1 protein on lung and prostate cancer cells","display_name":"Proapoptotic effects of PAI-1 protein on lung and prostate cancer cells","publication_year":2013,"publication_date":"2013-09-01","ids":{"openalex":"https://openalex.org/W1604861887","doi":"https://doi.org/10.1183/13993003/erj.42.suppl_57.p3112","mag":"1604861887"},"language":"en","primary_location":{"id":"doi:10.1183/13993003/erj.42.suppl_57.p3112","doi":"https://doi.org/10.1183/13993003/erj.42.suppl_57.p3112","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003/erj.42.suppl_57.p3112","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Journal","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006778522","display_name":"Adriana Ro\u017cy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adriana Rozy","raw_affiliation_strings":["1Laboratory of Molecular Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland","Laboratory of Molecular Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Laboratory of Molecular Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Molecular Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003324157","display_name":"Marta K\u0119dzior","orcid":"https://orcid.org/0000-0001-5385-4331","observed_orcids":["https://orcid.org/0000-0001-5385-4331"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marta Kedzior","raw_affiliation_strings":["1Laboratory of Molecular Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland","Laboratory of Molecular Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Laboratory of Molecular Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Molecular Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080173835","display_name":"Joanna Chorostowska\u2010Wynimko","orcid":"https://orcid.org/0000-0003-1743-2961","observed_orcids":["https://orcid.org/0000-0003-1743-2961"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joanna Chorostowska-Wynimko","raw_affiliation_strings":["1Laboratory of Molecular Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland","Laboratory of Molecular Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Laboratory of Molecular Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Molecular Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067025441","display_name":"Adam Szpechci\u0144ski","orcid":"https://orcid.org/0000-0002-8920-6931","observed_orcids":["https://orcid.org/0000-0002-8920-6931"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adam Szpechcinski","raw_affiliation_strings":["1Laboratory of Molecular Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland","Laboratory of Molecular Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Laboratory of Molecular Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Molecular Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026381921","display_name":"Ewa Skrzypczak\u2010Jankun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ewa Skrzypczak-Jankun","raw_affiliation_strings":["2Urology Research Center, The University of Toledo Health Science Campus, Toledo, OH, United States","Urology Research Center, The University of Toledo Health Science Campus, Toledo, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Urology Research Center, The University of Toledo Health Science Campus, Toledo, OH, United States","institution_ids":["https://openalex.org/I90871651"]},{"raw_affiliation_string":"Urology Research Center, The University of Toledo Health Science Campus, Toledo, OH, United States","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079636370","display_name":"Jerzy Jankun","orcid":"https://orcid.org/0000-0003-2354-4046","observed_orcids":["https://orcid.org/0000-0003-2354-4046"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerzy Jankun","raw_affiliation_strings":["2Urology Research Center, The University of Toledo Health Science Campus, Toledo, OH, United States","Urology Research Center, The University of Toledo Health Science Campus, Toledo, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Urology Research Center, The University of Toledo Health Science Campus, Toledo, OH, United States","institution_ids":["https://openalex.org/I90871651"]},{"raw_affiliation_string":"Urology Research Center, The University of Toledo Health Science Campus, Toledo, OH, United States","institution_ids":["https://openalex.org/I90871651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"Suppl 57","first_page":"P3112","last_page":"P3112"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9800000190734863},{"id":"https://openalex.org/keywords/proapoptotic-effects","display_name":"proapoptotic effects","score":0.8259999752044678},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.7139999866485596},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":1.0},{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.9549999833106995},{"id":"https://openalex.org/keywords/vitronectin","display_name":"vitronectin","score":0.8320000171661377},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7300000190734863},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.7390000224113464},{"id":"https://openalex.org/keywords/h1299-cells","display_name":"H1299 cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/du145-cells","display_name":"DU145 cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C2776438761","wikidata":"https://www.wikidata.org/wiki/Q5206280","display_name":"DU145","level":5,"score":0.960279107093811},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.863325834274292},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6328281164169312},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.6302616596221924},{"id":"https://openalex.org/C2776892390","wikidata":"https://www.wikidata.org/wiki/Q7119591","display_name":"Urokinase","level":2,"score":0.6137383580207825},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.592425525188446},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5593932271003723},{"id":"https://openalex.org/C56219504","wikidata":"https://www.wikidata.org/wiki/Q7900869","display_name":"Urokinase receptor","level":3,"score":0.5530046224594116},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.5245685577392578},{"id":"https://openalex.org/C164144092","wikidata":"https://www.wikidata.org/wiki/Q6587033","display_name":"Vitronectin","level":4,"score":0.4822271764278412},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.44208720326423645},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.44098758697509766},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4355127811431885},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.42121443152427673},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4131513237953186},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3748917281627655},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.37319138646125793},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3618396520614624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3603363037109375},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.268056184053421},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17506280541419983},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.10174134373664856},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1183/13993003/erj.42.suppl_57.p3112","doi":"https://doi.org/10.1183/13993003/erj.42.suppl_57.p3112","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003/erj.42.suppl_57.p3112","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Journal","raw_type":"journal-article"},{"id":"mag:1604861887","doi":null,"is_oa":false,"landing_page_url":"https://erj.ersjournals.com/content/42/Suppl_57/P3112.full.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"European Respiratory Journal","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2353654495","https://openalex.org/W1799476619","https://openalex.org/W2125865842","https://openalex.org/W1605543344","https://openalex.org/W7101022786","https://openalex.org/W2317106926","https://openalex.org/W2333773947","https://openalex.org/W2097786065","https://openalex.org/W2026996665","https://openalex.org/W2066583134"],"abstract_inverted_index":{"Plasminogen":[0],"activator":[1],"inhibitor":[2,11],"type":[3,218],"1":[4],"(PAI-1)":[5],"is":[6,236],"the":[7,45,79,95],"most":[8],"potent":[9],"physiological":[10],"of":[12,18,26,48,53,81,89,97,100,110,123,170,211,231],"urokinase":[13,27,49,54,142],"-":[14],"a":[15,57],"key":[16],"regulator":[17],"tumor":[19],"growth":[20],"and":[21,34,40,50,83,114,127,129,133,146,150,178,190,240],"metastasis.":[22],"The":[23,87],"proteolytic":[24],"activity":[25,47,73,77,122,184],"determines":[28],"its":[29],"effect":[30,203,230],"on":[31,78,120,233],"cell":[32,135,161,193,200],"migration":[33],"invasion,":[35],"as":[36,38,214,216],"well":[37,215],"proliferation":[39,80],"apoptosis.":[41],"PAI-1":[42,67,101,108,171,174,208,232],"directly":[43],"inhibits":[44],"enzymatic":[46],"stimulates":[51],"internalization":[52],"complexed":[55],"with":[56,70,155,167],"specific":[58],"receptor.":[59],"Previously":[60],"we":[61],"shown":[62],"that":[63],"very":[64],"long":[65],"half-life":[66],"(VLHL":[68],"PAI-1)":[69],"prolonged":[71],"anti-proteinase":[72],"demonstrated":[74],"considerable":[75],"inhibitory":[76],"lung":[82,124,189],"prostate":[84,130,191,198],"cancer":[85,125,131,192,199,223,234],"cells.":[86],"aim":[88],"this":[90,202],"study":[91],"was":[92,204],"to":[93,238],"analyze":[94],"impact":[96],"increasing":[98,168],"concentrations":[99],"mutant":[102],"forms:":[103],"VLHL":[104,173],"PAI-1,":[105],"Vn":[106],"neg":[107],"devoid":[109,210],"affinity":[111,213],"towards":[112],"vitronectin":[113,212],"wild":[115,217],"form":[116],"(wt":[117],"PAI":[118],"-1)":[119],"apoptotic":[121,183],"(A549":[126],"H1299)":[128],"(LNCaP":[132],"DU145)":[134],"lines,":[136],"characterized":[137],"by":[138],"normal":[139],"or":[140],"high":[141],"production,":[143],"respectively":[144],"A549":[145],"LNCaP":[147],"vs":[148],"H1299":[149],"DU145.":[151],"DNA":[152],"fragments":[153],"associated":[154],"histones":[156],"were":[157],"spectometrically":[158],"quantitated":[159],"in":[160,185,227],"cytoplasm":[162],"after":[163],"24":[164],"hrs":[165],"incubation":[166],"doses":[169],"proteins.":[172],"protein":[175,209],"(10":[176],"\u00b5g/ml":[177],"100":[179],"\u00b5g/ml)":[180],"strongly":[181],"up-regulated":[182],"all":[186],"examined":[187],"human":[188],"lines":[194],"(p<0,001).":[195],"In":[196,206],"DU145":[197],"line":[201],"dose-dependent.":[205],"contrast,":[207],"PAI-1apoptosis":[219],"did":[220],"not":[221],"affected":[222],"cells":[224,235],"apotosis.":[225],"Conclusion:":[226],"vitro":[228],"proapoptotic":[229],"due":[237],"anti-proteolitic":[239],"anti-adhesion":[241],"properties.":[242]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}