{"id":"https://openalex.org/W1604736734","doi":null,"title":"Structure-activity study of the inhibition of microtubule assembly in vitro by podophyllotoxin and its congeners.","display_name":"Structure-activity study of the inhibition of microtubule assembly in vitro by podophyllotoxin and its congeners.","publication_year":1978,"publication_date":"1978-09-01","ids":{"openalex":"https://openalex.org/W1604736734","mag":"1604736734","pmid":"https://pubmed.ncbi.nlm.nih.gov/679171"},"language":"en","primary_location":{"id":"pmid:679171","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/679171","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112775965","display_name":"John D. Loike","orcid":"https://orcid.org/0000-0002-9769-9772","observed_orcids":["https://orcid.org/0000-0002-9769-9772"]},"institutions":[{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J D Loike","raw_affiliation_strings":["Yeshiva University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yeshiva University","institution_ids":["https://openalex.org/I19772626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039138618","display_name":"C. Fred Brewer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200870766","display_name":"Brookhaven National Laboratory","ror":"https://ror.org/02ex6cf31","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I200870766","https://openalex.org/I39565521","https://openalex.org/I4210142672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C F Brewer","raw_affiliation_strings":["[Brookhaven National Laboratory]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[Brookhaven National Laboratory]","institution_ids":["https://openalex.org/I200870766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072038665","display_name":"Himan Sternlicht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Sternlicht","raw_affiliation_strings":["Yeshiva University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yeshiva University","institution_ids":["https://openalex.org/I19772626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111736642","display_name":"Walter J. Gensler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W J Gensler","raw_affiliation_strings":["Boston University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083740179","display_name":"Susan Band Horwitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S B Horwitz","raw_affiliation_strings":["Case Western Reserve University ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University ,","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9386,"has_fulltext":false,"cited_by_count":143,"citation_normalized_percentile":{"value":0.68012786,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"38","issue":"9","first_page":"2688","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12360","display_name":"Plant-derived Lignans Synthesis and Bioactivity","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12360","display_name":"Plant-derived Lignans Synthesis and Bioactivity","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.02590000070631504,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/podophyllotoxin","display_name":"podophyllotoxin","score":0.9580000042915344},{"id":"https://openalex.org/keywords/microtubule-assembly-inhibition","display_name":"microtubule assembly inhibition","score":0.9700000286102295},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8479999899864197},{"id":"https://openalex.org/keywords/taxanes","display_name":"taxanes","score":0.5630000233650208},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.8240000009536743},{"id":"https://openalex.org/keywords/teniposide","display_name":"teniposide","score":0.9760000109672546},{"id":"https://openalex.org/keywords/deoxypodophyllotoxin","display_name":"deoxypodophyllotoxin","score":0.8899999856948853},{"id":"https://openalex.org/keywords/epipodophyllotoxins","display_name":"epipodophyllotoxins","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cyclic-ethers","display_name":"cyclic ethers","score":0.5740000009536743},{"id":"https://openalex.org/keywords/cyclic-sulfides","display_name":"cyclic sulfides","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cyclic-sulfones","display_name":"cyclic sulfones","score":0.9660000205039978},{"id":"https://openalex.org/keywords/tubulin","display_name":"tubulin","score":0.5979999899864197},{"id":"https://openalex.org/keywords/van-der-waals-radii","display_name":"van der Waals radii","score":0.777999997138977},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C2778143360","wikidata":"https://www.wikidata.org/wiki/Q421193","display_name":"Podophyllotoxin","level":2,"score":0.9699068665504456},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.7267304062843323},{"id":"https://openalex.org/C2778689049","wikidata":"https://www.wikidata.org/wiki/Q898422","display_name":"Substituent","level":2,"score":0.6834739446640015},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6607867479324341},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.46918296813964844},{"id":"https://openalex.org/C201194858","wikidata":"https://www.wikidata.org/wiki/Q898238","display_name":"Steric effects","level":2,"score":0.45366886258125305},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.4353249669075012},{"id":"https://openalex.org/C2781347565","wikidata":"https://www.wikidata.org/wiki/Q137173","display_name":"Glucoside","level":3,"score":0.4301244616508484},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4193304777145386},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16852205991744995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1326061189174652},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11518767476081848},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011034","descriptor_name":"Podophyllotoxin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D011034","descriptor_name":"Podophyllotoxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013713","descriptor_name":"Teniposide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:679171","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/679171","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1604736734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/679171","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2007246397","https://openalex.org/W2124248613","https://openalex.org/W2751385922","https://openalex.org/W2051235129","https://openalex.org/W2895193396","https://openalex.org/W1993268085","https://openalex.org/W2516683459","https://openalex.org/W4388187983","https://openalex.org/W2771826103","https://openalex.org/W2093283271"],"abstract_inverted_index":{"This":[0],"study":[1],"investigates":[2],"the":[3,19,31,58,86,90,120],"inhibition":[4],"of":[5,39,52,62,74,89,111],"microtubule":[6],"assembly":[7],"in":[8,17,67,79,116,123],"vitro":[9],"by":[10,97],"podophyllotoxin":[11,40],"and":[12,26,36,41,45,60,70,109],"its":[13],"derivatives,":[14],"which":[15],"include":[16],"part":[18],"antitumor":[20],"compounds":[21],"4'-demethylepipodophyllotoxin":[22,27],"ethylidene":[23],"beta-D-glucoside":[24,29],"(VP-16-213)":[25],"thenylidene":[28],"(VM-26);":[30],"cyclic":[32,34,37],"ethers,":[33],"sulfides,":[35],"sulfones":[38],"deoxypodophyllotoxin;":[42],"epipodophyllotoxin;":[43],"picropodophyllotoxin;":[44],"several":[46],"4'-demethyl":[47],"compounds.":[48],"The":[49],"inhibitory":[50],"activity":[51,83],"these":[53,112],"derivatives":[54],"is":[55],"sensitive":[56],"to":[57,71],"configuration":[59],"size":[61,88],"substituents":[63,75],"at":[64,76,92],"position":[65,77,93],"4":[66],"ring":[68,80],"C":[69,108],"steric":[72],"features":[73],"12":[78],"D.":[81],"Decreasing":[82],"correlates":[84],"with":[85,119],"increasing":[87],"substituent":[91],"12,":[94],"as":[95],"indexed":[96],"their":[98,117],"van":[99],"der":[100],"Waals":[101],"radii.":[102],"These":[103],"results":[104],"suggest":[105],"that":[106],"rings":[107],"D":[110],"drugs":[113],"are":[114],"involved":[115],"interaction":[118],"podophyllotoxin-binding":[121],"site":[122],"tubulin.":[124]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}