{"id":"https://openalex.org/W1604660488","doi":null,"title":"Mechanism of silica-induced apoptosis in human alveolar macrophages","display_name":"Mechanism of silica-induced apoptosis in human alveolar macrophages","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W1604660488","mag":"1604660488"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:dissertations-1350","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/dissertations/AAI9807054","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Texas Medical Center Dissertations (via ProQuest)","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078581374","display_name":"Rashi S. Iyer","orcid":"https://orcid.org/0000-0003-0418-2158","observed_orcids":["https://orcid.org/0000-0003-0418-2158"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rashi Iyer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0418-2158","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5078581374"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.05139999836683273,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.996999979019165},{"id":"https://openalex.org/keywords/pulmonary-silicosis","display_name":"pulmonary silicosis","score":0.8640000224113464},{"id":"https://openalex.org/keywords/scavenger-receptors","display_name":"scavenger receptors","score":0.7450000047683716},{"id":"https://openalex.org/keywords/amorphous-silica","display_name":"amorphous silica","score":0.8799999952316284},{"id":"https://openalex.org/keywords/titanium-dioxide","display_name":"titanium dioxide","score":0.9950000047683716},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.7879999876022339},{"id":"https://openalex.org/keywords/parp-cleavage","display_name":"PARP cleavage","score":0.828000009059906},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.7139999866485596},{"id":"https://openalex.org/keywords/fucoidan","display_name":"fucoidan","score":0.7509999871253967},{"id":"https://openalex.org/keywords/polyinosinic-acid","display_name":"polyinosinic acid","score":0.8939999938011169},{"id":"https://openalex.org/keywords/high-density-lipoprotein","display_name":"high-density lipoprotein","score":0.984000027179718}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7286285758018494},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6392686367034912},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5428436398506165},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.4141855239868164},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4024565815925598},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3051697015762329},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14274311065673828},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12741142511367798},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1009373664855957},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.library.tmc.edu:dissertations-1350","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/dissertations/AAI9807054","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Texas Medical Center Dissertations (via ProQuest)","raw_type":"text"},{"id":"mag:1604660488","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1350&context=dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4234801656","https://openalex.org/W1942441654","https://openalex.org/W4403011672","https://openalex.org/W2187241866","https://openalex.org/W27086769","https://openalex.org/W7196936921","https://openalex.org/W2305964204","https://openalex.org/W2191101426","https://openalex.org/W2150054395","https://openalex.org/W2379999130"],"abstract_inverted_index":{"The":[0,48],"mechanisms":[1],"involved":[2,289,302],"in":[3,25,44,92,94,139,173,202,244,250,290,303],"the":[4,31,57,122,132,135,187,192,262,268,275,278,286,300],"development":[5],"of":[6,34,51,59,62,134,176,194,200,213,229,236,255,264,277,281,285],"pulmonary":[7],"silicosis":[8],"have":[9],"not":[10],"been":[11],"well":[12],"defined,":[13],"however":[14],"most":[15],"current":[16],"evidence":[17],"implicates":[18],"a":[19,35,241,296],"central":[20],"role":[21,133],"for":[22],"alveolar":[23,45,230,256],"macrophages":[24,257],"this":[26,52,233],"process.":[27],"We":[28],"propose":[29],"that":[30,180,220],"fibrotic":[32],"potential":[33,235],"particulate":[36],"depends":[37],"upon":[38],"its":[39],"ability":[40],"to":[41,55,163,261],"cause":[42],"apoptosis":[43,61,93,178,183,228,254,273,293],"macrophage":[46],"(AM).":[47],"overall":[49],"goal":[50],"study":[53],"was":[54],"determine":[56],"mechanism":[58,124,301],"silica-induced":[60,140,177,181,253,272],"AM.":[63],"Human":[64],"AM":[65,96,182],"were":[66,143],"treated":[67],"with":[68,89,145,167,267],"fibrogenic,":[69],"poorly":[70],"fibrogenic":[71,222,237,291],"and":[72,81,103,112,146,157,170,211,270],"nonfibrogenic":[73],"model":[74],"particulates,":[75,223],"such":[76,224],"as,":[77,225],"silica,":[78],"amorphous":[79,110],"silica":[80,90,111,127,164,226,265],"titanium":[82,113],"dioxide,":[83],"respectively":[84],"(equal":[85],"surface":[86],"area).":[87],"Treatment":[88],"resulted":[91,172],"human":[95],"as":[97],"observed":[98],"by":[99,125],"morphology,":[100],"DNA":[101],"fragmentation":[102],"Cell":[104],"Death":[105],"ELISA":[106],"assays.":[107],"In":[108],"contrast,":[109],"dioxide":[114],"demonstrated":[115],"no":[116],"significant":[117,174],"apoptotic":[118,234],"potential.":[119],"To":[120],"elucidate":[121],"possible":[123],"which":[126],"causes":[128],"apoptosis,":[129],"we":[130,190],"investigated":[131],"scavenger":[136],"receptor":[137],"(SR)":[138],"apoptosis.":[141,204],"Cells":[142],"pretreated":[144],"without":[147],"SR":[148],"ligand":[149],"binding":[150],"inhibitors,":[151],"polyinosinic":[152],"acid":[153],"(Poly":[154],"I),":[155],"fucoidan":[156,171],"high":[158],"density":[159],"lipoprotein":[160],"(HDL),":[161],"prior":[162],"treatment.":[165],"Pretreatment":[166],"Poly":[168],"I":[169],"inhibition":[175],"suggesting":[179],"is":[184],"mediated":[185],"via":[186],"SR.":[188],"Further,":[189],"examined":[191],"involvement":[193],"interleukin":[195],"converting":[196],"enzyme":[197],"(ICE)":[198],"family":[199,280],"proteases":[201],"silica-mediated":[203],"Silica":[205],"activated":[206],"ICE,":[207],"Ich-1L,":[208],"cpp32":[209],"beta":[210],"cleavage":[212],"PARP.":[214],"Taken":[215],"together,":[216],"these":[217],"results":[218],"suggested":[219],"(1)":[221],"caused":[227],"macrophages,":[231],"(2)":[232],"particulates":[238,266],"may":[239,258,294],"be":[240,259],"critical":[242],"factor":[243],"initiating":[245],"an":[246],"inflammatory":[247],"response":[248],"resulting":[249],"fibrosis,":[251],"(3)":[252],"due":[260],"interaction":[263],"SR,":[269],"(4)":[271],"involves":[274],"activation":[276],"ICE":[279],"proteases.":[282],"An":[283],"understanding":[284],"molecular":[287],"events":[288],"particulate-induced":[292,304],"provide":[295],"useful":[297],"insight":[298],"into":[299],"fibrosis.":[305]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}