{"id":"https://openalex.org/W160456375","doi":null,"title":"Interleukin 18 and cardiovascular disease in HIV-1 infection: a partner in crime?","display_name":"Interleukin 18 and cardiovascular disease in HIV-1 infection: a partner in crime?","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W160456375","mag":"160456375","pmid":"https://pubmed.ncbi.nlm.nih.gov/20216908"},"language":"en","primary_location":{"id":"pmid:20216908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20216908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS reviews","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108471615","display_name":"Donato Torre","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donato Torre","raw_affiliation_strings":["Section of Infectious Diseases, General Hospital, Cittiglio (Varese), Italy. donatotorre@libero.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Infectious Diseases, General Hospital, Cittiglio (Varese), Italy. donatotorre@libero.it","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107392565","display_name":"Agostino Pugliese","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agostino Pugliese","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.061,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.75754246,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"12","issue":"1","first_page":"31","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.7960000038146973},{"id":"https://openalex.org/keywords/hiv-1-infection","display_name":"HIV-1 infection","score":0.9990000128746033},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9610000252723694},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/atherosclerotic-plaque","display_name":"atherosclerotic plaque","score":0.8429999947547913},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8159999847412109},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.7889999747276306},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9419999718666077},{"id":"https://openalex.org/keywords/platelets","display_name":"platelets","score":0.9089999794960022},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9539999961853027},{"id":"https://openalex.org/keywords/lipodystrophy","display_name":"lipodystrophy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/simian-immunodeficiency-virus","display_name":"simian immunodeficiency virus","score":0.8880000114440918},{"id":"https://openalex.org/keywords/rhesus-macaques","display_name":"rhesus monkeys","score":0.9480000138282776},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.8827110528945923},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7324391603469849},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6415638327598572},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5835158228874207},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5809335112571716},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.5206015110015869},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.5091809630393982},{"id":"https://openalex.org/C2776246508","wikidata":"https://www.wikidata.org/wiki/Q5376428","display_name":"Endothelial activation","level":3,"score":0.4965594410896301},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.4837198555469513},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21347036957740784},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2080824375152588}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D020382","descriptor_name":"Interleukin-18","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:20216908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20216908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS reviews","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W24373389","https://openalex.org/W1497170016","https://openalex.org/W1514942862","https://openalex.org/W1542622008","https://openalex.org/W1579308444","https://openalex.org/W1942062746","https://openalex.org/W1966364313","https://openalex.org/W1971853868","https://openalex.org/W1976919684","https://openalex.org/W1979119858","https://openalex.org/W1979252165","https://openalex.org/W1987174800","https://openalex.org/W1989852026","https://openalex.org/W1991611246","https://openalex.org/W1993800499","https://openalex.org/W1994406154","https://openalex.org/W1995164773","https://openalex.org/W1996866382","https://openalex.org/W1997720968","https://openalex.org/W2003048832","https://openalex.org/W2012363746","https://openalex.org/W2016196756","https://openalex.org/W2016857337","https://openalex.org/W2018756235","https://openalex.org/W2023291145","https://openalex.org/W2028657303","https://openalex.org/W2028657736","https://openalex.org/W2030627771","https://openalex.org/W2032207767","https://openalex.org/W2036775607","https://openalex.org/W2039881470","https://openalex.org/W2041745835","https://openalex.org/W2042821389","https://openalex.org/W2044855047","https://openalex.org/W2045180319","https://openalex.org/W2047331834","https://openalex.org/W2052617165","https://openalex.org/W2055961415","https://openalex.org/W2060262441","https://openalex.org/W2063170999","https://openalex.org/W2063233844","https://openalex.org/W2063868272","https://openalex.org/W2072190804","https://openalex.org/W2078529164","https://openalex.org/W2083539882","https://openalex.org/W2094505389","https://openalex.org/W2095715637","https://openalex.org/W2098065069","https://openalex.org/W2099790921","https://openalex.org/W2105813877","https://openalex.org/W2117361576","https://openalex.org/W2123289485","https://openalex.org/W2124296466","https://openalex.org/W2124989653","https://openalex.org/W2127171522","https://openalex.org/W2139613376","https://openalex.org/W2143046247","https://openalex.org/W2144261800","https://openalex.org/W2149068470","https://openalex.org/W2150637250","https://openalex.org/W2151975228","https://openalex.org/W2152686325","https://openalex.org/W2155121555","https://openalex.org/W2157138119","https://openalex.org/W2159226285","https://openalex.org/W2160076389","https://openalex.org/W2160911126","https://openalex.org/W2164802862","https://openalex.org/W2166037275","https://openalex.org/W2166545507","https://openalex.org/W2166646911","https://openalex.org/W2168251511","https://openalex.org/W2169367420","https://openalex.org/W2182900237","https://openalex.org/W2258524519","https://openalex.org/W2294450137","https://openalex.org/W2328847723","https://openalex.org/W2417638286","https://openalex.org/W2615170291","https://openalex.org/W4313310005"],"related_works":["https://openalex.org/W1966364313","https://openalex.org/W2790636340","https://openalex.org/W1979119858","https://openalex.org/W4213094928","https://openalex.org/W4293761266","https://openalex.org/W2388593510","https://openalex.org/W4414640220","https://openalex.org/W7216437541","https://openalex.org/W2316307083","https://openalex.org/W2088855630"],"abstract_inverted_index":{"Cardiovascular":[0],"disease":[1,82,89],"has":[2],"been":[3],"frequent":[4],"in":[5,27,47,73,90,101,115,119,122,141,151,200,226,244],"HIV-infected":[6],"patients":[7],"both":[8],"before":[9],"and":[10,45,83,133,146,163,175,203,236,241],"after":[11],"the":[12,22,58,62,74,84,110,128,159,195],"advent":[13],"of":[14,24,42,54,80,86,96,112,153,155,161,185,197,207,213,238],"antiretroviral":[15],"therapy":[16],"(HAART).":[17],"The":[18],"pathogenic":[19],"basis":[20],"for":[21],"increase":[23],"cardiovascular":[25,116,246],"disease,":[26,117],"particular":[28],"myocardial":[29,120,201],"lesions,":[30,202],"may":[31,221],"involve":[32],"HIV-1":[33,92,102,123,142],"itself":[34],"or":[35],"other":[36,138,229],"mechanisms":[37],"including":[38,231],"endothelial":[39,173,232],"dysfunction,":[40,174,233],"activation":[41],"proinflammatory":[43,63,242],"cytokines,":[44,64],"changes":[46],"platelets,":[48],"which":[49],"lead":[50],"to":[51,68,78,108],"atherosclerotic":[52,81,134],"lesions":[53],"blood":[55],"vessels.":[56],"In":[57,217],"last":[59],"decade,":[60],"among":[61],"interleukin":[65,97,113,131,156,164,198,208,219],"18":[66,98,114,132,165,199,209,220],"seems":[67],"play":[69],"a":[70,224],"central":[71],"role":[72,111,160],"inflammatory":[75],"cascade,":[76],"leading":[77],"development":[79],"occurrence":[85],"ischemic":[87],"heart":[88,215],"uninfected":[91],"people.":[93],"Increased":[94],"levels":[95,206],"were":[99],"observed":[100],"infected":[103,188],"patients.":[104],"This":[105],"review":[106],"attempts":[107],"evaluate":[109],"especially":[118],"infarction,":[121],"infection,":[124,143],"as":[125,127,166],"well":[126],"relationship":[129],"between":[130,170],"plaque":[135],"formation.":[136],"Two":[137],"characteristic":[139],"aspects":[140],"metabolic":[144],"syndrome":[145],"lipodystrophy,":[147],"will":[148,177],"be":[149,178,222],"evaluated":[150],"light":[152],"activity":[154],"18.":[157],"Moreover,":[158],"platelets":[162],"an":[167,182],"important":[168,211],"linkage":[169],"chronic":[171],"inflammation,":[172],"atherogenesis":[176],"highlighted.":[179],"Finally,":[180],"experimental":[181],"animal":[183],"model":[184],"rhesus":[186],"macaques":[187],"with":[189,228],"simian":[190],"immunodeficiency":[191],"virus":[192],"clearly":[193],"demonstrates":[194],"involvement":[196],"that":[204],"circulating":[205],"are":[210],"predictors":[212],"coronary":[214],"disease.":[216,247],"conclusion,":[218],"considered":[223],"partner":[225],"crime":[227],"factors,":[230],"increased":[234],"expression":[235],"production":[237],"adhesion":[239],"molecules":[240],"cytokines":[243],"determining":[245]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}