{"id":"https://openalex.org/W160424062","doi":null,"title":"Amelioration of photic injury in rat retina by ascorbic acid: a histopathologic study.","display_name":"Amelioration of photic injury in rat retina by ascorbic acid: a histopathologic study.","publication_year":1985,"publication_date":"1985-11-01","ids":{"openalex":"https://openalex.org/W160424062","mag":"160424062","pmid":"https://pubmed.ncbi.nlm.nih.gov/4055291"},"language":"en","primary_location":{"id":"pmid:4055291","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4055291","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038128893","display_name":"Z. Y. Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z Y Li","raw_affiliation_strings":["University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002110704","display_name":"M. O.M. Tso","orcid":"https://orcid.org/0009-0000-5891-5826","observed_orcids":["https://orcid.org/0009-0000-5891-5826"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M O Tso","raw_affiliation_strings":["University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047556129","display_name":"Hsin-min Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H M Wang","raw_affiliation_strings":["University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113467139","display_name":"D.T. Organisciak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D T Organisciak","raw_affiliation_strings":["University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":null,"apc_paid":null,"fwci":5.0876,"has_fulltext":false,"cited_by_count":133,"citation_normalized_percentile":{"value":0.94912105,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"26","issue":"11","first_page":"1589","last_page":"98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13869","display_name":"Ocular and Laser Science Research","score":0.7271000146865845,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13869","display_name":"Ocular and Laser Science Research","score":0.7271000146865845,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.2150000035762787,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.026799999177455902,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.9070000052452087},{"id":"https://openalex.org/keywords/light-induced-retinal-injury","display_name":"light-induced retinal damage","score":0.9150000214576721},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7710000276565552},{"id":"https://openalex.org/keywords/retinal-histopathology","display_name":"retinal histopathology","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.9225521683692932},{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.8562102317810059},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.6440712213516235},{"id":"https://openalex.org/C2778024200","wikidata":"https://www.wikidata.org/wiki/Q2346242","display_name":"Retinal pigment epithelium","level":3,"score":0.48778682947158813},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4620046317577362},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4079130291938782},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17779836058616638},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1496257483959198},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008054","descriptor_name":"Lipid Peroxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010786","descriptor_name":"Photoreceptor Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D010857","descriptor_name":"Pigment Epithelium of Eye","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D012374","descriptor_name":"Rod Cell Outer Segment","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:4055291","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4055291","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:160424062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4055291","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W21528664","https://openalex.org/W46885568","https://openalex.org/W61809690","https://openalex.org/W195304691","https://openalex.org/W197505729","https://openalex.org/W1913824527","https://openalex.org/W1917727867","https://openalex.org/W1966271088","https://openalex.org/W1968632832","https://openalex.org/W1986281350","https://openalex.org/W2002782207","https://openalex.org/W2007675236","https://openalex.org/W2008432106","https://openalex.org/W2023514306","https://openalex.org/W2026735889","https://openalex.org/W2068905018"],"related_works":["https://openalex.org/W1486155398","https://openalex.org/W1913824527","https://openalex.org/W2741091319","https://openalex.org/W89593116","https://openalex.org/W2010619642","https://openalex.org/W2440275207","https://openalex.org/W1968328053","https://openalex.org/W985354578","https://openalex.org/W2007675236","https://openalex.org/W130328213"],"abstract_inverted_index":{"It":[0],"has":[1],"been":[2],"postulated":[3],"that":[4,88,131],"ascorbic":[5],"acid":[6],"may":[7],"help":[8],"to":[9,67,69,76,112,116],"protect":[10],"the":[11,22,53,59,84,98,109,117,134],"retina":[12,85,99,110],"from":[13],"oxidative":[14],"insult":[15],"by":[16,34],"light.":[17,74],"To":[18],"confirm":[19],"this":[20],"hypothesis,":[21],"authors":[23],"compared":[24],"light-damaged":[25],"retinas":[26],"of":[27,72,82,86,100,108],"rats":[28,87,122],"with":[29,123],"or":[30,124],"without":[31,125],"ascorbate":[32,90,126,132],"supplement":[33,91],"morphologic":[35,48],"and":[36,105],"morphometric":[37],"studies":[38],"at":[39],"different":[40],"time":[41],"periods":[42],"after":[43,64,79],"light":[44,65,118],"exposure.":[45],"No":[46],"dramatic":[47],"differences":[49],"were":[50],"observed":[51],"in":[52,137],"photoreceptor-retinal":[54],"pigment":[55],"epithelium":[56],"complex":[57],"between":[58],"two":[60],"groups":[61],"six":[62],"hr":[63,81],"exposure":[66],"200":[68],"250-foot":[70],"candles":[71],"visible":[73],"Six":[75],"13":[77],"days":[78],"24":[80],"exposure,":[83],"received":[89],"showed":[92],"significantly":[93],"less":[94],"severe":[95],"damage":[96,119],"than":[97],"unsupplemented":[101],"rats.":[102],"The":[103],"superior":[104],"temporal":[106],"quadrants":[107],"appeared":[111],"be":[113],"most":[114],"susceptible":[115],"when":[120],"comparing":[121],"supplement.":[127],"These":[128],"findings":[129],"suggested":[130],"ameliorates":[133],"photic":[135],"injury":[136],"rat":[138],"retina.":[139]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}