{"id":"https://openalex.org/W1604228906","doi":"https://doi.org/10.4049/jimmunol.192.supp.46.10","title":"TLR9 restricts survival of anergic anti-DNA B cells in systemic lupus erythematosus yet is also required for their activation (BA4P.219)","display_name":"TLR9 restricts survival of anergic anti-DNA B cells in systemic lupus erythematosus yet is also required for their activation (BA4P.219)","publication_year":2014,"publication_date":"2014-05-01","ids":{"openalex":"https://openalex.org/W1604228906","doi":"https://doi.org/10.4049/jimmunol.192.supp.46.10","mag":"1604228906"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.192.supp.46.10","doi":"https://doi.org/10.4049/jimmunol.192.supp.46.10","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.192.supp.46.10","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086668579","display_name":"Kevin M. Nickerson","orcid":"https://orcid.org/0000-0002-0114-2671","observed_orcids":["https://orcid.org/0000-0002-0114-2671"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Nickerson","raw_affiliation_strings":["Immunology, University of Pittsburgh , Pittsburgh, PA","1Immunology, University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, University of Pittsburgh , Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"1Immunology, University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070727750","display_name":"Sean R. Christensen","orcid":"https://orcid.org/0000-0003-2711-0026","observed_orcids":["https://orcid.org/0000-0003-2711-0026"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean Christensen","raw_affiliation_strings":["Laboratory Medicine and Immunobiology, Yale University , New Haven, CT","2Laboratory Medicine and Immunobiology, Yale University, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Medicine and Immunobiology, Yale University , New Haven, CT","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"2Laboratory Medicine and Immunobiology, Yale University, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033004140","display_name":"Jaime L. Cullen","orcid":"https://orcid.org/0000-0002-5444-7364","observed_orcids":["https://orcid.org/0000-0002-5444-7364"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaime Cullen","raw_affiliation_strings":["Laboratory Medicine and Immunobiology, Yale University , New Haven, CT","2Laboratory Medicine and Immunobiology, Yale University, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Medicine and Immunobiology, Yale University , New Haven, CT","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"2Laboratory Medicine and Immunobiology, Yale University, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038561930","display_name":"Wenzhou Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenzhou Meng","raw_affiliation_strings":["Pathology and Laboratory Medicine, University of Pennsylvania , Philadelphia, PA","3Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine, University of Pennsylvania , Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023609359","display_name":"Eline T. Luning Prak","orcid":"https://orcid.org/0000-0002-9478-9211","observed_orcids":["https://orcid.org/0000-0002-9478-9211"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eline Luning Prak","raw_affiliation_strings":["Pathology and Laboratory Medicine, University of Pennsylvania , Philadelphia, PA","3Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine, University of Pennsylvania , Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080114183","display_name":"Mark Jay Shlomchik","orcid":"https://orcid.org/0000-0002-2152-0959","observed_orcids":["https://orcid.org/0000-0002-2152-0959"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Shlomchik","raw_affiliation_strings":["Immunology, University of Pittsburgh , Pittsburgh, PA","1Immunology, University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, University of Pittsburgh , Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"1Immunology, University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"192","issue":"Supplement_1","first_page":"46.10","last_page":"46.10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr9","display_name":"TLR9","score":1.0},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9940000176429749},{"id":"https://openalex.org/keywords/b-cell-anergy","display_name":"B cell anergy","score":0.8899999856948853},{"id":"https://openalex.org/keywords/b-cell-tolerance","display_name":"B cell tolerance","score":0.9629999995231628},{"id":"https://openalex.org/keywords/b-cell-survival","display_name":"B cell survival","score":0.609000027179718},{"id":"https://openalex.org/keywords/b-cell-receptor-signaling","display_name":"B cell receptor signaling","score":0.7459999918937683},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.8080000281333923},{"id":"https://openalex.org/keywords/t-follicular-helper-cells","display_name":"T follicular helper cells","score":0.7049999833106995},{"id":"https://openalex.org/keywords/receptor-editing","display_name":"receptor editing","score":0.5239999890327454},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C2779138994","wikidata":"https://www.wikidata.org/wiki/Q15332550","display_name":"TLR9","level":5,"score":0.8837260007858276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6986939907073975},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5914937257766724},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.5897359848022461},{"id":"https://openalex.org/C43907098","wikidata":"https://www.wikidata.org/wiki/Q903924","display_name":"breakpoint cluster region","level":3,"score":0.5483660101890564},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.48604971170425415},{"id":"https://openalex.org/C2779062720","wikidata":"https://www.wikidata.org/wiki/Q529298","display_name":"Clonal anergy","level":5,"score":0.4788375198841095},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46877995133399963},{"id":"https://openalex.org/C2908999202","wikidata":"https://www.wikidata.org/wiki/Q15332550","display_name":"Toll-Like Receptor 9","level":5,"score":0.45957183837890625},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.4494030177593231},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.4281458258628845},{"id":"https://openalex.org/C2777868816","wikidata":"https://www.wikidata.org/wiki/Q5134952","display_name":"Clonal deletion","level":5,"score":0.41356295347213745},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.33133143186569214},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.23212939500808716},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2233787178993225},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.20530426502227783},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17746928334236145},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.12889528274536133},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10759323835372925},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08385369181632996},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07964763045310974},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.192.supp.46.10","doi":"https://doi.org/10.4049/jimmunol.192.supp.46.10","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.192.supp.46.10","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1905977298","https://openalex.org/W4404166081","https://openalex.org/W2166626628","https://openalex.org/W3115096716","https://openalex.org/W2947722573","https://openalex.org/W4387392094","https://openalex.org/W2078066300","https://openalex.org/W1510321095","https://openalex.org/W3011676113","https://openalex.org/W2135884655"],"abstract_inverted_index":{"Abstract":[0],"Anti-DNA":[1],"autoantibodies":[2],"are":[3,26],"a":[4,38],"clinical":[5],"hallmark":[6],"of":[7,40,54,79,104,122,145,179,208],"systemic":[8,47],"lupus":[9],"erythematosus.":[10],"Nucleic":[11],"acid":[12],"reactive":[13],"B":[14,68,93,109,125,181,200],"cells":[15,126,141,182,210],"arise":[16],"in":[17,22,49,59,73,112,133,148,168,197],"the":[18,52,65,74,83,113,120,134,205],"bone":[19],"marrow":[20],"even":[21],"healthy":[23],"individuals,":[24],"but":[25,51,156],"tolerized":[27],"by":[28],"mechanisms":[29,53],"including":[30],"receptor":[31,70],"editing,":[32],"functional":[33],"anergy,":[34,105],"and/or":[35],"deletion.":[36],"TLR9,":[37,123],"sensor":[39],"endosomal":[41],"dsDNA,":[42],"both":[43],"promotes":[44],"and":[45,91,102,115,131,160,183],"regulates":[46],"autoimmunity":[48,60],"vivo,":[50],"its":[55],"apparently":[56],"contradictory":[57],"roles":[58,196],"remained":[61],"unclear.":[62],"Here,":[63],"using":[64],"3H9":[66],"anti-DNA":[67,108,124,180,199],"cell":[69,94,110,163],"(BCR)":[71],"transgene":[72],"autoimmune-prone":[75,170],"MRL.Fas-lpr":[76],"mouse":[77],"model":[78],"lupus,":[80],"we":[81],"identify":[82],"stages":[84],"at":[85],"which":[86],"TLR9":[87,97,106,172,193],"contributes":[88],"to":[89],"establishing":[90],"breaking":[92],"tolerance.":[95],"Although":[96],"is":[98,116,173,212],"dispensable":[99],"for":[100,175,215],"editing":[101],"establishment":[103],"limits":[107],"lifespan":[111],"periphery":[114],"thus":[117],"tolerogenic.":[118],"In":[119],"absence":[121],"have":[127,151],"much":[128],"longer":[129],"lifespans":[130],"accumulate":[132],"follicle,":[135],"neither":[136],"activated":[137],"nor":[138],"deleted.":[139],"These":[140],"retain":[142],"some":[143],"characteristics":[144],"anergic":[146],"cells,":[147],"that":[149],"they":[150],"elevated":[152],"basal":[153],"BCR":[154,165],"signaling":[155],"impaired":[157],"induced":[158],"responses":[159],"downregulate":[161],"their":[162,184,216],"surface":[164],"expression.":[166],"Nonetheless,":[167],"older":[169],"animals,":[171],"required":[174,214],"spontaneous":[176],"peripheral":[177,206],"activation":[178],"differentiation":[185],"into":[186],"AFCs":[187],"via":[188],"an":[189],"extrafollicular":[190],"pathway.":[191],"Thus,":[192],"has":[194],"paradoxical":[195],"regulating":[198],"cells:":[201],"it":[202],"helps":[203],"purge":[204],"repertoire":[207],"autoreactive":[209],"yet":[211],"also":[213],"activation.":[217]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
