{"id":"https://openalex.org/W1603661711","doi":"https://doi.org/10.1074/s0021-9258(20)63868-6","title":"The Enzymology of Feedback Inhibition by Arthur B. Pardee","display_name":"The Enzymology of Feedback Inhibition by Arthur B. Pardee","publication_year":2005,"publication_date":"2005-10-01","ids":{"openalex":"https://openalex.org/W1603661711","doi":"https://doi.org/10.1074/s0021-9258(20)63868-6","mag":"1603661711"},"language":"en","primary_location":{"id":"doi:10.1074/s0021-9258(20)63868-6","doi":"https://doi.org/10.1074/s0021-9258(20)63868-6","is_oa":true,"landing_page_url":"https://doi.org/10.1074/s0021-9258(20)63868-6","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/s0021-9258(20)63868-6","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052226290","display_name":"Nicole Kresge","orcid":"https://orcid.org/0000-0003-1551-6627","observed_orcids":["https://orcid.org/0000-0003-1551-6627"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicole Kresge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112774387","display_name":"Robert Simoni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert D. Simoni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103081287","display_name":"Robert L. Hill","orcid":"https://orcid.org/0009-0001-2747-3997","observed_orcids":["https://orcid.org/0009-0001-2747-3997"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert L. Hill","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.08015988,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"280","issue":"41","first_page":"e38","last_page":"e40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14475","display_name":"History of Science and Medicine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/feedback-inhibition","display_name":"product inhibition","score":0.8709999918937683},{"id":"https://openalex.org/keywords/pyrimidine-biosynthesis","display_name":"pyrimidine synthesis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9829999804496765},{"id":"https://openalex.org/keywords/metabolic-regulation","display_name":"metabolic regulation","score":0.6940000057220459},{"id":"https://openalex.org/keywords/enzyme-regulation","display_name":"enzyme regulation","score":0.5619999766349792},{"id":"https://openalex.org/keywords/ribosome","display_name":"ribosome","score":0.460999995470047},{"id":"https://openalex.org/keywords/bacteriophage-lambda","display_name":"bacteriophage lambda","score":0.6069999933242798},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.3659999966621399},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.7710000276565552},{"id":"https://openalex.org/keywords/history-of-biochemistry","display_name":"history of biochemistry","score":0.5820000171661377},{"id":"https://openalex.org/keywords/ribonucleoprotein-particles","display_name":"ribonucleoprotein particles","score":0.6489999890327454},{"id":"https://openalex.org/keywords/chromatophores","display_name":"chromatophores","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cancer-research","display_name":"cancer research","score":0.40799999237060547},{"id":"https://openalex.org/keywords/linus-pauling","display_name":"Linus Pauling","score":0.5}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4846680462360382},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39702165126800537}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1074/s0021-9258(20)63868-6","doi":"https://doi.org/10.1074/s0021-9258(20)63868-6","is_oa":true,"landing_page_url":"https://doi.org/10.1074/s0021-9258(20)63868-6","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1074/s0021-9258(20)63868-6","doi":"https://doi.org/10.1074/s0021-9258(20)63868-6","is_oa":true,"landing_page_url":"https://doi.org/10.1074/s0021-9258(20)63868-6","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.5,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W52018598","https://openalex.org/W92551970","https://openalex.org/W111753330","https://openalex.org/W145875014","https://openalex.org/W198974371","https://openalex.org/W244386701","https://openalex.org/W1496794738","https://openalex.org/W1592731945","https://openalex.org/W1799960502","https://openalex.org/W1984156388","https://openalex.org/W2067730274","https://openalex.org/W2102489535","https://openalex.org/W3120701959"],"related_works":["https://openalex.org/W4388176327","https://openalex.org/W2070100740","https://openalex.org/W2097758310","https://openalex.org/W2065989286","https://openalex.org/W1583704529","https://openalex.org/W1497080620","https://openalex.org/W2110884412","https://openalex.org/W1516330936","https://openalex.org/W2432599531","https://openalex.org/W7099342467"],"abstract_inverted_index":{"Control":[0,27],"of":[1,26,57,65,78,89,114,121,144,162,173,232,253,263,272,289,309,330,336,366,386,395,420,425,451,457,463,525,537,552,559,563,586,596,606,611,669,677,686,710,752,809,884,896,904,911,944,958,972,994,1029,1067,1088,1135,1148,1159,1163,1169,1178],"Pyrimidine":[2,622],"Biosynthesis":[3],"in":[4,68,100,123,128,151,182,242,266,291,333,361,382,436,453,491,522,534,549,624,644,647,721,893,980,999,1016,1033,1044,1056,1103,1144,1150,1202],"Escherichia":[5,216,292,310,339,396,492,625],"coli":[6,217,459,652],"by":[7,28,338,391,423,514,775,797,806,839,961],"a":[8,63,104,230,387,392,465,474,531,560,574,670,690,732,776,783,828,851,870,1060],"Feed-back":[9],"Mechanism":[10],"(Yates,":[11],"R.":[12],"A.,":[13],"and":[14,34,147,166,258,435,441,468,488,600,639,646,716,724,760,800,881,898,921,938,963,983,1011,1018,1035,1048,1078,1091,1098,1116,1127,1165,1171,1184,1187,1210],"Pardee,":[15,35,568],"A.":[16,36,439],"B.":[17,37,45,414,934],"(1956)":[18],"J.":[19,32,39],"Biol.":[20,40,312,342,398,497,627,1212],"Chem.":[21,41,313,343,399,498,628,1213],"221,":[22],"757\u2013770)":[23],"The":[24,306,364],"Enzymology":[25],"Feedback":[29],"Inhibition":[30],"(Gerhart,":[31],"C.,":[33],"(1962)":[38],"237,":[42],"891\u2013896)":[43],"Arthur":[44],"Pardee":[46,102,125,140,158,599,620,638,663,759,822,953,985,1071,1152],"began":[47,1003],"his":[48,82,98,117,924,948,964,1203],"scientific":[49],"training":[50],"as":[51,189,191,1083,1176],"an":[52,675,769,787,890,1100],"undergraduate":[53],"at":[54,111,170,901,1093],"the":[55,75,90,112,142,148,160,163,167,171,179,192,223,250,261,267,334,418,446,449,454,461,479,519,523,535,550,557,579,584,587,604,609,666,683,707,711,736,745,750,753,793,833,840,857,879,894,902,908,912,927,941,956,967,973,991,995,1006,1021,1027,1030,1050,1063,1074,1086,1094,1133,1136,1146,1156,1161,1166,1179,1188],"University":[56,113,172,903],"California,":[58,174,905],"Berkeley":[59],"where":[60],"he":[61,131,177,208,1002],"earned":[62],"Bachelor":[64],"Science":[66],"degree":[67],"1942.":[69],"He":[70,916,1024,1081,1126,1173],"then":[71,641],"went":[72,875],"on":[73,358,516,650,876,950,1020,1109,1196],"to":[74,80,133,135,200,236,247,260,706,772,820,856,869,877,940,955,987,989,1004,1073,1121,1155],"California":[76],"Institute":[77,1077,1097,1162],"Technology":[79],"do":[81],"Ph.D.":[83,99],"with":[84,93,108,220,570,702,782,1132],"Linus":[85],"Pauling,":[86],"performing":[87],"some":[88],"first":[91,520,588,992],"studies":[92,649,949],"purified":[94],"antibodies.":[95],"After":[96,947],"earning":[97],"1947,":[101],"took":[103],"Merck":[105],"postdoctoral":[106],"fellowship":[107],"Van":[109],"Potter":[110],"Wisconsin.":[115],"Because":[116,813],"mother":[118],"had":[119,275,816],"died":[120],"cancer":[122,136,1009,1034,1057,1114,1123],"1942,":[124],"was":[126,218,472,481,696,795,804,837,1153],"interested":[127,241],"doing":[129],"what":[130],"could":[132,728,853],"contribute":[134],"research.":[137],"At":[138,692],"Wisconsin,":[139],"studied":[141,1026],"deregulation":[143],"oxidative":[145],"phosphorylation":[146],"Krebs":[149],"cycle":[150,1032],"cancers":[152],"using":[153,766],"tissue":[154],"homogenates.":[155],"In":[156,508,1069],"1949":[157],"joined":[159],"faculty":[161],"biochemistry":[164],"department":[165],"virus":[168,203],"laboratory":[169],"Berkeley.":[175],"There":[176],"discovered":[178,209,791,1036],"ribonucleoprotein":[180],"particles":[181,194],"bacteria":[183,244],"that":[184,195,210,448,470,603,665,693,699,792,801,824,842,1037,1049],"were":[185,196,227,245],"later":[186],"named":[187,197],"ribosomes":[188],"well":[190],"photosynthetic":[193],"chromatophores.":[198],"Wanting":[199],"learn":[201],"whether":[202],"infection":[204],"alters":[205],"host":[206],"metabolism,":[207],"nine":[211],"enzyme":[212,521,770,794,959],"activities":[213],"changed":[214],"after":[215],"infected":[219],"bacteriophage.":[221],"During":[222],"1950s,":[224],"when":[225],"biochemists":[226],"busy":[228],"creating":[229],"map":[231],"metabolism":[233,308,360,381,490],"without":[234],"regard":[235],"metabolic":[237,273],"regulation,":[238],"investigators":[239],"became":[240,966,1099],"how":[243,727],"able":[246],"produce":[248],"just":[249],"right":[251],"amount":[252],"components":[254],"necessary":[255],"for":[256,530,578,704,731,735,743,923,930,969,976,1039,1062,1085,1112,1118,1182,1191],"growth":[257,264,455],"responded":[259],"addition":[262],"factors":[265,416],"medium.":[268],"Earlier,":[269],"several":[270,919],"indications":[271],"control":[274,476,576],"been":[276],"reported":[277,445,511],"(1Roberts":[278],"R.B.":[279],"Abelson":[280],"P.H.":[281,324],"Cowie":[282],"D.B.":[283],"Bolton":[284,325],"E.T.":[285,326],"Britten":[286],"R.J.":[287],"Studies":[288,357],"biosynthesis":[290,524,536,623],"coli..Carnegie":[293],"Inst.":[294],"Wash.":[295],"Publ.":[296],"1955;":[297,400],"607Google":[298],"Scholar,":[299,322,352,375,408],"2Koch":[300],"A.L.":[301],"Putnam":[302],"F.W.":[303],"Evans":[304],"E.A.":[305,484],"purine":[307,359],"coli..J.":[311,397,626],"1952;":[314,344,370],"197:":[315],"105-112Abstract":[316],"Full":[317,347,403,502,632,1217,1219],"Text":[318,348,404,503,633,1218,1220],"PDF":[319,349,405,504,634,1221],"PubMed":[320,350,373,406,432,505,542,635,1222],"Google":[321,351,374,407,433,506,545,636,1225],"3Abelson":[323],"Aldous":[327],"E.":[328,458,597,651,933],"Utilization":[329],"carbon":[331],"dioxide":[332],"synthesis":[335],"proteins":[337],"coli.":[340],"II..J.":[341],"198:":[345],"173-178Abstract":[346],"4Gots":[353],"J.S.":[354,379],"Chu":[355],"E.C.":[356],"bacteria.":[362,383],"I.":[363],"role":[365,548],"p-aminobenzoic":[367],"acid..J.":[368],"Bacteriol.":[369,428],"64:":[371],"537-546Crossref":[372],"5Love":[376],"S.H.":[377],"Gots":[378],"Purine":[380],"III.":[384],"Accumulation":[385],"new":[388],"pentose-containing":[389],"arylamine":[390],"purine-requiring":[393],"mutant":[394],"212:":[401],"647-654Abstract":[402],"6Brooke":[409],"M.S.":[410],"Ushiba":[411],"D.":[412],"Magasanik":[413],"Some":[415],"affecting":[417],"excretion":[419],"orotic":[421,616],"acid":[422,495,617],"mutants":[424,595],"Aerobacter":[426],"aerogenes..J.":[427],"1954;":[429],"68:":[430],"534-540Crossref":[431],"Scholar),":[434],"1953":[437],"Edward":[438],"Adelberg":[440],"H.":[442],"Edwin":[443],"Umbarger":[444,485,510],"observation":[447,841],"presence":[450,605],"valine":[452,466,489],"medium":[456],"inhibited":[460,608,774,796],"formation":[462,610],"\u03b1-ketoisovalerate,":[464],"precursor,":[467],"noted":[469,602],"this":[471,764,802,861],"likely":[473],"general":[475,575],"phenomenon,":[477],"although":[478],"mechanism":[480,533,577,685,975],"unclear":[482],"(7Adelberg":[483],"H.E.":[486,528],"Isoleucine":[487],"coli.V.":[493],"\u03b1-Ketoisovaleric":[494],"accumulation..J.":[496],"1953;":[499],"205:":[500],"475-482Abstract":[501],"Scholar).":[507,546,637,1226],"1956,":[509],"negative":[512],"feedback":[513,553,687,951],"isoleucine":[515,526],"threonine":[517],"deaminase,":[518],"(8Umbarger":[527],"Evidence":[529],"negative-feedback":[532],"isoleucine..Science.":[538],"1956;":[539,629],"123:":[540],"848Crossref":[541],"Scopus":[543,1223],"(205)":[544],"Umbarger's":[547],"description":[551],"inhibition":[554,688,803],"will":[555],"be":[556,674,741,773,827,863,1200],"subject":[558,585,751],"future":[561],"Journal":[562],"Biological":[564],"Chemistry":[565],"(JBC)":[566],"Classic.":[567],"along":[569],"Richard":[571],"Yates,":[572],"described":[573],"pyrimidine":[580,612],"pathway.":[581],"This":[582,748,836],"is":[583,749,849,889,1042,1141],"JBC":[589,755,1204],"Classic":[590,756],"reprinted":[591,757],"here.":[592,758],"Using":[593],"pyrimidine-requiring":[594,653],"coli,":[598],"Yates":[601,640],"uracil":[607],"intermediates":[613],"earlier":[614,1115],"than":[615],"(9Yates":[618],"R.A.":[619],"A.B.":[621,1207],"221:":[630],"743-756Abstract":[631],"undertook":[642],"additional":[643],"vivo":[645],"vitro":[648],"mutants,":[654],"which":[655,738,780,848,1140],"confirmed":[656,838],"their":[657],"initial":[658,679],"observations.":[659],"From":[660],"these":[661],"experiments,":[662],"concluded":[664,823],"end":[667,714,746,778],"product":[668],"biosynthetic":[671],"pathway":[672],"can":[673,1199],"inhibitor":[676],"its":[678,810],"enzymatic":[680],"reaction.":[681],"However,":[682],"molecular":[684],"created":[689],"problem.":[691],"time,":[694],"it":[695,866],"generally":[697],"thought":[698],"inhibitors":[700],"compete":[701,730],"substrates":[703,717],"binding":[705,744],"active":[708,834,858],"site":[709,733,830,859],"enzyme.":[712],"Yet,":[713],"products":[715],"often":[718],"differed":[719],"greatly":[720],"size,":[722],"shape,":[723],"charge,":[725],"so":[726],"they":[729],"specific":[734],"substrate,":[737,786,811,852],"would":[739,862],"not":[740,850,854],"suited":[742],"product?":[747],"second":[754],"John":[761],"Gerhart":[762,874,888],"approached":[763],"problem":[765],"aspartate":[767,845,885],"transcarbamylase,":[768],"known":[771],"nucleotide":[777],"product,":[779],"competes":[781],"structurally":[784],"unrelated":[785],"amino":[788],"acid.":[789],"They":[790],"cytidine":[798,814],"triphosphate":[799,815],"reversed":[805],"high":[807],"concentrations":[808],"aspartate.":[812],"no":[817],"structural":[818],"similarity":[819],"aspartate,":[821],"there":[825],"must":[826,867],"regulatory":[829,872,880],"distinct":[831],"from":[832],"site.":[835,873],"ATP":[843],"activates":[844],"transcarbamylase.":[846,886],"ATP,":[847],"bind":[855,868],"because":[860],"inhibitory,":[864],"thus":[865],"different,":[871],"separate":[878],"catalytic":[882],"subunits":[883],"Currently,":[887],"emeritus":[891,1101],"professor":[892,1102],"Department":[895,998],"Molecular":[897,1185],"Cell":[899,931,1089],"Biology":[900,1186],"Berkeley,":[906],"studying":[907],"early":[909],"development":[910],"amphibian":[913],"Xenopus":[914],"laevis.":[915],"has":[917,1174],"received":[918],"awards":[920],"honors":[922],"research":[925,1198],"including":[926,1014],"American":[928,1167,1180,1189],"Society":[929,1181],"Biology's":[932],"Wilson":[935],"Award":[936],"(1997)":[937],"election":[939],"National":[942,1157],"Academy":[943,1158,1168],"Sciences":[945,997],"(1990).":[946],"inhibition,":[952],"turned":[954],"regulation":[957,1038],"expression":[960,979],"repression,":[962],"work":[965,1107],"basis":[968,1061],"current":[970,1106],"concepts":[971],"major":[974],"regulating":[977],"gene":[978],"both":[981],"prokaryotes":[982],"eukaryotes.":[984],"moved":[986,1072],"Princeton":[988],"become":[990],"Chairman":[993],"Biochemical":[996],"1961.":[1000],"There,":[1001],"investigate":[1005],"differences":[1007],"between":[1008],"cells":[1010,1041],"normal":[1012,1040],"cells,":[1013,1058],"changes":[1015],"transport":[1017],"carbohydrates":[1019],"cell":[1022,1031],"surfaces.":[1023],"also":[1025],"disregulation":[1028],"exerted":[1043],"late":[1045],"G1":[1046],"phase":[1047],"restriction":[1051],"point":[1052],"requirements":[1053],"are":[1054,1130],"relaxed":[1055],"providing":[1059],"greater":[1064],"proliferative":[1065],"capacity":[1066],"cancer.":[1068],"1975":[1070],"Dana-Farber":[1075,1095],"Cancer":[1076,1096,1192],"Harvard":[1079],"University.":[1080],"served":[1082,1175],"Chief":[1084],"Division":[1087],"Growth":[1090],"Regulation":[1092],"1992.":[1104],"His":[1105],"focuses":[1108],"finding":[1110],"methods":[1111],"detecting":[1113],"searching":[1117],"novel":[1119],"agents":[1120],"treat":[1122],"more":[1124],"effectively.":[1125],"Peng":[1128],"Liang":[1129],"credited":[1131],"discovery":[1134],"differential":[1137],"display":[1138],"technique,":[1139],"widely":[1142],"used":[1143],"examining":[1145],"activation":[1147],"genes":[1149],"cells.":[1151],"elected":[1154],"Sciences,":[1160],"Medicine,":[1164],"Arts":[1170],"Sciences.":[1172],"president":[1177],"Biochemistry":[1183],"Association":[1190],"Research.":[1193],"More":[1194],"information":[1195],"Pardee's":[1197],"found":[1201],"Reflections":[1205],"(10Pardee":[1206],"Regulation,":[1208],"restriction,":[1209],"reminiscences..J.":[1211],"2002;":[1214],"277:":[1215],"26709-26716Abstract":[1216],"(8)":[1224]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}