{"id":"https://openalex.org/W1603608973","doi":"https://doi.org/10.1002/9780470514146.ch9","title":"Six Years of Protein Structure Determination by NMR Spectroscopy: What Have we Learned?","display_name":"Six Years of Protein Structure Determination by NMR Spectroscopy: What Have we Learned?","publication_year":2007,"publication_date":"2007-09-28","ids":{"openalex":"https://openalex.org/W1603608973","doi":"https://doi.org/10.1002/9780470514146.ch9","mag":"1603608973","pmid":"https://pubmed.ncbi.nlm.nih.gov/1726080"},"language":"en","primary_location":{"id":"doi:10.1002/9780470514146.ch9","doi":"https://doi.org/10.1002/9780470514146.ch9","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9780470514146.ch9","pdf_url":null,"source":{"id":"https://openalex.org/S9764341","display_name":"Novartis Foundation symposium","issn_l":"1528-2511","issn":["1528-2511","1935-4657"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Novartis Foundation Symposia","raw_type":"other"},"volume":{"id":"https://openalex.org/W2492282701","display_name":"Ciba Foundation Symposium 161 \u2010 Protein Conformation"},"type":"other","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000254356","display_name":"Kurt W\u00fcthrich A","orcid":"https://orcid.org/0000-0001-8739-6965","observed_orcids":["https://orcid.org/0000-0001-8739-6965","https://orcid.org/0000-0003-2612-6616"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255162","display_name":"Institute of Molecular Biology and Biophysics","ror":"https://ror.org/02p702482","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255162"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Kurt W\u00fcthrich","raw_affiliation_strings":["Institut f\u00fcr Molekularbiologie und Biophysik, Eidgen\u00f6ssische Technische Hochschule-H\u00f6nggerberg, Z\u00fcrich, Switzerland","Institut f\u00fcr Molekularbiologie und Biophysik, Eidgenossische Technische Hochschule-Honggerberg, Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Molekularbiologie und Biophysik, Eidgen\u00f6ssische Technische Hochschule-H\u00f6nggerberg, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255162"]},{"raw_affiliation_string":"Institut f\u00fcr Molekularbiologie und Biophysik, Eidgenossische Technische Hochschule-Honggerberg, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255162"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000254356"],"corresponding_institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255162"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"161","issue":null,"first_page":"136","last_page":"149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.5454000234603882,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.5454000234603882,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.4027999937534332,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.04190000146627426,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-structure-determination","display_name":"protein structure determination","score":0.8199999928474426},{"id":"https://openalex.org/keywords/nmr-spectroscopy","display_name":"NMR spectroscopy","score":0.8199999928474426},{"id":"https://openalex.org/keywords/x-ray-crystallography","display_name":"X-ray crystallography","score":0.9449999928474426},{"id":"https://openalex.org/keywords/protein-hydration","display_name":"protein hydration","score":0.9909999966621399},{"id":"https://openalex.org/keywords/molecular-surface","display_name":"molecular surface","score":0.8709999918937683},{"id":"https://openalex.org/keywords/solution-structure","display_name":"solution structure","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.7270132899284363},{"id":"https://openalex.org/C67020732","wikidata":"https://www.wikidata.org/wiki/Q7068131","display_name":"Nuclear magnetic resonance crystallography","level":4,"score":0.6224290728569031},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.6162705421447754},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.6002810001373291},{"id":"https://openalex.org/C207114421","wikidata":"https://www.wikidata.org/wiki/Q133900","display_name":"Diffraction","level":2,"score":0.579084038734436},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5489691495895386},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.5247951745986938},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4443745017051697},{"id":"https://openalex.org/C3020199158","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"High resolution","level":2,"score":0.4357767701148987},{"id":"https://openalex.org/C153064111","wikidata":"https://www.wikidata.org/wiki/Q1281033","display_name":"Protein crystallization","level":3,"score":0.43323665857315063},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.3576851785182953},{"id":"https://openalex.org/C116447816","wikidata":"https://www.wikidata.org/wiki/Q3415253","display_name":"Fluorine-19 NMR","level":3,"score":0.3481599688529968},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1569913923740387},{"id":"https://openalex.org/C203036418","wikidata":"https://www.wikidata.org/wiki/Q284256","display_name":"Crystallization","level":2,"score":0.11952733993530273},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.10253414511680603},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.08221405744552612},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07921013236045837},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0706200897693634},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06964480876922607},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C62649853","wikidata":"https://www.wikidata.org/wiki/Q199687","display_name":"Remote sensing","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000681","descriptor_name":"Amylases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D008668","descriptor_name":"Metallothionein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014359","descriptor_name":"Trypsin Inhibitor, Kazal Pancreatic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/9780470514146.ch9","doi":"https://doi.org/10.1002/9780470514146.ch9","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9780470514146.ch9","pdf_url":null,"source":{"id":"https://openalex.org/S9764341","display_name":"Novartis Foundation symposium","issn_l":"1528-2511","issn":["1528-2511","1935-4657"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Novartis Foundation Symposia","raw_type":"other"},{"id":"pmid:1726080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1726080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ciba Foundation symposium","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W197372360","https://openalex.org/W611537134","https://openalex.org/W1493662245","https://openalex.org/W1499408335","https://openalex.org/W1518351177","https://openalex.org/W1539339671","https://openalex.org/W1969625355","https://openalex.org/W1981709590","https://openalex.org/W1982448541","https://openalex.org/W1989186646","https://openalex.org/W1992787746","https://openalex.org/W2001823906","https://openalex.org/W2005392755","https://openalex.org/W2015561631","https://openalex.org/W2016438910","https://openalex.org/W2017582391","https://openalex.org/W2019005479","https://openalex.org/W2019388715","https://openalex.org/W2028137906","https://openalex.org/W2030333654","https://openalex.org/W2030831704","https://openalex.org/W2032781098","https://openalex.org/W2033994918","https://openalex.org/W2035338880","https://openalex.org/W2037797286","https://openalex.org/W2041632275","https://openalex.org/W2057131034","https://openalex.org/W2058708926","https://openalex.org/W2066118904","https://openalex.org/W2076849893","https://openalex.org/W2081945921","https://openalex.org/W2105559126","https://openalex.org/W2133928103","https://openalex.org/W2136487343","https://openalex.org/W2147892060","https://openalex.org/W2152134406","https://openalex.org/W2333157284","https://openalex.org/W2949250147","https://openalex.org/W4255331927","https://openalex.org/W4301156095"],"related_works":["https://openalex.org/W1554093359","https://openalex.org/W2460455904","https://openalex.org/W1501162737","https://openalex.org/W265570916","https://openalex.org/W4246988288","https://openalex.org/W2515255216","https://openalex.org/W2054429712","https://openalex.org/W3115867843","https://openalex.org/W2019005479","https://openalex.org/W1493216986"],"abstract_inverted_index":{"Nuclear":[0],"magnetic":[1],"resonance":[2],"(NMR)":[3],"spectroscopy":[4,115],"in":[5,11,16],"solution":[6],"is":[7],"a":[8],"second":[9],"technique,":[10],"addition":[12],"to":[13],"X-ray":[14,61,117],"diffraction":[15],"single":[17],"crystals,":[18],"for":[19,40,68],"the":[20,47,65,87,109],"determination":[21],"of":[22,30,79,96,104],"three-dimensional":[23],"protein":[24,69,105],"structures":[25,76],"at":[26],"atomic":[27],"resolution.":[28],"Structures":[29],"proteins":[31,80],"derived":[32],"by":[33],"NMR":[34,75,114],"have":[35,52,82],"now":[36],"been":[37,84],"with":[38],"us":[39],"six":[41],"years,":[42],"and":[43,98,107],"here":[44],"I":[45],"entertain":[46],"following":[48],"question:":[49],"what":[50],"information":[51],"we":[53],"gained":[54],"that":[55,74,81,86,99],"would":[56],"not":[57,83],"be":[58],"available":[59,78],"if":[60],"crystallography":[62],"were":[63],"still":[64],"only":[66],"method":[67],"structure":[70],"determination?":[71],"Answers":[72],"include":[73],"are":[77],"crystallized,":[85],"two":[88],"techniques":[89],"afford":[90],"different":[91,102],"insights":[92],"into":[93],"internal":[94],"mobility":[95],"proteins,":[97],"one":[100],"gets":[101],"views":[103],"hydration":[106],"hence":[108],"molecular":[110],"surface":[111],"when":[112],"using":[113],"or":[116],"diffraction.":[118]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}