{"id":"https://openalex.org/W160359203","doi":null,"title":"Role of major histocompatibility complex class II in resistance of mice to naturally acquired infection with Syphacia obvelata.","display_name":"Role of major histocompatibility complex class II in resistance of mice to naturally acquired infection with Syphacia obvelata.","publication_year":2003,"publication_date":"2003-02-01","ids":{"openalex":"https://openalex.org/W160359203","mag":"160359203","pmid":"https://pubmed.ncbi.nlm.nih.gov/12625509"},"language":"en","primary_location":{"id":"pmid:12625509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12625509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comparative medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016305360","display_name":"Patricia W Stewart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia W Stewart","raw_affiliation_strings":["Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, 1800 Denison Ave., Kansas State University, Manhattan, Kansas 66506, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, 1800 Denison Ave., Kansas State University, Manhattan, Kansas 66506, USA","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088698561","display_name":"Stephen Keith Chapes","orcid":"https://orcid.org/0000-0003-2833-3096","observed_orcids":["https://orcid.org/0000-0003-2833-3096"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen K Chapes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5339,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.57809618,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"53","issue":"1","first_page":"70","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.46219998598098755,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.46219998598098755,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.3463999927043915,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10815","display_name":"Parasite Biology and Host Interactions","score":0.0333000011742115,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/syphacia-obvelata","display_name":"Syphacia obvelata","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pinworm-infection","display_name":"enterobiasis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/major-histocompatibility-complex-class-ii","display_name":"major histocompatibility complex class II","score":0.8709999918937683},{"id":"https://openalex.org/keywords/natural-infection","display_name":"natural infection","score":0.6669999957084656},{"id":"https://openalex.org/keywords/prevalence-of-infection","display_name":"infection prevalence","score":0.6150000095367432},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.8489999771118164},{"id":"https://openalex.org/keywords/slc11a1","display_name":"SLC11A1","score":0.9750000238418579},{"id":"https://openalex.org/keywords/mouse-strains","display_name":"mouse strains","score":0.4490000009536743},{"id":"https://openalex.org/keywords/congenic-strains","display_name":"congenic strains","score":0.5659999847412109},{"id":"https://openalex.org/keywords/host-parasite-interactions","display_name":"host-parasite interactions","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C84951073","wikidata":"https://www.wikidata.org/wiki/Q2379153","display_name":"Congenic","level":3,"score":0.8269028663635254},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7805832624435425},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.6427417397499084},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5491334795951843},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.548772931098938},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5479448437690735},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5339623093605042},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.416411429643631},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28409841656684875}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010123","descriptor_name":"Oxyuriasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12625509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12625509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comparative medicine","raw_type":"Journal Article"},{"id":"mag:160359203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12625509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5869845258","display_name":"Kansas IDeA Network of Biomedical Research Excellence","funder_award_id":"P20RR016475","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2312936314","https://openalex.org/W2105174331","https://openalex.org/W2226314573","https://openalex.org/W2063517235","https://openalex.org/W2002202316","https://openalex.org/W2417626763","https://openalex.org/W2325153063","https://openalex.org/W3172437110","https://openalex.org/W1595509256","https://openalex.org/W2078456757"],"abstract_inverted_index":{"Genetics":[0],"plays":[1],"a":[2,24,31,117],"substantial":[3],"role":[4],"in":[5,8,23,30,48,145,153,160,176,249],"host":[6],"resistance":[7,82],"many":[9],"host-parasite":[10],"interactions.":[11],"We":[12],"examined":[13],"the":[14,49,52,76,105,163,183,194,209,243],"prevalence":[15,120,159,210,228],"of":[16,26,75,78,90,104,121,190,200,211,219,229,242],"naturally":[17,230],"acquired":[18,231],"infection":[19,99,122,146,158,212,232],"with":[20,162,174,213,233],"Syphacia":[21],"obvelata":[22],"number":[25],"mouse":[27],"strains":[28,42],"housed":[29],"non-barrier":[32],"facility.":[33],"These":[34,236],"mice,":[35],"which":[36],"included":[37],"cross-bred":[38],"and":[39,65,87,135],"congenic,":[40],"inbred":[41],"on":[43,81,208],"various":[44,91],"genetic":[45],"backgrounds,":[46],"differ":[47,171],"loci":[50],"for":[51,181,203],"immune":[53,244],"function":[54],"genes--major":[55],"histocompatibility":[56],"complex":[57],"class":[58],"II":[59],"(MHCII),":[60],"toll-like":[61],"receptor":[62],"4":[63],"(Tlr4),":[64],"solute":[66],"carrier":[67],"family":[68],"11,":[69],"member":[70],"1":[71],"(Slc11a1)--which":[72],"allowed":[73],"comparisons":[74],"impact":[77],"these":[79],"genes":[80],"to":[83],"pinworm":[84,250],"infection.":[85],"Male":[86],"female":[88,136],"mice":[89,112,125,140,161,177],"ages":[92],"were":[93,114,127,130,179],"sampled":[94],"over":[95],"an":[96,142],"18-month":[97],"period;":[98],"was":[100,150],"determined":[101],"by":[102],"use":[103],"cellophane":[106],"tape":[107],"test.":[108],"Results":[109],"indicated":[110],"that":[111,113,126,175,178,191,246],"MHCII+/+":[115,139],"had":[116,141,205],"significantly":[118,172,226],"lower":[119],"than":[123],"did":[124,169],"MHCII-/-.":[128],"Differences":[129],"not":[131,151,170,222],"seen":[132,152],"between":[133],"male":[134],"mice.":[137,155],"Although":[138],"age-associated":[143],"decrease":[144,149],"prevalence,":[147],"such":[148],"MHCII-/-":[154],"In":[156,216],"contrast,":[157],"normal":[164],"Tlr4":[165,223],"gene":[166,168],"(Tlr4(LPS-n/LPS-n))":[167],"compared":[173],"homozygous":[180],"either":[182],"point":[184],"mutation":[185],"(Tlr4(LPS-d/LPS-d))":[186],"or":[187,197,224],"deletion":[188],"(Tlr4(LPS-del/LPS-del))":[189],"gene.":[192],"Likewise,":[193],"presence":[195,218],"(Sle11a1r/r)":[196],"absence":[198],"(Slc11a1s/s)":[199],"functional":[201],"alleles":[202],"Slc11a1":[204,225],"no":[206],"effect":[207],"S.":[214,234],"obvelata.":[215,235],"conclusion,":[217],"MHCII,":[220],"but":[221],"influences":[227],"data":[237],"justify":[238],"further":[239],"comprehensive":[240],"analyses":[241],"components":[245],"are":[247],"involved":[248],"resistance.":[251]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
