{"id":"https://openalex.org/W1603328416","doi":"https://doi.org/10.1016/s0021-9258(17)31971-3","title":"Localization of the affinity peptide-substrate inactivator site on recombinant vitamin K-dependent carboxylase.","display_name":"Localization of the affinity peptide-substrate inactivator site on recombinant vitamin K-dependent carboxylase.","publication_year":1994,"publication_date":"1994-08-01","ids":{"openalex":"https://openalex.org/W1603328416","doi":"https://doi.org/10.1016/s0021-9258(17)31971-3","mag":"1603328416","pmid":"https://pubmed.ncbi.nlm.nih.gov/8063763"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(17)31971-3","doi":"https://doi.org/10.1016/s0021-9258(17)31971-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)31971-3","pdf_url":"https://doi.org/10.1016/s0021-9258(17)31971-3","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(17)31971-3","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006545278","display_name":"Athan Kuliopulos","orcid":"https://orcid.org/0000-0002-9677-8540","observed_orcids":["https://orcid.org/0000-0002-9677-8540"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Kuliopulos","raw_affiliation_strings":["From the $ Department of Biological Chemistry and Molecular Pharmacology , Harvard Medical School , Boston , Massachusetts 02115 and the ICenter for Hemostasis and Thrombosis Research ,","Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the $ Department of Biological Chemistry and Molecular Pharmacology , Harvard Medical School , Boston , Massachusetts 02115 and the ICenter for Hemostasis and Thrombosis Research ,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"N.P. Nelson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N.P. Nelson","raw_affiliation_strings":["From the $ Department of Biological Chemistry and Molecular Pharmacology , Harvard Medical School , Boston , Massachusetts 02115 and the ICenter for Hemostasis and Thrombosis Research ,","Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the $ Department of Biological Chemistry and Molecular Pharmacology , Harvard Medical School , Boston , Massachusetts 02115 and the ICenter for Hemostasis and Thrombosis Research ,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Yamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Yamada","raw_affiliation_strings":["From the $ Department of Biological Chemistry and Molecular Pharmacology , Harvard Medical School , Boston , Massachusetts 02115 and the ICenter for Hemostasis and Thrombosis Research ,","Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the $ Department of Biological Chemistry and Molecular Pharmacology , Harvard Medical School , Boston , Massachusetts 02115 and the ICenter for Hemostasis and Thrombosis Research ,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060579310","display_name":"Christopher T. Walsh","orcid":"https://orcid.org/0000-0002-0355-1938","observed_orcids":["https://orcid.org/0000-0002-0355-1938","https://orcid.org/0000-0001-8867-4322"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.T. Walsh","raw_affiliation_strings":["From the $ Department of Biological Chemistry and Molecular Pharmacology , Harvard Medical School , Boston , Massachusetts 02115 and the ICenter for Hemostasis and Thrombosis Research ,","Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the $ Department of Biological Chemistry and Molecular Pharmacology , Harvard Medical School , Boston , Massachusetts 02115 and the ICenter for Hemostasis and Thrombosis Research ,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066321804","display_name":"Bruce Furie","orcid":"https://orcid.org/0000-0001-7610-1076","observed_orcids":["https://orcid.org/0000-0001-7610-1076"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Furie","raw_affiliation_strings":["Division of HematologylOncology , New England Medical Center , and Departments of Medicine and Biochemistry ,","Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of HematologylOncology , New England Medical Center , and Departments of Medicine and Biochemistry ,","institution_ids":["https://openalex.org/I1290900354"]},{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110912475","display_name":"Bruce Furie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B.C. Furie","raw_affiliation_strings":["Thfts University School of Medicine , Boston , Massachusetts 02111","Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thfts University School of Medicine , Boston , Massachusetts 02111","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034488510","display_name":"David A. Roth","orcid":"https://orcid.org/0000-0001-8356-0457","observed_orcids":["https://orcid.org/0000-0001-8356-0457"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.A. Roth","raw_affiliation_strings":["From the $ Department of Biological Chemistry and Molecular Pharmacology , Harvard Medical School , Boston , Massachusetts 02115 and the ICenter for Hemostasis and Thrombosis Research ,","Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the $ Department of Biological Chemistry and Molecular Pharmacology , Harvard Medical School , Boston , Massachusetts 02115 and the ICenter for Hemostasis and Thrombosis Research ,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.7805,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.92970902,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"269","issue":"33","first_page":"21364","last_page":"21370"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13004","display_name":"Vitamin K Research Studies","score":0.4584999978542328,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13004","display_name":"Vitamin K Research Studies","score":0.4584999978542328,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.3481000065803528,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.054999999701976776,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-k-dependent-carboxylase","display_name":"vitamin K-dependent carboxylase","score":0.8980000019073486},{"id":"https://openalex.org/keywords/gamma-glutamyl-carboxylase","display_name":"gamma-glutamyl carboxylase","score":0.9490000009536743},{"id":"https://openalex.org/keywords/affinity-labeling","display_name":"affinity labeling","score":0.6880000233650208},{"id":"https://openalex.org/keywords/enzyme-inactivation","display_name":"enzyme inactivation","score":0.7319999933242798},{"id":"https://openalex.org/keywords/active-site","display_name":"active site","score":0.5220000147819519},{"id":"https://openalex.org/keywords/recombinant-enzyme","display_name":"recombinant enzyme","score":0.6399999856948853},{"id":"https://openalex.org/keywords/baculovirus-expression-system","display_name":"baculovirus expression system","score":0.8460000157356262},{"id":"https://openalex.org/keywords/n-terminal-domain","display_name":"N-terminal domain","score":0.5260000228881836},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.7160000205039978},{"id":"https://openalex.org/keywords/gamma-carboxylation","display_name":"gamma-carboxylation","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.7080268859863281},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6259674429893494},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.6037921905517578},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5827654004096985},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5822852849960327},{"id":"https://openalex.org/C140137476","wikidata":"https://www.wikidata.org/wiki/Q21114968","display_name":"Pyruvate carboxylase","level":3,"score":0.4983649253845215},{"id":"https://openalex.org/C2994592520","wikidata":"https://www.wikidata.org/wiki/Q5090496","display_name":"Substrate specificity","level":3,"score":0.486868292093277},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.39080432057380676},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23949751257896423},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10620579123497009},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008025","descriptor_name":"Ligases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D008025","descriptor_name":"Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008025","descriptor_name":"Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008025","descriptor_name":"Ligases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009036","descriptor_name":"Moths","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019735","descriptor_name":"Carbon-Carbon Ligases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(17)31971-3","doi":"https://doi.org/10.1016/s0021-9258(17)31971-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)31971-3","pdf_url":"https://doi.org/10.1016/s0021-9258(17)31971-3","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:8063763","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8063763","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(17)31971-3","doi":"https://doi.org/10.1016/s0021-9258(17)31971-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)31971-3","pdf_url":"https://doi.org/10.1016/s0021-9258(17)31971-3","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1756987391","display_name":null,"funder_award_id":"F32HL08882-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G240978288","display_name":"VITAMIN K DEPENDENT CARBOXLYASE--MOLECULAR STUDIES","funder_award_id":"1f32hl008882-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7136052348","display_name":"KRINGLE DOMAINS IN BLOOD COAGULATION PROTEINS","funder_award_id":"K11HL002574","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7747736003","display_name":"MEMBRANE PROTEINS IN BLOOD COAGULATION","funder_award_id":"P01HL042443","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1603328416.pdf","grobid_xml":"https://content.openalex.org/works/W1603328416.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1485516489","https://openalex.org/W1488796712","https://openalex.org/W1562299317","https://openalex.org/W1583135347","https://openalex.org/W1600940333","https://openalex.org/W1987647241","https://openalex.org/W2020338953","https://openalex.org/W2020671837","https://openalex.org/W2021232224","https://openalex.org/W2026527319","https://openalex.org/W2027872963","https://openalex.org/W2034765580","https://openalex.org/W2035392907","https://openalex.org/W2036652061","https://openalex.org/W2041349540","https://openalex.org/W2057755727","https://openalex.org/W2068951060","https://openalex.org/W2069958139","https://openalex.org/W2070543174","https://openalex.org/W2083238386","https://openalex.org/W2090610366","https://openalex.org/W2115350007","https://openalex.org/W2164358316","https://openalex.org/W3142413541"],"related_works":["https://openalex.org/W2090610366","https://openalex.org/W2041516301","https://openalex.org/W2068685861","https://openalex.org/W1963493266","https://openalex.org/W1964168273","https://openalex.org/W1973880773","https://openalex.org/W2779128","https://openalex.org/W2036454152","https://openalex.org/W2086846056","https://openalex.org/W1894121415"],"abstract_inverted_index":{"A":[0],"recombinant":[1],"His,-tagged":[2],"vitamin":[3,172,196],"K-dependent":[4,173,197],"y-glutamyl":[5,174],"carboxylase":[6,175],"has":[7],"been":[8],"produced":[9],"in":[10,167],"baculovirus-infected":[11],"insect":[12],"cells.The":[13],"His,-carboxylase":[14,28],"shares":[15],"nearly":[16],"identical":[17],"kinetic":[18],"properties":[19],"with":[20,48,55,80,91],"the":[21,33,100,109,117,127,133,140,144,148,152,161,183,195],"wild-type":[22],"enzyme":[23,180],"from":[24],"bovine":[25],"liver":[26],"microsomes.The":[27],"was":[29,75],"irreversibly":[30],"inactivated":[31,60],"by":[32,46,66,70],"N-bro-moa~etyl-FLEEL-'~~1-Y":[34],"peptide":[35,52],"substrate/affinity":[36],"label":[37,129],"under":[38,63],"pseudo-first":[39],"order":[40],"conditions.This":[41],"inactivation":[42],"could":[43],"be":[44],"abolished":[45],"coincubation":[47],"a":[49,177],"high":[50],"affinity":[51],"substrate":[53],"consistent":[54],"an":[56],"active":[57],"site-directed":[58],"inactivation.The":[59],"His,-carboxylase-Ac-FLEEL-\"'I-Y,":[61],"purified":[62],"denaturing":[64],"conditions":[65],"Ni-chelation":[67],"chromatography":[68],"followed":[69],"preparative":[71],"polyacrylamide":[72],"gel":[73],"electrophoresis,":[74],"subjected":[76],"to":[77,106,126,190],"proteolytic":[78],"digestions":[79],"either":[81,151],"Glu-C":[82],"or":[83,159],"Lys-C":[84],"endoproteinases.The":[85],"resulting":[86],"polypeptide":[87],"fragments":[88],"were":[89],"probed":[90],"three":[92],"regiospecific":[93],"antibodies":[94],"which":[95],"recognized":[96],"epitopes":[97],"present":[98],"at":[99,108,116],"extreme":[101],"N":[102],"terminus":[103],"(residues":[104,113,121,157,165],"-23":[105],"-13),":[107],"hydrophobic":[110,155],"N-terminal":[111,162],"region":[112,120,156,164],"86-99),":[114],"and":[115,202],"hydrophilic":[118,163],"C-terminal":[119],"661-673).The":[122],"site":[123],"of":[124,139,150,169,187,194,205],"attachment":[125],"'2SI-affinity":[128],"is":[130,143,176],"located":[131],"within":[132],"first":[134,145],"218":[135],"amino":[136],"acid":[137],"residues":[138,189,193],"758-residue":[141],"carboxylase.This":[142],"evidence":[146],"for":[147,182],"involvement":[149],"putative":[153],"membrane-anchoring":[154],"50-314)":[158],"possibly":[160],"1-50]":[166],"y-carboxylation":[168],"glutamate-peptide":[170],"substrates.The":[171],"membrane-associated":[178],"microsomal":[179],"responsible":[181],"essential":[184],"post-translational":[185],"modification":[186],"glutamate":[188],"y-carboxyglutamate":[191],"(Gla)'":[192],"HL08882-01":[198],"(to":[199],"A.":[200],"K.)":[201],"National":[203],"Institutes":[204],"Health":[206],"Physician":[207],"Sci-*":[208]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
