{"id":"https://openalex.org/W1602307101","doi":"https://doi.org/10.1002/0471142956.cy0943s67","title":"Real\u2010Time Detection of Protein Trafficking with High\u2010Throughput Flow Cytometry (HTFC) and Fluorogen\u2010Activating Protein (FAP) Base Biosensor","display_name":"Real\u2010Time Detection of Protein Trafficking with High\u2010Throughput Flow Cytometry (HTFC) and Fluorogen\u2010Activating Protein (FAP) Base Biosensor","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W1602307101","doi":"https://doi.org/10.1002/0471142956.cy0943s67","mag":"1602307101","pmid":"https://pubmed.ncbi.nlm.nih.gov/24510772","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3961059"},"language":"en","primary_location":{"id":"doi:10.1002/0471142956.cy0943s67","doi":"https://doi.org/10.1002/0471142956.cy0943s67","is_oa":false,"landing_page_url":"https://doi.org/10.1002/0471142956.cy0943s67","pdf_url":null,"source":{"id":"https://openalex.org/S4210174854","display_name":"Current Protocols in Cytometry","issn_l":"1934-9297","issn":["1934-9297","1934-9300"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Protocols in Cytometry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3961059","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022010843","display_name":"Yang Wu","orcid":"https://orcid.org/0000-0002-7782-8290","observed_orcids":["https://orcid.org/0000-0002-7782-8290"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Wu","raw_affiliation_strings":["Center for Molecular Discovery, University of New Mexico School of Medicine, Albuquerque, New Mexico","Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Discovery, University of New Mexico School of Medicine, Albuquerque, New Mexico","institution_ids":["https://openalex.org/I169521973"]},{"raw_affiliation_string":"Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076062321","display_name":"Phillip H. Tapia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phillip H. Tapia","raw_affiliation_strings":["Center for Molecular Discovery, University of New Mexico School of Medicine, Albuquerque, New Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Discovery, University of New Mexico School of Medicine, Albuquerque, New Mexico","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030804059","display_name":"Jonathan W. Jarvik","orcid":"https://orcid.org/0000-0002-7803-5831","observed_orcids":["https://orcid.org/0000-0002-7803-5831"]},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Jarvik","raw_affiliation_strings":["Department of Biological Sciences, Molecular Biosensor and Imaging Center, Carnegie Mellon University, Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Molecular Biosensor and Imaging Center, Carnegie Mellon University, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007241191","display_name":"Alan S. Waggoner","orcid":"https://orcid.org/0000-0002-5188-4075","observed_orcids":["https://orcid.org/0000-0002-5188-4075"]},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan S. Waggoner","raw_affiliation_strings":["Department of Biological Sciences, Molecular Biosensor and Imaging Center, Carnegie Mellon University, Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Molecular Biosensor and Imaging Center, Carnegie Mellon University, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028187863","display_name":"Larry A. Sklar","orcid":"https://orcid.org/0000-0002-8196-5060","observed_orcids":["https://orcid.org/0000-0002-8196-5060"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry A. Sklar","raw_affiliation_strings":["Center for Molecular Discovery, University of New Mexico School of Medicine, Albuquerque, New Mexico","Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Discovery, University of New Mexico School of Medicine, Albuquerque, New Mexico","institution_ids":["https://openalex.org/I169521973"]},{"raw_affiliation_string":"Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico","institution_ids":["https://openalex.org/I169521973"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5050,"currency":"USD","value_usd":5050},"apc_paid":null,"fwci":0.5464,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.62359949,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"67","issue":"1","first_page":"9.43.1","last_page":"9.43.11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-trafficking","display_name":"protein trafficking","score":0.7950000166893005},{"id":"https://openalex.org/keywords/plasma-membrane","display_name":"plasma membrane","score":0.8259999752044678},{"id":"https://openalex.org/keywords/fluorogen-activating-protein","display_name":"fluorogen-activating protein","score":0.9589999914169312},{"id":"https://openalex.org/keywords/biosensors","display_name":"biosensors","score":0.6769999861717224},{"id":"https://openalex.org/keywords/high-throughput-flow-cytometry","display_name":"high-throughput flow cytometry","score":0.9039999842643738},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9739999771118164},{"id":"https://openalex.org/keywords/beta2-adrenergic-receptor","display_name":"beta2-adrenergic receptor","score":0.9700000286102295},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.8949999809265137},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.5210000276565552},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.765999972820282},{"id":"https://openalex.org/keywords/ion-channels","display_name":"ion channels","score":0.9490000009536743},{"id":"https://openalex.org/keywords/ligand-screening","display_name":"ligand screening","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.8070610761642456},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.764593243598938},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.7154560089111328},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6312201023101807},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5138752460479736},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5024924278259277},{"id":"https://openalex.org/C51323132","wikidata":"https://www.wikidata.org/wiki/Q626251","display_name":"High-throughput screening","level":2,"score":0.4884883165359497},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.468011736869812},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.4618605077266693},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.45206084847450256},{"id":"https://openalex.org/C2779057010","wikidata":"https://www.wikidata.org/wiki/Q2963679","display_name":"Chemical library","level":3,"score":0.41835159063339233},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3416990041732788},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.28519949316978455},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28219524025917053},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.19563192129135132},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.13538256287574768},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003199","descriptor_name":"Computer Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020298","descriptor_name":"U937 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1002/0471142956.cy0943s67","doi":"https://doi.org/10.1002/0471142956.cy0943s67","is_oa":false,"landing_page_url":"https://doi.org/10.1002/0471142956.cy0943s67","pdf_url":null,"source":{"id":"https://openalex.org/S4210174854","display_name":"Current Protocols in Cytometry","issn_l":"1934-9297","issn":["1934-9297","1934-9300"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Protocols in Cytometry","raw_type":"journal-article"},{"id":"pmid:24510772","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24510772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current protocols in cytometry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3252205","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3961059","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3961059","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3961059","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Protoc Cytom","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/6104108","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Real-time_detection_of_protein_trafficking_with_high-throughput_flow_cytometry_HTFC_and_fluorogen-activating_protein_FAP_base_biosensor_/6104108","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"doi:10.1184/r1/6104108","doi":"https://doi.org/10.1184/r1/6104108","is_oa":true,"landing_page_url":"https://doi.org/10.1184/r1/6104108","pdf_url":null,"source":{"id":"https://openalex.org/S7407050927","display_name":"KiltHub Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74973139","host_organization_name":"Carnegie Mellon University","host_organization_lineage":["https://openalex.org/I74973139"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.1184/r1/6104108.v1","doi":"https://doi.org/10.1184/r1/6104108.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1184/r1/6104108.v1","pdf_url":null,"source":{"id":"https://openalex.org/S7407050927","display_name":"KiltHub Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74973139","host_organization_name":"Carnegie Mellon University","host_organization_lineage":["https://openalex.org/I74973139"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3252205","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3961059","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6597471514","display_name":"Fluorescent Biosensors for Networks and Pathways","funder_award_id":"U54RR022241","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8187984429","display_name":"University of New Mexico Center for Molecular Discovery","funder_award_id":"U54MH084690","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1968682237","https://openalex.org/W1988264086","https://openalex.org/W1991001144","https://openalex.org/W2027402104","https://openalex.org/W2029335938","https://openalex.org/W2066048196","https://openalex.org/W2074370114","https://openalex.org/W2088371438","https://openalex.org/W2121161622","https://openalex.org/W2121165917","https://openalex.org/W2141382054","https://openalex.org/W2152350731","https://openalex.org/W2159101704","https://openalex.org/W2321823406"],"related_works":["https://openalex.org/W2121165917","https://openalex.org/W2027402104","https://openalex.org/W1525451596","https://openalex.org/W2806502945","https://openalex.org/W2159101704","https://openalex.org/W2074211893","https://openalex.org/W6922374256","https://openalex.org/W3166915379","https://openalex.org/W2416935218","https://openalex.org/W2200390015"],"abstract_inverted_index":{"We":[0],"combined":[1],"fluorogen-activating":[2],"protein":[3,13],"(FAP)":[4],"technology":[5],"with":[6,99,143],"high-throughput":[7,50],"flow":[8,53],"cytometry":[9],"to":[10,15,68,107],"detect":[11],"real-time":[12],"trafficking":[14,31],"and":[16,41,66],"from":[17],"the":[18,61,93,125],"plasma":[19],"membrane":[20],"in":[21,92,111],"living":[22],"cells.":[23],"The":[24,55,115],"hybrid":[25],"platform":[26],"allows":[27],"drug":[28],"discovery":[29,117],"for":[30,49,131],"receptors,":[32,37],"such":[33],"as":[34],"G":[35],"protein-coupled":[36],"receptor":[38,63,109],"tyrosine":[39],"kinases,":[40],"ion":[42],"channels,":[43],"which":[44],"were":[45,95,104],"previously":[46],"not":[47],"suitable":[48],"screening":[51],"by":[52,121],"cytometry.":[54],"system":[56,65],"has":[57],"been":[58],"validated":[59],"using":[60,128],"\u03b22-adrenergic":[62],"(\u03b22AR)":[64],"extended":[67],"other":[69],"GPCRs.":[70],"When":[71],"a":[72,100,112],"chemical":[73],"library":[74,94],"containing":[75],"\u223c":[76],"1200":[77],"off-patent":[78],"drugs":[79],"was":[80],"screened":[81],"against":[82],"cells":[83],"expressing":[84],"FAP-tagged":[85],"\u03b22AR,":[86],"all":[87],"known":[88],"\u03b22AR":[89],"active":[90],"ligands":[91,120],"successfully":[96],"identified,":[97],"together":[98],"few":[101],"compounds":[102],"that":[103],"later":[105],"confirmed":[106],"regulate":[108],"internalization":[110],"nontraditional":[113],"manner.":[114],"unexpected":[116],"of":[118,127,137],"new":[119],"this":[122,129],"approach":[123],"indicates":[124],"potential":[126],"protocol":[130,145],"GPCR":[132],"de-orphanization.":[133],"In":[134],"addition,":[135],"screens":[136],"multiplexed":[138],"targets":[139],"promise":[140],"improved":[141],"efficiency":[142],"minor":[144],"modification.":[146]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
