{"id":"https://openalex.org/W1602282202","doi":null,"title":"Hemicanales formados por conexinas en la regulaci\u00f3n del volumen del cardiomiocito expuesto a estr\u00e9s hiposm\u00f3tico","display_name":"Hemicanales formados por conexinas en la regulaci\u00f3n del volumen del cardiomiocito expuesto a estr\u00e9s hiposm\u00f3tico","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W1602282202","mag":"1602282202"},"language":"es","primary_location":{"id":"pmh:oai:repositorio.uchile.cl:2250/105307","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.uchile.cl/handle/2250/105307","pdf_url":null,"source":{"id":"https://openalex.org/S4306481413","display_name":"Universidad de Chile","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Tesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repositorio.uchile.cl/handle/2250/105307","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109904252","display_name":"Salas Castro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salas Castro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5033333387","display_name":"Daniela Paz","orcid":"https://orcid.org/0000-0002-6230-3221","observed_orcids":["https://orcid.org/0000-0002-6230-3221"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniela Paz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6230-3221","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.8374000191688538,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.8374000191688538,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.1324000060558319,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemichannels","display_name":"hemichannels","score":0.6710000038146973},{"id":"https://openalex.org/keywords/connexins","display_name":"connexins","score":0.9660000205039978},{"id":"https://openalex.org/keywords/connexin-43","display_name":"connexin 43","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cell-volume-regulation","display_name":"cell volume regulation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/hypotonic-stress","display_name":"hypotonic stress","score":0.8960000276565552},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.6700000166893005},{"id":"https://openalex.org/keywords/connexin-hemichannels","display_name":"connexin hemichannels","score":0.6549999713897705},{"id":"https://openalex.org/keywords/connexin-32","display_name":"connexin 32","score":0.7549999952316284},{"id":"https://openalex.org/keywords/connexin-31","display_name":"connexin 31","score":0.7200000286102295},{"id":"https://openalex.org/keywords/connexin-37","display_name":"connexin 37","score":0.7110000252723694},{"id":"https://openalex.org/keywords/connexin-36","display_name":"connexin 36","score":0.7120000123977661},{"id":"https://openalex.org/keywords/connexin-30","display_name":"connexin 30","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.41148680448532104},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.372558057308197},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.32326847314834595}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repositorio.uchile.cl:2250/105307","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.uchile.cl/handle/2250/105307","pdf_url":null,"source":{"id":"https://openalex.org/S4306481413","display_name":"Universidad de Chile","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Tesis"},{"id":"mag:1602282202","doi":null,"is_oa":false,"landing_page_url":"http://www.tesis.uchile.cl/tesis/uchile/2009/qf-salas_d/pdfAmont/qf-salas_d.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repositorio.uchile.cl:2250/105307","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.uchile.cl/handle/2250/105307","pdf_url":null,"source":{"id":"https://openalex.org/S4306481413","display_name":"Universidad de Chile","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Tesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W75521704","https://openalex.org/W1509985961","https://openalex.org/W1819101207","https://openalex.org/W1942690484","https://openalex.org/W1958525759","https://openalex.org/W1965951694","https://openalex.org/W1966125735","https://openalex.org/W1969173609","https://openalex.org/W1970977779","https://openalex.org/W1971429384","https://openalex.org/W1972241850","https://openalex.org/W1976792130","https://openalex.org/W1983460238","https://openalex.org/W1992170663","https://openalex.org/W1996565835","https://openalex.org/W1996631946","https://openalex.org/W2003802870","https://openalex.org/W2004431915","https://openalex.org/W2006653167","https://openalex.org/W2017203200","https://openalex.org/W2022231302","https://openalex.org/W2032529240","https://openalex.org/W2032745109","https://openalex.org/W2037189465","https://openalex.org/W2052544958","https://openalex.org/W2058555785","https://openalex.org/W2064383349","https://openalex.org/W2070426892","https://openalex.org/W2071219878","https://openalex.org/W2081673606","https://openalex.org/W2082810029","https://openalex.org/W2083987985","https://openalex.org/W2089047096","https://openalex.org/W2090744245","https://openalex.org/W2095149999","https://openalex.org/W2095231337","https://openalex.org/W2095238429","https://openalex.org/W2101299206","https://openalex.org/W2101942763","https://openalex.org/W2105703558","https://openalex.org/W2108088025","https://openalex.org/W2110614144","https://openalex.org/W2111469368","https://openalex.org/W2119393589","https://openalex.org/W2119996978","https://openalex.org/W2125951597","https://openalex.org/W2129410980","https://openalex.org/W2130422445","https://openalex.org/W2132392851","https://openalex.org/W2140454162","https://openalex.org/W2150719255","https://openalex.org/W2151388300","https://openalex.org/W2152905330","https://openalex.org/W2154009044","https://openalex.org/W2161142660","https://openalex.org/W2168079862","https://openalex.org/W2224021986","https://openalex.org/W2255395598","https://openalex.org/W2317164129","https://openalex.org/W2413789555","https://openalex.org/W2415255873"],"related_works":["https://openalex.org/W7001738990","https://openalex.org/W819192335","https://openalex.org/W3107807092","https://openalex.org/W2002942271","https://openalex.org/W2094916678","https://openalex.org/W7048063394","https://openalex.org/W7028333036","https://openalex.org/W7004978018","https://openalex.org/W2102501327","https://openalex.org/W6983369495"],"abstract_inverted_index":{"El":[0,298],"correcto":[1],"funcionamiento":[2],"celular":[3,30,286],"requiere":[4],"condiciones":[5,176],"f\u00edsicas":[6],"espec\u00edficas,":[7],"como":[8,57,62,427],"pH,":[9],"temperatura":[10],"y":[11,46,51,81,103,129,219,245,339,424],"fuerza":[12,44],"i\u00f3nica.":[13],"Cualquier":[14],"alteraci\u00f3n":[15],"de":[16,33,49,79,92,108,116,154,162,177,198,213,226,232,240,249,252,273,275,291,300,316,329,331,351,356,359,361,371,380,392,397,399,401,411,422,429,432,434,445,470,490,502,506,509],"estos":[17,517],"par\u00e1metros":[18,35],"puede":[19],"producir":[20],"consecuencias":[21],"graves":[22],"para":[23,37,94,125],"las":[24,47,84,120,227,253,276,460],"c\u00e9lulas.":[25,228],"La":[26],"mantenci\u00f3n":[27],"del":[28,70,140,145,318,413,472,531,533],"volumen":[29,71,128,174,274,317,412,433,471,532],"es":[31,189,196],"otro":[32],"los":[34,168,199,250,260,307,352,365,372,381,405,430,452,491,522],"importantes":[36],"la":[38,43,58,74,100,106,111,132,138,148,155,223,247,264,271,284,314,357,378,385,395,409,435,468,507,513],"c\u00e9lula":[39,112,436],"ya":[40,278,474],"que":[41,88,158,167,181,193,205,215,259,279,287,451,466,475,486,521],"regula":[42],"i\u00f3nica":[45],"concentraciones":[48],"osmolitos":[50],"segundos":[52],"mensajeros":[53],"intracelulares.":[54],"En":[55,142],"patolog\u00edas":[56],"diabetes":[59],"o":[60,387,504],"isqu\u00e9micas":[61],"el":[63,77,90,143,194,289,344,348,368,420,439,442,487,500,529],"infarto":[64],"agudo":[65],"al":[66,458,476],"miocardio,":[67],"ocurren":[68],"alteraciones":[69,505],"celular.":[72,515],"Durante":[73],"isquemia":[75],"disminuye":[76,159],"aporte":[78],"nutrientes":[80,93],"ox\u00edgeno":[82],"a":[83,110,131,135,185,321,336,354,375,416,462],"c\u00e9lulas":[85,121,233,254,461],"por":[86,203,263,295,310,497,525],"lo":[87,157,180,465],"aumenta":[89,99],"catabolismo":[91],"obtener":[95],"energ\u00eda.":[96],"Como":[97],"consecuencia,":[98],"osmolaridad":[101,139],"intracelular":[102],"con":[104,441,478],"ello,":[105],"entrada":[107],"agua":[109,292],"produci\u00e9ndose":[113],"un":[114,238],"aumento":[115,488],"su":[117,127,160,173,390,455,481],"volumen.":[118,482],"Pero":[119],"han":[122],"desarrollado":[123],"mecanismos":[124],"regular":[126],"volver":[130],"normalidad":[133],"frente":[134],"cambios":[136,366,388,431,498],"en":[137,151,175,222,243,270,283,304,313,367,377,384,389,408,499,512,528],"medio.":[141],"caso":[144],"estr\u00e9s":[146,178,322,337,345,417,463],"hiposm\u00f3tico,":[147,179,418,464],"estrategia":[149],"consiste":[150],"sacar":[152],"iones":[153,294],"c\u00e9lula,":[156],"contenido":[161],"agua.":[163],"Se":[164,256],"ha":[165,183,257],"descrito":[166],"cardiomiocitos":[169,330],"no":[170,493],"regulan":[171],"espont\u00e1neamente":[172],"se":[182,220,235,334,340,484,494,519],"asociado":[184],"muerte.":[186],"Este":[187],"hecho":[188],"importante":[190],"si":[191,306],"consideramos":[192],"coraz\u00f3n":[195],"uno":[197],"\u00f3rganos":[200],"m\u00e1s":[201],"afectados":[202],"enfermedades":[204],"incluyen":[206],"episodios":[207],"isqu\u00e9micos.":[208],"Las":[209],"conexinas":[210,311,526],"son":[211],"prote\u00ednas":[212,400],"transmembrana":[214],"forman":[216,237,280],"hex\u00e1meros":[217],"(hemicanal)":[218],"insertan":[221],"membrana":[224,386,514],"plasm\u00e1tica":[225],"Si":[229,343,364,404],"dos":[230],"hemicanales":[231,261,308,523],"adyacentes":[234],"unen":[236],"canal":[239],"una":[241],"uni\u00f3n":[242],"hendidura,":[244],"permiten":[246],"comunicaci\u00f3n":[248],"citoplasmas":[251],"vecinas.":[255],"propuesto":[258],"formados":[262,309,524],"conexina":[265],"43":[266],"(Hcs-Cx43)":[267],"podr\u00edan":[268],"participar":[269],"regulaci\u00f3n":[272,315,410,469],"c\u00e9lulas,":[277],"verdaderos":[281],"poros":[282],"superficie":[285,402],"permite":[288],"paso":[290],"e":[293,437],"difusi\u00f3n":[296],"simple.":[297],"objetivo":[299],"esta":[301],"tesis":[302],"consisti\u00f3":[303],"determinar":[305],"participan":[312,407,527],"cardiomiocito":[319,414,534],"expuesto":[320,415],"hiposm\u00f3tico.":[323],"Para":[324],"este":[325],"fin":[326],"cultivos":[327],"primarios":[328],"ratas":[332],"neonatas":[333],"expusieron":[335],"hiposm\u00f3tico":[338,346],"estudi\u00f3:":[341],"\u2022":[342,363,403],"modifica":[347],"estado":[349,369,391,456,501],"funcional":[350,370,457,489],"Hcs-Cx43":[353,382,406],"trav\u00e9s":[355],"t\u00e9cnica":[358,396],"captaci\u00f3n":[360],"etidio":[362],"Hcs-Cx":[373,453,492,510],"obedecen":[374],"modificaciones":[376],"cantidad":[379,508],"expuestos":[383,511],"fosforilaci\u00f3n,":[393],"mediante":[394,419],"biotinilaci\u00f3n":[398],"uso":[421],"calceina-AM":[423],"microscop\u00eda":[425],"confocal":[426],"indicador":[428],"interviniendo":[438],"sistema":[440],"inhibidor":[443],"espec\u00edfico":[444],"Hcs-Cx43,":[446],"Gap26.":[447],"Los":[448],"resultados":[449,518],"muestran":[450],"aumentan":[454],"exponer":[459],"impide":[467],"cardiomiocito,":[473],"inhibirlos":[477],"Gap26":[479],"recuperan":[480],"Adem\u00e1s":[483],"sugiere":[485],"podr\u00eda":[495],"explicar":[496],"fosforilaci\u00f3n":[503],"De":[516],"concluye":[520],"control":[530]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
