{"id":"https://openalex.org/W1602252011","doi":null,"title":"INFECCION POR EL VIRUS DEL PAPILOMA HUMANO. BIOLOGIA MOLECULAR","display_name":"INFECCION POR EL VIRUS DEL PAPILOMA HUMANO. BIOLOGIA MOLECULAR","publication_year":2014,"publication_date":"2014-06-29","ids":{"openalex":"https://openalex.org/W1602252011","mag":"1602252011"},"language":"es","primary_location":{"id":"mag:1602252011","doi":null,"is_oa":true,"landing_page_url":"https://eujournal.org/index.php/esj/article/download/3604/3376","pdf_url":null,"source":{"id":"https://openalex.org/S2764799362","display_name":"European Scientific Journal ESJ","issn_l":"1857-7431","issn":["1857-7431","1857-7881"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","vabb-shw"],"host_organization":"https://openalex.org/P4320800573","host_organization_name":"European Scientific Institute","host_organization_lineage":["https://openalex.org/P4320800573"],"host_organization_lineage_names":["European Scientific Institute"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"European Scientific Journal ESJ","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://eujournal.org/index.php/esj/article/download/3604/3376","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032504096","display_name":"Genaro Vega-Malag\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157492648","display_name":"Autonomous University of Queretaro","ror":"https://ror.org/00v8fdc16","country_code":"MX","type":"education","lineage":["https://openalex.org/I157492648"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Genaro Vega-Malag\u00f3n","raw_affiliation_strings":["Facultad de Medicina de la Universidad Aut\u00f3noma de Quer\u00e9taro, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Medicina de la Universidad Aut\u00f3noma de Quer\u00e9taro, M\u00e9xico","institution_ids":["https://openalex.org/I157492648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077121314","display_name":"Javier \u00c1vila-Morales","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157492648","display_name":"Autonomous University of Queretaro","ror":"https://ror.org/00v8fdc16","country_code":"MX","type":"education","lineage":["https://openalex.org/I157492648"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Javier \u00c1vila-Morales","raw_affiliation_strings":["Facultad de Medicina de la Universidad Aut\u00f3noma de Quer\u00e9taro, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Medicina de la Universidad Aut\u00f3noma de Quer\u00e9taro, M\u00e9xico","institution_ids":["https://openalex.org/I157492648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021019530","display_name":"Pablo Garc\u00eda\u2010Sol\u00eds","orcid":"https://orcid.org/0000-0002-7483-0555","observed_orcids":["https://orcid.org/0000-0002-7483-0555"]},"institutions":[{"id":"https://openalex.org/I157492648","display_name":"Autonomous University of Queretaro","ror":"https://ror.org/00v8fdc16","country_code":"MX","type":"education","lineage":["https://openalex.org/I157492648"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Pablo Garc\u00eda\u2010Sol\u00eds","raw_affiliation_strings":["Facultad de Medicina de la Universidad Aut\u00f3noma de Quer\u00e9taro, M\u00e9xico"],"raw_orcid":"https://orcid.org/0000-0002-7483-0555","affiliations":[{"raw_affiliation_string":"Facultad de Medicina de la Universidad Aut\u00f3noma de Quer\u00e9taro, M\u00e9xico","institution_ids":["https://openalex.org/I157492648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021122537","display_name":"Nicol\u00e1s Camacho-Calder\u00f3n","orcid":"https://orcid.org/0000-0003-0238-1559","observed_orcids":["https://orcid.org/0000-0003-0238-1559"]},"institutions":[{"id":"https://openalex.org/I157492648","display_name":"Autonomous University of Queretaro","ror":"https://ror.org/00v8fdc16","country_code":"MX","type":"education","lineage":["https://openalex.org/I157492648"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Nicol\u00e1s Camacho-Calder\u00f3n","raw_affiliation_strings":["Facultad de Medicina de la Universidad Aut\u00f3noma de Quer\u00e9taro, M\u00e9xico"],"raw_orcid":"https://orcid.org/0000-0003-0238-1559","affiliations":[{"raw_affiliation_string":"Facultad de Medicina de la Universidad Aut\u00f3noma de Quer\u00e9taro, M\u00e9xico","institution_ids":["https://openalex.org/I157492648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087172637","display_name":"Alma Becerril-Santos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157492648","display_name":"Autonomous University of Queretaro","ror":"https://ror.org/00v8fdc16","country_code":"MX","type":"education","lineage":["https://openalex.org/I157492648"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Alma Becerril-Santos","raw_affiliation_strings":["Facultad de Medicina de la Universidad Aut\u00f3noma de Quer\u00e9taro, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Medicina de la Universidad Aut\u00f3noma de Quer\u00e9taro, M\u00e9xico","institution_ids":["https://openalex.org/I157492648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020222955","display_name":"Alfredo Jes\u00fas Vega Malag\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157492648","display_name":"Autonomous University of Queretaro","ror":"https://ror.org/00v8fdc16","country_code":"MX","type":"education","lineage":["https://openalex.org/I157492648"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Alfredo Jes\u00fas Vega Malag\u00f3n","raw_affiliation_strings":["Facultad de Medicina de la Universidad Aut\u00f3noma de Quer\u00e9taro, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Medicina de la Universidad Aut\u00f3noma de Quer\u00e9taro, M\u00e9xico","institution_ids":["https://openalex.org/I157492648"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113524141","display_name":"Guillermo Enrique Leo\u2010Amador","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157492648","display_name":"Autonomous University of Queretaro","ror":"https://ror.org/00v8fdc16","country_code":"MX","type":"education","lineage":["https://openalex.org/I157492648"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Guillermo Enrique Leo\u2010Amador","raw_affiliation_strings":["Facultad de Medicina de la Universidad Aut\u00f3noma de Quer\u00e9taro, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Medicina de la Universidad Aut\u00f3noma de Quer\u00e9taro, M\u00e9xico","institution_ids":["https://openalex.org/I157492648"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I157492648"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"18","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":1.0},{"id":"https://openalex.org/keywords/hpv-e6","display_name":"E6 oncoprotein","score":0.8320000171661377},{"id":"https://openalex.org/keywords/hpv-e7","display_name":"E7 oncoprotein","score":0.9990000128746033},{"id":"https://openalex.org/keywords/p53-inactivation","display_name":"p53 inactivation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.8669999837875366},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.6769999861717224},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.9309999942779541},{"id":"https://openalex.org/keywords/viral-oncogenes","display_name":"viral oncogenes","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.7557908892631531},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7438578009605408},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6563066244125366},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5863597989082336},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.571652889251709},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.48659956455230713},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4677113890647888},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4569653868675232},{"id":"https://openalex.org/C2776062698","wikidata":"https://www.wikidata.org/wiki/Q21111463","display_name":"Retinoblastoma protein","level":4,"score":0.428609162569046},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.41344964504241943},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3949694037437439},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3831552267074585},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.33950185775756836},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3375009298324585},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.28806209564208984}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1602252011","doi":null,"is_oa":true,"landing_page_url":"https://eujournal.org/index.php/esj/article/download/3604/3376","pdf_url":null,"source":{"id":"https://openalex.org/S2764799362","display_name":"European Scientific Journal ESJ","issn_l":"1857-7431","issn":["1857-7431","1857-7881"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","vabb-shw"],"host_organization":"https://openalex.org/P4320800573","host_organization_name":"European Scientific Institute","host_organization_lineage":["https://openalex.org/P4320800573"],"host_organization_lineage_names":["European Scientific Institute"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"European Scientific Journal ESJ","raw_type":null}],"best_oa_location":{"id":"mag:1602252011","doi":null,"is_oa":true,"landing_page_url":"https://eujournal.org/index.php/esj/article/download/3604/3376","pdf_url":null,"source":{"id":"https://openalex.org/S2764799362","display_name":"European Scientific Journal ESJ","issn_l":"1857-7431","issn":["1857-7431","1857-7881"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","vabb-shw"],"host_organization":"https://openalex.org/P4320800573","host_organization_name":"European Scientific Institute","host_organization_lineage":["https://openalex.org/P4320800573"],"host_organization_lineage_names":["European Scientific Institute"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"European Scientific Journal ESJ","raw_type":null},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7132334066","https://openalex.org/W4213427376","https://openalex.org/W1543602708","https://openalex.org/W2096738057","https://openalex.org/W3021119717","https://openalex.org/W2058726245","https://openalex.org/W3101091698","https://openalex.org/W2129883116","https://openalex.org/W4206902234","https://openalex.org/W2776654401"],"abstract_inverted_index":{"The":[0,74,130],"human":[1,134],"papillomavirus":[2,135],"(HPV":[3],")":[4,104,110],",":[5,17,25,44,67,88,117,165,171,206,215,220],"is":[6,10,77,81,98,136],"important":[7],"because":[8],"it":[9],"the":[11,83,112,119,122,151,161,172,180,189,221],"sexually":[12],"transmitted":[13],"disease":[14],"more":[15],"common":[16],"worldwide,":[18],"to":[19,160,185,188,244,254],"be":[20],"associated":[21],"with":[22,61,89,228],"cervical":[23,140,235],"cancer":[24],"all":[26],"therapeutic":[27],"modalities":[28],"have":[29,48],"a":[30,62,68],"high":[31],"recurrence":[32],"rate":[33],"and":[34,46,80,105,118,147,155,195,230,239,248],"probably":[35],"not":[36],"eradicated":[37],".":[38,73,129,157,199,257],"With":[39],"advances":[40],"in":[41,59,82,138,167],"molecular":[42],"biology":[43],"diagnosis":[45],"classification":[47],"changed":[49],"their":[50],"treatment.":[51],"HPVs":[52],"are":[53,92],"icosahedral":[54],"structures":[55],"of":[56,85,96,111,121,132,143,169,182,224],"55":[57],"microns":[58],"diameter":[60],"dense":[63],"central":[64],"core":[65],"DNA":[66,76,202,214],"protein":[69,164,223],"capsule":[70],"surrounding":[71],"him":[72],"HPV":[75,97,226],"double-":[78],"band":[79],"form":[84],"closed":[86],"loop":[87],"800":[90],"bp":[91],"epitheliotropic":[93],"viruses,":[94],"genomes":[95],"divided":[99],"into":[100],"early":[101],"(":[102,108],"E":[103],"late":[106],"regions":[107],"L":[109],"latter":[113],"encoding":[114],"structural":[115],"proteins":[116,125],"genes":[120,153],"first":[123],"encode":[124],"required":[126],"for":[127],"replication":[128,205],"genome":[131,191],"certain":[133],"present":[137],"most":[139],"tumors":[141],"products":[142,149],"viral":[144],"oncogenes":[145,241],"E6":[146,158,222,238],"E7":[148,173,240],"inactivate":[150],"suppressor":[152,163],"p53":[154,162,192,229],"Rb":[156,175],"binds":[159,174],"resulting":[166],"loss":[168],"function":[170],"retinoblastoma":[176],"gene.":[177],"P53":[178],"controls":[179],"progression":[181,198],"resting":[183],"cells":[184,207],"growth.":[186],"Damage":[187],"cell":[190],"levels":[193],"rise":[194],"inhibit":[196],"this":[197,209],"This":[200],"allows":[201],"repair":[203],"before":[204],"lose":[208],"control":[210],"replicate":[211],"its":[212,232],"damaged":[213],"which":[216],"generates":[217],"genomic":[218,246],"instability":[219,247],"high-risk":[225],"interacts":[227],"induces":[231],"degradation.":[233],"In":[234],"lesions":[236],"expressing":[237],"could":[242],"contribute":[243],"cellular":[245],"alterations":[249],"that":[250],"accumulate":[251],"would":[252],"take":[253],"tumor":[255],"development":[256]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}