{"id":"https://openalex.org/W1602189126","doi":null,"title":"Loss of TRF2 by radiation-induced apoptosis in HL60 cells.","display_name":"Loss of TRF2 by radiation-induced apoptosis in HL60 cells.","publication_year":2002,"publication_date":"2002-05-01","ids":{"openalex":"https://openalex.org/W1602189126","mag":"1602189126","pmid":"https://pubmed.ncbi.nlm.nih.gov/12126084"},"language":"en","primary_location":{"id":"pmid:12126084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12126084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054227099","display_name":"Yoshihiro Nakagami","orcid":"https://orcid.org/0000-0002-3245-1370","observed_orcids":["https://orcid.org/0000-0002-3245-1370"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Nakagami","raw_affiliation_strings":["Department of Radiology, Yokohama City University School of Medicine, Fukuura, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Yokohama City University School of Medicine, Fukuura, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083611562","display_name":"Megumi Ito","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Megumi Ito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113556275","display_name":"Takamitsu Hara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takamitsu Hara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086542330","display_name":"Tomio Inoue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomio Inoue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2463,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.43575038,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"20","issue":"3","first_page":"121","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.03739999979734421,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trf2","display_name":"TRF2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/radiation-induced-apoptosis","display_name":"radiation-induced apoptosis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/gamma-irradiation","display_name":"gamma irradiation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.9409999847412109},{"id":"https://openalex.org/keywords/elastase","display_name":"elastase","score":0.847000002861023},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.6669999957084656},{"id":"https://openalex.org/keywords/telomere-protection","display_name":"telomere protection","score":0.796999990940094},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/telomeric-repeats","display_name":"telomeric repeats","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.6972967982292175},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6106595993041992},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.6062920093536377},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6001885533332825},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5703203678131104},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.5166090130805969},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.452613890171051},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4220705032348633},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35891419649124146},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3556164503097534},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3104267120361328},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17696630954742432},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11248093843460083},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005720","descriptor_name":"Gamma Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D019272","descriptor_name":"Leukocyte Elastase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035341","descriptor_name":"Telomeric Repeat Binding Protein 2","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:12126084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12126084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation medicine","raw_type":"Journal Article"},{"id":"mag:1602189126","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12126084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1522890891","https://openalex.org/W1966636232","https://openalex.org/W1968309671","https://openalex.org/W1972303536","https://openalex.org/W1976705448","https://openalex.org/W1979657792","https://openalex.org/W1983673827","https://openalex.org/W1998663807","https://openalex.org/W2008443270","https://openalex.org/W2013073993","https://openalex.org/W2020038227","https://openalex.org/W2021643453","https://openalex.org/W2032038280","https://openalex.org/W2044521786","https://openalex.org/W2062395030","https://openalex.org/W2068409711","https://openalex.org/W2072744580","https://openalex.org/W2086992094","https://openalex.org/W2088438330","https://openalex.org/W2089362593","https://openalex.org/W2090083872","https://openalex.org/W2100915449","https://openalex.org/W2102839588","https://openalex.org/W2115076934","https://openalex.org/W2123105653","https://openalex.org/W2168184899","https://openalex.org/W2169455407","https://openalex.org/W2175722093"],"related_works":["https://openalex.org/W4252137209","https://openalex.org/W2102839588","https://openalex.org/W1758534631","https://openalex.org/W4248580047","https://openalex.org/W2021643453","https://openalex.org/W2757916344","https://openalex.org/W2106937417","https://openalex.org/W2802979095","https://openalex.org/W2296342528","https://openalex.org/W2351347946"],"abstract_inverted_index":{"PURPOSE:":[0],"A":[1],"telomere":[2],"consists":[3],"of":[4,10,17,31,42,55,85,116,122,131,151,156,165,171,176,185],"the":[5,14,29,40,53,64,83,110,120,129,146,149,157,169,172,179,183],"short":[6],"tandem":[7],"DNA":[8,79,127,188],"repeats":[9],"(T2AG3)n":[11],"localized":[12],"to":[13],"distal":[15],"ends":[16],"chromosomes.":[18],"Telomere":[19],"repeat":[20],"binding":[21],"factor":[22],"2":[23],"(TRF2)":[24],"has":[25,36,190],"been":[26,37],"implicated":[27],"in":[28,98,119,182],"protection":[30],"chromosome":[32],"ends.":[33],"Recently,":[34],"it":[35],"reported":[38],"that":[39,107,160],"loss":[41,115,130,150],"TRF2":[43,67,94,117,132,136,186],"induces":[44,163],"apoptosis":[45,86],"by":[46,140],"various":[47],"stimuli":[48],"or":[49],"genetic":[50],"technique,":[51],"however,":[52],"effects":[54],"radiation":[56],"are":[57],"not":[58],"known.":[59],"Therefore,":[60],"this":[61],"study":[62,158],"investigated":[63,97],"interaction":[65,90],"between":[66,91],"and":[68,77,93,104,113],"radiation.":[69],"MATERIALS":[70],"AND":[71],"METHODS:":[72],"Western":[73,101],"blot":[74,102],"analysis,":[75],"immunohistochemistry,":[76],"a":[78],"fragmentation":[80,189],"assay":[81],"for":[82],"detection":[84],"were":[87],"performed.":[88],"The":[89,154],"elastase":[92,177],"was":[95,137,143],"also":[96],"vitro.":[99],"RESULTS:":[100],"analyses":[103],"immunohistochemistry":[105],"showed":[106,159],"gamma-rays":[108],"induce":[109],"temporary":[111],"accumulation":[112],"subsequent":[114],"protein":[118],"nuclei":[121],"irradiated":[123],"HL60":[124],"cells.":[125],"Following":[126],"fragmentation,":[128],"could":[133],"be":[134],"detected.":[135],"broken":[138],"down":[139],"elastase,":[141],"which":[142],"translocated":[144],"into":[145,178],"nucleus":[147,180],"before":[148],"TRF2.":[152],"CONCLUSIONS:":[153],"results":[155,181],"irradiation":[161],"first":[162],"activation":[164],"TRF2,":[166],"consequently":[167],"protecting":[168],"end":[170],"chromosome.":[173],"Subsequently,":[174],"translocation":[175],"breakdown":[184],"after":[187],"occurred.":[191]},"counts_by_year":[{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}