{"id":"https://openalex.org/W16019997","doi":null,"title":"[Hepatic metastasis of unknown primary site].","display_name":"[Hepatic metastasis of unknown primary site].","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W16019997","mag":"16019997","pmid":"https://pubmed.ncbi.nlm.nih.gov/1932839"},"language":"fr","primary_location":{"id":"pmid:1932839","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1932839","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin du cancer","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111066022","display_name":"Mirerille Mousseau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162920","display_name":"H\u00f4pital Albert Michallon","ror":"https://ror.org/05kfvx519","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2800555055","https://openalex.org/I4210162920"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M Mousseau","raw_affiliation_strings":["Service d'oncologie m\u00e9dicale, h\u00f4pital A Michallon, Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'oncologie m\u00e9dicale, h\u00f4pital A Michallon, Grenoble, France","institution_ids":["https://openalex.org/I4210162920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109162488","display_name":"R Schaerer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Schaerer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107870739","display_name":"Jean Michel Lutz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Lutz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"F M\u00e9n\u00e9goz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F M\u00e9n\u00e9goz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110538316","display_name":"Henri Faure","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Faure","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110174373","display_name":"Patrycja \u015awiercz","orcid":"https://orcid.org/0009-0005-6389-2960","observed_orcids":["https://orcid.org/0009-0005-6389-2960"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Swiercz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.00168887,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"78","issue":"8","first_page":"725","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"adenocarcinoma","score":0.7630000114440918},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.3970000147819519},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.8899999856948853},{"id":"https://openalex.org/keywords/vinblastine","display_name":"vinblastine","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8450000286102295},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7570000290870667},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.7929999828338623},{"id":"https://openalex.org/keywords/objective-response","display_name":"objective response","score":0.5950000286102295},{"id":"https://openalex.org/keywords/primary-tumor-search","display_name":"primary tumor search","score":0.6399999856948853},{"id":"https://openalex.org/keywords/second-line-chemotherapy","display_name":"second-line chemotherapy","score":0.6679999828338623},{"id":"https://openalex.org/keywords/karnofsky-performance-status","display_name":"Karnofsky performance status","score":0.625},{"id":"https://openalex.org/keywords/carcinoembryonic-antigen","display_name":"carcinoembryonic antigen","score":0.9660000205039978},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.9819999933242798}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9271236062049866},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6860383749008179},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5875948667526245},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5872393846511841},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5843842029571533},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5088620185852051},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49747565388679504},{"id":"https://openalex.org/C2778336483","wikidata":"https://www.wikidata.org/wiki/Q5090632","display_name":"Chemotherapy regimen","level":3,"score":0.4698057770729065},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.4614606499671936},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4474661946296692},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.44349002838134766},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.43385380506515503}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009382","descriptor_name":"Neoplasms, Unknown Primary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1932839","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1932839","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin du cancer","raw_type":"English Abstract"},{"id":"mag:16019997","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1932839","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2908188120","https://openalex.org/W2358983825","https://openalex.org/W2072484182","https://openalex.org/W1878896819","https://openalex.org/W1630293510","https://openalex.org/W2073303609","https://openalex.org/W2412015055","https://openalex.org/W4244177175","https://openalex.org/W2057626125","https://openalex.org/W1558044166"],"abstract_inverted_index":{"In":[0,88,211],"this":[1,335],"retrospective":[2,336],"study,":[3],"91":[4,241],"patients":[5,55,64,140,190,231,242,250,287,356],"(30%)":[6],"out":[7,239,284,329],"of":[8,11,16,73,216,240,270,285,317,330,349],"a":[9,267],"series":[10],"304":[12],"with":[13,40,141,246,346,359],"metastatic":[14,31],"cancer":[15,82,100],"unknown":[17,350],"primary":[18,75,81,99,351],"site":[19,32,352],"were":[20,65,95,173,191,244,251,264,291],"found":[21,84,102],"to":[22,67,193,219,282,302,315,334],"have":[23,183],"liver":[24,27,145,347],"metastases.":[25],"The":[26,106,133],"was":[28,38,49,83,101,109,136,156,198,224,257,296,300],"the":[29,74,98,144,151,164,176,214,221,253,318,321],"only":[30,92,325],"in":[33,43,52,59,71,85,103,111,116,121,130,139,143,150,175,213,344],"28":[34],"(31%)":[35],"cases":[36,124],"and":[37,56,97,125,147,170,273,353],"associated":[39],"other":[41,90,152],"sites":[42],"63":[44],"(69%)":[45],"cases.":[46,105,132],"Median":[47],"age":[48],"62":[50],"yr":[51,58],"61":[53,89],"male":[54],"59":[57],"30":[60],"female":[61],"patients.":[62,87,153,332],"Thirty":[63],"submitted":[66],"an":[68],"extensive":[69],"investigation":[70],"search":[72],"tumor,":[76],"including":[77],"systematic":[78],"endoscopies:":[79],"no":[80],"these":[86,179,355],"patients,":[91,345],"symptom-oriented":[93],"investigations":[94],"performed":[96],"11":[104,117,258],"histologic":[107],"type":[108],"adenocarcinoma":[110],"71":[112],"(78%)":[113],"cases,":[114,119],"undifferentiated":[115],"(12%)":[118],"epidermoid":[120],"5":[122,148],"(6%)":[123],"determined":[126],"by":[127],"cytology":[128],"alone":[129],"4":[131,137],"median":[134,196,222],"survival":[135,197,223],"months":[138,149,226,229],"metastases":[142,348],"only,":[146],"This":[154],"difference":[155],"not":[157,182],"significant,":[158],"so":[159],"prognostic":[160,185],"factors":[161,180],"such":[162],"as":[163],"Karnofsky":[165],"index,":[166],"weight":[167],"loss,":[168],"CEA":[169],"LDH":[171],"levels":[172],"evaluated":[174],"entire":[177],"group;":[178],"do":[181],"significant":[184,294],"value.":[186],"By":[187],"contrast,":[188],"when":[189,298],"able":[192],"receive":[194],"chemotherapy,":[195,220],"better":[199],"(4":[200],"months)":[201],"than":[202,279],"without":[203,232],"(median":[204],"survival:":[205],"1":[206],"month;":[207],"P":[208],"=":[209,236],"0.005).":[210],"addition,":[212],"case":[215],"objective":[217,233,254,327],"response":[218,234,255,328],"9":[225],"versus":[227],"3.5":[228],"for":[230],"(P":[235],"0.001).":[237],"Seventy-three":[238],"(80%)":[243],"treated":[245,358],"chemotherapy":[247,312],"regimen;":[248],"65":[249],"evaluable:":[252],"rate":[256],"+/-":[259,289,306],"7%":[260],"(7/65).":[261],"Different":[262],"regimens":[263],"used.":[265],"With":[266],"non-toxic":[268,360],"combination":[269,323],"fluorouracil,":[271],"vinblastine":[272],"cyclophosphamide,":[274],"3":[275],"partial":[276],"responses":[277],"greater":[278],"or":[280,309],"equal":[281],"50%":[283],"43":[286],"(7":[288],"8%)":[290],"obtained.":[292],"No":[293],"advantage":[295],"observed":[297],"adriamycin":[299],"added":[301],"FU":[303],"(4/13):":[304],"31":[305],"25%.":[307],"Second-":[308],"third":[310],"line":[311],"regimen":[313],"due":[314],"progression":[316],"disease":[319],"after":[320],"first-line":[322],"provided":[324],"one":[326],"36":[331],"According":[333],"study":[337],"we":[338],"recommend":[339],"that":[340,354],"overinvestigation":[341],"be":[342,357],"avoided":[343],"drug":[361],"combinations.":[362]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}