{"id":"https://openalex.org/W1601733154","doi":null,"title":"Hypertonietherapie durch direkte Reninhemmung mit Aliskiren","display_name":"Hypertonietherapie durch direkte Reninhemmung mit Aliskiren","publication_year":2010,"publication_date":"2010-03-08","ids":{"openalex":"https://openalex.org/W1601733154","mag":"1601733154"},"language":"de","primary_location":{"id":"pmh:oai:kup.at:8672","doi":null,"is_oa":true,"landing_page_url":"http://www.kup.at/kup/pdf/8672.pdf","pdf_url":"http://www.kup.at/kup/pdf/8672.pdf","source":{"id":"https://openalex.org/S4306402201","display_name":"Journal f\u00fcr Kardiologie (Krause & Pachernegg GmbH)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"application/pdf"},"volume":null,"type":"other","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.kup.at/kup/pdf/8672.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"H H\u00f6lzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"H H\u00f6lzer","raw_affiliation_strings":["Medical University of Graz#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Graz#TAB#","institution_ids":["https://openalex.org/I202276237"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I202276237"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"1","first_page":"18","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aliskiren","display_name":"aliskiren","score":0.9980000257492065},{"id":"https://openalex.org/keywords/direct-renin-inhibition","display_name":"direct renin inhibition","score":0.9200000166893005},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.9190000295639038},{"id":"https://openalex.org/keywords/antihypertensive-therapy","display_name":"antihypertensive therapy","score":0.9430000185966492},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7110000252723694},{"id":"https://openalex.org/keywords/plasma-renin-activity","display_name":"plasma renin activity","score":0.8949999809265137},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.8050000071525574},{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":0.9900000095367432},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.7580000162124634},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9879999756813049},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6209999918937683},{"id":"https://openalex.org/keywords/once-daily-dosing","display_name":"once-daily dosing","score":0.75},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.6330000162124634},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C2779838083","wikidata":"https://www.wikidata.org/wiki/Q414904","display_name":"Aliskiren","level":4,"score":0.9963951110839844},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.8097292184829712},{"id":"https://openalex.org/C2777425892","wikidata":"https://www.wikidata.org/wiki/Q409255","display_name":"Renin inhibitor","level":4,"score":0.7684351205825806},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5638743042945862},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.4881065785884857},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4049844443798065},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40047571063041687},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3894835114479065},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3422279953956604},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.11346036195755005}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:kup.at:8672","doi":null,"is_oa":true,"landing_page_url":"http://www.kup.at/kup/pdf/8672.pdf","pdf_url":"http://www.kup.at/kup/pdf/8672.pdf","source":{"id":"https://openalex.org/S4306402201","display_name":"Journal f\u00fcr Kardiologie (Krause & Pachernegg GmbH)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"application/pdf"},{"id":"mag:1601733154","doi":null,"is_oa":false,"landing_page_url":"https://www.kup.at/kup/pdf/8672.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764597451","display_name":"Journal f\u00fcr Hypertonie","issn_l":"1028-2327","issn":["1028-2327"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal fu\u0308r Hypertonie","raw_type":null}],"best_oa_location":{"id":"pmh:oai:kup.at:8672","doi":null,"is_oa":true,"landing_page_url":"http://www.kup.at/kup/pdf/8672.pdf","pdf_url":"http://www.kup.at/kup/pdf/8672.pdf","source":{"id":"https://openalex.org/S4306402201","display_name":"Journal f\u00fcr Kardiologie (Krause & Pachernegg GmbH)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"application/pdf"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1601733154.pdf","grobid_xml":"https://content.openalex.org/works/W1601733154.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W14674810","https://openalex.org/W1975603373","https://openalex.org/W1994199177","https://openalex.org/W2007772636","https://openalex.org/W2015569360","https://openalex.org/W2026881482","https://openalex.org/W2027617419","https://openalex.org/W2044773944","https://openalex.org/W2051801861","https://openalex.org/W2055123579","https://openalex.org/W2055420779","https://openalex.org/W2055451981","https://openalex.org/W2056893352","https://openalex.org/W2056976690","https://openalex.org/W2061170043","https://openalex.org/W2063624516","https://openalex.org/W2077362814","https://openalex.org/W2085927807","https://openalex.org/W2118772456","https://openalex.org/W2119869567","https://openalex.org/W2121754021","https://openalex.org/W2122340355","https://openalex.org/W2145632481","https://openalex.org/W2148232557","https://openalex.org/W2151295696","https://openalex.org/W2166710642","https://openalex.org/W2313231090","https://openalex.org/W2313938778","https://openalex.org/W2318134107","https://openalex.org/W2327763895","https://openalex.org/W2469805673","https://openalex.org/W2585382523","https://openalex.org/W2615684303","https://openalex.org/W4320300920"],"related_works":["https://openalex.org/W2315337330","https://openalex.org/W2352160378","https://openalex.org/W2068190346","https://openalex.org/W2106285152","https://openalex.org/W2417777944","https://openalex.org/W2138386879","https://openalex.org/W2018441116","https://openalex.org/W2031278591","https://openalex.org/W2086448255","https://openalex.org/W2389396840"],"abstract_inverted_index":{"Der":[0],"direkte":[1],"Renininhibitor":[2],"Aliskiren":[3,16,44,90,135],"ist":[4,147],"seit":[5],"10":[6],"Jahren":[7],"die":[8,47,58,71,126],"erste":[9],"antihypertensive":[10],"Substanz":[11],"mit":[12,81,87,144],"einem":[13],"neuen":[14],"Wirkansatz.":[15],"greift":[17],"wie":[18],"ACE-Hemmer":[19],"und":[20,51,53,83,114],"Angiotensinrezeptorblocker":[21],"in":[22,94,99,137],"das":[23,106,142],"Renin-Angiotensin-System":[24],"(RAS)":[25],"ein,":[26],"hemmt":[27],"dieses":[28],"aber":[29],"im":[30],"Unterschied":[31],"zu":[32,111],"beiden":[33],"etablierten":[34],"Substanzgruppen":[35],"bereits":[36,77],"an":[37],"seinem":[38],"Ursprung,":[39],"dem":[40,74],"Renin.":[41],"Dadurch":[42],"senkt":[43],"nicht":[45],"nur":[46],"Spiegel":[48],"von":[49,134],"Angiotensin-I":[50],"-II":[52],"den":[54],"Aldosteronspiegel,":[55],"sondern":[56],"auch":[57,98],"Plasmareninaktivit\u00e4t":[59],"(PRA).":[60],"Durch":[61],"diesen":[62],"Umstand":[63],"erhofft":[64],"man":[65],"sich":[66,92],"zus\u00e4tzliche":[67],"organprotektive":[68],"Effekte,":[69],"f\u00fcr":[70],"es":[72],"aus":[73],"kardiorenalen":[75],"Studienprogramm":[76],"Hinweise":[78],"bei":[79,84,107],"Patienten":[80],"Herzinsuffizienz":[82],"hypertensiven":[85],"Diabetikern":[86],"Nephropathie":[88],"gibt.":[89],"hat":[91],"sowohl":[93],"der":[95,100],"Mono-":[96],"als":[97,102],"Kombinationstherapie":[101],"wirksames":[103],"Antihypertensivum":[104],"erwiesen,":[105],"einmal":[108,124],"t\u00e4glicher":[109],"Gabe":[110],"einer":[112,128],"starken":[113],"anhaltenden":[115],"Blutdrucksenkung":[116],"f\u00fchrt.":[117],"Die":[118,132],"lange":[119],"Wirkdauer":[120],"verzeiht":[121],"auch,":[122],"wenn":[123],"auf":[125,140],"Einnahme":[127],"Tablette":[129],"vergessen":[130],"wird.":[131],"Nebenwirkungsrate":[133],"lag":[136],"bisherigen":[138],"Studien":[139],"Placeboniveau,":[141],"Interaktionspotenzial":[143],"anderen":[145],"Medikamenten":[146],"gering.":[148]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}