{"id":"https://openalex.org/W16014603","doi":null,"title":"Novel Methodology for the Synthesis of Isoindole Derived Heterocycles","display_name":"Novel Methodology for the Synthesis of Isoindole Derived Heterocycles","publication_year":2014,"publication_date":"2014-06-06","ids":{"openalex":"https://openalex.org/W16014603","mag":"16014603"},"language":"en","primary_location":{"id":"pmh:oai:opus.bath.ac.uk:39676","doi":null,"is_oa":false,"landing_page_url":"http://opus.bath.ac.uk/39676/1/L_Peacock_Thesis.pdf","pdf_url":"http://opus.bath.ac.uk/39676/1/L_Peacock_Thesis.pdf","source":{"id":"https://openalex.org/S4306401631","display_name":"The University of Bath Online Publications Store (The University of Bath)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I51601045","host_organization_name":"University of Bath","host_organization_lineage":["https://openalex.org/I51601045"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077169075","display_name":"Lucy R. Peacock","orcid":"https://orcid.org/0000-0002-2873-9849","observed_orcids":["https://orcid.org/0000-0002-2873-9849"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lucy R. Peacock","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5077169075"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12973","display_name":"Synthesis of Indole Derivatives","score":0.16169999539852142,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12973","display_name":"Synthesis of Indole Derivatives","score":0.16169999539852142,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13208","display_name":"Synthesis of heterocyclic compounds","score":0.1477999985218048,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.09799999743700027,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitrone-synthesis","display_name":"nitrone synthesis","score":0.8479999899864197},{"id":"https://openalex.org/keywords/conjugate-addition","display_name":"conjugate addition","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cyclization","display_name":"cyclization","score":0.7760000228881836},{"id":"https://openalex.org/keywords/hydroxylamine","display_name":"hydroxylamine","score":0.8920000195503235},{"id":"https://openalex.org/keywords/alpha-beta-unsaturated-esters","display_name":"\u03b1,\u03b2-unsaturated esters","score":0.8500000238418579},{"id":"https://openalex.org/keywords/reaction-mechanism","display_name":"reaction mechanism","score":0.9049999713897705},{"id":"https://openalex.org/keywords/1-3-dipolar-cycloaddition","display_name":"1,3-dipolar cycloaddition","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tert-butyl-acrylate","display_name":"tert-butyl acrylate","score":0.9190000295639038},{"id":"https://openalex.org/keywords/diels-alder-reaction","display_name":"Diels-Alder reaction","score":0.8889999985694885},{"id":"https://openalex.org/keywords/substituted-naphthalenes","display_name":"substituted naphthalenes","score":0.8790000081062317},{"id":"https://openalex.org/keywords/heterocycle-synthesis","display_name":"heterocyclic synthesis","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C2779440280","wikidata":"https://www.wikidata.org/wiki/Q415778","display_name":"Nitrone","level":4,"score":0.90982985496521},{"id":"https://openalex.org/C2776356293","wikidata":"https://www.wikidata.org/wiki/Q760735","display_name":"Isoindole","level":2,"score":0.8129274845123291},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6148689985275269},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.467628538608551},{"id":"https://openalex.org/C2775999725","wikidata":"https://www.wikidata.org/wiki/Q259997","display_name":"Hydroxylamine","level":2,"score":0.4531288146972656},{"id":"https://openalex.org/C111233374","wikidata":"https://www.wikidata.org/wiki/Q334640","display_name":"Tautomer","level":2,"score":0.4475991725921631},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.428881973028183},{"id":"https://openalex.org/C2779664164","wikidata":"https://www.wikidata.org/wiki/Q898648","display_name":"Cycloaddition","level":3,"score":0.42655766010284424},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3942180573940277},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3238247036933899},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.13483238220214844},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.06880611181259155},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:opus.bath.ac.uk:39676","doi":null,"is_oa":false,"landing_page_url":"http://opus.bath.ac.uk/39676/1/L_Peacock_Thesis.pdf","pdf_url":"http://opus.bath.ac.uk/39676/1/L_Peacock_Thesis.pdf","source":{"id":"https://openalex.org/S4306401631","display_name":"The University of Bath Online Publications Store (The University of Bath)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I51601045","host_organization_name":"University of Bath","host_organization_lineage":["https://openalex.org/I51601045"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:16014603","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.629658","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1964731923","https://openalex.org/W2951768156","https://openalex.org/W2950350948","https://openalex.org/W4308982003","https://openalex.org/W2161239479","https://openalex.org/W1938043588","https://openalex.org/W2042838640","https://openalex.org/W135212829","https://openalex.org/W2950806404","https://openalex.org/W2580960312"],"abstract_inverted_index":{"This":[0],"thesis":[1,264],"presents":[2],"research":[3],"into":[4,203],"the":[5,13,24,37,43,63,105,110,116,126,142,168,173,185,204,222,225,266,269,283],"development":[6],"of":[7,15,23,36,40,48,57,104,141,167,172,179,206,215,262,268,285],"a":[8,21,34,87,136,148,163,197,231,248,254,279],"novel":[9,280],"conjugate-addition/cyclisation":[10,79,145],"methodology":[11],"for":[12,27,45,282],"synthesis":[14,56,284],"isoindole":[16,53,181,207,236],"derived":[17,182,194,208],"nitrones.":[18,183],"To":[19],"begin,":[20],"review":[22],"principle":[25],"methods":[26],"synthesising":[28],"nitrones":[29,41,49,195,209],"is":[30,74,119,210],"reported,":[31],"followed":[32],"by":[33,98,253],"discussion":[35,103],"current":[38],"uses":[39],"and":[42,71,113,170,196,275],"requirement":[44],"straightforward":[46],"syntheses":[47],"contained":[50],"within":[51],"an":[52,58,68,276],"scaffold.":[54],"The":[55,77,259],"aryl":[59],"cyclisation":[60,189],"substrate":[61,150,226],"possessing":[62],"key":[64],"ortho-":[65],"relationship":[66],"between":[67,273],"alpha,beta-unsaturated":[69],"ester":[70],"formyl":[72],"group":[73],"then":[75,211],"described.":[76],"planned":[78],"reaction":[80,117,176,242,272],"using":[81],"hydroxylamine":[82,250],"was":[83,95,128],"carried":[84],"to":[85,91,108,114,130,135,147,158,187,221],"afford":[86],"different":[88],"nitrone":[89,123,174,274],"structure":[90,112],"that":[92,224],"expected,":[93],"which":[94],"later":[96],"confirmed":[97],"X-ray":[99],"crystallography.":[100],"A":[101,121],"full":[102],"work":[106],"undertaken":[107],"elucidate":[109],"compound":[111],"probe":[115],"mechanism":[118,161],"reported.":[120],"monocyclic":[122,154],"reported":[124],"in":[125],"literature":[127],"thought":[129],"have":[131],"been":[132],"synthesised":[133,252],"according":[134],"1,3-azaprotio":[137],"cyclotransfer":[138],"mechanism.":[139],"Application":[140],"newly":[143],"discovered":[144],"protocol":[146,186],"linear":[149],"successfully":[151],"afforded":[152,177,191,247],"this":[153,263],"nitrone,":[155,232],"leading":[156],"us":[157],"propose":[159],"our":[160],"as":[162,230,234,278],"plausible":[164],"alternative.":[165],"Exploration":[166],"scope":[169],"limitation":[171],"forming":[175],"total":[178],"fourteen":[180],"Applying":[184],"modified":[188],"substrates":[190],"five":[192],"dihydroisoquinoline":[193],"bicyclic":[198],"hydroxamic":[199],"acid":[200],"also.":[201],"Research":[202],"reactivity":[205],"presented.":[212],"Varying":[213],"degrees":[214],"success":[216],"were":[217],"obtained,":[218],"largely":[219],"due":[220],"fact":[223],"does":[227],"not":[228],"react":[229],"but":[233],"its":[235],"tautomer.":[237],"An":[238],"attempted":[239],"1,3-dipolar":[240],"cycloaddition":[241,257,271],"with":[243],"tert-butyl":[244],"acrylate":[245],"instead":[246],"bridged":[249],"product,":[251],"[4+2]":[255,270],"Diels-Alder":[256],"reaction.":[258],"final":[260],"part":[261],"reports":[265],"application":[267],"alkyne":[277],"route":[281],"substituted":[286],"naphthalenes.":[287]},"counts_by_year":[],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2016-06-24T00:00:00"}
