{"id":"https://openalex.org/W1601088787","doi":"https://doi.org/10.4049/jimmunol.110.1.213","title":"Hapten-Specific Tolerance: Depressed Humoral and Normal Cellular Immune Responses","display_name":"Hapten-Specific Tolerance: Depressed Humoral and Normal Cellular Immune Responses","publication_year":1973,"publication_date":"1973-01-01","ids":{"openalex":"https://openalex.org/W1601088787","doi":"https://doi.org/10.4049/jimmunol.110.1.213","mag":"1601088787","pmid":"https://pubmed.ncbi.nlm.nih.gov/4539833"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.110.1.213","doi":"https://doi.org/10.4049/jimmunol.110.1.213","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.110.1.213","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037256279","display_name":"Benjamin E. Cohen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin E Cohen","raw_affiliation_strings":["Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, and Laboratory of Pathology, National Cancer Institute, National Institutes of Health , Bethesda, Maryland 20014","Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, and Laboratory of Pathology, National Cancer Institute, National Institutes of Health From the , Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, and Laboratory of Pathology, National Cancer Institute, National Institutes of Health , Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, and Laboratory of Pathology, National Cancer Institute, National Institutes of Health From the , Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109829740","display_name":"Joseph M. Davie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph M Davie","raw_affiliation_strings":["Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, and Laboratory of Pathology, National Cancer Institute, National Institutes of Health , Bethesda, Maryland 20014","Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, and Laboratory of Pathology, National Cancer Institute, National Institutes of Health From the , Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, and Laboratory of Pathology, National Cancer Institute, National Institutes of Health , Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, and Laboratory of Pathology, National Cancer Institute, National Institutes of Health From the , Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110180932","display_name":"William E. Paul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E Paul","raw_affiliation_strings":["Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, and Laboratory of Pathology, National Cancer Institute, National Institutes of Health , Bethesda, Maryland 20014","Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, and Laboratory of Pathology, National Cancer Institute, National Institutes of Health From the , Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, and Laboratory of Pathology, National Cancer Institute, National Institutes of Health , Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, and Laboratory of Pathology, National Cancer Institute, National Institutes of Health From the , Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.563,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.81120068,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"110","issue":"1","first_page":"213","last_page":"218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hapten-specific-tolerance","display_name":"hapten-specific tolerance","score":0.9890000224113464},{"id":"https://openalex.org/keywords/delayed-type-hypersensitivity","display_name":"delayed-type hypersensitivity","score":0.8619999885559082},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.8700000047683716},{"id":"https://openalex.org/keywords/thymidine-incorporation","display_name":"thymidine incorporation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/lymph-node-cells","display_name":"lymph node cells","score":0.5899999737739563},{"id":"https://openalex.org/keywords/immunoparalysis","display_name":"immunoparalysis","score":0.48500001430511475},{"id":"https://openalex.org/keywords/receptor-specificity","display_name":"receptor specificity","score":0.6269999742507935},{"id":"https://openalex.org/keywords/guinea-pig","display_name":"guinea pig","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C29144244","wikidata":"https://www.wikidata.org/wiki/Q506441","display_name":"Hapten","level":3,"score":0.7406520247459412},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7311095595359802},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5888171195983887},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.557031512260437},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5380129218101501},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5008537769317627},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.4537513554096222},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.44405853748321533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44080352783203125},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.4365845322608948},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3586770296096802},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3513493537902832},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23130375146865845}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000921","descriptor_name":"Antibody-Producing Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001666","descriptor_name":"Binding Sites, Antibody","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004140","descriptor_name":"Dinitrophenols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005971","descriptor_name":"Glutamates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006241","descriptor_name":"Haptens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006968","descriptor_name":"Hypersensitivity, Delayed","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007456","descriptor_name":"Iodine Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012882","descriptor_name":"Skin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.110.1.213","doi":"https://doi.org/10.4049/jimmunol.110.1.213","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.110.1.213","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:4539833","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4539833","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7100765549","https://openalex.org/W2056194756","https://openalex.org/W7099172143","https://openalex.org/W2133164292","https://openalex.org/W70022377","https://openalex.org/W1612149416","https://openalex.org/W2000337198","https://openalex.org/W2056418282","https://openalex.org/W4313339409","https://openalex.org/W1566294071"],"abstract_inverted_index":{"Abstract":[0],"A":[1],"profound":[2],"depression":[3,97],"of":[4,18,25,28,46,48,57,76,176],"the":[5,22,26,44,58,62,74,99,164],"anti-DNP":[6,49],"antibody":[7],"response":[8,101,113],"to":[9,66,69,114,136,150],"DNP-guinea":[10,105,115],"pig":[11,106,116],"albumin":[12],"(GPA)":[13],"is":[14,36,52,86],"induced":[15],"by":[16],"pretreatment":[17],"guinea":[19,155],"pigs":[20,156],"with":[21,91,104,131,158],"DNP":[23],"conjugate":[24],"copolymer":[27],"d-glutamic":[29],"acid":[30],"and":[31,38,179],"d-lysine":[32],"(DNP-d-GL).":[33],"This":[34],"tolerance":[35,59],"hapten-specific":[37],"previous":[39],"studies":[40,161],"have":[41],"indicated":[42],"that":[43,88,166],"number":[45],"precursors":[47,75,175],"antibody-secreting":[50,77,177],"cells":[51,78,121,137,178,182],"diminished":[53],"as":[54],"a":[55,95,109,167],"result":[56],"induction.":[60],"Thus,":[61,142],"tolerant":[63],"state":[64],"appears":[65],"be":[67],"due":[68],"an":[70],"immune":[71,140,144,186],"paralysis":[72],"within":[73],"(bone":[79],"marrow-derived":[80],"cells).":[81],"In":[82],"this":[83],"study,":[84],"it":[85],"shown":[87],"animals":[89,124],"tolerized":[90,123],"DNP-d-GL,":[92],"although":[93],"manifesting":[94],"marked":[96],"in":[98,133,154,184],"humoral":[100],"after":[102],"immunization":[103],"albumin,":[107],"display":[108],"normal":[110,139,153],"delayed":[111],"hypersensitivity":[112],"albumin.":[117],"Furthermore,":[118],"lymph":[119],"node":[120],"from":[122,138],"incorporate":[125],"thymidine":[126],"into":[127],"DNA":[128],"when":[129],"stimulated":[130],"antigen":[132],"amounts":[134],"equivalent":[135],"animals.":[141],"cellular":[143,185],"responses":[145],"(thymus-derived":[146],"cell":[147],"mediated":[148],"functions)":[149],"DNP-GPA":[151],"are":[152],"pretreated":[157],"DNP-d-GL.":[159],"These":[160],"strongly":[162],"reinforce":[163],"concept":[165],"basic":[168],"specificity":[169],"distinction":[170],"exists":[171],"between":[172],"receptors":[173],"on":[174,181],"those":[180],"participating":[183],"responses.":[187]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
