{"id":"https://openalex.org/W160068046","doi":null,"title":"Matrix metalloproteinase activity and glycosaminoglycans in chronic venous disease: the linkage among cell biology, pathology and translational research.","display_name":"Matrix metalloproteinase activity and glycosaminoglycans in chronic venous disease: the linkage among cell biology, pathology and translational research.","publication_year":2011,"publication_date":"2011-02-01","ids":{"openalex":"https://openalex.org/W160068046","mag":"160068046","pmid":"https://pubmed.ncbi.nlm.nih.gov/21416057","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3056561"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3056561","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3056561","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3056561","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059218162","display_name":"Ferdinando Mannello","orcid":"https://orcid.org/0000-0001-8112-6139","observed_orcids":["https://orcid.org/0000-0001-8112-6139"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ferdinando Mannello","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012715891","display_name":"J.D. Raffetto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph D Raffetto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.2909,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.95290026,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"3","issue":"2","first_page":"149","last_page":"58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11453","display_name":"Diagnosis and Treatment of Venous Diseases","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11453","display_name":"Diagnosis and Treatment of Venous Diseases","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-venous-disease","display_name":"chronic venous disease","score":0.9729999899864197},{"id":"https://openalex.org/keywords/varicose-veins","display_name":"varicose veins","score":0.871999979019165},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mmp-timp-balance","display_name":"MMP/TIMP balance","score":0.8320000171661377},{"id":"https://openalex.org/keywords/glycosaminoglycans","display_name":"glycosaminoglycans","score":0.9919999837875366},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.9279999732971191},{"id":"https://openalex.org/keywords/vascular-inflammation","display_name":"vascular inflammation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/leg-ulcers","display_name":"leg ulcers","score":0.7699999809265137},{"id":"https://openalex.org/keywords/collagen-and-elastin","display_name":"collagen and elastin","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C2777475103","wikidata":"https://www.wikidata.org/wiki/Q201180","display_name":"Varicose veins","level":2,"score":0.7812291383743286},{"id":"https://openalex.org/C2779869378","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Elastin","level":2,"score":0.7086679935455322},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6994192600250244},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.6745562553405762},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5477631688117981},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.501089334487915},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.48383036255836487},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.47492605447769165},{"id":"https://openalex.org/C2777202286","wikidata":"https://www.wikidata.org/wiki/Q9609","display_name":"Vein","level":2,"score":0.4531746506690979},{"id":"https://openalex.org/C2776106345","wikidata":"https://www.wikidata.org/wiki/Q1088042","display_name":"Chronic venous insufficiency","level":2,"score":0.4340737760066986},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3415567874908447},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2694510221481323},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2238495647907257},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.18037763237953186},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15882685780525208}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:3056561","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3056561","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"pmid:21416057","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21416057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"pmh:oai:ora.uniurb.it:11576/2528774","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11576/2528774","pdf_url":null,"source":{"id":"https://openalex.org/S4377196377","display_name":"CINECA IRIS Institutional Research information system (University of Urbino)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I190397597","host_organization_name":"University of Urbino","host_organization_lineage":["https://openalex.org/I190397597"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:160068046","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21416057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3056561","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3056561","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W66574086","https://openalex.org/W88714683","https://openalex.org/W88922837","https://openalex.org/W309980051","https://openalex.org/W1481506630","https://openalex.org/W1523254950","https://openalex.org/W1563393647","https://openalex.org/W1588625112","https://openalex.org/W1608390647","https://openalex.org/W1919519471","https://openalex.org/W1963595488","https://openalex.org/W1967232207","https://openalex.org/W1969293717","https://openalex.org/W1973692647","https://openalex.org/W1975401446","https://openalex.org/W1976343520","https://openalex.org/W1980363157","https://openalex.org/W1984865543","https://openalex.org/W1987292245","https://openalex.org/W1988125891","https://openalex.org/W1988908776","https://openalex.org/W1990653503","https://openalex.org/W1993357017","https://openalex.org/W1996399843","https://openalex.org/W1997077559","https://openalex.org/W1997412930","https://openalex.org/W1997826997","https://openalex.org/W2001922497","https://openalex.org/W2005220614","https://openalex.org/W2007732720","https://openalex.org/W2009548691","https://openalex.org/W2009581835","https://openalex.org/W2013322971","https://openalex.org/W2015262545","https://openalex.org/W2015291456","https://openalex.org/W2021319806","https://openalex.org/W2022238493","https://openalex.org/W2026186036","https://openalex.org/W2033002781","https://openalex.org/W2033996199","https://openalex.org/W2036004839","https://openalex.org/W2039536419","https://openalex.org/W2045005706","https://openalex.org/W2052490255","https://openalex.org/W2053043355","https://openalex.org/W2056119618","https://openalex.org/W2061992885","https://openalex.org/W2062982081","https://openalex.org/W2063025997","https://openalex.org/W2064944758","https://openalex.org/W2069559840","https://openalex.org/W2072451870","https://openalex.org/W2074317540","https://openalex.org/W2079757313","https://openalex.org/W2081469880","https://openalex.org/W2087509954","https://openalex.org/W2090162584","https://openalex.org/W2093979559","https://openalex.org/W2095167161","https://openalex.org/W2095371179","https://openalex.org/W2095422692","https://openalex.org/W2095506460","https://openalex.org/W2097539919","https://openalex.org/W2100496955","https://openalex.org/W2118196531","https://openalex.org/W2120630138","https://openalex.org/W2128065213","https://openalex.org/W2130611882","https://openalex.org/W2136362394","https://openalex.org/W2140032703","https://openalex.org/W2140779700","https://openalex.org/W2141209718","https://openalex.org/W2146631283","https://openalex.org/W2160615581","https://openalex.org/W2164412016","https://openalex.org/W2170888434","https://openalex.org/W2186508448","https://openalex.org/W2316976340","https://openalex.org/W2417780094","https://openalex.org/W2471901435","https://openalex.org/W2756918512"],"related_works":["https://openalex.org/W1963595488","https://openalex.org/W2241154923","https://openalex.org/W3182157019","https://openalex.org/W2776636584","https://openalex.org/W2301950756","https://openalex.org/W2016616010","https://openalex.org/W2600864533","https://openalex.org/W1922996316","https://openalex.org/W2140032703","https://openalex.org/W3029624741"],"abstract_inverted_index":{"Primary":[0],"chronic":[1],"venous":[2,16,66],"disease":[3],"(CVD)":[4],"is":[5,43],"an":[6,10],"inflammatory":[7],"pathology":[8],"involving":[9],"erratic":[11],"structural":[12],"remodeling":[13],"in":[14,51,60,77],"the":[15,23,36,45,78,104],"well":[17],"leading":[18],"to":[19,102,109,117],"vascular":[20,55],"incompetence":[21],"and":[22,32,54,62,71,83,88,111,121,125],"development":[24],"of":[25,39,47,65,80,92,106,127],"varicose":[26,40,81,107],"vein,":[27],"characterized":[28],"by":[29],"altered":[30],"collagen":[31],"elastin":[33],"content.":[34],"In":[35],"early":[37,61],"steps":[38],"vein":[41,82,108],"formation":[42],"crucial":[44],"role":[46],"MMP/TIMP":[48],"balance,":[49],"implicated":[50],"both":[52],"ECM":[53],"degradation":[56],"during":[57],"inflammation":[58],"processes":[59],"late":[63],"stages":[64],"diseases.":[67],"Although":[68],"several":[69],"pharmacological":[70],"surgical":[72],"strategies":[73],"are":[74],"being":[75],"utilized":[76],"management":[79],"CVD":[84,110],"with":[85],"variable":[86],"success":[87],"recurrence":[89],"rate,":[90],"inhibition":[91],"MMP":[93],"through":[94],"glycosaminoglycans":[95],"may":[96],"represent":[97],"a":[98],"novel":[99],"therapeutic":[100],"intervention":[101],"limit":[103],"progression":[105],"leg":[112],"ulceration,":[113],"suggesting":[114],"possible":[115],"opportunity":[116],"prevent":[118],"future":[119],"morbidity":[120],"enhancing":[122],"clinical":[123],"benefits":[124],"quality":[126],"life.":[128]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}