{"id":"https://openalex.org/W160053844","doi":null,"title":"MANIPULATION OF REGULATORY MYELOID CELL DIFFERENTIATION AND FUNCTION AND ITS THERAPEUTIC IMPLICATIONS","display_name":"MANIPULATION OF REGULATORY MYELOID CELL DIFFERENTIATION AND FUNCTION AND ITS THERAPEUTIC IMPLICATIONS","publication_year":2013,"publication_date":"2013-07-19","ids":{"openalex":"https://openalex.org/W160053844","mag":"160053844"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:19368","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/19368/1/ROSBOROUGH_ETD2013.pdf","pdf_url":"http://d-scholarship.pitt.edu/19368/1/ROSBOROUGH_ETD2013.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/19368/1/ROSBOROUGH_ETD2013.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039438470","display_name":"Brian R. Rosborough","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Brian Rosborough","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5039438470"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01402344,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.4708999991416931,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.4708999991416931,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.3783999979496002,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.024700000882148743,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/organ-transplantation","display_name":"organ transplantation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/allograft-rejection","display_name":"allograft rejection","score":0.8510000109672546},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.8939999938011169},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9890000224113464},{"id":"https://openalex.org/keywords/flt3-ligand","display_name":"Flt3 ligand","score":0.9900000095367432},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9440000057220459},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.9649999737739563},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.6669999957084656},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6207278370857239},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5797306299209595},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5607556104660034},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5376317501068115},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5166778564453125},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.5128229260444641},{"id":"https://openalex.org/C55721878","wikidata":"https://www.wikidata.org/wiki/Q15220362","display_name":"Myeloid-derived Suppressor Cell","level":4,"score":0.49106359481811523},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.4812152683734894},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.41879206895828247},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3949967622756958},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35909807682037354},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19539687037467957},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.10475349426269531},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07949867844581604}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:19368","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/19368/1/ROSBOROUGH_ETD2013.pdf","pdf_url":"http://d-scholarship.pitt.edu/19368/1/ROSBOROUGH_ETD2013.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:160053844","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/19368/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:19368","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/19368/1/ROSBOROUGH_ETD2013.pdf","pdf_url":"http://d-scholarship.pitt.edu/19368/1/ROSBOROUGH_ETD2013.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W160053844.pdf","grobid_xml":"https://content.openalex.org/works/W160053844.grobid-xml"},"referenced_works_count":221,"referenced_works":["https://openalex.org/W78744612","https://openalex.org/W193748226","https://openalex.org/W768435811","https://openalex.org/W1489480103","https://openalex.org/W1494453913","https://openalex.org/W1520072576","https://openalex.org/W1521357129","https://openalex.org/W1526617084","https://openalex.org/W1536028944","https://openalex.org/W1561121245","https://openalex.org/W1568317937","https://openalex.org/W1574881121","https://openalex.org/W1584203472","https://openalex.org/W1585754595","https://openalex.org/W1661544713","https://openalex.org/W1740009701","https://openalex.org/W1788753937","https://openalex.org/W1847326477","https://openalex.org/W1875254393","https://openalex.org/W1877245175","https://openalex.org/W1888919129","https://openalex.org/W1905007654","https://openalex.org/W1907062065","https://openalex.org/W1913322240","https://openalex.org/W1918052238","https://openalex.org/W1919712230","https://openalex.org/W1931877212","https://openalex.org/W1933912253","https://openalex.org/W1947199545","https://openalex.org/W1960585934","https://openalex.org/W1966577330","https://openalex.org/W1967994686","https://openalex.org/W1968306285","https://openalex.org/W1969061377","https://openalex.org/W1971278669","https://openalex.org/W1971789451","https://openalex.org/W1972363513","https://openalex.org/W1972486638","https://openalex.org/W1972544648","https://openalex.org/W1974706491","https://openalex.org/W1975907987","https://openalex.org/W1976979132","https://openalex.org/W1978883524","https://openalex.org/W1986957385","https://openalex.org/W1987060272","https://openalex.org/W1987481383","https://openalex.org/W1987618029","https://openalex.org/W1989472173","https://openalex.org/W1989673842","https://openalex.org/W1992439632","https://openalex.org/W1995232616","https://openalex.org/W1997553523","https://openalex.org/W1997561905","https://openalex.org/W1997708871","https://openalex.org/W1998511171","https://openalex.org/W2008450208","https://openalex.org/W2008926857","https://openalex.org/W2010665897","https://openalex.org/W2011435677","https://openalex.org/W2012053514","https://openalex.org/W2012405690","https://openalex.org/W2013057057","https://openalex.org/W2015036988","https://openalex.org/W2016983859","https://openalex.org/W2018252938","https://openalex.org/W2020920210","https://openalex.org/W2022380404","https://openalex.org/W2022682404","https://openalex.org/W2023495487","https://openalex.org/W2023618871","https://openalex.org/W2025635725","https://openalex.org/W2026578487","https://openalex.org/W2028298372","https://openalex.org/W2031603575","https://openalex.org/W2032724602","https://openalex.org/W2034892461","https://openalex.org/W2035456945","https://openalex.org/W2036735368","https://openalex.org/W2038254594","https://openalex.org/W2039146285","https://openalex.org/W2040793402","https://openalex.org/W2041168245","https://openalex.org/W2042851093","https://openalex.org/W2044311801","https://openalex.org/W2046739604","https://openalex.org/W2046768931","https://openalex.org/W2047526240","https://openalex.org/W2050700127","https://openalex.org/W2051083170","https://openalex.org/W2052665644","https://openalex.org/W2053583666","https://openalex.org/W2053601970","https://openalex.org/W2053782627","https://openalex.org/W2054246680","https://openalex.org/W2055061133","https://openalex.org/W2056461632","https://openalex.org/W2056721231","https://openalex.org/W2057499380","https://openalex.org/W2058781233","https://openalex.org/W2059423024","https://openalex.org/W2059604791","https://openalex.org/W2060672294","https://openalex.org/W2061568638","https://openalex.org/W2062029576","https://openalex.org/W2062254683","https://openalex.org/W2063013559","https://openalex.org/W2063565113","https://openalex.org/W2063680739","https://openalex.org/W2065086280","https://openalex.org/W2065720111","https://openalex.org/W2066761700","https://openalex.org/W2069089745","https://openalex.org/W2069109607","https://openalex.org/W2070437897","https://openalex.org/W2070968699","https://openalex.org/W2071688942","https://openalex.org/W2072769860","https://openalex.org/W2072845025","https://openalex.org/W2073694191","https://openalex.org/W2075420367","https://openalex.org/W2075819066","https://openalex.org/W2076610281","https://openalex.org/W2076936113","https://openalex.org/W2078450673","https://openalex.org/W2079822769","https://openalex.org/W2081522241","https://openalex.org/W2087013294","https://openalex.org/W2087143957","https://openalex.org/W2089327657","https://openalex.org/W2090648684","https://openalex.org/W2090672759","https://openalex.org/W2090685407","https://openalex.org/W2093442991","https://openalex.org/W2093943334","https://openalex.org/W2094941596","https://openalex.org/W2094991897","https://openalex.org/W2095083502","https://openalex.org/W2095482125","https://openalex.org/W2096340973","https://openalex.org/W2097998083","https://openalex.org/W2100446366","https://openalex.org/W2102689053","https://openalex.org/W2103748070","https://openalex.org/W2106274007","https://openalex.org/W2106684817","https://openalex.org/W2106900373","https://openalex.org/W2107130188","https://openalex.org/W2107152905","https://openalex.org/W2107752337","https://openalex.org/W2108639843","https://openalex.org/W2108933323","https://openalex.org/W2109305602","https://openalex.org/W2109424201","https://openalex.org/W2112227887","https://openalex.org/W2113393768","https://openalex.org/W2115889659","https://openalex.org/W2116013738","https://openalex.org/W2116705704","https://openalex.org/W2117576368","https://openalex.org/W2118471749","https://openalex.org/W2118537722","https://openalex.org/W2123639873","https://openalex.org/W2123900004","https://openalex.org/W2124927041","https://openalex.org/W2126099199","https://openalex.org/W2126747080","https://openalex.org/W2127407773","https://openalex.org/W2128957395","https://openalex.org/W2132929600","https://openalex.org/W2134138119","https://openalex.org/W2134421457","https://openalex.org/W2134677648","https://openalex.org/W2134719928","https://openalex.org/W2138170994","https://openalex.org/W2138807559","https://openalex.org/W2138997493","https://openalex.org/W2141272060","https://openalex.org/W2141383323","https://openalex.org/W2141615498","https://openalex.org/W2141880432","https://openalex.org/W2143300196","https://openalex.org/W2144156694","https://openalex.org/W2144700815","https://openalex.org/W2146437446","https://openalex.org/W2146749592","https://openalex.org/W2148044949","https://openalex.org/W2148139455","https://openalex.org/W2148369910","https://openalex.org/W2149912273","https://openalex.org/W2150780552","https://openalex.org/W2151551667","https://openalex.org/W2151940597","https://openalex.org/W2152345008","https://openalex.org/W2153410053","https://openalex.org/W2153550772","https://openalex.org/W2154755100","https://openalex.org/W2154836325","https://openalex.org/W2155402153","https://openalex.org/W2155792963","https://openalex.org/W2156831625","https://openalex.org/W2156915900","https://openalex.org/W2157633798","https://openalex.org/W2160245658","https://openalex.org/W2160390319","https://openalex.org/W2161354474","https://openalex.org/W2161792071","https://openalex.org/W2163825883","https://openalex.org/W2163984243","https://openalex.org/W2165028688","https://openalex.org/W2166584906","https://openalex.org/W2167889476","https://openalex.org/W2168478794","https://openalex.org/W2168577269","https://openalex.org/W2168595347","https://openalex.org/W2170240282","https://openalex.org/W2170264508","https://openalex.org/W2170390714","https://openalex.org/W2172845396","https://openalex.org/W2187986743","https://openalex.org/W2275872217","https://openalex.org/W2400110439"],"related_works":["https://openalex.org/W1991711981","https://openalex.org/W2064511268","https://openalex.org/W2886874101","https://openalex.org/W2116705704","https://openalex.org/W2782456453","https://openalex.org/W2921354001","https://openalex.org/W2790188328","https://openalex.org/W2009244095","https://openalex.org/W2544842693","https://openalex.org/W3097322956"],"abstract_inverted_index":{"Organ":[0],"transplantation":[1,315],"is":[2,214,275,329],"the":[3,69,179,190,242,250,292],"definitive":[4],"treatment":[5],"for":[6,291],"end-stage":[7],"organ":[8,314],"diseases":[9],"that":[10,97,118,142,160,189,265,287,336],"are":[11,77,93,102,139],"otherwise":[12],"untreatable.":[13],"Modern":[14],"immunosuppressants":[15],"have":[16,61],"largely":[17],"subverted":[18],"acute":[19],"allograft":[20,205],"rejection":[21,206],"through":[22],"non-specific":[23],"inhibition":[24,225,298],"of":[25,40,48,128,178,200,203,218,228,245,249,253,270,294,299,323],"T":[26],"cell":[27,145,221,325],"activation":[28,199],"and":[29,43,72,88,101,125,148,170,198,273,284,297,317,327],"proliferation;":[30],"however,":[31],"chronic":[32,58],"immunosuppression":[33],"with":[34],"current":[35],"therapies":[36,66],"carries":[37],"increased":[38],"risks":[39],"malignancy,":[41],"infection":[42],"drug-associated":[44],"toxicities.":[45],"Furthermore,":[46],"rates":[47],"long-term":[49,74],"graft":[50,75],"failure,":[51],"mediated":[52],"at":[53],"least":[54],"in":[55,185,256],"part":[56],"by":[57],"alloimmune":[59],"responses,":[60],"not":[62],"improved":[63],"significantly.":[64],"New":[65],"to":[67,105,122,176,209,308,333,339],"modify":[68],"immune":[70,95,107,334],"system":[71],"promote":[73,106,123,143,162],"survival":[76],"urgently":[78],"needed.":[79],"Myeloid":[80],"lineage":[81],"antigen-presenting":[82],"cells,":[83],"including":[84],"dendritic":[85],"cells":[86,91,96],"(DC)":[87],"myeloid-derived":[89],"suppressor":[90],"(MDSC),":[92],"innate":[94],"regulate":[98],"antigen-specific":[99],"immunity":[100],"valuable":[103],"targets":[104],"modulation.":[108],"In":[109,174,277],"this":[110,186],"dissertation,":[111],"I":[112],"present":[113],"data":[114,157,183,280],"on":[115],"three":[116],"pathways":[117,286],"can":[119,288],"be":[120,289,306],"modulated":[121],"expansion":[124,197,222,227,296],"immunosuppressive":[126,341],"function":[127,328],"MDSC":[129,164,201,234,295],"or":[130],"downregulate":[131],"DC":[132,168,230,257,268,300],"immunostimulatory":[133,229],"function.":[134,302],"Histone":[135],"deacetylase":[136],"inhibitors":[137],"(HDACi)":[138],"anti-neoplastic":[140],"agents":[141],"tumor":[144],"growth":[146,282],"arrest":[147],"apoptosis.":[149],"Recent":[150],"findings":[151,311],"describe":[152,281],"novel":[153,261],"anti-inflammatory":[154,271],"properties.":[155],"The":[156],"presented":[158,184],"demonstrate":[159,188],"HDACi":[161],"GM-CSF-mediated":[163],"expansion,":[165,235],"while":[166],"impeding":[167],"differentiation":[169],"co-stimulatory":[171],"molecule":[172],"expression.":[173],"addition":[175],"modulation":[177,335],"GM-CSF":[180],"pathway,":[181],"new":[182,340],"thesis":[187],"DC-poietin":[191],"Flt3":[192],"ligand":[193],"(Flt3L)":[194],"also":[195],"promotes":[196,233],"capable":[202],"delaying":[204],"when":[207],"transferred":[208],"heart":[210],"transplant":[211],"recipients.":[212],"STAT3":[213,224],"a":[215],"pivotal":[216],"regulator":[217],"Flt3L-driven":[219],"myeloid":[220,324],"as":[223],"blocks":[226],"but":[231],"further":[232],"without":[236],"altering":[237],"their":[238,319],"suppressive":[239],"capacity.":[240],"Lastly,":[241],"immunoregulatory":[243],"role":[244],"newly-described":[246],"rapamycin-resistant":[247],"outputs":[248],"mammalian/mechanistic":[251],"Target":[252],"Rapamycin":[254],"(mTOR)":[255],"was":[258],"examined.":[259],"A":[260],"mTOR":[262],"signaling":[263,285],"pathway":[264],"negatively":[266],"regulates":[267],"expression":[269],"IL-10":[272],"B7-H1":[274],"described.":[276],"summary,":[278],"these":[279,310],"factor":[283],"manipulated":[290],"promotion":[293],"stimulatory":[301],"Future":[303],"studies":[304],"will":[305],"required":[307],"translate":[309],"into":[312],"relevant":[313],"models":[316],"develop":[318],"therapeutic":[320],"potential.":[321],"Manipulation":[322],"development":[326],"an":[330],"innovative":[331],"approach":[332],"may":[337],"lead":[338],"strategies.":[342]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
